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Chronic kidney disease mineral and bone disorder

MedGen UID:
885556
Concept ID:
C4076240
Disease or Syndrome
Synonyms: Chronic Kidney Disease Mineral and Bone Disorder; Chronic Kidney Disease-Mineral and Bone Disorder; CKD-MBD
SNOMED CT: Chronic kidney disease mineral and bone disorder (713313000); CKD-MBD - chronic kidney disease mineral and bone disorder (713313000)

Definition

Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic kidney disease mineral and bone disorder

Professional guidelines

PubMed

Ginsberg C, Ix JH
Am J Kidney Dis 2022 Mar;79(3):427-436. Epub 2021 Aug 20 doi: 10.1053/j.ajkd.2021.06.031. PMID: 34419519
Isakova T, Nickolas TL, Denburg M, Yarlagadda S, Weiner DE, Gutiérrez OM, Bansal V, Rosas SE, Nigwekar S, Yee J, Kramer H
Am J Kidney Dis 2017 Dec;70(6):737-751. Epub 2017 Sep 21 doi: 10.1053/j.ajkd.2017.07.019. PMID: 28941764
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995

Recent clinical studies

Etiology

Sridharan K
Aust J Gen Pract 2023 Jan-Feb;52(1-2):52-57. doi: 10.31128/AJGP-03-22-6365. PMID: 36796773
Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Lunyera J, Scialla JJ
Semin Nephrol 2018 Nov;38(6):542-558. doi: 10.1016/j.semnephrol.2018.08.001. PMID: 30413250Free PMC Article
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995

Diagnosis

Sridharan K
Aust J Gen Pract 2023 Jan-Feb;52(1-2):52-57. doi: 10.31128/AJGP-03-22-6365. PMID: 36796773
Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Floege J, Drüeke TB
Kidney Int 2020 Oct;98(4):807-811. doi: 10.1016/j.kint.2020.07.002. PMID: 32998807
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995
Moe S, Drüeke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G; Kidney Disease: Improving Global Outcomes (KDIGO)
Kidney Int 2006 Jun;69(11):1945-53. doi: 10.1038/sj.ki.5000414. PMID: 16641930

Therapy

Shen Y
Medicine (Baltimore) 2023 Apr 7;102(14):e33477. doi: 10.1097/MD.0000000000033477. PMID: 37026958Free PMC Article
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Nowak KL, Hung A, Ikizler TA, Farmer-Bailey H, Salas-Cruz N, Sarkar S, Hoofnagle A, You Z, Chonchol M
Clin Nephrol 2017 Sep;88(9):132-143. doi: 10.5414/CN109122. PMID: 28699886Free PMC Article
Liu Z, Su G, Guo X, Wu Y, Liu X, Zou C, Zhang L, Yang Q, Xu Y, Ma W
Cochrane Database Syst Rev 2015 Sep 16;2015(9):CD010350. doi: 10.1002/14651858.CD010350.pub2. PMID: 26376110Free PMC Article
Komaba H, Tanaka M, Fukagawa M
Intern Med 2008;47(11):989-94. Epub 2008 Jun 2 doi: 10.2169/internalmedicine.47.1051. PMID: 18520108

Prognosis

Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Bellorin-Font E, Rojas E, Martin KJ
Nutrients 2022 Dec 29;15(1) doi: 10.3390/nu15010167. PMID: 36615824Free PMC Article
Hu L, Napoletano A, Provenzano M, Garofalo C, Bini C, Comai G, La Manna G
Int J Mol Sci 2022 Oct 13;23(20) doi: 10.3390/ijms232012223. PMID: 36293076Free PMC Article
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI
Am J Kidney Dis 2015 Jul;66(1):133-46. Epub 2015 May 7 doi: 10.1053/j.ajkd.2015.01.034. PMID: 25960299Free PMC Article

Clinical prediction guides

Zhang H, Li G, Yu X, Yang J, Jiang A, Cheng H, Fu J, Liang X, Liu J, Lou J, Wang M, Xing C, Zhang A, Zhang M, Xiao X, Yu C, Wang R, Wang L, Chen Y, Guan T, Peng A, Chen N, Hao C, Liu B, Wang S, Shen D, Jia Z, Liu Z; China Dialysis Calcification Study Group
JAMA Netw Open 2023 May 1;6(5):e2310909. doi: 10.1001/jamanetworkopen.2023.10909. PMID: 37126347Free PMC Article
Abdalbary M, Sobh M, Elnagar S, Elhadedy MA, Elshabrawy N, Abdelsalam M, Asadipooya K, Sabry A, Halawa A, El-Husseini A
Osteoporos Int 2022 Nov;33(11):2259-2274. Epub 2022 Jun 24 doi: 10.1007/s00198-022-06462-3. PMID: 35748896
Haffner D, Leifheit-Nestler M
Pediatr Nephrol 2021 Jan;36(1):41-50. Epub 2019 Dec 19 doi: 10.1007/s00467-019-04421-5. PMID: 31858226
Barreto FC, Costa CRVD, Reis LMD, Custódio MR
J Bras Nefrol 2018 Oct-Dec;40(4):366-374. Epub 2018 Nov 29 doi: 10.1590/2175-8239-jbn-2017-0012. PMID: 30525179Free PMC Article
Cejka D
Wien Med Wochenschr 2013 Sep;163(17-18):403-8. Epub 2013 May 9 doi: 10.1007/s10354-013-0195-3. PMID: 23657637

Recent systematic reviews

Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Apetrii M, Goldsmith D, Nistor I, Siriopol D, Voroneanu L, Scripcariu D, Vervloet M, Covic A
PLoS One 2017;12(11):e0187025. Epub 2017 Nov 6 doi: 10.1371/journal.pone.0187025. PMID: 29107998Free PMC Article
Liu Z, Su G, Guo X, Wu Y, Liu X, Zou C, Zhang L, Yang Q, Xu Y, Ma W
Cochrane Database Syst Rev 2015 Sep 16;2015(9):CD010350. doi: 10.1002/14651858.CD010350.pub2. PMID: 26376110Free PMC Article

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