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Systemic Lupus Erythematosus Nephritis Class V

MedGen UID:
887958
Concept ID:
C4053952
Disease or Syndrome

Definition

Systemic lupus erythematosus nephritis, with global or segmental subepithelial immune deposits or their morphologic sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. (Weening, Jan J. et al. (2004). The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. Journal of the American Society of Nephrology 15(2), 241-50.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSystemic Lupus Erythematosus Nephritis Class V

Professional guidelines

PubMed

Anders HJ, Loutan J, Bruchfeld A, Fernández-Juárez GM, Floege J, Goumenos D, Turkmen K, van Kooten C, Frangou E, Stevens KI, Kronbichler A, Segelmark M, Tesar V
Nephrol Dial Transplant 2023 Feb 28;38(3):551-561. doi: 10.1093/ndt/gfab351. PMID: 34888694
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500

Recent clinical studies

Etiology

Rovin BH, Teng YKO, Ginzler EM, Arriens C, Caster DJ, Romero-Diaz J, Gibson K, Kaplan J, Lisk L, Navarra S, Parikh SV, Randhawa S, Solomons N, Huizinga RB
Lancet 2021 May 29;397(10289):2070-2080. Epub 2021 May 7 doi: 10.1016/S0140-6736(21)00578-X. PMID: 33971155
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500
Appel GB, Contreras G, Dooley MA, Ginzler EM, Isenberg D, Jayne D, Li LS, Mysler E, Sánchez-Guerrero J, Solomons N, Wofsy D; Aspreva Lupus Management Study Group
J Am Soc Nephrol 2009 May;20(5):1103-12. Epub 2009 Apr 15 doi: 10.1681/ASN.2008101028. PMID: 19369404Free PMC Article
Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M; International Society of Nephrology Working Group on the Classification of Lupus Nephritis; Renal Pathology Society Working Group on the Classification of Lupus Nephritis
Kidney Int 2004 Feb;65(2):521-30. doi: 10.1111/j.1523-1755.2004.00443.x. PMID: 14717922

Diagnosis

Rovin BH, Teng YKO, Ginzler EM, Arriens C, Caster DJ, Romero-Diaz J, Gibson K, Kaplan J, Lisk L, Navarra S, Parikh SV, Randhawa S, Solomons N, Huizinga RB
Lancet 2021 May 29;397(10289):2070-2080. Epub 2021 May 7 doi: 10.1016/S0140-6736(21)00578-X. PMID: 33971155
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500
Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M; International Society of Nephrology Working Group on the Classification of Lupus Nephritis; Renal Pathology Society Working Group on the Classification of Lupus Nephritis
Kidney Int 2004 Feb;65(2):521-30. doi: 10.1111/j.1523-1755.2004.00443.x. PMID: 14717922

Therapy

Wang W, He S, Zhang W, Zhang H, DeStefano VM, Wada M, Pinz K, Deener G, Shah D, Hagag N, Wang M, Hong M, Zeng R, Lan T, Ma Y, Li F, Liang Y, Guo Z, Zou C, Wang M, Ding L, Ma Y, Yuan Y
Ann Rheum Dis 2024 Sep 30;83(10):1304-1314. doi: 10.1136/ard-2024-225785. PMID: 38777376
Anders HJ, Loutan J, Bruchfeld A, Fernández-Juárez GM, Floege J, Goumenos D, Turkmen K, van Kooten C, Frangou E, Stevens KI, Kronbichler A, Segelmark M, Tesar V
Nephrol Dial Transplant 2023 Feb 28;38(3):551-561. doi: 10.1093/ndt/gfab351. PMID: 34888694
Rovin BH, Teng YKO, Ginzler EM, Arriens C, Caster DJ, Romero-Diaz J, Gibson K, Kaplan J, Lisk L, Navarra S, Parikh SV, Randhawa S, Solomons N, Huizinga RB
Lancet 2021 May 29;397(10289):2070-2080. Epub 2021 May 7 doi: 10.1016/S0140-6736(21)00578-X. PMID: 33971155
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S
Ann Rheum Dis 2017 Dec;76(12):1965-1973. Epub 2017 Sep 6 doi: 10.1136/annrheumdis-2017-211898. PMID: 28877866
Appel GB, Contreras G, Dooley MA, Ginzler EM, Isenberg D, Jayne D, Li LS, Mysler E, Sánchez-Guerrero J, Solomons N, Wofsy D; Aspreva Lupus Management Study Group
J Am Soc Nephrol 2009 May;20(5):1103-12. Epub 2009 Apr 15 doi: 10.1681/ASN.2008101028. PMID: 19369404Free PMC Article

