U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pauci-Immune Glomerulonephritis associated with Microscopic Polyangiitis

MedGen UID:
889022
•Concept ID:
C4054224
•
Disease or Syndrome

Definition

Glomerulonephritis in the context of systemic, small vessel vasculitis in which anti neutrophil cytoplasm antibody (ANCA) is almost always present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPauci-Immune Glomerulonephritis associated with Microscopic Polyangiitis

Professional guidelines

PubMed

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS INVESTIGATORS
Ann Rheum Dis 2022 Mar;81(3):321-326. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221796. PMID: 35110332
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):400-406. Epub 2022 Feb 2 doi: 10.1002/art.41983. PMID: 35106973
ANCA-associated vasculitis: diagnosis, clinical characteristics and treatment.
Haubitz M
Vasa 2007 May;36(2):81-9. doi: 10.1024/0301-1526.36.2.81. PMID: 17708098

Recent clinical studies

Etiology

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS INVESTIGATORS
Ann Rheum Dis 2022 Mar;81(3):321-326. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221796. PMID: 35110332
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):400-406. Epub 2022 Feb 2 doi: 10.1002/art.41983. PMID: 35106973
ANCA Glomerulonephritis and Vasculitis.
Jennette JC, Nachman PH
Clin J Am Soc Nephrol 2017 Oct 6;12(10):1680-1691. Epub 2017 Aug 25 doi: 10.2215/CJN.02500317. PMID: 28842398Free PMC Article
ANCA-associated pauci-immune glomerulonephritis: always pauci-immune?
Scaglioni V, Scolnik M, Catoggio LJ, Christiansen SB, Varela CF, Greloni G, Rosa-Diez G, Soriano ER
Clin Exp Rheumatol 2017 Mar-Apr;35 Suppl 103(1):55-58. Epub 2017 Jan 31 PMID: 28229825
Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement.
Geetha D, Specks U, Stone JH, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Tchao NK, Ikle D, Jepson B, Brunetta P, Fervenza FC; Rituximab for ANCA-Associated Vasculitis Immune Tolerance Network Research Group
J Am Soc Nephrol 2015 Apr;26(4):976-85. Epub 2014 Nov 7 doi: 10.1681/ASN.2014010046. PMID: 25381429Free PMC Article

Diagnosis

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS INVESTIGATORS
Ann Rheum Dis 2022 Mar;81(3):321-326. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221796. PMID: 35110332
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):400-406. Epub 2022 Feb 2 doi: 10.1002/art.41983. PMID: 35106973
ANCA Glomerulonephritis and Vasculitis.
Jennette JC, Nachman PH
Clin J Am Soc Nephrol 2017 Oct 6;12(10):1680-1691. Epub 2017 Aug 25 doi: 10.2215/CJN.02500317. PMID: 28842398Free PMC Article
ANCA-associated pauci-immune glomerulonephritis: always pauci-immune?
Scaglioni V, Scolnik M, Catoggio LJ, Christiansen SB, Varela CF, Greloni G, Rosa-Diez G, Soriano ER
Clin Exp Rheumatol 2017 Mar-Apr;35 Suppl 103(1):55-58. Epub 2017 Jan 31 PMID: 28229825
Pauci-immune necrotizing glomerulonephritis.
Rutgers A, Sanders JS, Stegeman CA, Kallenberg CG
Rheum Dis Clin North Am 2010 Aug;36(3):559-72. doi: 10.1016/j.rdc.2010.05.002. PMID: 20688250

