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Testicular Hypotrophy

MedGen UID:
888144
•Concept ID:
C4053943
•
Disease or Syndrome

Definition

Less than expected testicular size. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Hypotrophy

Professional guidelines

PubMed

Treating varicocele in 2018: current knowledge and treatment options.
Zavattaro M, Ceruti C, Motta G, Allasia S, Marinelli L, Di Bisceglie C, Tagliabue MP, Sibona M, Rolle L, Lanfranco F
J Endocrinol Invest 2018 Dec;41(12):1365-1375. Epub 2018 Oct 3 doi: 10.1007/s40618-018-0952-7. PMID: 30284221
Evaluation and Management of the Adolescent Varicocele.
Kolon TF
J Urol 2015 Nov;194(5):1194-201. Epub 2015 Jun 25 doi: 10.1016/j.juro.2015.06.079. PMID: 26119668
Varicocele: strategies in diagnosis and treatment.
Cornud F, Belin X, Amar E, Delafontaine D, Hélénon O, Moreau JF
Eur Radiol 1999;9(3):536-45. doi: 10.1007/s003300050706. PMID: 10087130

Recent clinical studies

Etiology

Testicular function and sexuality in adult patients with anorectal malformation.
Trovalusci E, Rossato M, Gamba P, Midrio P
J Pediatr Surg 2020 Sep;55(9):1839-1845. Epub 2020 Jan 29 doi: 10.1016/j.jpedsurg.2019.12.028. PMID: 32057441
The Role of Sonoelastography in the Evaluation of Testes With Varicocele.
Camoglio FS, Bruno C, Peretti M, Bianchi F, Bucci A, Scirè G, Patanè S, Zampieri N
Urology 2017 Feb;100:203-206. Epub 2016 Aug 9 doi: 10.1016/j.urology.2016.08.005. PMID: 27521065
Evaluation and Management of the Adolescent Varicocele.
Kolon TF
J Urol 2015 Nov;194(5):1194-201. Epub 2015 Jun 25 doi: 10.1016/j.juro.2015.06.079. PMID: 26119668
Testicular hypotrophy does not correlate with grade of adolescent varicocele.
Alukal JP, Zurakowski D, Atala A, Bauer SB, Borer JG, Cilento BG Jr, Mandell J, Peters CA, Paltiel HJ, Retik AB, Diamond DA
J Urol 2005 Dec;174(6):2367-70, discussion 2370. doi: 10.1097/01.ju.0000180418.23208.1d. PMID: 16280845
Varicocele: strategies in diagnosis and treatment.
Cornud F, Belin X, Amar E, Delafontaine D, Hélénon O, Moreau JF
Eur Radiol 1999;9(3):536-45. doi: 10.1007/s003300050706. PMID: 10087130

Diagnosis

Testicular function and sexuality in adult patients with anorectal malformation.
Trovalusci E, Rossato M, Gamba P, Midrio P
J Pediatr Surg 2020 Sep;55(9):1839-1845. Epub 2020 Jan 29 doi: 10.1016/j.jpedsurg.2019.12.028. PMID: 32057441
The Role of Sonoelastography in the Evaluation of Testes With Varicocele.
Camoglio FS, Bruno C, Peretti M, Bianchi F, Bucci A, Scirè G, Patanè S, Zampieri N
Urology 2017 Feb;100:203-206. Epub 2016 Aug 9 doi: 10.1016/j.urology.2016.08.005. PMID: 27521065
Evaluation and Management of the Adolescent Varicocele.
Kolon TF
J Urol 2015 Nov;194(5):1194-201. Epub 2015 Jun 25 doi: 10.1016/j.juro.2015.06.079. PMID: 26119668
The dilemma of adolescent varicocele.
Garcia-Roig ML, Kirsch AJ
Pediatr Surg Int 2015 Jul;31(7):617-25. Epub 2015 Apr 19 doi: 10.1007/s00383-015-3698-8. PMID: 25895069
Varicocele: strategies in diagnosis and treatment.
Cornud F, Belin X, Amar E, Delafontaine D, Hélénon O, Moreau JF
Eur Radiol 1999;9(3):536-45. doi: 10.1007/s003300050706. PMID: 10087130

