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Nephrotic Syndrome - Relapse

MedGen UID:
885786
•Concept ID:
C4054368
•
Disease or Syndrome

Definition

Nephrotic syndrome characterized by recurrent proteinuria by dipstick of first morning urine: 2+ or greater for three days or longer, or the presence of edema with proteinuria of any duration following a remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrotic Syndrome - Relapse

Professional guidelines

PubMed

IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome.
Trautmann A, Boyer O, Hodson E, Bagga A, Gipson DS, Samuel S, Wetzels J, Alhasan K, Banerjee S, Bhimma R, Bonilla-Felix M, Cano F, Christian M, Hahn D, Kang HG, Nakanishi K, Safouh H, Trachtman H, Xu H, Cook W, Vivarelli M, Haffner D; International Pediatric Nephrology Association
Pediatr Nephrol 2023 Mar;38(3):877-919. Epub 2022 Oct 21 doi: 10.1007/s00467-022-05739-3. PMID: 36269406Free PMC Article
IPNA clinical practice recommendations for the diagnosis and management of children with steroid-resistant nephrotic syndrome.
Trautmann A, Vivarelli M, Samuel S, Gipson D, Sinha A, Schaefer F, Hui NK, Boyer O, Saleem MA, Feltran L, Müller-Deile J, Becker JU, Cano F, Xu H, Lim YN, Smoyer W, Anochie I, Nakanishi K, Hodson E, Haffner D; International Pediatric Nephrology Association
Pediatr Nephrol 2020 Aug;35(8):1529-1561. Epub 2020 May 7 doi: 10.1007/s00467-020-04519-1. PMID: 32382828Free PMC Article
Nephrotic syndrome in infants and children: pathophysiology and management.
Downie ML, Gallibois C, Parekh RS, Noone DG
Paediatr Int Child Health 2017 Nov;37(4):248-258. Epub 2017 Sep 15 doi: 10.1080/20469047.2017.1374003. PMID: 28914167

Recent clinical studies

Etiology

Primary nephrotic syndrome relapse within 1 year after glucocorticoid therapy in children is associated with gut microbiota composition at syndrome onset.
Wang C, Qu W, Chen Q, Huang WY, Kang Y, Shen J
Nephrol Dial Transplant 2023 Aug 31;38(9):1969-1980. doi: 10.1093/ndt/gfac328. PMID: 36815457
Rates of idiopathic childhood nephrotic syndrome relapse are lower during the COVID-19 pandemic.
Crane C, Bakhoum C, Ingulli E
Pediatr Nephrol 2022 Nov;37(11):2679-2685. Epub 2022 Feb 24 doi: 10.1007/s00467-022-05483-8. PMID: 35211788Free PMC Article
Short-Duration Prednisolone in Children with Nephrotic Syndrome Relapse: A Noninferiority Randomized Controlled Trial.
Kainth D, Hari P, Sinha A, Pandey S, Bagga A
Clin J Am Soc Nephrol 2021 Feb 8;16(2):225-232. Epub 2021 Jan 21 doi: 10.2215/CJN.06140420. PMID: 33478976Free PMC Article
Comparison of the Efficacy and Safety of Tacrolimus and Low-Dose Corticosteroid with High-Dose Corticosteroid for Minimal Change Nephrotic Syndrome in Adults.
Chin HJ, Chae DW, Kim YC, An WS, Ihm C, Jin DC, Kim SG, Kim YL, Kim YS, Kim YG, Koo HS, Lee JE, Lee KW, Oh J, Park JH, Jiang H, Lee H, Lee SK
J Am Soc Nephrol 2021 Jan;32(1):199-210. Epub 2020 Nov 9 doi: 10.1681/ASN.2019050546. PMID: 33168602Free PMC Article
Lower prednisone dosing for steroid-sensitive nephrotic syndrome relapse: a prospective randomized pilot study.
Borovitz Y, Alfandary H, Haskin O, Levi S, Kaz S, Davidovits M, Dagan A
Eur J Pediatr 2020 Feb;179(2):279-283. Epub 2019 Nov 14 doi: 10.1007/s00431-019-03506-5. PMID: 31728673

Diagnosis

High Albumin Clearance Predicts the Minimal Change Nephrotic Syndrome Relapse.
Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
Outcome Of Short And Long Duration Steroid Therapy In Childhood Nephrotic Syndrome In Terms Of Frequency Of Relapse Rate.
Jamshaid AA, Akhtar N, Adnan A, Perveen S, Chaudhry A, Fatima T
J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):300-303. doi: 10.55519/JAMC-02-9324. PMID: 35576290
Rates of idiopathic childhood nephrotic syndrome relapse are lower during the COVID-19 pandemic.
Crane C, Bakhoum C, Ingulli E
Pediatr Nephrol 2022 Nov;37(11):2679-2685. Epub 2022 Feb 24 doi: 10.1007/s00467-022-05483-8. PMID: 35211788Free PMC Article
Lower prednisone dosing for steroid-sensitive nephrotic syndrome relapse: a prospective randomized pilot study.
Borovitz Y, Alfandary H, Haskin O, Levi S, Kaz S, Davidovits M, Dagan A
Eur J Pediatr 2020 Feb;179(2):279-283. Epub 2019 Nov 14 doi: 10.1007/s00431-019-03506-5. PMID: 31728673
High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse.
Bakkaloglu SA, Soylemezoglu O, Buyan N, Funahashi T, Elhan AH, Peru H, Fidan K, Yilmaz S, Hasanoglu E
Pediatr Nephrol 2005 Apr;20(4):474-7. Epub 2005 Feb 3 doi: 10.1007/s00467-004-1770-z. PMID: 15690190