Therapy

ANCA Glomerulonephritis and Vasculitis.
Jennette JC, Nachman PH
Clin J Am Soc Nephrol 2017 Oct 6;12(10):1680-1691. Epub 2017 Aug 25 doi: 10.2215/CJN.02500317. PMID: 28842398Free PMC Article
Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement.
Geetha D, Specks U, Stone JH, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Tchao NK, Ikle D, Jepson B, Brunetta P, Fervenza FC; Rituximab for ANCA-Associated Vasculitis Immune Tolerance Network Research Group
J Am Soc Nephrol 2015 Apr;26(4):976-85. Epub 2014 Nov 7 doi: 10.1681/ASN.2014010046. PMID: 25381429Free PMC Article
The diagnosis and classification of microscopic polyangiitis.
Kallenberg CG
J Autoimmun 2014 Feb-Mar;48-49:90-3. Epub 2014 Jan 22 doi: 10.1016/j.jaut.2014.01.023. PMID: 24461388
Pauci-immune necrotizing glomerulonephritis.
Rutgers A, Sanders JS, Stegeman CA, Kallenberg CG
Rheum Dis Clin North Am 2010 Aug;36(3):559-72. doi: 10.1016/j.rdc.2010.05.002. PMID: 20688250
Silicon exposure and vasculitis.
Tervaert JW, Stegeman CA, Kallenberg CG
Curr Opin Rheumatol 1998 Jan;10(1):12-7. doi: 10.1097/00002281-199801000-00003. PMID: 9448985

Prognosis

Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Zonozi R, Niles JL, Cortazar FB
Rheum Dis Clin North Am 2018 Nov;44(4):525-543. Epub 2018 Sep 7 doi: 10.1016/j.rdc.2018.06.001. PMID: 30274621
The diagnosis and classification of microscopic polyangiitis.
Kallenberg CG
J Autoimmun 2014 Feb-Mar;48-49:90-3. Epub 2014 Jan 22 doi: 10.1016/j.jaut.2014.01.023. PMID: 24461388
Renal involvement in anti-neutrophil cytoplasmic autoantibody associated vasculitis.
Sinico RA, Di Toma L, Radice A
Autoimmun Rev 2013 Feb;12(4):477-82. Epub 2012 Aug 16 doi: 10.1016/j.autrev.2012.08.006. PMID: 22921791
Pauci-immune necrotizing glomerulonephritis.
Rutgers A, Sanders JS, Stegeman CA, Kallenberg CG
Rheum Dis Clin North Am 2010 Aug;36(3):559-72. doi: 10.1016/j.rdc.2010.05.002. PMID: 20688250
Childhood microscopic polyangiitis associated with MPO-ANCA.
Peco-Antic A, Bonaci-Nikolic B, Basta-Jovanovic G, Kostic M, Markovic-Lipkovski J, Nikolic M, Spasojevic B
Pediatr Nephrol 2006 Jan;21(1):46-53. Epub 2005 Oct 27 doi: 10.1007/s00467-005-2063-x. PMID: 16252100

Clinical prediction guides

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for microscopic polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS INVESTIGATORS
Ann Rheum Dis 2022 Mar;81(3):321-326. Epub 2022 Feb 2 doi: 10.1136/annrheumdis-2021-221796. PMID: 35110332
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis.
Suppiah R, Robson JC, Grayson PC, Ponte C, Craven A, Khalid S, Judge A, Hutchings A, Merkel PA, Luqmani RA, Watts RA; DCVAS Study Group
Arthritis Rheumatol 2022 Mar;74(3):400-406. Epub 2022 Feb 2 doi: 10.1002/art.41983. PMID: 35106973
Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement.
Geetha D, Specks U, Stone JH, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Tchao NK, Ikle D, Jepson B, Brunetta P, Fervenza FC; Rituximab for ANCA-Associated Vasculitis Immune Tolerance Network Research Group
J Am Soc Nephrol 2015 Apr;26(4):976-85. Epub 2014 Nov 7 doi: 10.1681/ASN.2014010046. PMID: 25381429Free PMC Article
Renal involvement in anti-neutrophil cytoplasmic autoantibody associated vasculitis.
Sinico RA, Di Toma L, Radice A
Autoimmun Rev 2013 Feb;12(4):477-82. Epub 2012 Aug 16 doi: 10.1016/j.autrev.2012.08.006. PMID: 22921791
Childhood microscopic polyangiitis associated with MPO-ANCA.
Peco-Antic A, Bonaci-Nikolic B, Basta-Jovanovic G, Kostic M, Markovic-Lipkovski J, Nikolic M, Spasojevic B
Pediatr Nephrol 2006 Jan;21(1):46-53. Epub 2005 Oct 27 doi: 10.1007/s00467-005-2063-x. PMID: 16252100

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...