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Congenital Urinary Tract Obstruction

MedGen UID:
890021
•Concept ID:
C0854260
•
Congenital Abnormality

Definition

An impediment to the flow of urine along the urinary tract, which is present at birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital Urinary Tract Obstruction

Professional guidelines

PubMed

Management of antenatal hydronephrosis.
Yalçınkaya F, Özçakar ZB
Pediatr Nephrol 2020 Dec;35(12):2231-2239. Epub 2019 Dec 6 doi: 10.1007/s00467-019-04420-6. PMID: 31811536
Hydronephrosis in the course of ureteropelvic junction obstruction: An underestimated problem? Current opinions on the pathogenesis, diagnosis and treatment.
Krajewski W, Wojciechowska J, Dembowski J, Zdrojowy R, Szydełko T
Adv Clin Exp Med 2017 Aug;26(5):857-864. doi: 10.17219/acem/59509. PMID: 29068584
Primary and Secondary Enuresis: Pathophysiology, Diagnosis, and Treatment.
Haid B, Tekgül S
Eur Urol Focus 2017 Apr;3(2-3):198-206. Epub 2017 Sep 6 doi: 10.1016/j.euf.2017.08.010. PMID: 28888814

Recent clinical studies

Etiology

The role of renal biomarkers to predict the need of surgery in congenital urinary tract obstruction in infants.
Kostic D, Beozzo GPNS, do Couto SB, Kato AHT, Lima L, Palmeira P, Krebs VLJ, Bunduki V, Francisco RPV, Zugaib M, Dénes FT, de Carvalho WB, Koch VHK
J Pediatr Urol 2019 May;15(3):242.e1-242.e9. Epub 2019 Mar 16 doi: 10.1016/j.jpurol.2019.03.009. PMID: 30979613
Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578
First-year profile of biomarkers for early detection of renal injury in infants with congenital urinary tract obstruction.
Kostic D, Dos Santos Beozzo GPN, do Couto SB, Kato AHT, Lima L, Palmeira P, Krebs VLJ, Bunduki V, Francisco RPV, Zugaib M, de Carvalho WB, Koch VHK
Pediatr Nephrol 2019 Jun;34(6):1117-1128. Epub 2019 Jan 29 doi: 10.1007/s00467-019-4195-4. PMID: 30694385
Cell type specific changes in BMP-7 expression contribute to the progression of kidney disease in patients with obstructive uropathy.
Manson SR, Song JB, Guo Q, Liapis H, Austin PF
J Urol 2015 May;193(5 Suppl):1860-1869. Epub 2015 Mar 24 doi: 10.1016/j.juro.2014.10.117. PMID: 25813565Free PMC Article
Chronic partial ureteral obstruction and the developing kidney.
Chevalier RL
Pediatr Radiol 2008 Jan;38 Suppl 1:S35-40. Epub 2007 Dec 11 doi: 10.1007/s00247-007-0585-z. PMID: 18071697

Diagnosis

Roles for urothelium in normal and aberrant urinary tract development.
Jackson AR, Ching CB, McHugh KM, Becknell B
Nat Rev Urol 2020 Aug;17(8):459-468. Epub 2020 Jul 9 doi: 10.1038/s41585-020-0348-2. PMID: 32647226Free PMC Article
Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578
Congenital urinary tract obstruction: defining markers of developmental kidney injury.
Trnka P, Hiatt MJ, Tarantal AF, Matsell DG
Pediatr Res 2012 Nov;72(5):446-54. Epub 2012 Aug 17 doi: 10.1038/pr.2012.113. PMID: 22902433
Congenital urinary tract obstruction.
Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2008 Feb;22(1):97-122. Epub 2007 Sep 29 doi: 10.1016/j.bpobgyn.2007.08.007. PMID: 17904905
Urinary tract obstruction and infection in the neonate.
el-Dahr SS, Lewy JE
Clin Perinatol 1992 Mar;19(1):213-22. PMID: 1576769

Therapy

Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578
Mechanisms of fetal and neonatal renal impairment by pharmacologic inhibition of angiotensin.
Chevalier RL
Curr Med Chem 2012;19(27):4572-80. doi: 10.2174/092986712803306411. PMID: 22876894

Prognosis

Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578
Congenital urinary tract obstruction: defining markers of developmental kidney injury.
Trnka P, Hiatt MJ, Tarantal AF, Matsell DG
Pediatr Res 2012 Nov;72(5):446-54. Epub 2012 Aug 17 doi: 10.1038/pr.2012.113. PMID: 22902433
Antenatal ultrasound to predict postnatal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy.
Morris RK, Malin GL, Khan KS, Kilby MD
BJOG 2009 Sep;116(10):1290-9. Epub 2009 May 8 doi: 10.1111/j.1471-0528.2009.02194.x. PMID: 19438489
Congenital urinary tract obstruction.
Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2008 Feb;22(1):97-122. Epub 2007 Sep 29 doi: 10.1016/j.bpobgyn.2007.08.007. PMID: 17904905
Urinary tract obstruction and infection in the neonate.
el-Dahr SS, Lewy JE
Clin Perinatol 1992 Mar;19(1):213-22. PMID: 1576769

Clinical prediction guides

The role of renal biomarkers to predict the need of surgery in congenital urinary tract obstruction in infants.
Kostic D, Beozzo GPNS, do Couto SB, Kato AHT, Lima L, Palmeira P, Krebs VLJ, Bunduki V, Francisco RPV, Zugaib M, Dénes FT, de Carvalho WB, Koch VHK
J Pediatr Urol 2019 May;15(3):242.e1-242.e9. Epub 2019 Mar 16 doi: 10.1016/j.jpurol.2019.03.009. PMID: 30979613
Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578
Congenital urinary tract obstruction: defining markers of developmental kidney injury.
Trnka P, Hiatt MJ, Tarantal AF, Matsell DG
Pediatr Res 2012 Nov;72(5):446-54. Epub 2012 Aug 17 doi: 10.1038/pr.2012.113. PMID: 22902433
Antenatal ultrasound to predict postnatal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy.
Morris RK, Malin GL, Khan KS, Kilby MD
BJOG 2009 Sep;116(10):1290-9. Epub 2009 May 8 doi: 10.1111/j.1471-0528.2009.02194.x. PMID: 19438489
Congenital urinary tract obstruction.
Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2008 Feb;22(1):97-122. Epub 2007 Sep 29 doi: 10.1016/j.bpobgyn.2007.08.007. PMID: 17904905

Recent systematic reviews

Antenatal ultrasound to predict postnatal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy.
Morris RK, Malin GL, Khan KS, Kilby MD
BJOG 2009 Sep;116(10):1290-9. Epub 2009 May 8 doi: 10.1111/j.1471-0528.2009.02194.x. PMID: 19438489
Systematic review of accuracy of fetal urine analysis to predict poor postnatal renal function in cases of congenital urinary tract obstruction.
Morris RK, Quinlan-Jones E, Kilby MD, Khan KS
Prenat Diagn 2007 Oct;27(10):900-11. doi: 10.1002/pd.1810. PMID: 17610312

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