Therapy

'Burned-Out' primary testicular tumour: Is retroperitoneal lymph node biopsy mandatory prior to initiation of chemotherapy? Report of three cases and a review of the literature.
Vukovic M, Kavaric P, Vukmirovic F, Lekic S
Andrologia 2022 Mar;54(2):e14283. Epub 2021 Oct 21 doi: 10.1111/and.14283. PMID: 34676571
Testicular Growth and Pubertal Onset in GH-Deficient Children Treated With Growth Hormone: A Retrospective Study.
Cannarella R, Caruso M, Crafa A, Timpanaro TA, Lo Bianco M, Presti S, Condorelli RA, La Vignera S, Calogero AE
Front Endocrinol (Lausanne) 2021;12:619895. Epub 2021 Apr 2 doi: 10.3389/fendo.2021.619895. PMID: 33868165Free PMC Article
Risk behaviours and alcohol in adolescence are negatively associated with testicular volume: results from the Amico-Andrologo survey.
Gianfrilli D, Ferlin A, Isidori AM, Garolla A, Maggi M, Pivonello R, Santi D, Sansone A, Balercia G, Granata ARM, Sinisi A, Lanfranco F, Pasqualetti P, Foresta C, Lenzi A; ‘Amico-Andrologo’ Study Group
Andrology 2019 Nov;7(6):769-777. Epub 2019 Jun 11 doi: 10.1111/andr.12659. PMID: 31187607
Congenital hypogonadotropic hypogonadism and Kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions.
Trabado S, Lamothe S, Maione L, Bouvattier C, Sarfati J, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2014 May;75(2):79-87. Epub 2014 May 9 doi: 10.1016/j.ando.2014.04.011. PMID: 24815726
The feasibility of fertility preservation in adolescents with Klinefelter syndrome.
Rives N, Milazzo JP, Perdrix A, Castanet M, Joly-Hélas G, Sibert L, Bironneau A, Way A, Macé B
Hum Reprod 2013 Jun;28(6):1468-79. Epub 2013 Mar 28 doi: 10.1093/humrep/det084. PMID: 23539613

Prognosis

Testicular function and sexuality in adult patients with anorectal malformation.
Trovalusci E, Rossato M, Gamba P, Midrio P
J Pediatr Surg 2020 Sep;55(9):1839-1845. Epub 2020 Jan 29 doi: 10.1016/j.jpedsurg.2019.12.028. PMID: 32057441
The Role of Sonoelastography in the Evaluation of Testes With Varicocele.
Camoglio FS, Bruno C, Peretti M, Bianchi F, Bucci A, Scirè G, Patanè S, Zampieri N
Urology 2017 Feb;100:203-206. Epub 2016 Aug 9 doi: 10.1016/j.urology.2016.08.005. PMID: 27521065
Elevation of testicular temperature predicts testicular catch-up growth and hypotrophy after varicocelectomy and observation in adolescent varicocele.
Shiraishi K, Matsuyama H
Urology 2013 Jul;82(1):205-9. Epub 2013 Mar 20 doi: 10.1016/j.urology.2013.01.043. PMID: 23523290
Relationship of varicocele grade and testicular hypotrophy to semen parameters in adolescents.
Diamond DA, Zurakowski D, Bauer SB, Borer JG, Peters CA, Cilento BG Jr, Paltiel HJ, Rosoklija I, Retik AB
J Urol 2007 Oct;178(4 Pt 2):1584-8. Epub 2007 Aug 16 doi: 10.1016/j.juro.2007.03.169. PMID: 17707046
Testicular hypotrophy in varicocele: pre and postoperative echographic follow-up in the pediatric age.
Messina M, Zagordo L, Di Maggio G, Molinaro F, Abate V, Nardi N
Minerva Urol Nefrol 2006 Sep;58(3):151-5. PMID: 17124484

Clinical prediction guides

The Role of Sonoelastography in the Evaluation of Testes With Varicocele.
Camoglio FS, Bruno C, Peretti M, Bianchi F, Bucci A, Scirè G, Patanè S, Zampieri N
Urology 2017 Feb;100:203-206. Epub 2016 Aug 9 doi: 10.1016/j.urology.2016.08.005. PMID: 27521065
Evaluation and Management of the Adolescent Varicocele.
Kolon TF
J Urol 2015 Nov;194(5):1194-201. Epub 2015 Jun 25 doi: 10.1016/j.juro.2015.06.079. PMID: 26119668
Single scrotal incision orchiopexy - a systematic review.
Novaes HF, Carneiro Neto JA, Macedo A Jr, Barroso Júnior U
Int Braz J Urol 2013 May-Jun;39(3):305-11. doi: 10.1590/S1677-5538.IBJU.2013.03.02. PMID: 23849581
Elevation of testicular temperature predicts testicular catch-up growth and hypotrophy after varicocelectomy and observation in adolescent varicocele.
Shiraishi K, Matsuyama H
Urology 2013 Jul;82(1):205-9. Epub 2013 Mar 20 doi: 10.1016/j.urology.2013.01.043. PMID: 23523290
Testicular hypotrophy does not correlate with grade of adolescent varicocele.
Alukal JP, Zurakowski D, Atala A, Bauer SB, Borer JG, Cilento BG Jr, Mandell J, Peters CA, Paltiel HJ, Retik AB, Diamond DA
J Urol 2005 Dec;174(6):2367-70, discussion 2370. doi: 10.1097/01.ju.0000180418.23208.1d. PMID: 16280845

Recent systematic reviews

Evaluation and Management of the Adolescent Varicocele.
Kolon TF
J Urol 2015 Nov;194(5):1194-201. Epub 2015 Jun 25 doi: 10.1016/j.juro.2015.06.079. PMID: 26119668
Single scrotal incision orchiopexy - a systematic review.
Novaes HF, Carneiro Neto JA, Macedo A Jr, Barroso Júnior U
Int Braz J Urol 2013 May-Jun;39(3):305-11. doi: 10.1590/S1677-5538.IBJU.2013.03.02. PMID: 23849581

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