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MLL Gene Rearrangement

MedGen UID:
890459
Concept ID:
C1506987
Cell or Molecular Dysfunction
Synonyms: KMT2A Gene Rearrangement; KMT2A Rearrangement; Lysine (K)-Specific Methyltransferase 2A Gene Rearrangement; Lysine Methyltransferase 2A Gene Rearrangement; Mixed Lineage Leukemia Gene Rearrangement; MLL Rearrangement; Myeloid/Lymphoid Leukemia Gene Rearrangement; Myeloid/Lymphoid or Mixed Lineage Leukemia Gene Rearrangement; Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the MLL (KMT2A) gene. [from NCI]

Professional guidelines

PubMed

Al-Sudairy R, Al-Nasser A, Alsultan A, Al Ahmari A, Abosoudah I, Al-Hayek R, Al-Harbi T, Al-Manjomi F, Al-Harbi M, Al-Ghamdi H, Al-Shahrani M, Belgaumi AF
Pediatr Blood Cancer 2014 Jan;61(1):74-80. Epub 2013 Aug 12 doi: 10.1002/pbc.24584. PMID: 23940019
Chen SH, Yang CP, Hung IJ, Jaing TH, Shih LY, Tsai MH
Pediatr Blood Cancer 2010 Dec 15;55(7):1264-71. doi: 10.1002/pbc.22731. PMID: 20979094
Megonigal MD, Rappaport EF, Jones DH, Kim CS, Nowell PC, Lange BJ, Felix CA
Proc Natl Acad Sci U S A 1997 Oct 14;94(21):11583-8. doi: 10.1073/pnas.94.21.11583. PMID: 9326653Free PMC Article

Recent clinical studies

Etiology

Mohiuddin Malla T, Amin Shah Z, Hussain Bhat A, Ahmad Malik M, Anjum Baba R, Rasool R, Rasool J, Ashaq S, Haq F
Gene 2023 Mar 10;856:147128. Epub 2022 Dec 21 doi: 10.1016/j.gene.2022.147128. PMID: 36565795
Aldoss I, Douer D, Pullarkat V
Blood Rev 2019 Sep;37:100584. Epub 2019 Jun 19 doi: 10.1016/j.blre.2019.06.001. PMID: 31235377
Xu X, Schneider B
Cell Oncol (Dordr) 2019 Apr;42(2):117-130. Epub 2018 Nov 16 doi: 10.1007/s13402-018-0414-4. PMID: 30446944
Sun YN, Hu YX, Gao L, Xiao PF, Lu J, Wu SY, Wang M, Shao XJ, Zhou CY, Ling J, Li JQ, Pan J, Gao J, Hu SY
Eur Rev Med Pharmacol Sci 2018 Sep;22(18):6020-6029. doi: 10.26355/eurrev_201809_15938. PMID: 30280786
Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van der Poel S, Kaneko Y, Morgan R, Sandberg AA
N Engl J Med 1993 Sep 23;329(13):909-14. doi: 10.1056/NEJM199309233291302. PMID: 8361504

Diagnosis

Zhu YY, Wu RN, Li X, Chen XB
Zhongguo Dang Dai Er Ke Za Zhi 2021 Oct 15;23(10):1021-1026. doi: 10.7499/j.issn.1008-8830.2105148. PMID: 34719417Free PMC Article
Duguid A, Mattiucci D, Ottersbach K
Dis Model Mech 2021 Oct 1;14(10) Epub 2021 Oct 29 doi: 10.1242/dmm.049189. PMID: 34713888Free PMC Article
Tang G, Lu X, Wang SA, Roney EK, Zhang L, Hu S, Lu G, Medeiros LJ, Patel A
Int J Clin Exp Pathol 2014;7(6):3196-201. Epub 2014 May 15 PMID: 25031740Free PMC Article
Silverman LB
Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1070-3. doi: 10.1002/pbc.21352. PMID: 17943956
Jansen MW, Corral L, van der Velden VH, Panzer-Grümayer R, Schrappe M, Schrauder A, Marschalek R, Meyer C, den Boer ML, Hop WJ, Valsecchi MG, Basso G, Biondi A, Pieters R, van Dongen JJ
Leukemia 2007 Apr;21(4):633-41. Epub 2007 Feb 1 doi: 10.1038/sj.leu.2404578. PMID: 17268512

