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Hepatitis E virus infection

MedGen UID:
88376
•Concept ID:
C0085293
•
Disease or Syndrome
Synonyms: Enterically Transmitted Non A, Non B Hepatitis; Enterically-Transmitted Non-A, Non-B Hepatitis; Epidemic Non A, Non B Hepatitis; Epidemic Non-A, Non-B Hepatitis; ET-NANBH; Hepatitides, Water-Borne; Hepatitis E; Hepatitis, Viral, Non-A, Non-B, Enterically-Transmitted; Hepatitis, Water Borne; Hepatitis, Water-Borne; Water-Borne Hepatitides; Water-Borne Hepatitis
SNOMED CT: Hepatitis E virus infection (7111000119109); Viral hepatitis E (7111000119109); Viral hepatitis type E (7111000119109); Hepatitis E (7111000119109)
 
Monarch Initiative: MONDO:0005788

Definition

Acute inflammation of the liver in humans; caused by hepatitis E virus, a non-enveloped single-stranded rna virus. Similar to hepatitis A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis E virus infection

Professional guidelines

PubMed

Screening, diagnosis and risks associated with Hepatitis E virus infection.
Lhomme S, Legrand-Abravanel F, Kamar N, Izopet J
Expert Rev Anti Infect Ther 2019 Jun;17(6):403-418. Epub 2019 May 13 doi: 10.1080/14787210.2019.1613889. PMID: 31082277
EASL Clinical Practice Guidelines on hepatitis E virus infection.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jun;68(6):1256-1271. Epub 2018 Mar 31 doi: 10.1016/j.jhep.2018.03.005. PMID: 29609832
Pathogenesis and treatment of hepatitis e virus infection.
Wedemeyer H, Pischke S, Manns MP
Gastroenterology 2012 May;142(6):1388-1397.e1. doi: 10.1053/j.gastro.2012.02.014. PMID: 22537448

Recent clinical studies

Etiology

Hepatitis E Virus Infection in Cancer Patients.
Chiu CY, Zhang HC, Westin J, Hosing C, Torres HA
Transplant Cell Ther 2022 Nov;28(11):788.e1-788.e5. Epub 2022 Aug 27 doi: 10.1016/j.jtct.2022.08.020. PMID: 36031077
Viral hepatitis and pregnancy.
Terrault NA, Levy MT, Cheung KW, Jourdain G
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):117-130. Epub 2020 Oct 12 doi: 10.1038/s41575-020-00361-w. PMID: 33046891
Epidemiology of hepatitis E virus infection.
Kasem A, Azeem K, Vlčková J, Zatloukalová S, Štěpánek L, Kyselý Z, Kollárová H
Epidemiol Mikrobiol Imunol 2019 Winter;68(4):176-182. PMID: 31914774
Hepatitis E virus infection.
Kamar N, Izopet J, Pavio N, Aggarwal R, Labrique A, Wedemeyer H, Dalton HR
Nat Rev Dis Primers 2017 Nov 16;3:17086. doi: 10.1038/nrdp.2017.86. PMID: 29154369
Hepatitis E virus: Infection beyond the liver?
Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Van der Eijk AA
J Hepatol 2017 May;66(5):1082-1095. Epub 2016 Nov 29 doi: 10.1016/j.jhep.2016.11.016. PMID: 27913223

Diagnosis

Screening, diagnosis and risks associated with Hepatitis E virus infection.
Lhomme S, Legrand-Abravanel F, Kamar N, Izopet J
Expert Rev Anti Infect Ther 2019 Jun;17(6):403-418. Epub 2019 May 13 doi: 10.1080/14787210.2019.1613889. PMID: 31082277
Hepatitis E virus infection.
Kamar N, Izopet J, Pavio N, Aggarwal R, Labrique A, Wedemeyer H, Dalton HR
Nat Rev Dis Primers 2017 Nov 16;3:17086. doi: 10.1038/nrdp.2017.86. PMID: 29154369
Hepatitis E virus infection.
Kamar N, Dalton HR, Abravanel F, Izopet J
Clin Microbiol Rev 2014 Jan;27(1):116-38. doi: 10.1128/CMR.00057-13. PMID: 24396139Free PMC Article
Hepatitis E virus infection.
Kamar N, Izopet J, Rostaing L
Curr Opin Gastroenterol 2013 May;29(3):271-8. doi: 10.1097/MOG.0b013e32835ff238. PMID: 23507918
Hepatitis E virus.
Khuroo MS, Khuroo MS
Curr Opin Infect Dis 2008 Oct;21(5):539-43. doi: 10.1097/QCO.0b013e32830ee08a. PMID: 18725805

Therapy

Viral hepatitis and pregnancy.
Terrault NA, Levy MT, Cheung KW, Jourdain G
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):117-130. Epub 2020 Oct 12 doi: 10.1038/s41575-020-00361-w. PMID: 33046891
Immunity against hepatitis E virus infection: Implications for therapy and vaccine development.
Hakim MS, Ikram A, Zhou J, Wang W, Peppelenbosch MP, Pan Q
Rev Med Virol 2018 Mar;28(2) Epub 2017 Dec 22 doi: 10.1002/rmv.1964. PMID: 29272060
Hepatitis E virus infection.
Kamar N, Izopet J, Pavio N, Aggarwal R, Labrique A, Wedemeyer H, Dalton HR
Nat Rev Dis Primers 2017 Nov 16;3:17086. doi: 10.1038/nrdp.2017.86. PMID: 29154369
Hepatitis E virus infection.
Kamar N, Izopet J, Rostaing L
Curr Opin Gastroenterol 2013 May;29(3):271-8. doi: 10.1097/MOG.0b013e32835ff238. PMID: 23507918
Hepatitis E virus.
Khuroo MS, Khuroo MS
Curr Opin Infect Dis 2008 Oct;21(5):539-43. doi: 10.1097/QCO.0b013e32830ee08a. PMID: 18725805

