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Chronic kidney disease mineral and bone disorder

MedGen UID:
885556
Concept ID:
C4076240
Disease or Syndrome
Synonyms: Chronic Kidney Disease Mineral and Bone Disorder; Chronic Kidney Disease-Mineral and Bone Disorder; CKD-MBD
SNOMED CT: Chronic kidney disease mineral and bone disorder (713313000); CKD-MBD - chronic kidney disease mineral and bone disorder (713313000)

Definition

Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic kidney disease mineral and bone disorder

Professional guidelines

PubMed

Ginsberg C, Ix JH
Am J Kidney Dis 2022 Mar;79(3):427-436. Epub 2021 Aug 20 doi: 10.1053/j.ajkd.2021.06.031. PMID: 34419519
Isakova T, Nickolas TL, Denburg M, Yarlagadda S, Weiner DE, Gutiérrez OM, Bansal V, Rosas SE, Nigwekar S, Yee J, Kramer H
Am J Kidney Dis 2017 Dec;70(6):737-751. Epub 2017 Sep 21 doi: 10.1053/j.ajkd.2017.07.019. PMID: 28941764
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995

Recent clinical studies

Etiology

Bellorin-Font E, Rojas E, Martin KJ
Nutrients 2022 Dec 29;15(1) doi: 10.3390/nu15010167. PMID: 36615824Free PMC Article
Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995

Diagnosis

Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Kakani E, Elyamny M, Ayach T, El-Husseini A
Semin Dial 2019 Nov;32(6):553-561. Epub 2019 Aug 29 doi: 10.1111/sdi.12840. PMID: 31464003
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995
Bover J, Bailone L, López-Báez V, Benito S, Ciceri P, Galassi A, Cozzolino M
J Nephrol 2017 Oct;30(5):677-687. Epub 2017 Apr 21 doi: 10.1007/s40620-017-0404-z. PMID: 28432640
Cejka D
Wien Med Wochenschr 2013 Sep;163(17-18):403-8. Epub 2013 May 9 doi: 10.1007/s10354-013-0195-3. PMID: 23657637

Therapy

Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995
Bover J, Bailone L, López-Báez V, Benito S, Ciceri P, Galassi A, Cozzolino M
J Nephrol 2017 Oct;30(5):677-687. Epub 2017 Apr 21 doi: 10.1007/s40620-017-0404-z. PMID: 28432640

Prognosis

Hu L, Napoletano A, Provenzano M, Garofalo C, Bini C, Comai G, La Manna G
Int J Mol Sci 2022 Oct 13;23(20) doi: 10.3390/ijms232012223. PMID: 36293076Free PMC Article
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI
Am J Kidney Dis 2015 Jul;66(1):133-46. Epub 2015 May 7 doi: 10.1053/j.ajkd.2015.01.034. PMID: 25960299Free PMC Article

Clinical prediction guides

Abdalbary M, Sobh M, Elnagar S, Elhadedy MA, Elshabrawy N, Abdelsalam M, Asadipooya K, Sabry A, Halawa A, El-Husseini A
Osteoporos Int 2022 Nov;33(11):2259-2274. Epub 2022 Jun 24 doi: 10.1007/s00198-022-06462-3. PMID: 35748896
Yamada S, Tsuruya K, Kitazono T, Nakano T
Clin Exp Nephrol 2022 Jul;26(7):613-629. Epub 2022 Mar 30 doi: 10.1007/s10157-022-02216-x. PMID: 35353283Free PMC Article
Rysz J, Franczyk B, Rokicki R, Gluba-Brzózka A
Nutrients 2021 Jun 16;13(6) doi: 10.3390/nu13062065. PMID: 34208727Free PMC Article
Haarhaus M, Evenepoel P; European Renal Osteodystrophy (EUROD) workgroup; Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) working group of the European Renal Association–European Dialysis and Transplant Association (ERA-EDTA)
Kidney Int 2021 Sep;100(3):546-558. Epub 2021 Jun 5 doi: 10.1016/j.kint.2021.04.043. PMID: 34102219
Bover J, Ureña-Torres P, Laiz Alonso AM, Torregrosa JV, Rodríguez-García M, Castro-Alonso C, Górriz JL, Benito S, López-Báez V, Lloret Cora MJ, Cigarrán S, DaSilva I, Sánchez-Bayá M, Mateu Escudero S, Guirado L, Cannata-Andía J
Nefrologia (Engl Ed) 2019 May-Jun;39(3):227-242. Epub 2019 Feb 20 doi: 10.1016/j.nefro.2018.10.009. PMID: 30797619

Recent systematic reviews

Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Apetrii M, Goldsmith D, Nistor I, Siriopol D, Voroneanu L, Scripcariu D, Vervloet M, Covic A
PLoS One 2017;12(11):e0187025. Epub 2017 Nov 6 doi: 10.1371/journal.pone.0187025. PMID: 29107998Free PMC Article
Kanbay M, Solak Y, Siriopol D, Aslan G, Afsar B, Yazici D, Covic A
Int Urol Nephrol 2016 Dec;48(12):2029-2042. Epub 2016 Aug 6 doi: 10.1007/s11255-016-1387-8. PMID: 27497736

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