Therapy

Sun YN, Hu YX, Gao L, Xiao PF, Lu J, Wu SY, Wang M, Shao XJ, Zhou CY, Ling J, Li JQ, Pan J, Gao J, Hu SY
Eur Rev Med Pharmacol Sci 2018 Sep;22(18):6020-6029. doi: 10.26355/eurrev_201809_15938. PMID: 30280786
Aldoss I, Stiller T, Tsai NC, Song JY, Cao T, Bandara NA, Salhotra A, Khaled S, Aribi A, Al Malki MM, Mei M, Ali H, Spielberger R, O'Donnell M, Snyder D, Slavin T, Nakamura R, Stein AS, Forman SJ, Marcucci G, Pullarkat V
Haematologica 2018 Oct;103(10):1662-1668. Epub 2018 Jun 14 doi: 10.3324/haematol.2018.193599. PMID: 29903756Free PMC Article
Mosad E, Abdou M, Zaky AH
Oncology 2012;83(3):128-34. Epub 2012 Jul 18 doi: 10.1159/000338769. PMID: 22814291
Tomizawa D, Koh K, Sato T, Kinukawa N, Morimoto A, Isoyama K, Kosaka Y, Oda T, Oda M, Hayashi Y, Eguchi M, Horibe K, Nakahata T, Mizutani S, Ishii E
Leukemia 2007 Nov;21(11):2258-63. Epub 2007 Aug 9 doi: 10.1038/sj.leu.2404903. PMID: 17690691
Nishii K, Katayama N, Chen F, Usui E, Kadowaki S, Mitani H, Masuya M, Kageyama SI, Kita K, Shiku H
Bone Marrow Transplant 2001 Mar;27(5):555-8. doi: 10.1038/sj.bmt.1702817. PMID: 11313693

Prognosis

Xu X, Schneider B
Cell Oncol (Dordr) 2019 Apr;42(2):117-130. Epub 2018 Nov 16 doi: 10.1007/s13402-018-0414-4. PMID: 30446944
Sun YN, Hu YX, Gao L, Xiao PF, Lu J, Wu SY, Wang M, Shao XJ, Zhou CY, Ling J, Li JQ, Pan J, Gao J, Hu SY
Eur Rev Med Pharmacol Sci 2018 Sep;22(18):6020-6029. doi: 10.26355/eurrev_201809_15938. PMID: 30280786
Silverman LB
Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1070-3. doi: 10.1002/pbc.21352. PMID: 17943956
Kiyoi H, Yanada M, Ozekia K
Int J Hematol 2005 Aug;82(2):85-92. doi: 10.1532/IJH97.05066. PMID: 16146837
Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van der Poel S, Kaneko Y, Morgan R, Sandberg AA
N Engl J Med 1993 Sep 23;329(13):909-14. doi: 10.1056/NEJM199309233291302. PMID: 8361504

Clinical prediction guides

Pan F, Iwasaki M, Wu W, Jiang Y, Yang X, Zhu L, Zhao Z, Cleary ML
Blood Adv 2023 Jun 13;7(11):2504-2519. doi: 10.1182/bloodadvances.2022008787. PMID: 36705973Free PMC Article
Sun YN, Hu YX, Gao L, Xiao PF, Lu J, Wu SY, Wang M, Shao XJ, Zhou CY, Ling J, Li JQ, Pan J, Gao J, Hu SY
Eur Rev Med Pharmacol Sci 2018 Sep;22(18):6020-6029. doi: 10.26355/eurrev_201809_15938. PMID: 30280786
Bardini M, Woll PS, Corral L, Luc S, Wittmann L, Ma Z, Lo Nigro L, Basso G, Biondi A, Cazzaniga G, Jacobsen SE
Leukemia 2015 Jan;29(1):38-50. Epub 2014 May 6 doi: 10.1038/leu.2014.154. PMID: 24798483
Silverman LB
Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1070-3. doi: 10.1002/pbc.21352. PMID: 17943956
Nishii K, Katayama N, Chen F, Usui E, Kadowaki S, Mitani H, Masuya M, Kageyama SI, Kita K, Shiku H
Bone Marrow Transplant 2001 Mar;27(5):555-8. doi: 10.1038/sj.bmt.1702817. PMID: 11313693

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