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Secondary carcinoma

MedGen UID:
88450
•Concept ID:
C0085668
•
Neoplastic Process
Synonyms: Secondary Carcinoma; secondary carcinoma
SNOMED CT: Secondary carcinoma (79282002)
 
Monarch Initiative: MONDO:0024878

Definition

A carcinoma that arises from a pre-existing lower grade epithelial lesion, or as a result of a primary carcinoma that has spread to secondary sites, or due to a complication of a cancer treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary carcinoma

Professional guidelines

PubMed

Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis.
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Current position of diagnostics and surgical treatment for upper tract urothelial carcinoma.
Bus MT, de Bruin DM, Kamphuis GM, Zondervan PJ, Laguna Pes MP, de Reijke TM, van Leeuwen TG, de la Rosette JJ
Minerva Urol Nefrol 2017 Apr;69(2):159-165. Epub 2016 Oct 21 doi: 10.23736/S0393-2249.16.02720-X. PMID: 27768021
Techniques and therapies for primary and metastatic liver cancer.
Ong GB
Curr Probl Cancer 1977 Dec;2(6):1-48. doi: 10.1016/s0147-0272(77)80005-6. PMID: 83219

Recent clinical studies

Etiology

Secondary malignancy risk for patients with localized prostate cancer after intensity-modulated radiotherapy with and without flattening filter.
Treutwein M, Loeschel R, Hipp M, Koelbl O, Dobler B
J Appl Clin Med Phys 2020 Dec;21(12):197-205. Epub 2020 Nov 4 doi: 10.1002/acm2.13088. PMID: 33147377Free PMC Article
Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies.
Rosty C, Pai RK, Graham RP
Histopathology 2020 Oct;77(4):622-630. Epub 2020 Sep 12 doi: 10.1111/his.14195. PMID: 32590886
Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial.
Gnant M, Pfeiler G, Steger GG, Egle D, Greil R, Fitzal F, Wette V, Balic M, Haslbauer F, Melbinger-Zeinitzer E, Bjelic-Radisic V, Jakesz R, Marth C, Sevelda P, Mlineritsch B, Exner R, Fesl C, Frantal S, Singer CF; Austrian Breast and Colorectal Cancer Study Group
Lancet Oncol 2019 Mar;20(3):339-351. Epub 2019 Feb 19 doi: 10.1016/S1470-2045(18)30862-3. PMID: 30795951
Anaplastic pelvic carcinoma secondary to low-grade endometrial carcinoma.
Watrowski R, Möckel J, Venzke T, Jäger C, Bauknecht T
Anticancer Res 2014 Jan;34(1):239-42. PMID: 24403469
Secondary carcinomas of the kidney.
Wagle DG, Moore RH, Murphy GP
J Urol 1975 Jul;114(1):30-2. doi: 10.1016/s0022-5347(17)66935-0. PMID: 1142495

Diagnosis

Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies.
Rosty C, Pai RK, Graham RP
Histopathology 2020 Oct;77(4):622-630. Epub 2020 Sep 12 doi: 10.1111/his.14195. PMID: 32590886
Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma From Secondary Carcinoma Involvement of the Bladder.
Borhan WM, Cimino-Mathews AM, Montgomery EA, Epstein JI
Am J Surg Pathol 2017 Nov;41(11):1570-1575. doi: 10.1097/PAS.0000000000000922. PMID: 28786878
Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers.
Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S
J Clin Pathol 2013 Oct;66(10):847-53. Epub 2013 Jun 27 doi: 10.1136/jclinpath-2012-201303. PMID: 23814259
Pleural effusions.
Turton CW
Br J Hosp Med 1980 Mar;23(3):239-40, 244, 246-7 passim. PMID: 6991044
Secondary esophageal tumors.
Anderson MF, Harell GS
AJR Am J Roentgenol 1980 Dec;135(6):1243-6. doi: 10.2214/ajr.135.6.1243. PMID: 6779532

