U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gram-negative bacterial infections

MedGen UID:
88406
Concept ID:
C0085423
Disease or Syndrome
Synonyms: Bacterial Infection, Gram-Negative; Bacterial Infections, Gram-Negative; Gram Negative Bacterial Infections; Gram-Negative Bacterial Infection; Gram-Negative Bacterial Infections; Infection, Gram-Negative Bacterial; Infections, Gram-Negative Bacterial
SNOMED CT: Disease caused by Gram-negative bacteria (371583007)
 
Monarch Initiative: MONDO:0021678

Definition

Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGram-negative bacterial infections

Professional guidelines

PubMed

Chen Y, Huang HB, Peng JM, Weng L, Du B
Microbiol Spectr 2022 Apr 27;10(2):e0260321. Epub 2022 Apr 4 doi: 10.1128/spectrum.02603-21. PMID: 35377233Free PMC Article
Doi Y
Clin Infect Dis 2019 Nov 13;69(Suppl 7):S565-S575. doi: 10.1093/cid/ciz830. PMID: 31724043Free PMC Article
Shirley M
Drugs 2018 Apr;78(6):675-692. doi: 10.1007/s40265-018-0902-x. PMID: 29671219

Recent clinical studies

Etiology

Russo A, Trecarichi EM, Torti C
Curr Opin Infect Dis 2022 Apr 1;35(2):95-102. doi: 10.1097/QCO.0000000000000807. PMID: 34840273
Flannery DD, Chiotos K, Gerber JS, Puopolo KM
Pediatr Res 2022 Jan;91(2):380-391. Epub 2021 Oct 1 doi: 10.1038/s41390-021-01745-7. PMID: 34599280Free PMC Article
Brink AJ
Curr Opin Infect Dis 2019 Dec;32(6):609-616. doi: 10.1097/QCO.0000000000000608. PMID: 31567571
Zajkowska J, Król M, Falkowski D, Syed N, Kamieńska A
Przegl Epidemiol 2016;70(2):289-295. PMID: 27837588
Owens CD, Stoessel K
J Hosp Infect 2008 Nov;70 Suppl 2:3-10. doi: 10.1016/S0195-6701(08)60017-1. PMID: 19022115

Diagnosis

Nordmann P, Poirel L
Clin Infect Dis 2019 Nov 13;69(Suppl 7):S521-S528. doi: 10.1093/cid/ciz824. PMID: 31724045Free PMC Article
Weinberg GA
Pediatr Rev 2018 May;39(5):270-272. doi: 10.1542/pir.2017-0147. PMID: 29716975
Messinger AI, Kupfer O, Hurst A, Parker S
Pediatr Rev 2017 Sep;38(9):394-409. doi: 10.1542/pir.2016-0183. PMID: 28864731
Caniaux I, van Belkum A, Zambardi G, Poirel L, Gros MF
Eur J Clin Microbiol Infect Dis 2017 Mar;36(3):415-420. Epub 2016 Nov 21 doi: 10.1007/s10096-016-2846-y. PMID: 27873028
Janda JM, Abbott SL, McIver CJ
Clin Microbiol Rev 2016 Apr;29(2):349-74. doi: 10.1128/CMR.00103-15. PMID: 26960939Free PMC Article

Therapy

Kaye KS, Belley A, Barth P, Lahlou O, Knechtle P, Motta P, Velicitat P
JAMA 2022 Oct 4;328(13):1304-1314. doi: 10.1001/jama.2022.17034. PMID: 36194218Free PMC Article
Bassetti M, Echols R, Matsunaga Y, Ariyasu M, Doi Y, Ferrer R, Lodise TP, Naas T, Niki Y, Paterson DL, Portsmouth S, Torre-Cisneros J, Toyoizumi K, Wunderink RG, Nagata TD
Lancet Infect Dis 2021 Feb;21(2):226-240. Epub 2020 Oct 12 doi: 10.1016/S1473-3099(20)30796-9. PMID: 33058795
Doi Y
Clin Infect Dis 2019 Nov 13;69(Suppl 7):S565-S575. doi: 10.1093/cid/ciz830. PMID: 31724043Free PMC Article
Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, Lagacé-Wiens PRS, Walkty AJ, Noreddin A, Lynch Iii JP, Karlowsky JA
Drugs 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2. PMID: 30712199
Yahav D, Franceschini E, Koppel F, Turjeman A, Babich T, Bitterman R, Neuberger A, Ghanem-Zoubi N, Santoro A, Eliakim-Raz N, Pertzov B, Steinmetz T, Stern A, Dickstein Y, Maroun E, Zayyad H, Bishara J, Alon D, Edel Y, Goldberg E, Venturelli C, Mussini C, Leibovici L, Paul M; Bacteremia Duration Study Group
Clin Infect Dis 2019 Sep 13;69(7):1091-1098. doi: 10.1093/cid/ciy1054. PMID: 30535100

