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Hepatitis E virus infection

MedGen UID:
88376
•Concept ID:
C0085293
•
Disease or Syndrome
Synonyms: Enterically Transmitted Non A, Non B Hepatitis; Enterically-Transmitted Non-A, Non-B Hepatitis; Epidemic Non A, Non B Hepatitis; Epidemic Non-A, Non-B Hepatitis; ET-NANBH; Hepatitides, Water-Borne; Hepatitis E; Hepatitis, Viral, Non-A, Non-B, Enterically-Transmitted; Hepatitis, Water Borne; Hepatitis, Water-Borne; Water-Borne Hepatitides; Water-Borne Hepatitis
SNOMED CT: Hepatitis E virus infection (7111000119109); Viral hepatitis E (7111000119109); Viral hepatitis type E (7111000119109); Hepatitis E (7111000119109)
 
Monarch Initiative: MONDO:0005788

Definition

Acute inflammation of the liver in humans; caused by hepatitis E virus, a non-enveloped single-stranded rna virus. Similar to hepatitis A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis E virus infection

Professional guidelines

PubMed

Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing.
Stahl Y, Kabar I, Heinzow H, Maasoumy B, Bremer B, Wedemeyer H, Schmidt HH, Pietschmann T, Schlevogt B, Behrendt P
Emerg Microbes Infect 2023 Dec;12(2):2251598. Epub 2023 Aug 31 doi: 10.1080/22221751.2023.2251598. PMID: 37649441Free PMC Article
Screening, diagnosis and risks associated with Hepatitis E virus infection.
Lhomme S, Legrand-Abravanel F, Kamar N, Izopet J
Expert Rev Anti Infect Ther 2019 Jun;17(6):403-418. Epub 2019 May 13 doi: 10.1080/14787210.2019.1613889. PMID: 31082277
EASL Clinical Practice Guidelines on hepatitis E virus infection.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jun;68(6):1256-1271. Epub 2018 Mar 31 doi: 10.1016/j.jhep.2018.03.005. PMID: 29609832

Recent clinical studies

Etiology

Hepatitis E virus infection of transplanted kidneys.
Schmitz J, Kracht J, Evert K, Wenzel JJ, Schemmerer M, Lehmann U, Panning M, Pape L, Pohl M, Bräsen JH
Am J Transplant 2024 Mar;24(3):491-497. Epub 2023 Dec 10 doi: 10.1016/j.ajt.2023.11.016. PMID: 38072120
Hepatitis E virus infection and risk of hepatocellular carcinoma: A systematic review and meta-analysis.
Yin X, Kan F
Cancer Epidemiol 2023 Dec;87:102457. Epub 2023 Oct 3 doi: 10.1016/j.canep.2023.102457. PMID: 37797398
Janus kinase-inhibition modulates hepatitis E virus infection.
Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E
Antiviral Res 2023 Sep;217:105690. Epub 2023 Jul 28 doi: 10.1016/j.antiviral.2023.105690. PMID: 37517633
Viral hepatitis and pregnancy.
Terrault NA, Levy MT, Cheung KW, Jourdain G
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):117-130. Epub 2020 Oct 12 doi: 10.1038/s41575-020-00361-w. PMID: 33046891
Hepatitis E virus infection.
Kamar N, Izopet J, Pavio N, Aggarwal R, Labrique A, Wedemeyer H, Dalton HR
Nat Rev Dis Primers 2017 Nov 16;3:17086. doi: 10.1038/nrdp.2017.86. PMID: 29154369

Diagnosis

Hepatitis E virus infection and risk of hepatocellular carcinoma: A systematic review and meta-analysis.
Yin X, Kan F
Cancer Epidemiol 2023 Dec;87:102457. Epub 2023 Oct 3 doi: 10.1016/j.canep.2023.102457. PMID: 37797398
Transfusion-Transmitted Hepatitis E Virus Infection in France.
Gallian P, Pouchol E, Djoudi R, Lhomme S, Mouna L, Gross S, Bierling P, Assal A, Kamar N, Mallet V, Roque-Afonso AM, Izopet J, Tiberghien P
Transfus Med Rev 2019 Jul;33(3):146-153. Epub 2019 Jun 20 doi: 10.1016/j.tmrv.2019.06.001. PMID: 31327668
Hepatitis E virus infection.
Kamar N, Izopet J, Pavio N, Aggarwal R, Labrique A, Wedemeyer H, Dalton HR
Nat Rev Dis Primers 2017 Nov 16;3:17086. doi: 10.1038/nrdp.2017.86. PMID: 29154369
Hepatitis E virus: Infection beyond the liver?
Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Van der Eijk AA
J Hepatol 2017 May;66(5):1082-1095. Epub 2016 Nov 29 doi: 10.1016/j.jhep.2016.11.016. PMID: 27913223
Hepatitis E virus infection.
Kamar N, Dalton HR, Abravanel F, Izopet J
Clin Microbiol Rev 2014 Jan;27(1):116-38. doi: 10.1128/CMR.00057-13. PMID: 24396139Free PMC Article

