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Refractory Malignant Germ Cell Tumor

MedGen UID:
884048
•Concept ID:
C4054083
•
Neoplastic Process
Synonym: Refractory Malignant Germ Cell Neoplasm

Definition

Malignant germ cell tumor resistant to treatment. [from NCI]

Professional guidelines

PubMed

Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?
Kazemi MH, Sadri M, Najafi A, Rahimi A, Baghernejadan Z, Khorramdelazad H, Falak R
Front Immunol 2022;13:1018962. Epub 2022 Oct 28 doi: 10.3389/fimmu.2022.1018962. PMID: 36389779Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper.
Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, Cauquil C, Chanson P, Collins M, Durrbach A, Ederhy S, Feuillet S, François H, Lazarovici J, Le Pavec J, De Martin E, Mateus C, Michot JM, Samuel D, Soria JC, Robert C, Eggermont A, Marabelle A
Ann Oncol 2016 Apr;27(4):559-74. Epub 2015 Dec 28 doi: 10.1093/annonc/mdv623. PMID: 26715621

Recent clinical studies

Etiology

High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.
DuBois SG, Macy ME, Henderson TO
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-13. doi: 10.1200/EDBK_349783. PMID: 35522915
Recent advances in the developmental origin of neuroblastoma: an overview.
Ponzoni M, Bachetti T, Corrias MV, Brignole C, Pastorino F, Calarco E, Bensa V, Giusto E, Ceccherini I, Perri P
J Exp Clin Cancer Res 2022 Mar 11;41(1):92. doi: 10.1186/s13046-022-02281-w. PMID: 35277192Free PMC Article
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Brain Tumors.
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158

Diagnosis

High-Risk and Relapsed Neuroblastoma: Toward More Cures and Better Outcomes.
DuBois SG, Macy ME, Henderson TO
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-13. doi: 10.1200/EDBK_349783. PMID: 35522915
Brain Tumors.
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Merkel cell carcinoma.
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article
Retinoblastoma.
Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731

Therapy

Radiopharmaceuticals for Neuroendocrine Tumors.
Chin RI, Wu FS, Menda Y, Kim H
Semin Radiat Oncol 2021 Jan;31(1):60-70. doi: 10.1016/j.semradonc.2020.07.007. PMID: 33246637
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma.
Poff A, Koutnik AP, Egan KM, Sahebjam S, D'Agostino D, Kumar NB
Semin Cancer Biol 2019 Jun;56:135-148. Epub 2017 Dec 30 doi: 10.1016/j.semcancer.2017.12.011. PMID: 29294371Free PMC Article
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
TI-CE high-dose chemotherapy for patients with previously treated germ cell tumors: results and prognostic factor analysis.
Feldman DR, Sheinfeld J, Bajorin DF, Fischer P, Turkula S, Ishill N, Patil S, Bains M, Reich LM, Bosl GJ, Motzer RJ
J Clin Oncol 2010 Apr 1;28(10):1706-13. Epub 2010 Mar 1 doi: 10.1200/JCO.2009.25.1561. PMID: 20194867Free PMC Article

Prognosis

Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma.
Poff A, Koutnik AP, Egan KM, Sahebjam S, D'Agostino D, Kumar NB
Semin Cancer Biol 2019 Jun;56:135-148. Epub 2017 Dec 30 doi: 10.1016/j.semcancer.2017.12.011. PMID: 29294371Free PMC Article
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Brain Tumors.
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158
Carcinoid-syndrome: recent advances, current status and controversies.
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Merkel cell carcinoma.
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article

Clinical prediction guides

Single-cell RNA sequencing reveals tumor heterogeneity, microenvironment, and drug-resistance mechanisms of recurrent glioblastoma.
Wu H, Guo C, Wang C, Xu J, Zheng S, Duan J, Li Y, Bai H, Xu Q, Ning F, Wang F, Yang Q
Cancer Sci 2023 Jun;114(6):2609-2621. Epub 2023 Mar 10 doi: 10.1111/cas.15773. PMID: 36853018Free PMC Article
Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma.
Huuhtanen J, Kasanen H, Peltola K, Lönnberg T, Glumoff V, Brück O, Dufva O, Peltonen K, Vikkula J, Jokinen E, Ilander M, Lee MH, Mäkelä S, Nyakas M, Li B, Hernberg M, Bono P, Lähdesmäki H, Kreutzman A, Mustjoki S
J Clin Invest 2023 Mar 15;133(6) doi: 10.1172/JCI164809. PMID: 36719749Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma.
Poff A, Koutnik AP, Egan KM, Sahebjam S, D'Agostino D, Kumar NB
Semin Cancer Biol 2019 Jun;56:135-148. Epub 2017 Dec 30 doi: 10.1016/j.semcancer.2017.12.011. PMID: 29294371Free PMC Article
The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors.
Strosberg JR, Halfdanarson TR, Bellizzi AM, Chan JA, Dillon JS, Heaney AP, Kunz PL, O'Dorisio TM, Salem R, Segelov E, Howe JR, Pommier RF, Brendtro K, Bashir MA, Singh S, Soulen MC, Tang L, Zacks JS, Yao JC, Bergsland EK
Pancreas 2017 Jul;46(6):707-714. doi: 10.1097/MPA.0000000000000850. PMID: 28609356Free PMC Article

Recent systematic reviews

Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update.
Bautista F, Fioravantti V, de Rojas T, Carceller F, Madero L, Lassaletta A, Moreno L
Cancer Med 2017 Nov;6(11):2606-2624. Epub 2017 Oct 4 doi: 10.1002/cam4.1171. PMID: 28980418Free PMC Article
PD-1 Antibody Monotherapy for Malignant Melanoma: A Systematic Review and Meta-Analysis.
Lin Z, Chen X, Li Z, Luo Y, Fang Z, Xu B, Han M
PLoS One 2016;11(8):e0160485. Epub 2016 Aug 2 doi: 10.1371/journal.pone.0160485. PMID: 27483468Free PMC Article
Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR: a systematic literature review.
Broder MS, Beenhouwer D, Strosberg JR, Neary MP, Cherepanov D
World J Gastroenterol 2015 Feb 14;21(6):1945-55. doi: 10.3748/wjg.v21.i6.1945. PMID: 25684964Free PMC Article
New therapeutic options for advanced forms of thyroid cancer.
Bernet V, Smallridge R
Expert Opin Emerg Drugs 2014 Jun;19(2):225-41. Epub 2014 Mar 3 doi: 10.1517/14728214.2014.894017. PMID: 24588376
A systematic review of 131I-meta iodobenzylguanidine molecular radiotherapy for neuroblastoma.
Wilson JS, Gains JE, Moroz V, Wheatley K, Gaze MN
Eur J Cancer 2014 Mar;50(4):801-15. Epub 2013 Dec 12 doi: 10.1016/j.ejca.2013.11.016. PMID: 24333097

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