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Neoplasms, Second Primary

MedGen UID:
88350
Concept ID:
C0085183
Neoplastic Process
Synonyms: Malignancies, Second; Malignancy, Second; Metachronous Neoplasm; Metachronous Neoplasms; Metachronous Second Primary Neoplasms; Neoplasm, Metachronous; Neoplasm, Second; Neoplasm, Second Primary; Neoplasms, Metachronous; Neoplasms, Metachronous Second Primary; Neoplasms, Second; Second Malignancies; Second Malignancy; Second Neoplasm; Second Neoplasms; Second Primary Neoplasm; Second Primary Neoplasms; Second Primary Neoplasms, Metachronous

Definition

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasms, Second Primary

Professional guidelines

PubMed

Youlden DR, Roder DM, Walker R, Bradford NK, Aitken JF
J Adolesc Young Adult Oncol 2023 Aug;12(4):537-545. Epub 2022 Sep 30 doi: 10.1089/jayao.2022.0074. PMID: 36178981
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Chung A, Liedtke M
Best Pract Res Clin Haematol 2019 Mar;32(1):54-64. Epub 2019 Feb 8 doi: 10.1016/j.beha.2019.02.003. PMID: 30927976

Recent clinical studies

Etiology

Hawkins M, Bhatia S, Henderson TO, Nathan PC, Yan A, Teepen JC, Morton LM
Pediatr Clin North Am 2020 Dec;67(6):1135-1154. doi: 10.1016/j.pcl.2020.07.006. PMID: 33131538
Chung J, Sallman DA, Padron E
Best Pract Res Clin Haematol 2019 Mar;32(1):98-103. Epub 2019 Feb 19 doi: 10.1016/j.beha.2019.02.009. PMID: 30927980
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389
Lohmann D
Adv Exp Med Biol 2010;685:220-7. doi: 10.1007/978-1-4419-6448-9_21. PMID: 20687510

Diagnosis

Liu Y, Chu Y, Liu J, Ge X, Ding M, Li P, Liu F, Zhou X, Wang X
Ann Med 2023;55(2):2282652. Epub 2023 Nov 27 doi: 10.1080/07853890.2023.2282652. PMID: 38010751Free PMC Article
Kreinbrink PJ, Lewis LM, Redmond KP, Takiar V
Curr Treat Options Oncol 2022 Mar;23(3):295-310. Epub 2022 Feb 28 doi: 10.1007/s11864-021-00936-y. PMID: 35226310
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389
Koubková L, Hrstka R, Dobes P, Vojtesek B, Vyzula R
Klin Onkol 2014;27(1):11-7. doi: 10.14735/amko201411. PMID: 24635432

Therapy

Iwase T, Saji S, Iijima K, Higaki K, Ohtani S, Sato Y, Hozumi Y, Hasegawa Y, Yanagita Y, Takei H, Tanaka M, Masuoka H, Tanabe M, Egawa C, Komoike Y, Nakamura T, Ohtsu H, Mukai H
J Clin Oncol 2023 Jun 20;41(18):3329-3338. Epub 2023 Apr 20 doi: 10.1200/JCO.22.00577. PMID: 37079878
Morschhauser F, Nastoupil L, Feugier P, Schiano de Colella JM, Tilly H, Palomba ML, Bachy E, Fruchart C, Libby EN, Casasnovas RO, Flinn IW, Haioun C, Maisonneuve H, Ysebaert L, Bartlett NL, Bouabdallah K, Brice P, Ribrag V, Le Gouill S, Daguindau N, Guidez S, Pica GM, García-Sancho AM, López-Guillermo A, Larouche JF, Ando K, Gomes da Silva M, André M, Kalung W, Sehn LH, Izutsu K, Cartron G, Gkasiamis A, Crowe R, Xerri L, Fowler NH, Salles G
J Clin Oncol 2022 Oct 1;40(28):3239-3245. Epub 2022 Aug 10 doi: 10.1200/JCO.22.00843. PMID: 35947804Free PMC Article
Basch E, Schrag D, Henson S, Jansen J, Ginos B, Stover AM, Carr P, Spears PA, Jonsson M, Deal AM, Bennett AV, Thanarajasingam G, Rogak LJ, Reeve BB, Snyder C, Bruner D, Cella D, Kottschade LA, Perlmutter J, Geoghegan C, Samuel-Ryals CA, Given B, Mazza GL, Miller R, Strasser JF, Zylla DM, Weiss A, Blinder VS, Dueck AC
JAMA 2022 Jun 28;327(24):2413-2422. doi: 10.1001/jama.2022.9265. PMID: 35661856Free PMC Article
Jin J, Tang Y, Hu C, Jiang LM, Jiang J, Li N, Liu WY, Chen SL, Li S, Lu NN, Cai Y, Li YH, Zhu Y, Cheng GH, Zhang HY, Wang X, Zhu SY, Wang J, Li GF, Yang JL, Zhang K, Chi Y, Yang L, Zhou HT, Zhou AP, Zou SM, Fang H, Wang SL, Zhang HZ, Wang XS, Wei LC, Wang WL, Liu SX, Gao YH, Li YX
J Clin Oncol 2022 May 20;40(15):1681-1692. Epub 2022 Mar 9 doi: 10.1200/JCO.21.01667. PMID: 35263150Free PMC Article
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article

