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Mammary-Type Myofibroblastoma

MedGen UID:
884167
Concept ID:
C4054575
Neoplastic Process

Definition

A benign mesenchymal neoplasm characterized by the presence of spindle shaped myofibroblasts and mast cells in a collagenous stroma. It is histologically identical to the myofibroblastoma of breast. It usually arises from the subcutaneous tissue and the most common sites of involvement are the inguinal/groin, paratesticular, and vulvovaginal areas. [from NCI]

Recent clinical studies

Etiology

Fankhauser CD, Issa A, Lee EWC, Oing C, Oliveira P, Parnham A, Oates J, Sangar V, Gulamhusein A, Clarke N
Ann Surg Oncol 2021 Dec;28(13):9217-9222. Epub 2021 Jul 16 doi: 10.1245/s10434-021-10315-4. PMID: 34272613Free PMC Article
Fritchie K, Ghosh T, Graham RP, Roden AC, Schembri-Wismayer D, Folpe A, Rivera M
Head Neck Pathol 2020 Dec;14(4):974-981. Epub 2020 May 14 doi: 10.1007/s12105-020-01171-x. PMID: 32410132Free PMC Article
Mariño-Enriquez A, Nascimento AF, Ligon AH, Liang C, Fletcher CD
Am J Surg Pathol 2017 Feb;41(2):234-244. doi: 10.1097/PAS.0000000000000770. PMID: 27879515
Howitt BE, Fletcher CD
Am J Surg Pathol 2016 Mar;40(3):361-7. doi: 10.1097/PAS.0000000000000540. PMID: 26523539
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211

Diagnosis

Bauer AH, Fletcher CDM, Hornick JL, Papke DJ Jr
Histopathology 2024 Jan;84(2):381-386. Epub 2023 Oct 19 doi: 10.1111/his.15070. PMID: 37855220
Ross JA, Reith J, Asirvatham JR
Int J Surg Pathol 2019 Jun;27(4):446-449. Epub 2019 Jan 20 doi: 10.1177/1066896918824406. PMID: 30663457
Khan K, Mavanur AA
BMJ Case Rep 2016 Oct 14;2016 doi: 10.1136/bcr-2016-217862. PMID: 27742646Free PMC Article
Mentzel T, Rütten A, Hantschke M, Hornick JL, Brenn T
Virchows Arch 2016 Oct;469(4):435-8. Epub 2016 Jul 21 doi: 10.1007/s00428-016-1996-8. PMID: 27444171
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211

Prognosis

McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Pan J, Wang S, Zhang Y, Fan Z
World J Surg Oncol 2016 Feb 24;14:55. doi: 10.1186/s12957-016-0796-6. PMID: 26911514Free PMC Article
Howitt BE, Fletcher CD
Am J Surg Pathol 2016 Mar;40(3):361-7. doi: 10.1097/PAS.0000000000000540. PMID: 26523539
Fritchie KJ, Carver P, Sun Y, Batiouchko G, Billings SD, Rubin BP, Tubbs RR, Goldblum JR
Am J Clin Pathol 2012 Jun;137(6):963-70. doi: 10.1309/AJCPQEG6YNN6CNAL. PMID: 22586056

Clinical prediction guides

McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Mariño-Enriquez A, Nascimento AF, Ligon AH, Liang C, Fletcher CD
Am J Surg Pathol 2017 Feb;41(2):234-244. doi: 10.1097/PAS.0000000000000770. PMID: 27879515
Howitt BE, Fletcher CD
Am J Surg Pathol 2016 Mar;40(3):361-7. doi: 10.1097/PAS.0000000000000540. PMID: 26523539
Flucke U, van Krieken JH, Mentzel T
Mod Pathol 2011 Jan;24(1):82-9. Epub 2010 Sep 17 doi: 10.1038/modpathol.2010.170. PMID: 20852591

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