Prognosis

Janus kinase-inhibition modulates hepatitis E virus infection.
Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E
Antiviral Res 2023 Sep;217:105690. Epub 2023 Jul 28 doi: 10.1016/j.antiviral.2023.105690. PMID: 37517633
Viral hepatitis and pregnancy.
Terrault NA, Levy MT, Cheung KW, Jourdain G
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):117-130. Epub 2020 Oct 12 doi: 10.1038/s41575-020-00361-w. PMID: 33046891
Epidemiology of hepatitis E virus infection.
Kasem A, Azeem K, Vlčková J, Zatloukalová S, Štěpánek L, Kyselý Z, Kollárová H
Epidemiol Mikrobiol Imunol 2019 Winter;68(4):176-182. PMID: 31914774
Risk factors for hepatitis E virus infection and disease.
Kmush BL, Nelson KE, Labrique AB
Expert Rev Anti Infect Ther 2015 Jan;13(1):41-53. Epub 2014 Nov 15 doi: 10.1586/14787210.2015.981158. PMID: 25399510
Immunopathogenesis of hepatitis E virus infection.
Wedemeyer H, Rybczynska J, Pischke S, Krawczynski K
Semin Liver Dis 2013 Feb;33(1):71-8. Epub 2013 Apr 5 doi: 10.1055/s-0033-1338118. PMID: 23564391

Clinical prediction guides

Fulminant Transfusion-Associated Hepatitis E Virus Infection Despite Screening, England, 2016-2020.
Harvala H, Reynolds C, Brailsford S, Davison K
Emerg Infect Dis 2022 Sep;28(9):1805-1813. doi: 10.3201/eid2809.220487. PMID: 35997399Free PMC Article
Characterization of Chronic Hepatitis E Virus Infection in Immunocompetent Rabbits.
Liang C, Zhao C, Liu T, Liu B, Liu Z, Huang H, Liu W, Zhao M, Xu N, Lu Q, Nie J, Zhang L, Huang W, She R, Wang Y
Viruses 2022 Jun 9;14(6) doi: 10.3390/v14061252. PMID: 35746723Free PMC Article
Hepatitis E virus infection and rejection in kidney transplant recipients.
Wasuwanich P, Sirisreetreerux P, Ingviya T, Kraus ES, Brennan DC, Sue PK, Jackson AM, Oshima K, Philosophe B, Montgomery RA, Karnsakul W
Transpl Immunol 2022 Feb;70:101517. Epub 2021 Dec 17 doi: 10.1016/j.trim.2021.101517. PMID: 34923120
Clinical features of sporadic hepatitis E virus infection in pregnant women in Shanghai, China.
Zhang F, Wang J, Cheng J, Zhang X, He Q, Zhaochao L, Shu J, Yan L, Wang L, Wang L, Zhang J
J Infect 2022 Jan;84(1):64-70. Epub 2021 Nov 9 doi: 10.1016/j.jinf.2021.11.004. PMID: 34767838
Hepatitis E virus: Infection beyond the liver?
Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Van der Eijk AA
J Hepatol 2017 May;66(5):1082-1095. Epub 2016 Nov 29 doi: 10.1016/j.jhep.2016.11.016. PMID: 27913223

Recent systematic reviews

Seroprevalence of Hepatitis E Virus Infection in Middle Eastern Countries: A Systematic Review and Meta-Analysis.
Qashqari FS
Medicina (Kaunas) 2022 Jul 6;58(7) doi: 10.3390/medicina58070905. PMID: 35888624Free PMC Article
Treatment for chronic hepatitis E virus infection: A systematic review and meta-analysis.
Gorris M, van der Lecq BM, van Erpecum KJ, de Bruijne J
J Viral Hepat 2021 Mar;28(3):454-463. Epub 2020 Dec 20 doi: 10.1111/jvh.13456. PMID: 33301609Free PMC Article
The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis.
Li P, Liu J, Li Y, Su J, Ma Z, Bramer WM, Cao W, de Man RA, Peppelenbosch MP, Pan Q
Liver Int 2020 Jul;40(7):1516-1528. Epub 2020 Apr 24 doi: 10.1111/liv.14468. PMID: 32281721Free PMC Article
Hepatitis E virus infection in Turkey: a systematic review.
Leblebicioglu H, Ozaras R
Ann Clin Microbiol Antimicrob 2018 May 2;17(1):17. doi: 10.1186/s12941-018-0269-6. PMID: 29716597Free PMC Article
A systematic review of hepatitis E virus infection in children.
Verghese VP, Robinson JL
Clin Infect Dis 2014 Sep 1;59(5):689-97. Epub 2014 May 20 doi: 10.1093/cid/ciu371. PMID: 24846637

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