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Acral Fibromyxoma

MedGen UID:
887580
•Concept ID:
C4055500
•
Neoplastic Process
Synonyms: Digital Fibromyxoma; Superficial Acral Fibromyxoma

Definition

A benign fibroblastic neoplasm that arises from acral sites, usually the periungual area of the digits. It is characterized by the proliferation of spindled and stellate-shaped fibroblasts in the dermis in a myxoid or collagenous stroma. Nuclear atypia is usually minimal. It usually presents as a solitary and slow-growing dome-shaped mass on a digit. The recurrence rate is low. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcral Fibromyxoma

Professional guidelines

PubMed

Onychomatricoma Versus Superficial Acral Fibromyxoma: Nestin Immunohistochemistry Is a Help in the Differential Diagnosis.
Perrin C
Am J Dermatopathol 2024 May 1;46(5):328-329. Epub 2024 Feb 7 doi: 10.1097/DAD.0000000000002628. PMID: 38354374
Diagnosis and surgical treatment of benign nail unit tumors.
Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456

Recent clinical studies

Etiology

Superficial acral fibromyxoma: a case report with radiological review.
Lee S, Reid MAR
Skeletal Radiol 2018 Jul;47(7):1021-1028. Epub 2018 Feb 8 doi: 10.1007/s00256-018-2895-7. PMID: 29423724
WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition.
Jo VY, Fletcher CD
Pathology 2014 Feb;46(2):95-104. doi: 10.1097/PAT.0000000000000050. PMID: 24378391
Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases.
Hollmann TJ, Bovée JV, Fletcher CD
Am J Surg Pathol 2012 Jun;36(6):789-98. doi: 10.1097/PAS.0b013e31824a0b83. PMID: 22367301
Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169

Diagnosis

Diagnosis and surgical treatment of benign nail unit tumors.
Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456
Acral fibromyxoma: a rare plantar nodule.
Sivasaththivel M, Howard MD, Yazdabadi A
BMJ Case Rep 2022 Jun 24;15(6) doi: 10.1136/bcr-2021-247565. PMID: 35750432Free PMC Article
Superficial Acral Fibromyxoma.
Bostanci S, Akay BN, Akkaya Z, Aygun M, Başarır K, Kaygusuz G, Kiremitçi S
J Am Podiatr Med Assoc 2021 Sep 1;111(5) doi: 10.7547/20-119. PMID: 34861690
Superficial acral fibromyxoma.
Sawaya JL, Khachemoune A
Int J Dermatol 2015;54(5):499-508. Epub 2015 Mar 13 doi: 10.1111/ijd.12750. PMID: 25772615
Superficial acral fibromyxoma: an overview.
Ashby-Richardson H, Rogers GS, Stadecker MJ
Arch Pathol Lab Med 2011 Aug;135(8):1064-6. doi: 10.5858/2009-0684-RSR1. PMID: 21810002

Therapy

Superficial acral fibromyxoma of the great toe: case report and mini-review of the literature.
Wakabayashi Y, Nakai N, Takenaka H, Katoh N
Acta Dermatovenerol Croat 2012;20(4):263-6. PMID: 23317489
Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases.
Hollmann TJ, Bovée JV, Fletcher CD
Am J Surg Pathol 2012 Jun;36(6):789-98. doi: 10.1097/PAS.0b013e31824a0b83. PMID: 22367301
Superficial acral fibromyxoma: report of 4 cases with CD10 expression and lipomatous component, two previously underrecognized features.
Tardío JC, Butrón M, Martín-Fragueiro LM
Am J Dermatopathol 2008 Oct;30(5):431-5. doi: 10.1097/DAD.0b013e31817eec0f. PMID: 18806483
Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169

Prognosis

Superficial Acral Fibromyxoma: Report of 13 Cases With New Immunohistochemical Findings.
Cullen D, Díaz Recuero JL, Cullen R, Rodríguez Peralto JL, Kutzner H, Requena L
Am J Dermatopathol 2017 Jan;39(1):14-22. doi: 10.1097/DAD.0000000000000639. PMID: 28045748
Superficial acral fibromyxoma: clinicopathological, immunohistochemical, and molecular study of 11 cases highlighting frequent Rb1 loss/deletions.
Agaimy A, Michal M, Giedl J, Hadravsky L, Michal M
Hum Pathol 2017 Feb;60:192-198. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.016. PMID: 27825811
Myxoid dermatofibroma on a great toe: a case report.
Moon A, Yoon N, Kim HS
Int J Clin Exp Pathol 2015;8(6):7605-9. Epub 2015 Jun 1 PMID: 26261677Free PMC Article
Superficial acral fibromyxoma: a clinicopathological and immunohistochemical analysis of 12 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fanti PA, Dika E, Piraccini BM, Infusino SD, Baraldi C, Misciali C
G Ital Dermatol Venereol 2011 Aug;146(4):283-7. PMID: 21785394
Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169

Clinical prediction guides

RB1 loss in the mesenchymal component of onychomatricoma.
Liu Y, Zou D, Huang Q, Wang L
J Cutan Pathol 2023 Dec;50(12):1094-1098. Epub 2023 Aug 19 doi: 10.1111/cup.14514. PMID: 37596842
Superficial Acral Fibromyxoma: Report of 13 Cases With New Immunohistochemical Findings.
Cullen D, Díaz Recuero JL, Cullen R, Rodríguez Peralto JL, Kutzner H, Requena L
Am J Dermatopathol 2017 Jan;39(1):14-22. doi: 10.1097/DAD.0000000000000639. PMID: 28045748
Superficial acral fibromyxoma: clinicopathological, immunohistochemical, and molecular study of 11 cases highlighting frequent Rb1 loss/deletions.
Agaimy A, Michal M, Giedl J, Hadravsky L, Michal M
Hum Pathol 2017 Feb;60:192-198. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.016. PMID: 27825811
Superficial acral fibromyxoma: a clinicopathological and immunohistochemical analysis of 12 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fanti PA, Dika E, Piraccini BM, Infusino SD, Baraldi C, Misciali C
G Ital Dermatol Venereol 2011 Aug;146(4):283-7. PMID: 21785394
Superficial acral fibromyxoma: a clinicopathological study of new 41 cases from the U.K.: should myxoma (NOS) and fibroma (NOS) continue as part of 21st-century reporting?
Prescott RJ, Husain EA, Abdellaoui A, Al-Mahmoud RM, Khan M, Salman WD, Twaij Z, Zelger BG, Zelger B, Al-Daraji WI
Br J Dermatol 2008 Dec;159(6):1315-21. Epub 2008 Sep 1 doi: 10.1111/j.1365-2133.2008.08798.x. PMID: 18764846

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