Prognosis

Almaani S, Parikh SV
Adv Chronic Kidney Dis 2019 Sep;26(5):393-403. doi: 10.1053/j.ackd.2019.08.009. PMID: 31733724
Oliva-Damaso N, Payan J, Oliva-Damaso E, Pereda T, Bomback AS
Adv Chronic Kidney Dis 2019 Sep;26(5):369-375. doi: 10.1053/j.ackd.2019.08.011. PMID: 31733721Free PMC Article
Bomback AS
Rheum Dis Clin North Am 2018 Nov;44(4):561-569. Epub 2018 Sep 7 doi: 10.1016/j.rdc.2018.06.003. PMID: 30274623Free PMC Article
Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S, Reddi AS, Kothari N
Clin Exp Nephrol 2016 Feb;20(1):1-13. Epub 2015 Oct 16 doi: 10.1007/s10157-015-1179-y. PMID: 26471017
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500

Clinical prediction guides

Fava A, Wagner CA, Guthridge CJ, Kheir J, Macwana S, DeJager W, Gross T, Izmirly P, Belmont HM, Diamond B, Davidson A, Utz PJ, Weisman MH, Magder LS; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Guthridge JM, Petri M, Buyon J, James JA
Arthritis Rheumatol 2024 Nov;76(11):1611-1622. Epub 2024 Aug 9 doi: 10.1002/art.42941. PMID: 38962936Free PMC Article
Zheng Z, Zhang H, Peng X, Zhang C, Xing C, Xu G, Fu P, Ni Z, Chen J, Xu Z, Zhao MH, Li S, Huang X, Miao L, Chen X, Liu B, He Y, Li J, Liu L, Kadeerbai H, Liu Z, Liu Z
JAMA Netw Open 2022 Mar 1;5(3):e224492. doi: 10.1001/jamanetworkopen.2022.4492. PMID: 35353167Free PMC Article
Tang Y, Zhang W, Zhu M, Zheng L, Xie L, Yao Z, Zhang H, Cao D, Lu B
Sci Rep 2018 Jul 6;8(1):10231. doi: 10.1038/s41598-018-28611-7. PMID: 29980727Free PMC Article
Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S, Reddi AS, Kothari N
Clin Exp Nephrol 2016 Feb;20(1):1-13. Epub 2015 Oct 16 doi: 10.1007/s10157-015-1179-y. PMID: 26471017
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500

Recent systematic reviews

Reis-Neto ETD, Seguro LPC, Sato EI, Borba EF, Klumb EM, Costallat LTL, Medeiros MMDC, Bonfá E, Araújo NC, Appenzeller S, Montandon ACOES, Yuki EFN, Teixeira RCA, Telles RW, Egypto DCSD, Ribeiro FM, Gasparin AA, Junior ASA, Neiva CLS, Calderaro DC, Monticielo OA
Adv Rheumatol 2024 Jun 18;64(1):48. doi: 10.1186/s42358-024-00386-8. PMID: 38890752
Kostopoulou M, Fanouriakis A, Cheema K, Boletis J, Bertsias G, Jayne D, Boumpas DT
RMD Open 2020 Jul;6(2) doi: 10.1136/rmdopen-2020-001263. PMID: 32699043Free PMC Article
Tunnicliffe DJ, Palmer SC, Henderson L, Masson P, Craig JC, Tong A, Singh-Grewal D, Flanc RS, Roberts MA, Webster AC, Strippoli GF
Cochrane Database Syst Rev 2018 Jun 29;6(6):CD002922. doi: 10.1002/14651858.CD002922.pub4. PMID: 29957821Free PMC Article
Tunnicliffe DJ, Singh-Grewal D, Kim S, Craig JC, Tong A
Arthritis Care Res (Hoboken) 2015 Oct;67(10):1440-52. doi: 10.1002/acr.22591. PMID: 25778500
Henderson L, Masson P, Craig JC, Flanc RS, Roberts MA, Strippoli GF, Webster AC
Cochrane Database Syst Rev 2012 Dec 12;12:CD002922. doi: 10.1002/14651858.CD002922.pub3. PMID: 23235592

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