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Ureterovesical junction obstruction

MedGen UID:
888535
•Concept ID:
C2609249
•
Finding
Synonyms: Obstruction of ureterovesical junction; Obstruction of vesicoureteric junction
SNOMED CT: Obstruction of vesicoureteric junction (1259363003); Obstruction of ureterovesical junction (1259363003)
 
HPO: HP:0030735

Definition

Blockage at the level of the bladder and the ureter caused by stenosis of the ureteral valves or failure of a narrow juxtavesical ureteral segment to dilate due to segmented fibrosis or localized absence of muscle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUreterovesical junction obstruction

Professional guidelines

PubMed

Prenatal diagnosis and outcome of fetal urinomas in relation to the underlying etiology.
Simonini C, Strizek B, Strömer A, Gembruch U, Geipel A
Prenat Diagn 2024 Feb;44(2):138-147. Epub 2023 Apr 26 doi: 10.1002/pd.6355. PMID: 37060206
Comparison of polyacrylate polyalcohol copolymer (PPC) and dextranomer/hyaluronic acid (Dx/HA) for treatment of vesicoureteral reflux. A systematic review and meta-analysis.
Gholami B, Gholami S, Khodaei B, Sharifiaghdas F
J Pediatr Urol 2022 Oct;18(5):664-673. Epub 2022 Aug 20 doi: 10.1016/j.jpurol.2022.08.012. PMID: 36153243
Endoureterotomy as the initial management of concurrent ureteropelvic and ureterovesical junction obstruction after failed conservative therapy.
Ebadi M, Kajbafzadeh AM, Tourchi A, Mousavian AA
Urology 2013 Jul;82(1):214-9. Epub 2013 Apr 17 doi: 10.1016/j.urology.2013.02.048. PMID: 23601441

Recent clinical studies

Etiology

Pilot Study on the Molecular Pathogenesis of Pyeloureteral Junction Obstruction: Underdevelopment or Fibrosis?
Tamasauske RZ, Kazlauskas V, Barasa P, Krestnikova N, Dasevicius D, Bilius V, Verkauskas G
Medicina (Kaunas) 2023 Sep 27;59(10) doi: 10.3390/medicina59101729. PMID: 37893447Free PMC Article
Rare Single Nucleotide and Copy Number Variants and the Etiology of Congenital Obstructive Uropathy: Implications for Genetic Diagnosis.
Ahram DF, Lim TY, Ke J, Jin G, Verbitsky M, Bodria M, Kil BH, Chatterjee D, Piva SE, Marasa M, Zhang JY, Cocchi E, Caridi G, Gucev Z, Lozanovski VJ, Pisani I, Izzi C, Savoldi G, Gnutti B, Capone VP, Morello W, Guarino S, Esposito P, Lambert S, Radhakrishnan J, Appel GB, Uy NS, Rao MK, Canetta PA, Bomback AS, Nestor JG, Hays T, Cohen DJ, Finale C, Wijk JAEV, La Scola C, Baraldi O, Tondolo F, Di Renzo D, Jamry-Dziurla A, Pezzutto A, Manca V, Mitrotti A, Santoro D, Conti G, Martino M, Giordano M, Gesualdo L, Zibar L, Masnata G, Bonomini M, Alberti D, La Manna G, Caliskan Y, Ranghino A, Marzuillo P, Kiryluk K, Krzemień G, Miklaszewska M, Lin F, Montini G, Scolari F, Fiaccadori E, Arapović A, Saraga M, McKiernan J, Alam S, Zaniew M, Szczepańska M, Szmigielska A, Sikora P, Drożdż D, Mizerska-Wasiak M, Mane S, Lifton RP, Tasic V, Latos-Bielenska A, Gharavi AG, Ghiggeri GM, Materna-Kiryluk A, Westland R, Sanna-Cherchi S
J Am Soc Nephrol 2023 Jun 1;34(6):1105-1119. Epub 2023 Mar 30 doi: 10.1681/ASN.0000000000000132. PMID: 36995132Free PMC Article
Pathological changes in ureterovesical and ureteropelvic junction obstruction explained by fetal ureter histology.
Babu R, Vittalraj P, Sundaram S, Shalini S
J Pediatr Urol 2019 May;15(3):240.e1-240.e7. Epub 2019 Feb 11 doi: 10.1016/j.jpurol.2019.02.001. PMID: 30850354
Coexisting ureteropelvic junction obstruction and ureterovesical junction obstruction: is pyeloplasty always the preferred initial surgery?
Lee YS, Im YJ, Lee H, Kim MJ, Lee MJ, Jung HJ, Han SW
Urology 2014 Feb;83(2):443-9. Epub 2013 Nov 16 doi: 10.1016/j.urology.2013.08.087. PMID: 24246322
Ureteral reimplantation in infants.
Greenfield SP, Griswold JJ, Wan J
J Urol 1993 Nov;150(5 Pt 1):1460-2. doi: 10.1016/s0022-5347(17)35809-3. PMID: 8411425