Prognosis

Willems RPJ, van Dijk K, Vehreschild MJGT, Biehl LM, Ket JCF, Remmelzwaal S, Vandenbroucke-Grauls CMJE
Lancet Infect Dis 2023 Jun;23(6):719-731. Epub 2023 Jan 30 doi: 10.1016/S1473-3099(22)00811-8. PMID: 36731484
Jabbour JF, Kanj SS
Infect Dis Clin North Am 2021 Mar;35(1):157-167. Epub 2020 Dec 7 doi: 10.1016/j.idc.2020.10.008. PMID: 33303333
Markewitz RDH, Graf T
N Engl J Med 2020 Sep 17;383(12):1167. doi: 10.1056/NEJMicm1916407. PMID: 32937049
Owens CD, Stoessel K
J Hosp Infect 2008 Nov;70 Suppl 2:3-10. doi: 10.1016/S0195-6701(08)60017-1. PMID: 19022115
Vinh DC, Embil JM
J Long Term Eff Med Implants 2005;15(5):467-88. doi: 10.1615/jlongtermeffmedimplants.v15.i5.20. PMID: 16218897

Clinical prediction guides

Sakoh T, Kimura M, Takagi S, Ogura S, Morishima M, Yamamuro R, Yamaguchi K, Yuasa M, Kaji D, Kageyama K, Taya Y, Nishida A, Ishiwata K, Yamamoto H, Yamamoto G, Asano-Mori Y, Wake A, Uchida N, Taniguchi S, Araoka H
Ann Hematol 2023 May;102(5):1239-1246. Epub 2023 Mar 27 doi: 10.1007/s00277-023-05185-7. PMID: 36971808
Tabak YP, Sung A, Ye G, Vankeepuram L, Gupta V, McCann E
PLoS One 2020;15(2):e0229393. Epub 2020 Feb 21 doi: 10.1371/journal.pone.0229393. PMID: 32084236Free PMC Article
Burnham JP, Wallace MA, Fuller BM, Shupe A, Burnham CD, Kollef MH
J Appl Lab Med 2019 Jan;3(4):569-579. Epub 2018 Nov 30 doi: 10.1373/jalm.2018.027201. PMID: 31639726
Bassetti M, Taramasso L, Giacobbe DR, Pelosi P
Expert Rev Anti Infect Ther 2012 May;10(5):585-96. doi: 10.1586/eri.12.36. PMID: 22702322
Chishti AS, Maul EC, Nazario RJ, Bennett JS, Kiessling SG
Ann Saudi Med 2010 Sep-Oct;30(5):341-9. doi: 10.4103/0256-4947.68549. PMID: 20716830Free PMC Article

Recent systematic reviews

Righi E, Mutters NT, Guirao X, Del Toro MD, Eckmann C, Friedrich AW, Giannella M, Kluytmans J, Presterl E, Christaki E, Cross ELA, Visentin A, Sganga G, Tsioutis C, Tacconelli E
Clin Microbiol Infect 2023 Apr;29(4):463-479. Epub 2022 Dec 22 doi: 10.1016/j.cmi.2022.12.012. PMID: 36566836
Chen Y, Huang HB, Peng JM, Weng L, Du B
Microbiol Spectr 2022 Apr 27;10(2):e0260321. Epub 2022 Apr 4 doi: 10.1128/spectrum.02603-21. PMID: 35377233Free PMC Article
Paul M, Carrara E, Retamar P, Tängdén T, Bitterman R, Bonomo RA, de Waele J, Daikos GL, Akova M, Harbarth S, Pulcini C, Garnacho-Montero J, Seme K, Tumbarello M, Lindemann PC, Gandra S, Yu Y, Bassetti M, Mouton JW, Tacconelli E, Rodríguez-Baño J
Clin Microbiol Infect 2022 Apr;28(4):521-547. Epub 2021 Dec 16 doi: 10.1016/j.cmi.2021.11.025. PMID: 34923128
Scudeller L, Righi E, Chiamenti M, Bragantini D, Menchinelli G, Cattaneo P, Giske CG, Lodise T, Sanguinetti M, Piddock LJV, Franceschi F, Ellis S, Carrara E, Savoldi A, Tacconelli E
Int J Antimicrob Agents 2021 May;57(5):106344. Epub 2021 Apr 20 doi: 10.1016/j.ijantimicag.2021.106344. PMID: 33857539
Tacconelli E, Cataldo MA, Dancer SJ, De Angelis G, Falcone M, Frank U, Kahlmeter G, Pan A, Petrosillo N, Rodríguez-Baño J, Singh N, Venditti M, Yokoe DS, Cookson B; European Society of Clinical Microbiology
Clin Microbiol Infect 2014 Jan;20 Suppl 1:1-55. doi: 10.1111/1469-0691.12427. PMID: 24329732

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...