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High Risk Acute Leukemia

MedGen UID:
886563
Concept ID:
C4050568
Finding
Synonym: High Risk

Definition

Acute leukemia patients are stratified into the high risk group when their minimal residual disease levels are higher than 0.05%. [from NCI]

Professional guidelines

PubMed

Zhu L, Wang Z, Zheng X, Ding L, Han D, Yan H, Guo Z, Wang H
Leuk Lymphoma 2015 May;56(5):1346-52. Epub 2014 Sep 8 doi: 10.3109/10428194.2014.939970. PMID: 25098431
Aversa F, Martelli MF
Springer Semin Immunopathol 2004 Nov;26(1-2):155-68. Epub 2004 Sep 11 doi: 10.1007/s00281-004-0161-7. PMID: 15378270
Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F, Ruggeri L, Barbabietola G, Aristei C, Latini P, Reisner Y, Martelli MF
N Engl J Med 1998 Oct 22;339(17):1186-93. doi: 10.1056/NEJM199810223391702. PMID: 9780338

Recent clinical studies

Etiology

Pikman Y, Stegmaier K
Blood 2018 Sep 20;132(12):1241-1247. Epub 2018 Jul 26 doi: 10.1182/blood-2018-04-784157. PMID: 30049809Free PMC Article
Martelli MF, Ianni MD, Ruggeri L, Falzetti F, Carotti A, Reisner Y, Velardi A
Bone Marrow Transplant 2015 Jun;50 Suppl 2:S63-6. doi: 10.1038/bmt.2015.98. PMID: 26039211
Glouchkova L, Ackermann B, Dilloo D
Acta Haematol 2003;110(2-3):160-70. doi: 10.1159/000072466. PMID: 14583677
Aversa F, Velardi A, Tabilio A, Reisner Y, Martelli MF
Blood Rev 2001 Sep;15(3):111-9. doi: 10.1054/blre.2001.0157. PMID: 11735159
Sanz MA, Sanz GF, Martínez JA, Senent L, López F, Palau J, Martín G, Jarque I
Ann Oncol 1992 Aug;3 Suppl 3:39-42. doi: 10.1093/annonc/3.suppl_3.s39. PMID: 1390315

Diagnosis

El Cheikh J, Bidaoui G, Atoui A, Terro K, Sharrouf L, Zahreddine A, Moukalled N, Abou Dalle I, Bazarbachi A, Mohty M, Dulery R
Bone Marrow Transplant 2023 Jun;58(6):667-672. Epub 2023 Mar 13 doi: 10.1038/s41409-023-01947-z. PMID: 36914730
Kranjčec I, Matijašić N, Abdović S, Hižar Gašpar I, La Grasta Sabolić L, Jadrijević-Cvrlje F
J Med Case Rep 2022 Apr 11;16(1):147. doi: 10.1186/s13256-022-03366-y. PMID: 35399095Free PMC Article
Fuse K, Uemura S, Tamura S, Suwabe T, Katagiri T, Tanaka T, Ushiki T, Shibasaki Y, Sato N, Yano T, Kuroha T, Hashimoto S, Furukawa T, Narita M, Sone H, Masuko M
Cancer Med 2019 Sep;8(11):5058-5067. Epub 2019 Jul 15 doi: 10.1002/cam4.2401. PMID: 31305031Free PMC Article
Gayoso J, Balsalobre P, Kwon M, Herrera P, Bermúdez A, Sampol A, Jiménez S, López-Corral L, Serrano D, Piñana JL, Pascual MJ, Heras I, Bento L, Varela R, Humala K, Zabalza A, Laiglesia A, Bastos-Oreiro M, Pérez-Corral A, Martínez-Laperche C, Buño I, Díez-Martín JL; GETH (Grupo Español de Trasplante Hematopoyético), Spain
Eur J Haematol 2018 Sep;101(3):332-339. Epub 2018 Aug 3 doi: 10.1111/ejh.13103. PMID: 29846964
Pagano L, Valentini CG, Pulsoni A, Fisogni S, Carluccio P, Mannelli F, Lunghi M, Pica G, Onida F, Cattaneo C, Piccaluga PP, Di Bona E, Todisco E, Musto P, Spadea A, D'Arco A, Pileri S, Leone G, Amadori S, Facchetti F; GIMEMA-ALWP (Gruppo Italiano Malattie EMatologiche dell'Adulto, Acute Leukemia Working Party)
Haematologica 2013 Feb;98(2):239-46. Epub 2012 Oct 12 doi: 10.3324/haematol.2012.072645. PMID: 23065521Free PMC Article

