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Chinese restaurant syndrome

MedGen UID:
891
Concept ID:
C0008127
Disease or Syndrome
Synonym: MONOSODIUM GLUTAMATE SENSITIVITY
SNOMED CT: Intolerance to monosodium glutamate (782338006); E621 intolerance (782338006); Sodium hydrogen L-glutamate intolerance (782338006); Monosodium glutamate intolerance (782338006); MSG (monosodium glutamate) intolerance (782338006)
 
Monarch Initiative: MONDO:0009280
OMIM®: 231630

Clinical features

From HPO
Chest pain
MedGen UID:
2992
Concept ID:
C0008031
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
Palpitations
MedGen UID:
14579
Concept ID:
C0030252
Finding
A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.
Nausea
MedGen UID:
10196
Concept ID:
C0027497
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.
Headache
MedGen UID:
9149
Concept ID:
C0018681
Sign or Symptom
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
Dyspnea
MedGen UID:
3938
Concept ID:
C0013404
Sign or Symptom
Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.
Flushing
MedGen UID:
5234
Concept ID:
C0016382
Sign or Symptom
Recurrent episodes of redness of the skin together with a sensation of warmth or burning of the affected areas of skin.

Recent clinical studies

Etiology

Freeman M
J Am Acad Nurse Pract 2006 Oct;18(10):482-6. doi: 10.1111/j.1745-7599.2006.00160.x. PMID: 16999713
Walker R, Lupien JR
J Nutr 2000 Apr;130(4S Suppl):1049S-52S. doi: 10.1093/jn/130.4.1049S. PMID: 10736380
Walker R
Regul Toxicol Pharmacol 1999 Oct;30(2 Pt 2):S119-21. doi: 10.1006/rtph.1999.1337. PMID: 10597625
Allen DH, Delohery J, Baker G
J Allergy Clin Immunol 1987 Oct;80(4):530-7. doi: 10.1016/0091-6749(87)90003-0. PMID: 3312372
Ebadi M, Gessert CF, Al-Sayegh A
Q Rev Drug Metab Drug Interact 1982;4(4):289-331. doi: 10.1515/dmdi.1982.4.4.289. PMID: 6087425

Diagnosis

Shastri M, Raval DM, Rathod VM
J Assoc Physicians India 2023 Jun;71(6):11-12. doi: 10.5005/japi-11001-0264. PMID: 37355848
Jinap S, Hajeb P
Appetite 2010 Aug;55(1):1-10. Epub 2010 May 12 doi: 10.1016/j.appet.2010.05.002. PMID: 20470841
Walker R, Lupien JR
J Nutr 2000 Apr;130(4S Suppl):1049S-52S. doi: 10.1093/jn/130.4.1049S. PMID: 10736380
Zautcke JL, Schwartz JA, Mueller EJ
Ann Emerg Med 1986 Oct;15(10):1210-3. doi: 10.1016/s0196-0644(86)80869-1. PMID: 3530064
Kenney RA
Food Chem Toxicol 1986 Apr;24(4):351-4. doi: 10.1016/0278-6915(86)90014-1. PMID: 3525357

Therapy

Zautcke JL, Schwartz JA, Mueller EJ
Ann Emerg Med 1986 Oct;15(10):1210-3. doi: 10.1016/s0196-0644(86)80869-1. PMID: 3530064
Berglund F
Arch Toxicol Suppl 1978;(1):33-46. doi: 10.1007/978-3-642-66896-8_4. PMID: 277126
Alston RM
N Engl J Med 1976 Jan 22;294(4):225. doi: 10.1056/NEJM197601222940416. PMID: 942671
Upton AR, Barrows HS
N Engl J Med 1972 Apr 20;286(16):893-4. PMID: 5061082
Himms-Hagen J
Nature 1970 Oct 3;228(5266):97. doi: 10.1038/228097a0. PMID: 5456223

Prognosis

Zautcke JL, Schwartz JA, Mueller EJ
Ann Emerg Med 1986 Oct;15(10):1210-3. doi: 10.1016/s0196-0644(86)80869-1. PMID: 3530064

Clinical prediction guides

Zhou Y, Yang M, Dong BR
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD004357. doi: 10.1002/14651858.CD004357.pub4. PMID: 22696342Free PMC Article
Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A
J Nutr 2000 Apr;130(4S Suppl):1058S-62S. doi: 10.1093/jn/130.4.1058S. PMID: 10736382

Recent systematic reviews

Obayashi Y, Nagamura Y
J Headache Pain 2016;17:54. Epub 2016 May 17 doi: 10.1186/s10194-016-0639-4. PMID: 27189588Free PMC Article
Zhou Y, Yang M, Dong BR
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD004357. doi: 10.1002/14651858.CD004357.pub4. PMID: 22696342Free PMC Article

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