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Malignant germ cell tumor

MedGen UID:
890580
Concept ID:
C4048549
Neoplastic Process
Synonyms: cancer of germ cell; germ cell cancer; germ cell tumor, malignant; Malignant germ cell neoplasm; Malignant Germ Cell Neoplasm; malignant germ cell neoplasm; Malignant Germ Cell Tumor; malignant germ cell tumor; Malignant Neoplasm of Germ Cell; malignant neoplasm of germ cell; Malignant Neoplasm of the Germ Cell; malignant neoplasm of the germ cell; Malignant Tumor of Germ Cell; malignant tumor of germ cell; Malignant Tumor of the Germ Cell; malignant tumor of the germ cell; malignant tumour of germ cell; malignant tumour of the germ cell
SNOMED CT: Malignant germ cell neoplasm (713582000)
 
Monarch Initiative: MONDO:0006290

Definition

A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant germ cell tumor

Professional guidelines

PubMed

Tokunaga H, Mikami M, Nagase S, Kobayashi Y, Tabata T, Kaneuchi M, Satoh T, Hirashima Y, Matsumura N, Yokoyama Y, Kawana K, Kyo S, Aoki D, Katabuchi H
J Gynecol Oncol 2021 Mar;32(2):e49. doi: 10.3802/jgo.2021.32.e49. PMID: 33650343Free PMC Article
Hu T, Fang Y, Sun Q, Zhao H, Ma D, Zhu T, Wang C
Surg Oncol 2019 Dec;31:8-13. Epub 2019 Aug 20 doi: 10.1016/j.suronc.2019.08.006. PMID: 31446304
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594

Recent clinical studies

Etiology

Abu Arja MH, Stanek JR, Finlay JL, AbdelBaki MS
Childs Nerv Syst 2018 Nov;34(11):2179-2186. Epub 2018 Aug 3 doi: 10.1007/s00381-018-3940-5. PMID: 30076436
Hersmus R, van Bever Y, Wolffenbuttel KP, Biermann K, Cools M, Looijenga LH
Clin Genet 2017 Feb;91(2):292-301. Epub 2016 Nov 24 doi: 10.1111/cge.12882. PMID: 27716895
Kodama M, Grubbs BH, Blake EA, Cahoon SS, Murakami R, Kimura T, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Oct;181:145-56. Epub 2014 Aug 7 doi: 10.1016/j.ejogrb.2014.07.047. PMID: 25150953
Cools M, Wolffenbuttel KP, Drop SL, Oosterhuis JW, Looijenga LH
Sex Dev 2011;5(4):167-80. Epub 2011 Jul 22 doi: 10.1159/000329477. PMID: 21791949
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Diagnosis

Rogers D, Menias C, Shaaban A
Radiol Clin North Am 2023 Jul;61(4):579-594. Epub 2023 Apr 3 doi: 10.1016/j.rcl.2023.02.004. PMID: 37169425
Murray MJ, Scarpini CG, Coleman N
Methods Mol Biol 2021;2195:225-243. doi: 10.1007/978-1-0716-0860-9_15. PMID: 32852767
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594

Therapy

La Rocca R, Capece M, Spirito L, Cumberbatch MK, Creta M, Altieri V, Franco G, Albisinni S, Mirone V, Esperto F; EAU-ESRU (European Associations of Urology-European Society of Residents Urologist)
Minerva Urol Nefrol 2019 Aug;71(4):359-364. Epub 2019 Apr 5 doi: 10.23736/S0393-2249.19.03315-0. PMID: 30957472
Abu Arja MH, Stanek JR, Finlay JL, AbdelBaki MS
Childs Nerv Syst 2018 Nov;34(11):2179-2186. Epub 2018 Aug 3 doi: 10.1007/s00381-018-3940-5. PMID: 30076436
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Schrader M, Kempkensteffen C, Christoph F, Hinz S, Weikert S, Lein M, Krause H, Stephan C, Jung K, Hoepfner M, Albers P, Miller K, Schostak M
Oncology 2009;76(2):77-84. Epub 2008 Dec 20 doi: 10.1159/000187426. PMID: 19122465
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594

Prognosis

Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550
Euscher ED
Arch Pathol Lab Med 2017 Feb;141(2):293-297. Epub 2016 Dec 13 doi: 10.5858/arpa.2016-0151-SA. PMID: 27959583
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594

Clinical prediction guides

Piao J, Lafin JT, Scarpini CG, Nuño MM, Syring I, Dieckmann KP, Belge G, Ellinger J, Amatruda JF, Bagrodia A, Coleman N, Krailo MD, Frazier AL, Murray MJ
Clin Genitourin Cancer 2021 Dec;19(6):469-479. Epub 2021 Sep 15 doi: 10.1016/j.clgc.2021.08.006. PMID: 34629299Free PMC Article
Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128
Bremmer F, Bohnenberger H, Küffer S, Oellerich T, Serve H, Urlaub H, Strauss A, Maatoug Y, Behnes CL, Oing C, Radzun HJ, Ströbel P, Balabanov S, Honecker F
Dis Markers 2019;2019:8298524. Epub 2019 Sep 3 doi: 10.1155/2019/8298524. PMID: 31565104Free PMC Article
Solheim O, Førsund M, Tropé CG, Kraggerud SM, Nesland JM, Davidson B
APMIS 2017 Sep;125(9):781-786. Epub 2017 Jun 6 doi: 10.1111/apm.12715. PMID: 28585395
Ulbright TM
Adv Anat Pathol 2004 Jan;11(1):10-23. doi: 10.1097/00125480-200401000-00002. PMID: 14676637

Recent systematic reviews

Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128
Jiang T, Raynald, Yang H, Zhang W, Li C
J Clin Neurosci 2019 Mar;61:93-101. Epub 2018 Nov 12 doi: 10.1016/j.jocn.2018.10.136. PMID: 30442453
Kodama M, Grubbs BH, Blake EA, Cahoon SS, Murakami R, Kimura T, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Oct;181:145-56. Epub 2014 Aug 7 doi: 10.1016/j.ejogrb.2014.07.047. PMID: 25150953

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