Therapy

Yang L, Lai X, Yang T, Lu Y, Liu L, Shi J, Zhao Y, Wu Y, Chen Y, Yu J, Xiao H, Ouyang G, Ren J, Cao J, Hu Y, Tan Y, Ye Y, Cai Z, Xu W, Huang H, Luo Y
Bone Marrow Transplant 2024 Jan;59(1):85-92. Epub 2023 Oct 31 doi: 10.1038/s41409-023-02137-7. PMID: 37907756
Li L, Zhang R, Cao W, Bian Z, Qin Y, Guo R, Zhang S, Peng Y, Wan D, Ma W
Leuk Lymphoma 2023 Dec;64(13):2113-2122. Epub 2023 Dec 23 doi: 10.1080/10428194.2023.2252948. PMID: 37732615
Pikman Y, Stegmaier K
Blood 2018 Sep 20;132(12):1241-1247. Epub 2018 Jul 26 doi: 10.1182/blood-2018-04-784157. PMID: 30049809Free PMC Article
Aversa F, Velardi A, Tabilio A, Reisner Y, Martelli MF
Blood Rev 2001 Sep;15(3):111-9. doi: 10.1054/blre.2001.0157. PMID: 11735159
Sanz MA, Sanz GF, Martínez JA, Senent L, López F, Palau J, Martín G, Jarque I
Ann Oncol 1992 Aug;3 Suppl 3:39-42. doi: 10.1093/annonc/3.suppl_3.s39. PMID: 1390315

Prognosis

Gómez SM, Varela MA, Ruiz C, Sung L
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e1020-e1024. doi: 10.1097/MPH.0000000000002174. PMID: 33974585
Zhang R, Lu X, Wang H, You Y, Zhong Z, Zang S, Zhang C, Shi W, Li J, Wu Q, Fang J, Xia L
Biol Blood Marrow Transplant 2019 Jan;25(1):47-55. Epub 2018 Jul 19 doi: 10.1016/j.bbmt.2018.07.021. PMID: 30031936
Tsirigotis P, Liga M, Gkirkas K, Stamouli M, Triantafyllou E, Marangos M, Pessach I, Sarantopoulos A, Spyridis N, Spyridonidis A
Bone Marrow Transplant 2017 Mar;52(3):445-451. Epub 2016 Dec 12 doi: 10.1038/bmt.2016.272. PMID: 27941776
Martelli MF, Ianni MD, Ruggeri L, Falzetti F, Carotti A, Reisner Y, Velardi A
Bone Marrow Transplant 2015 Jun;50 Suppl 2:S63-6. doi: 10.1038/bmt.2015.98. PMID: 26039211
Markovic A, MacKenzie KL, Lock RB
Int J Biochem Cell Biol 2005 Jun;37(6):1168-72. Epub 2005 Jan 26 doi: 10.1016/j.biocel.2004.12.005. PMID: 15778081

Clinical prediction guides

El Cheikh J, Bidaoui G, Atoui A, Terro K, Sharrouf L, Zahreddine A, Moukalled N, Abou Dalle I, Bazarbachi A, Mohty M, Dulery R
Bone Marrow Transplant 2023 Jun;58(6):667-672. Epub 2023 Mar 13 doi: 10.1038/s41409-023-01947-z. PMID: 36914730
Cho BS, Min GJ, Park SS, Yoon SY, Park S, Jeon YW, Shin SH, Yahng SA, Yoon JH, Lee SE, Eom KS, Kim YJ, Min CK, Cho SG, Kim DW, Lee JW, Kim HJ, Lee S
Am J Hematol 2021 Nov 1;96(11):1441-1449. Epub 2021 Aug 27 doi: 10.1002/ajh.26320. PMID: 34390504
Fuse K, Uemura S, Tamura S, Suwabe T, Katagiri T, Tanaka T, Ushiki T, Shibasaki Y, Sato N, Yano T, Kuroha T, Hashimoto S, Furukawa T, Narita M, Sone H, Masuko M
Cancer Med 2019 Sep;8(11):5058-5067. Epub 2019 Jul 15 doi: 10.1002/cam4.2401. PMID: 31305031Free PMC Article
Sestili S, Labopin M, Ruggeri A, Velardi A, Ciceri F, Maertens J, Kanz L, Aversa F, Lewalle P, Bunjes D, Mohty M, Nagler A
Cancer 2018 May 15;124(10):2142-2150. Epub 2018 Feb 22 doi: 10.1002/cncr.31310. PMID: 29469924
Guo M, Sun Z, Sun QY, Han Q, Yu CL, Wang DH, Qiao JH, Chen B, Sun WJ, Hu KX, Liu GX, Liu B, Zhao RC, Ai H
Biol Blood Marrow Transplant 2009 Aug;15(8):930-7. doi: 10.1016/j.bbmt.2009.04.006. PMID: 19589482

Recent systematic reviews

Robenshtok E, Gafter-Gvili A, Goldberg E, Weinberger M, Yeshurun M, Leibovici L, Paul M
J Clin Oncol 2007 Dec 1;25(34):5471-89. Epub 2007 Oct 1 doi: 10.1200/JCO.2007.12.3851. PMID: 17909198

Supplemental Content

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