Therapy

Secondary malignancy risk for patients with localized prostate cancer after intensity-modulated radiotherapy with and without flattening filter.
Treutwein M, Loeschel R, Hipp M, Koelbl O, Dobler B
J Appl Clin Med Phys 2020 Dec;21(12):197-205. Epub 2020 Nov 4 doi: 10.1002/acm2.13088. PMID: 33147377Free PMC Article
Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial.
Gnant M, Pfeiler G, Steger GG, Egle D, Greil R, Fitzal F, Wette V, Balic M, Haslbauer F, Melbinger-Zeinitzer E, Bjelic-Radisic V, Jakesz R, Marth C, Sevelda P, Mlineritsch B, Exner R, Fesl C, Frantal S, Singer CF; Austrian Breast and Colorectal Cancer Study Group
Lancet Oncol 2019 Mar;20(3):339-351. Epub 2019 Feb 19 doi: 10.1016/S1470-2045(18)30862-3. PMID: 30795951
Clinical outcome of primary versus secondary bladder carcinoma in situ.
Chade DC, Shariat SF, Adamy A, Bochner BH, Donat SM, Herr HW, Dalbagni G
J Urol 2010 Aug;184(2):464-9. Epub 2010 Jun 17 doi: 10.1016/j.juro.2010.03.134. PMID: 20620399Free PMC Article
Pleural effusions.
Turton CW
Br J Hosp Med 1980 Mar;23(3):239-40, 244, 246-7 passim. PMID: 6991044
Techniques and therapies for primary and metastatic liver cancer.
Ong GB
Curr Probl Cancer 1977 Dec;2(6):1-48. doi: 10.1016/s0147-0272(77)80005-6. PMID: 83219

Prognosis

Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma From Secondary Carcinoma Involvement of the Bladder.
Borhan WM, Cimino-Mathews AM, Montgomery EA, Epstein JI
Am J Surg Pathol 2017 Nov;41(11):1570-1575. doi: 10.1097/PAS.0000000000000922. PMID: 28786878
Anaplastic pelvic carcinoma secondary to low-grade endometrial carcinoma.
Watrowski R, Möckel J, Venzke T, Jäger C, Bauknecht T
Anticancer Res 2014 Jan;34(1):239-42. PMID: 24403469
Clinical outcome of primary versus secondary bladder carcinoma in situ.
Chade DC, Shariat SF, Adamy A, Bochner BH, Donat SM, Herr HW, Dalbagni G
J Urol 2010 Aug;184(2):464-9. Epub 2010 Jun 17 doi: 10.1016/j.juro.2010.03.134. PMID: 20620399Free PMC Article
Pleural effusions.
Turton CW
Br J Hosp Med 1980 Mar;23(3):239-40, 244, 246-7 passim. PMID: 6991044
Secondary carcinomas of the kidney.
Wagle DG, Moore RH, Murphy GP
J Urol 1975 Jul;114(1):30-2. doi: 10.1016/s0022-5347(17)66935-0. PMID: 1142495

Clinical prediction guides

Clinical and histological features of secondary carcinomas in gastrointestinal tract biopsies.
Rosty C, Pai RK, Graham RP
Histopathology 2020 Oct;77(4):622-630. Epub 2020 Sep 12 doi: 10.1111/his.14195. PMID: 32590886
Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial.
Gnant M, Pfeiler G, Steger GG, Egle D, Greil R, Fitzal F, Wette V, Balic M, Haslbauer F, Melbinger-Zeinitzer E, Bjelic-Radisic V, Jakesz R, Marth C, Sevelda P, Mlineritsch B, Exner R, Fesl C, Frantal S, Singer CF; Austrian Breast and Colorectal Cancer Study Group
Lancet Oncol 2019 Mar;20(3):339-351. Epub 2019 Feb 19 doi: 10.1016/S1470-2045(18)30862-3. PMID: 30795951
Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma From Secondary Carcinoma Involvement of the Bladder.
Borhan WM, Cimino-Mathews AM, Montgomery EA, Epstein JI
Am J Surg Pathol 2017 Nov;41(11):1570-1575. doi: 10.1097/PAS.0000000000000922. PMID: 28786878
Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers.
Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S
J Clin Pathol 2013 Oct;66(10):847-53. Epub 2013 Jun 27 doi: 10.1136/jclinpath-2012-201303. PMID: 23814259
Clinical outcome of primary versus secondary bladder carcinoma in situ.
Chade DC, Shariat SF, Adamy A, Bochner BH, Donat SM, Herr HW, Dalbagni G
J Urol 2010 Aug;184(2):464-9. Epub 2010 Jun 17 doi: 10.1016/j.juro.2010.03.134. PMID: 20620399Free PMC Article

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