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Radiation Nephropathy

MedGen UID:
890011
•Concept ID:
C4054127
•
Disease or Syndrome

Definition

Tissue damage to the glomerulus and renal tubules resulting from irradiation, which is characterized by vascular endothelial damage, mesangial damage, platelet aggregation in the capillary loops, thickening of the glomerular arteriolar intimal layer, and atrophic tubules. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation Nephropathy

Professional guidelines

PubMed

Pharmacological Interventions for the Prevention and Treatment of Kidney Injury Induced by Radiotherapy: Molecular Mechanisms and Clinical Perspectives.
Sahebnasagh A, Saghafi F, Azimi S, Salehifar E, Hosseinimehr SJ
Curr Mol Pharmacol 2022;15(4):607-619. doi: 10.2174/1874467214666210824123212. PMID: 34429052
Overcoming nephrotoxicity in peptide receptor radionuclide therapy using [(177)Lu]Lu-DOTA-TATE for the treatment of neuroendocrine tumours.
Geenen L, Nonnekens J, Konijnenberg M, Baatout S, De Jong M, Aerts A
Nucl Med Biol 2021 Nov-Dec;102-103:1-11. Epub 2021 Jul 1 doi: 10.1016/j.nucmedbio.2021.06.006. PMID: 34242948
Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists.
Moulder JE, Fish BL, Cohen EP
Curr Pharm Des 2007;13(13):1317-25. doi: 10.2174/138161207780618821. PMID: 17506717

Recent clinical studies

Therapy

Radiation-induced kidney toxicity: molecular and cellular pathogenesis.
Klaus R, Niyazi M, Lange-Sperandio B
Radiat Oncol 2021 Feb 25;16(1):43. doi: 10.1186/s13014-021-01764-y. PMID: 33632272Free PMC Article
Mitigation of radiation injuries via suppression of the renin-angiotensin system: emphasis on radiation nephropathy.
Cohen EP, Fish BL, Moulder JE
Curr Drug Targets 2010 Nov;11(11):1423-9. doi: 10.2174/1389450111009011423. PMID: 20583975Free PMC Article
Radiation-associated kidney injury.
Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C, Ten Haken RK, Schultheiss TE
Int J Radiat Oncol Biol Phys 2010 Mar 1;76(3 Suppl):S108-15. doi: 10.1016/j.ijrobp.2009.02.089. PMID: 20171504
Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists.
Moulder JE, Fish BL, Cohen EP
Curr Pharm Des 2007;13(13):1317-25. doi: 10.2174/138161207780618821. PMID: 17506717
Radiation nephropathy.
Cohen EP, Robbins ME
Semin Nephrol 2003 Sep;23(5):486-99. doi: 10.1016/s0270-9295(03)00093-7. PMID: 13680538

Prognosis

Pharmacological Interventions for the Prevention and Treatment of Kidney Injury Induced by Radiotherapy: Molecular Mechanisms and Clinical Perspectives.
Sahebnasagh A, Saghafi F, Azimi S, Salehifar E, Hosseinimehr SJ
Curr Mol Pharmacol 2022;15(4):607-619. doi: 10.2174/1874467214666210824123212. PMID: 34429052
Urinary miRNAs as Biomarkers for Noninvasive Evaluation of Radiation-Induced Renal Tubular Injury.
Bhayana S, Song F, Jacob J, Fadda P, Denko NC, Xu-Welliver M, Chakravarti A, Jacob NK
Radiat Res 2017 Dec;188(6):626-635. Epub 2017 Oct 4 doi: 10.1667/RR14828.1. PMID: 28977780Free PMC Article
Kidney complications of hematopoietic stem cell transplantation.
Singh N, McNeely J, Parikh S, Bhinder A, Rovin BH, Shidham G
Am J Kidney Dis 2013 May;61(5):809-21. Epub 2013 Jan 4 doi: 10.1053/j.ajkd.2012.09.020. PMID: 23291149
Radiation-associated kidney injury.
Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C, Ten Haken RK, Schultheiss TE
Int J Radiat Oncol Biol Phys 2010 Mar 1;76(3 Suppl):S108-15. doi: 10.1016/j.ijrobp.2009.02.089. PMID: 20171504
Unilateral radiation nephropathy--the long-term significance.
Kim TH, Somerville PJ, Freeman CR
Int J Radiat Oncol Biol Phys 1984 Nov;10(11):2053-9. doi: 10.1016/0360-3016(84)90202-5. PMID: 6436205

Clinical prediction guides

Human CD34(+) Hematopoietic Stem Cell-Engrafted NSG Mice: Morphological and Immunophenotypic Features.
Blümich S, Zdimerova H, Münz C, Kipar A, Pellegrini G
Vet Pathol 2021 Jan;58(1):161-180. Epub 2020 Sep 9 doi: 10.1177/0300985820948822. PMID: 32901581
Urinary miRNAs as Biomarkers for Noninvasive Evaluation of Radiation-Induced Renal Tubular Injury.
Bhayana S, Song F, Jacob J, Fadda P, Denko NC, Xu-Welliver M, Chakravarti A, Jacob NK
Radiat Res 2017 Dec;188(6):626-635. Epub 2017 Oct 4 doi: 10.1667/RR14828.1. PMID: 28977780Free PMC Article
Radiation-associated kidney injury.
Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C, Ten Haken RK, Schultheiss TE
Int J Radiat Oncol Biol Phys 2010 Mar 1;76(3 Suppl):S108-15. doi: 10.1016/j.ijrobp.2009.02.089. PMID: 20171504
Radiation nephropathy: a review.
Robbins ME, Bonsib SM
Scanning Microsc 1995 Jun;9(2):535-60. PMID: 8714748
Unilateral radiation nephropathy--the long-term significance.
Kim TH, Somerville PJ, Freeman CR
Int J Radiat Oncol Biol Phys 1984 Nov;10(11):2053-9. doi: 10.1016/0360-3016(84)90202-5. PMID: 6436205

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