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Resistant ovary syndrome

MedGen UID:
88557
Concept ID:
C0086367
Disease or Syndrome
Synonyms: Gonadotropin Resistant Ovary Syndrome; Gonadotropin-Resistant Ovary Syndrome; Resistant Ovary Syndrome
SNOMED CT: Resistant ovary syndrome (80956002)

Definition

Ovarian dysfunction due to a defect at the receptor or post receptor level, or due to the presence of antibodies against gonadotropin receptors, resulting in deficient gonadotropin signaling that causes elevated concentrations of follicle stimulating hormone and/or luteinizing hormone. A distinguishing feature is the presence of normal numbers of ova. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResistant ovary syndrome

Professional guidelines

PubMed

Kornilov NV, Pavlova MN, Yakovlev PP
J Assist Reprod Genet 2021 Jun;38(6):1303-1309. Epub 2021 Jan 26 doi: 10.1007/s10815-021-02085-5. PMID: 33495936Free PMC Article
Api M
Fertil Steril 2009 Dec;92(6):2039-40. Epub 2009 Jul 15 doi: 10.1016/j.fertnstert.2009.06.024. PMID: 19608164
Menon V, Edwards RL, Lynch SS, Butt WR
Br J Obstet Gynaecol 1983 Jun;90(6):539-42. doi: 10.1111/j.1471-0528.1983.tb08964.x. PMID: 6407517

Recent clinical studies

Etiology

Zhang F, Zhang H, Du H, Li X, Jin H, Li G
BMC Pregnancy Childbirth 2023 Mar 15;23(1):178. doi: 10.1186/s12884-023-05477-w. PMID: 36922772Free PMC Article
Sundblad V, Chiauzzi VA, Escobar ME, Dain L, Charreau EH
Mol Cell Endocrinol 2004 Jul 30;222(1-2):53-9. doi: 10.1016/j.mce.2004.05.002. PMID: 15249125
Arici A, Matalliotakis IM, Koumantakis GE, Goumenou AG, Neonaki MA, Koumantakis EE
Fertil Steril 2002 Dec;78(6):1324-6. doi: 10.1016/s0015-0282(02)04239-5. PMID: 12477534
Conway GS, Conway E, Walker C, Hoppner W, Gromoll J, Simoni M
Clin Endocrinol (Oxf) 1999 Jul;51(1):97-9. doi: 10.1046/j.1365-2265.1999.00745.x. PMID: 10468971
Mehta AE, Matwijiw I, Lyons EA, Faiman C
Fertil Steril 1992 Jan;57(1):56-61. PMID: 1730331

Diagnosis

Mu Z, Song J, Yu Y, Sun Z
Medicine (Baltimore) 2020 May;99(20):e20199. doi: 10.1097/MD.0000000000020199. PMID: 32443342Free PMC Article
Rogenhofer N, Pavlik R, Jeschke U, Wypior G, Ochsenkühn R, Thaler CJ
Am J Reprod Immunol 2015 Feb;73(2):185-91. Epub 2014 Aug 14 doi: 10.1111/aji.12306. PMID: 25123925
Arici A, Matalliotakis IM, Koumantakis GE, Goumenou AG, Neonaki MA, Koumantakis EE
Fertil Steril 2002 Dec;78(6):1324-6. doi: 10.1016/s0015-0282(02)04239-5. PMID: 12477534
Mehta AE, Matwijiw I, Lyons EA, Faiman C
Fertil Steril 1992 Jan;57(1):56-61. PMID: 1730331
Dewhurst CJ, de Koos EB, Ferreira HP
Br J Obstet Gynaecol 1975 Apr;82(4):341-5. doi: 10.1111/j.1471-0528.1975.tb00646.x. PMID: 1125157

Therapy

Hsueh AJW, Kawamura K
Fertil Steril 2020 Sep;114(3):458-464. Epub 2020 Aug 8 doi: 10.1016/j.fertnstert.2020.07.031. PMID: 32782158
Mu Z, Song J, Yu Y, Sun Z
Medicine (Baltimore) 2020 May;99(20):e20199. doi: 10.1097/MD.0000000000020199. PMID: 32443342Free PMC Article
Jequier AM
Aust N Z J Obstet Gynaecol 1990 May;30(2):176-8. doi: 10.1111/j.1479-828x.1990.tb03257.x. PMID: 2400366
Amos WL Jr
Am J Obstet Gynecol 1985 Sep 15;153(2):154-5. doi: 10.1016/0002-9378(85)90101-2. PMID: 2994481
Starup J, Pedersen H
Acta Endocrinol (Copenh) 1978 Dec;89(4):744-52. doi: 10.1530/acta.0.0890744. PMID: 716779

Prognosis

Chen X, Chen L, Wang Y, Shu C, Zhou Y, Wu R, Jin B, Yang L, Sun J, Qi M, Shu J
Front Endocrinol (Lausanne) 2022;13:1013894. Epub 2023 Jan 10 doi: 10.3389/fendo.2022.1013894. PMID: 36704038Free PMC Article
Le HL, Ho VNA, Le TTN, Tran VTT, Ma MPQ, Le AH, Nguyen LK, Ho TM, Vuong LN
J Assist Reprod Genet 2021 Dec;38(12):3243-3249. Epub 2021 Nov 30 doi: 10.1007/s10815-021-02355-2. PMID: 34846627Free PMC Article
He WB, Du J, Yang XW, Li W, Tang WL, Dai C, Chen YZ, Zhang YX, Lu GX, Lin G, Gong F, Tan YQ
Reprod Biomed Online 2019 Mar;38(3):397-406. Epub 2018 Dec 8 doi: 10.1016/j.rbmo.2018.11.011. PMID: 30691934
Chiauzzi VA, Bussmann L, Calvo JC, Sundblad V, Charreau EH
Clin Endocrinol (Oxf) 2004 Jul;61(1):46-54. doi: 10.1111/j.1365-2265.2004.02054.x. PMID: 15212644
Twigg S, Wallman L, McElduff A
J Clin Endocrinol Metab 1996 Apr;81(4):1329-31. doi: 10.1210/jcem.81.4.8636327. PMID: 8636327

Clinical prediction guides

Chen X, Chen L, Wang Y, Shu C, Zhou Y, Wu R, Jin B, Yang L, Sun J, Qi M, Shu J
Front Endocrinol (Lausanne) 2022;13:1013894. Epub 2023 Jan 10 doi: 10.3389/fendo.2022.1013894. PMID: 36704038Free PMC Article
Le HL, Ho VNA, Le TTN, Tran VTT, Ma MPQ, Le AH, Nguyen LK, Ho TM, Vuong LN
J Assist Reprod Genet 2021 Dec;38(12):3243-3249. Epub 2021 Nov 30 doi: 10.1007/s10815-021-02355-2. PMID: 34846627Free PMC Article
He WB, Du J, Yang XW, Li W, Tang WL, Dai C, Chen YZ, Zhang YX, Lu GX, Lin G, Gong F, Tan YQ
Reprod Biomed Online 2019 Mar;38(3):397-406. Epub 2018 Dec 8 doi: 10.1016/j.rbmo.2018.11.011. PMID: 30691934
Chiauzzi VA, Bussmann L, Calvo JC, Sundblad V, Charreau EH
Clin Endocrinol (Oxf) 2004 Jul;61(1):46-54. doi: 10.1111/j.1365-2265.2004.02054.x. PMID: 15212644
Starup J, Pedersen H
Acta Endocrinol (Copenh) 1978 Dec;89(4):744-52. doi: 10.1530/acta.0.0890744. PMID: 716779

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