Diagnosis

Rare Single Nucleotide and Copy Number Variants and the Etiology of Congenital Obstructive Uropathy: Implications for Genetic Diagnosis.
Ahram DF, Lim TY, Ke J, Jin G, Verbitsky M, Bodria M, Kil BH, Chatterjee D, Piva SE, Marasa M, Zhang JY, Cocchi E, Caridi G, Gucev Z, Lozanovski VJ, Pisani I, Izzi C, Savoldi G, Gnutti B, Capone VP, Morello W, Guarino S, Esposito P, Lambert S, Radhakrishnan J, Appel GB, Uy NS, Rao MK, Canetta PA, Bomback AS, Nestor JG, Hays T, Cohen DJ, Finale C, Wijk JAEV, La Scola C, Baraldi O, Tondolo F, Di Renzo D, Jamry-Dziurla A, Pezzutto A, Manca V, Mitrotti A, Santoro D, Conti G, Martino M, Giordano M, Gesualdo L, Zibar L, Masnata G, Bonomini M, Alberti D, La Manna G, Caliskan Y, Ranghino A, Marzuillo P, Kiryluk K, Krzemień G, Miklaszewska M, Lin F, Montini G, Scolari F, Fiaccadori E, Arapović A, Saraga M, McKiernan J, Alam S, Zaniew M, Szczepańska M, Szmigielska A, Sikora P, Drożdż D, Mizerska-Wasiak M, Mane S, Lifton RP, Tasic V, Latos-Bielenska A, Gharavi AG, Ghiggeri GM, Materna-Kiryluk A, Westland R, Sanna-Cherchi S
J Am Soc Nephrol 2023 Jun 1;34(6):1105-1119. Epub 2023 Mar 30 doi: 10.1681/ASN.0000000000000132. PMID: 36995132Free PMC Article
Bilateral Ureterovesical Junction Obstruction Resulting in Anuria in a 3-Week-Old Infant.
Baiocco JA, Malhotra NR, Ferrer FA
Urology 2022 Nov;169:214-217. Epub 2022 May 24 doi: 10.1016/j.urology.2022.05.011. PMID: 35623500
The Whitaker test.
Johnston RB, Porter C
Urol J 2014 Jul 8;11(3):1727-30. PMID: 25015627
Coexisting ureteropelvic junction obstruction and ureterovesical junction obstruction: is pyeloplasty always the preferred initial surgery?
Lee YS, Im YJ, Lee H, Kim MJ, Lee MJ, Jung HJ, Han SW
Urology 2014 Feb;83(2):443-9. Epub 2013 Nov 16 doi: 10.1016/j.urology.2013.08.087. PMID: 24246322
Nonrenovascular renal hypertension in children.
Shapiro SR, Adelman RD, Tesluk H
Urology 1977 Dec;10(6):517-28. doi: 10.1016/0090-4295(77)90093-0. PMID: 203075

Therapy

Comparison of polyacrylate polyalcohol copolymer (PPC) and dextranomer/hyaluronic acid (Dx/HA) for treatment of vesicoureteral reflux. A systematic review and meta-analysis.
Gholami B, Gholami S, Khodaei B, Sharifiaghdas F
J Pediatr Urol 2022 Oct;18(5):664-673. Epub 2022 Aug 20 doi: 10.1016/j.jpurol.2022.08.012. PMID: 36153243
Effectiveness and Complications of Augmentation Cystoplasty with or without Nonrefluxing Ureteral Reimplantation in Patients with Bladder Dysfunction: A Single Center 11-Year Experience.
Wang Z, Liao L
J Urol 2018 Jan;199(1):200-205. Epub 2017 Jul 23 doi: 10.1016/j.juro.2017.07.073. PMID: 28743527
Continuous antibiotic prophylaxis reduces the risk of febrile UTI in children with asymptomatic antenatal hydronephrosis with either ureteral dilation, high-grade vesicoureteral reflux, or ureterovesical junction obstruction.
Herz D, Merguerian P, McQuiston L
J Pediatr Urol 2014 Aug;10(4):650-4. Epub 2014 Jul 22 doi: 10.1016/j.jpurol.2014.06.009. PMID: 25155409
Concomitant endoureterotomy and dextranomer/hyaluronic acid subureteral injection for management of obstructive refluxing megaureter.
Kajbafzadeh AM, Tourchi A
J Endourol 2012 Apr;26(4):318-24. doi: 10.1089/end.2011.0256. PMID: 22059739
Urological complications in ureteric stenting live related renal transplantation.
Ashraf HS, Khan MU, Hussain I, Hyder I
J Coll Physicians Surg Pak 2011 Jan;21(1):34-6. PMID: 21276383

