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Neoplasms, Second Primary

MedGen UID:
88350
Concept ID:
C0085183
Neoplastic Process
Synonyms: Malignancies, Second; Malignancy, Second; Metachronous Neoplasm; Metachronous Neoplasms; Metachronous Second Primary Neoplasms; Neoplasm, Metachronous; Neoplasm, Second; Neoplasm, Second Primary; Neoplasms, Metachronous; Neoplasms, Metachronous Second Primary; Neoplasms, Second; Second Malignancies; Second Malignancy; Second Neoplasm; Second Neoplasms; Second Primary Neoplasm; Second Primary Neoplasms; Second Primary Neoplasms, Metachronous

Definition

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasms, Second Primary

Professional guidelines

PubMed

Chung A, Liedtke M
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Recent clinical studies

Etiology

Hawkins M, Bhatia S, Henderson TO, Nathan PC, Yan A, Teepen JC, Morton LM
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Ganser A, Heuser M
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Diagnosis

Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389
Shanmugalingam T, Bosco C, Ridley AJ, Van Hemelrijck M
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Therapy

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Prognosis

Thomas JW, Jamy O, Shah MV, Vachhani P, Go RS, Goyal G
Leuk Res 2022 Jan;112:106770. Epub 2021 Dec 9 doi: 10.1016/j.leukres.2021.106770. PMID: 34920340
Guan X, Wei R, Yang R, Lu Z, Liu E, Zhao Z, Chen H, Yang M, Liu Z, Jiang Z, Wang X
JAMA Netw Open 2021 Jan 4;4(1):e2031661. doi: 10.1001/jamanetworkopen.2020.31661. PMID: 33416884Free PMC Article
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
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Ginsberg RJ, Rubinstein LV
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Clinical prediction guides

Zhong Y, She Y, Deng J, Chen S, Wang T, Yang M, Ma M, Song Y, Qi H, Wang Y, Shi J, Wu C, Xie D, Chen C; Multi-omics Classifier for Pulmonary Nodules (MISSION) Collaborative Group
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Nenova I, Grudeva-Popova J
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Recent systematic reviews

Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Saleem K, Franz J, Klem ML, Yabes JG, Boyiadzis M, Jones JR, Shaikh N, Lontos K
Lancet Haematol 2022 Dec;9(12):e906-e918. Epub 2022 Oct 27 doi: 10.1016/S2352-3026(22)00289-7. PMID: 36354020
Corrie P, Meyer N, Berardi R, Guidoboni M, Schlueter M, Kolovos S, Macabeo B, Trouiller JB, Laramée P
Cancer Treat Rev 2022 Nov;110:102463. Epub 2022 Sep 6 doi: 10.1016/j.ctrv.2022.102463. PMID: 36099854
Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
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Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
CA Cancer J Clin 2016 Jan-Feb;66(1):43-73. Epub 2015 Dec 7 doi: 10.3322/caac.21319. PMID: 26641959

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