Therapy

Primary nephrotic syndrome relapse within 1 year after glucocorticoid therapy in children is associated with gut microbiota composition at syndrome onset.
Wang C, Qu W, Chen Q, Huang WY, Kang Y, Shen J
Nephrol Dial Transplant 2023 Aug 31;38(9):1969-1980. doi: 10.1093/ndt/gfac328. PMID: 36815457
Outcome Of Short And Long Duration Steroid Therapy In Childhood Nephrotic Syndrome In Terms Of Frequency Of Relapse Rate.
Jamshaid AA, Akhtar N, Adnan A, Perveen S, Chaudhry A, Fatima T
J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):300-303. doi: 10.55519/JAMC-02-9324. PMID: 35576290
Short-Duration Prednisolone in Children with Nephrotic Syndrome Relapse: A Noninferiority Randomized Controlled Trial.
Kainth D, Hari P, Sinha A, Pandey S, Bagga A
Clin J Am Soc Nephrol 2021 Feb 8;16(2):225-232. Epub 2021 Jan 21 doi: 10.2215/CJN.06140420. PMID: 33478976Free PMC Article
Comparison of the Efficacy and Safety of Tacrolimus and Low-Dose Corticosteroid with High-Dose Corticosteroid for Minimal Change Nephrotic Syndrome in Adults.
Chin HJ, Chae DW, Kim YC, An WS, Ihm C, Jin DC, Kim SG, Kim YL, Kim YS, Kim YG, Koo HS, Lee JE, Lee KW, Oh J, Park JH, Jiang H, Lee H, Lee SK
J Am Soc Nephrol 2021 Jan;32(1):199-210. Epub 2020 Nov 9 doi: 10.1681/ASN.2019050546. PMID: 33168602Free PMC Article
Lower prednisone dosing for steroid-sensitive nephrotic syndrome relapse: a prospective randomized pilot study.
Borovitz Y, Alfandary H, Haskin O, Levi S, Kaz S, Davidovits M, Dagan A
Eur J Pediatr 2020 Feb;179(2):279-283. Epub 2019 Nov 14 doi: 10.1007/s00431-019-03506-5. PMID: 31728673

Prognosis

High Albumin Clearance Predicts the Minimal Change Nephrotic Syndrome Relapse.
Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
SARS-CoV-2 infection in children with chronic kidney disease.
Krishnasamy S, Mantan M, Mishra K, Kapoor K, Brijwal M, Kumar M, Sharma S, Swarnim S, Gaind R, Khandelwal P, Hari P, Sinha A, Bagga A
Pediatr Nephrol 2022 Apr;37(4):849-857. Epub 2021 Sep 14 doi: 10.1007/s00467-021-05218-1. PMID: 34519896Free PMC Article
Nephrotic syndrome relapse in a boy with COVID-19.
Enya T, Morimoto Y, Oshima R, Miyazaki K, Miyazawa T, Okada M, Sugimoto K
CEN Case Rep 2021 Aug;10(3):431-434. Epub 2021 Feb 22 doi: 10.1007/s13730-021-00587-w. PMID: 33616881Free PMC Article
Lower prednisone dosing for steroid-sensitive nephrotic syndrome relapse: a prospective randomized pilot study.
Borovitz Y, Alfandary H, Haskin O, Levi S, Kaz S, Davidovits M, Dagan A
Eur J Pediatr 2020 Feb;179(2):279-283. Epub 2019 Nov 14 doi: 10.1007/s00431-019-03506-5. PMID: 31728673
Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort.
Riar SS, Banh THM, Borges K, Subbarao P, Patel V, Vasilevska-Ristovska J, Chanchlani R, Hussain-Shamsy N, Noone D, Hebert D, Licht CPB, Langlois V, Pearl RJ, Parekh RS
J Pediatr 2019 May;208:251-257.e1. Epub 2019 Feb 4 doi: 10.1016/j.jpeds.2018.12.048. PMID: 30732999

Clinical prediction guides

High Albumin Clearance Predicts the Minimal Change Nephrotic Syndrome Relapse.
Kuno H, Kanzaki G, Sasaki T, Haruhara K, Okabe M, Yokote S, Koike K, Tsuboi N, Yokoo T
Kidney360 2023 Jun 1;4(6):e787-e795. Epub 2023 May 10 doi: 10.34067/KID.0000000000000143. PMID: 37166949Free PMC Article
SARS-CoV-2 infection in children with chronic kidney disease.
Krishnasamy S, Mantan M, Mishra K, Kapoor K, Brijwal M, Kumar M, Sharma S, Swarnim S, Gaind R, Khandelwal P, Hari P, Sinha A, Bagga A
Pediatr Nephrol 2022 Apr;37(4):849-857. Epub 2021 Sep 14 doi: 10.1007/s00467-021-05218-1. PMID: 34519896Free PMC Article
Comparison of the Efficacy and Safety of Tacrolimus and Low-Dose Corticosteroid with High-Dose Corticosteroid for Minimal Change Nephrotic Syndrome in Adults.
Chin HJ, Chae DW, Kim YC, An WS, Ihm C, Jin DC, Kim SG, Kim YL, Kim YS, Kim YG, Koo HS, Lee JE, Lee KW, Oh J, Park JH, Jiang H, Lee H, Lee SK
J Am Soc Nephrol 2021 Jan;32(1):199-210. Epub 2020 Nov 9 doi: 10.1681/ASN.2019050546. PMID: 33168602Free PMC Article
Nephrotic syndrome after insect sting: a case report.
Junqueira V, Donato B, Teixeira C, Mascarenhas MI, Silva IC, Almeida E
J Bras Nefrol 2020 Oct-Dec;42(4):498-501. doi: 10.1590/2175-8239-JBN-2020-0014. PMID: 32818223Free PMC Article

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