Prognosis

Rare Single Nucleotide and Copy Number Variants and the Etiology of Congenital Obstructive Uropathy: Implications for Genetic Diagnosis.
Ahram DF, Lim TY, Ke J, Jin G, Verbitsky M, Bodria M, Kil BH, Chatterjee D, Piva SE, Marasa M, Zhang JY, Cocchi E, Caridi G, Gucev Z, Lozanovski VJ, Pisani I, Izzi C, Savoldi G, Gnutti B, Capone VP, Morello W, Guarino S, Esposito P, Lambert S, Radhakrishnan J, Appel GB, Uy NS, Rao MK, Canetta PA, Bomback AS, Nestor JG, Hays T, Cohen DJ, Finale C, Wijk JAEV, La Scola C, Baraldi O, Tondolo F, Di Renzo D, Jamry-Dziurla A, Pezzutto A, Manca V, Mitrotti A, Santoro D, Conti G, Martino M, Giordano M, Gesualdo L, Zibar L, Masnata G, Bonomini M, Alberti D, La Manna G, Caliskan Y, Ranghino A, Marzuillo P, Kiryluk K, Krzemień G, Miklaszewska M, Lin F, Montini G, Scolari F, Fiaccadori E, Arapović A, Saraga M, McKiernan J, Alam S, Zaniew M, Szczepańska M, Szmigielska A, Sikora P, Drożdż D, Mizerska-Wasiak M, Mane S, Lifton RP, Tasic V, Latos-Bielenska A, Gharavi AG, Ghiggeri GM, Materna-Kiryluk A, Westland R, Sanna-Cherchi S
J Am Soc Nephrol 2023 Jun 1;34(6):1105-1119. Epub 2023 Mar 30 doi: 10.1681/ASN.0000000000000132. PMID: 36995132Free PMC Article
Does Renal Function Remain Stable after Puberty in Children who underwent Ureteral Reimplantation due to Ureterovesical Junction Obstruction?
Neeman BB, Jaber J, Kocherov S, Farkas A, Chertin B
Eur J Pediatr Surg 2021 Apr;31(2):187-190. Epub 2020 May 25 doi: 10.1055/s-0040-1712172. PMID: 32450580
The natural history of the multicystic dysplastic kidney--is limited follow-up warranted?
Eickmeyer AB, Casanova NF, He C, Smith EA, Wan J, Bloom DA, Dillman JR
J Pediatr Urol 2014 Aug;10(4):655-61. Epub 2014 Jul 4 doi: 10.1016/j.jpurol.2014.06.001. PMID: 25087179
Intermittent ureterovesical junction obstruction in children.
Botelho L, Rincon JA, Nguyen HT, Bauer SB, Rust D, Estrada CR
J Pediatr Urol 2011 Oct;7(5):579-81. Epub 2011 Mar 5 doi: 10.1016/j.jpurol.2011.01.014. PMID: 21377934
Ureteral reimplantation in infants.
Greenfield SP, Griswold JJ, Wan J
J Urol 1993 Nov;150(5 Pt 1):1460-2. doi: 10.1016/s0022-5347(17)35809-3. PMID: 8411425

Clinical prediction guides

Pilot Study on the Molecular Pathogenesis of Pyeloureteral Junction Obstruction: Underdevelopment or Fibrosis?
Tamasauske RZ, Kazlauskas V, Barasa P, Krestnikova N, Dasevicius D, Bilius V, Verkauskas G
Medicina (Kaunas) 2023 Sep 27;59(10) doi: 10.3390/medicina59101729. PMID: 37893447Free PMC Article
Outcomes of complex robot-assisted laparoscopic ureteral reimplantation after failed ipsilateral endoscopic treatment of vesicoureteral reflux.
Janssen KM, Kirsch AJ
J Pediatr Urol 2021 Aug;17(4):547.e1-547.e6. Epub 2021 Jun 9 doi: 10.1016/j.jpurol.2021.05.029. PMID: 34274237
Rectourethral and rectovesical fistula as serious and rare complications after Hirschsprung disease operation: Experience in seven patients.
Peng C, Tan SS, Pang W, Wang Z, Wu D, Wang K, Chen Y
J Pediatr Surg 2021 Feb;56(2):263-268. Epub 2020 Jul 3 doi: 10.1016/j.jpedsurg.2020.06.042. PMID: 32732163
Clinical outcome and follow-up of prenatal hydronephrosis.
Asl AS, Maleknejad S
Saudi J Kidney Dis Transpl 2012 May;23(3):526-31. PMID: 22569439
Ureteral reimplantation in infants.
Greenfield SP, Griswold JJ, Wan J
J Urol 1993 Nov;150(5 Pt 1):1460-2. doi: 10.1016/s0022-5347(17)35809-3. PMID: 8411425

Recent systematic reviews

Comparison of polyacrylate polyalcohol copolymer (PPC) and dextranomer/hyaluronic acid (Dx/HA) for treatment of vesicoureteral reflux. A systematic review and meta-analysis.
Gholami B, Gholami S, Khodaei B, Sharifiaghdas F
J Pediatr Urol 2022 Oct;18(5):664-673. Epub 2022 Aug 20 doi: 10.1016/j.jpurol.2022.08.012. PMID: 36153243

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