Prognosis

Guan X, Wei R, Yang R, Lu Z, Liu E, Zhao Z, Chen H, Yang M, Liu Z, Jiang Z, Wang X
JAMA Netw Open 2021 Jan 4;4(1):e2031661. doi: 10.1001/jamanetworkopen.2020.31661. PMID: 33416884Free PMC Article
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N
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Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E
N Engl J Med 2002 Oct 17;347(16):1227-32. doi: 10.1056/NEJMoa020989. PMID: 12393819
Ginsberg RJ, Rubinstein LV
Ann Thorac Surg 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. PMID: 7677489

Clinical prediction guides

Hou F, Cheng T, Yang CL, Sun XD, Yang ZX, Lv J, Liu C, Deng ZY
J Cancer Res Clin Oncol 2023 Oct;149(13):12379-12391. Epub 2023 Jul 12 doi: 10.1007/s00432-023-05135-w. PMID: 37436512
Zhong Y, She Y, Deng J, Chen S, Wang T, Yang M, Ma M, Song Y, Qi H, Wang Y, Shi J, Wu C, Xie D, Chen C; Multi-omics Classifier for Pulmonary Nodules (MISSION) Collaborative Group
Radiology 2022 Jan;302(1):200-211. Epub 2021 Oct 26 doi: 10.1148/radiol.2021210902. PMID: 34698568
Choi E, Sanyal N, Ding VY, Gardner RM, Aredo JV, Lee J, Wu JT, Hickey TP, Barrett B, Riley TL, Wilkens LR, Leung AN, Le Marchand L, Tammemägi MC, Hung RJ, Amos CI, Freedman ND, Cheng I, Wakelee HA, Han SS
J Natl Cancer Inst 2022 Jan 11;114(1):87-96. doi: 10.1093/jnci/djab138. PMID: 34255071Free PMC Article
Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article

Recent systematic reviews

Wang X, Zeng M, Ju X, Lin A, Zhou C, Shen J, Liu Z, Tang B, Cheng Q, Wang Y, Zhang J, Luo P
Br J Surg 2024 Jan 3;111(1) doi: 10.1093/bjs/znad377. PMID: 38055899
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Saleem K, Franz J, Klem ML, Yabes JG, Boyiadzis M, Jones JR, Shaikh N, Lontos K
Lancet Haematol 2022 Dec;9(12):e906-e918. Epub 2022 Oct 27 doi: 10.1016/S2352-3026(22)00289-7. PMID: 36354020
Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
J Clin Oncol 2016 Feb 20;34(6):611-35. Epub 2015 Dec 7 doi: 10.1200/JCO.2015.64.3809. PMID: 26644543
Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
CA Cancer J Clin 2016 Jan-Feb;66(1):43-73. Epub 2015 Dec 7 doi: 10.3322/caac.21319. PMID: 26641959

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