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Late diastolic murmur

MedGen UID:
883990
•Concept ID:
C0920079
•
Finding
Synonyms: Late Diastolic Heart Murmur; Late Diastolic Murmur
SNOMED CT: Late diastolic murmur (713066006)

Definition

A heart murmur that occurs during the last half of the ventricular filling phase. This may or may not extend to the first heart sound. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLate diastolic murmur

Professional guidelines

PubMed

Current management of mitral valve prolapse.
Bouknight DP, O'Rourke RA
Am Fam Physician 2000 Jun 1;61(11):3343-50, 3353-4. PMID: 10865929
Mitral valve prolapse: causes, clinical manifestations, and management.
Devereux RB, Kramer-Fox R, Kligfield P
Ann Intern Med 1989 Aug 15;111(4):305-17. doi: 10.7326/0003-4819-111-4-305. PMID: 2667419
Diagnosis and management of complications of prosthetic heart valves.
Kloster FE
Am J Cardiol 1975 Jun;35(6):872-85. doi: 10.1016/0002-9149(75)90124-1. PMID: 1093375

Recent clinical studies

Etiology

The Right Ventricular-Pulmonary Arterial Coupling and Diastolic Function Response to Therapy in Pulmonary Arterial Hypertension.
Vanderpool RR, Hunter KS, Insel M, Garcia JGN, Bedrick EJ, Tedford RJ, Rischard FP
Chest 2022 Apr;161(4):1048-1059. Epub 2021 Oct 9 doi: 10.1016/j.chest.2021.09.040. PMID: 34637777Free PMC Article
Aneurysm of the sinus of valsalva.
Ott DA
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2006:165-76. doi: 10.1053/j.pcsu.2006.02.014. PMID: 16638563
Mitral valve prolapse: causes, clinical manifestations, and management.
Devereux RB, Kramer-Fox R, Kligfield P
Ann Intern Med 1989 Aug 15;111(4):305-17. doi: 10.7326/0003-4819-111-4-305. PMID: 2667419
Prosthetic valve endocarditis.
Masur H, Johnson WD Jr
J Thorac Cardiovasc Surg 1980 Jul;80(1):31-7. PMID: 6991824
Prosthetic valve endocarditis.
Wilson WR, Jaumin PM, Danielson GK, Giuliani ER, Washington JA II, Geraci JE
Ann Intern Med 1975 Jun;82(6):751-6. doi: 10.7326/0003-4819-82-6-751. PMID: 1138584

Diagnosis

How to differentiate ejection murmurs from systolic regurgitant murmurs.
Constant J
Keio J Med 1995 Sep;44(3):85-7. doi: 10.2302/kjm.44.85. PMID: 7474646
Prosthetic valve endocarditis.
Masur H, Johnson WD Jr
J Thorac Cardiovasc Surg 1980 Jul;80(1):31-7. PMID: 6991824
Mitral valve prolapse.
Wigle ED, Rakowski H, Ranganathan N, Silver MC
Annu Rev Med 1976;27:165-80. doi: 10.1146/annurev.me.27.020176.001121. PMID: 779595
Nonrheumatic mitral incompetence.
Yahini JH, Deutsch V, Miller HI, Shem-Tov A, Atlas P, Neufeld HN
Isr J Med Sci 1975 Sep;11(9):928-67. PMID: 1184367
Diagnosis and management of complications of prosthetic heart valves.
Kloster FE
Am J Cardiol 1975 Jun;35(6):872-85. doi: 10.1016/0002-9149(75)90124-1. PMID: 1093375

Therapy

Saw-tooth cardiomyopathy.
Davlouros PA, Danias PG, Karatza AA, Kiaffas MG, Alexopoulos D
J Cardiovasc Magn Reson 2009 Dec 16;11(1):54. doi: 10.1186/1532-429X-11-54. PMID: 20015374Free PMC Article
Prosthetic valve endocarditis: an overview.
Gnann JW, Dismukes WE
Herz 1983 Dec;8(6):320-31. PMID: 6363238
Prosthetic valve endocarditis.
Masur H, Johnson WD Jr
J Thorac Cardiovasc Surg 1980 Jul;80(1):31-7. PMID: 6991824
Prosthetic valve endocarditis.
Wilson WR, Jaumin PM, Danielson GK, Giuliani ER, Washington JA II, Geraci JE
Ann Intern Med 1975 Jun;82(6):751-6. doi: 10.7326/0003-4819-82-6-751. PMID: 1138584
Diagnosis and management of complications of prosthetic heart valves.
Kloster FE
Am J Cardiol 1975 Jun;35(6):872-85. doi: 10.1016/0002-9149(75)90124-1. PMID: 1093375

Prognosis

Aneurysm of the sinus of valsalva.
Ott DA
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2006:165-76. doi: 10.1053/j.pcsu.2006.02.014. PMID: 16638563
Current management of mitral valve prolapse.
Bouknight DP, O'Rourke RA
Am Fam Physician 2000 Jun 1;61(11):3343-50, 3353-4. PMID: 10865929
Mitral valve prolapse.
Gould L, Gopalaswamy C
Angiology 1984 May;35(5):290-9. doi: 10.1177/000331978403500505. PMID: 6144281
Prosthetic valve endocarditis.
Masur H, Johnson WD Jr
J Thorac Cardiovasc Surg 1980 Jul;80(1):31-7. PMID: 6991824
Nonrheumatic mitral incompetence.
Yahini JH, Deutsch V, Miller HI, Shem-Tov A, Atlas P, Neufeld HN
Isr J Med Sci 1975 Sep;11(9):928-67. PMID: 1184367

Clinical prediction guides

The Right Ventricular-Pulmonary Arterial Coupling and Diastolic Function Response to Therapy in Pulmonary Arterial Hypertension.
Vanderpool RR, Hunter KS, Insel M, Garcia JGN, Bedrick EJ, Tedford RJ, Rischard FP
Chest 2022 Apr;161(4):1048-1059. Epub 2021 Oct 9 doi: 10.1016/j.chest.2021.09.040. PMID: 34637777Free PMC Article
Does this patient have an abnormal systolic murmur?
Etchells E, Bell C, Robb K
JAMA 1997 Feb 19;277(7):564-71. PMID: 9032164
Clinical significance of the apical late systolic ejection murmur: a new phonocardiographic sign indicating dynamic mid-left ventricular obstruction.
Fukuda N, Oki T, Iuchi A, Tabata T, Manabe K, Kageji Y, Sasaki M, Yamada H, Ito S
Clin Cardiol 1996 Feb;19(2):121-7. doi: 10.1002/clc.4960190210. PMID: 8821422
Mitral valve prolapse: causes, clinical manifestations, and management.
Devereux RB, Kramer-Fox R, Kligfield P
Ann Intern Med 1989 Aug 15;111(4):305-17. doi: 10.7326/0003-4819-111-4-305. PMID: 2667419
Correlation between left ventriculography, auscultation, and M-mode and two-dimensional echocardiography in mitral valve prolapse.
Cohen MV, Spindola-Franco H
Herz 1988 Oct;13(5):293-308. PMID: 3053382

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