Therapy

Hepatitis E virus infection of transplanted kidneys.
Schmitz J, Kracht J, Evert K, Wenzel JJ, Schemmerer M, Lehmann U, Panning M, Pape L, Pohl M, Bräsen JH
Am J Transplant 2024 Mar;24(3):491-497. Epub 2023 Dec 10 doi: 10.1016/j.ajt.2023.11.016. PMID: 38072120
Hepatitis E virus infection and risk of hepatocellular carcinoma: A systematic review and meta-analysis.
Yin X, Kan F
Cancer Epidemiol 2023 Dec;87:102457. Epub 2023 Oct 3 doi: 10.1016/j.canep.2023.102457. PMID: 37797398
Janus kinase-inhibition modulates hepatitis E virus infection.
Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E
Antiviral Res 2023 Sep;217:105690. Epub 2023 Jul 28 doi: 10.1016/j.antiviral.2023.105690. PMID: 37517633
Viral hepatitis and pregnancy.
Terrault NA, Levy MT, Cheung KW, Jourdain G
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):117-130. Epub 2020 Oct 12 doi: 10.1038/s41575-020-00361-w. PMID: 33046891
Hepatitis E virus infection.
Kamar N, Izopet J, Pavio N, Aggarwal R, Labrique A, Wedemeyer H, Dalton HR
Nat Rev Dis Primers 2017 Nov 16;3:17086. doi: 10.1038/nrdp.2017.86. PMID: 29154369

Prognosis

Hepatitis E virus infection of transplanted kidneys.
Schmitz J, Kracht J, Evert K, Wenzel JJ, Schemmerer M, Lehmann U, Panning M, Pape L, Pohl M, Bräsen JH
Am J Transplant 2024 Mar;24(3):491-497. Epub 2023 Dec 10 doi: 10.1016/j.ajt.2023.11.016. PMID: 38072120
Janus kinase-inhibition modulates hepatitis E virus infection.
Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR, Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E
Antiviral Res 2023 Sep;217:105690. Epub 2023 Jul 28 doi: 10.1016/j.antiviral.2023.105690. PMID: 37517633
Viral hepatitis and pregnancy.
Terrault NA, Levy MT, Cheung KW, Jourdain G
Nat Rev Gastroenterol Hepatol 2021 Feb;18(2):117-130. Epub 2020 Oct 12 doi: 10.1038/s41575-020-00361-w. PMID: 33046891
Hepatitis E virus-associated Guillain-Barre syndrome: Revision of the literature.
Liu H, Ma Y
Brain Behav 2020 Jan;10(1):e01496. Epub 2019 Dec 11 doi: 10.1002/brb3.1496. PMID: 31828968Free PMC Article
Risk factors for hepatitis E virus infection and disease.
Kmush BL, Nelson KE, Labrique AB
Expert Rev Anti Infect Ther 2015 Jan;13(1):41-53. Epub 2014 Nov 15 doi: 10.1586/14787210.2015.981158. PMID: 25399510

Clinical prediction guides

Hepatitis E virus infection of transplanted kidneys.
Schmitz J, Kracht J, Evert K, Wenzel JJ, Schemmerer M, Lehmann U, Panning M, Pape L, Pohl M, Bräsen JH
Am J Transplant 2024 Mar;24(3):491-497. Epub 2023 Dec 10 doi: 10.1016/j.ajt.2023.11.016. PMID: 38072120
Hepatitis E virus infection and risk of hepatocellular carcinoma: A systematic review and meta-analysis.
Yin X, Kan F
Cancer Epidemiol 2023 Dec;87:102457. Epub 2023 Oct 3 doi: 10.1016/j.canep.2023.102457. PMID: 37797398
Hepatitis E Virus Infection in Pediatric Oncology.
Lenglart A, Chappé C, Grulois I, Hervé F, Gandemer V, Robert G
J Pediatr Hematol Oncol 2023 Jan 1;45(1):e150-e153. Epub 2022 Dec 13 doi: 10.1097/MPH.0000000000002539. PMID: 36598968
Hepatitis E virus infection and rejection in kidney transplant recipients.
Wasuwanich P, Sirisreetreerux P, Ingviya T, Kraus ES, Brennan DC, Sue PK, Jackson AM, Oshima K, Philosophe B, Montgomery RA, Karnsakul W
Transpl Immunol 2022 Feb;70:101517. Epub 2021 Dec 17 doi: 10.1016/j.trim.2021.101517. PMID: 34923120
Hepatitis E virus: Infection beyond the liver?
Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Van der Eijk AA
J Hepatol 2017 May;66(5):1082-1095. Epub 2016 Nov 29 doi: 10.1016/j.jhep.2016.11.016. PMID: 27913223

Recent systematic reviews

Hepatitis E virus infection and risk of hepatocellular carcinoma: A systematic review and meta-analysis.
Yin X, Kan F
Cancer Epidemiol 2023 Dec;87:102457. Epub 2023 Oct 3 doi: 10.1016/j.canep.2023.102457. PMID: 37797398
Seroprevalence of Hepatitis E Virus Infection in Middle Eastern Countries: A Systematic Review and Meta-Analysis.
Qashqari FS
Medicina (Kaunas) 2022 Jul 6;58(7) doi: 10.3390/medicina58070905. PMID: 35888624Free PMC Article
Hepatitis E virus infection in Turkey: a systematic review.
Leblebicioglu H, Ozaras R
Ann Clin Microbiol Antimicrob 2018 May 2;17(1):17. doi: 10.1186/s12941-018-0269-6. PMID: 29716597Free PMC Article
Systematic review with meta-analysis: the association between hepatitis E seroprevalence and haemodialysis.
Haffar S, Bazerbachi F, Leise MD, Dillon JJ, Albright RC, Murad MH, Kamath PS, Watt KD
Aliment Pharmacol Ther 2017 Nov;46(9):790-799. Epub 2017 Sep 4 doi: 10.1111/apt.14285. PMID: 28869287
A systematic review of hepatitis E virus infection in children.
Verghese VP, Robinson JL
Clin Infect Dis 2014 Sep 1;59(5):689-97. Epub 2014 May 20 doi: 10.1093/cid/ciu371. PMID: 24846637

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