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Pituitary Stalk Lesion

MedGen UID:
891069
•Concept ID:
C4054176
•
Finding

Definition

An anomaly in the pituitary stalk that can be developmental, inflammatory, infiltrative, iatrogenic or traumatic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary Stalk Lesion

Professional guidelines

PubMed

Hypophysitis - new insights into diagnosis and treatment.
Kluczyński Ł, Gilis-Januszewska A, Rogoziński D, Pantofliński J, Hubalewska-Dydejczyk A
Endokrynol Pol 2019;70(3):260-269. doi: 10.5603/EP.a2019.0015. PMID: 31290557

Recent clinical studies

Etiology

Central diabetes insipidus caused by a pituitary stalk germinoma resembling infundibuloneurohypophysitis.
Dias D, Vilar H, Passos J, Leite V
BMJ Case Rep 2020 Sep 9;13(9) doi: 10.1136/bcr-2020-234724. PMID: 32912882Free PMC Article
Hypophysitis - new insights into diagnosis and treatment.
Kluczyński Ł, Gilis-Januszewska A, Rogoziński D, Pantofliński J, Hubalewska-Dydejczyk A
Endokrynol Pol 2019;70(3):260-269. doi: 10.5603/EP.a2019.0015. PMID: 31290557
Single center study of 53 consecutive patients with pituitary stalk lesions.
Doknic M, Miljic D, Pekic S, Stojanovic M, Savic D, Manojlovic-Gacic E, Milenkovic T, Zdravkovic V, Jesic M, Damjanovic D, Lavrnic S, Soldatovic I, Djukic A, Petakov M
Pituitary 2018 Dec;21(6):605-614. doi: 10.1007/s11102-018-0914-2. PMID: 30276501
Uncommon manifestations of sarcoidosis.
Sharma SK, Mohan A
J Assoc Physicians India 2004 Mar;52:210-4. PMID: 15636311
Pituitary stalk thickening with diabetes insipidus preceding typical manifestations of Langerhans cell histiocytosis in children.
Schmitt S, Wichmann W, Martin E, Zachmann M, Schoenle EJ
Eur J Pediatr 1993 May;152(5):399-401. doi: 10.1007/BF01955896. PMID: 8319704

Diagnosis

Hypophysitis - new insights into diagnosis and treatment.
Kluczyński Ł, Gilis-Januszewska A, Rogoziński D, Pantofliński J, Hubalewska-Dydejczyk A
Endokrynol Pol 2019;70(3):260-269. doi: 10.5603/EP.a2019.0015. PMID: 31290557
Single center study of 53 consecutive patients with pituitary stalk lesions.
Doknic M, Miljic D, Pekic S, Stojanovic M, Savic D, Manojlovic-Gacic E, Milenkovic T, Zdravkovic V, Jesic M, Damjanovic D, Lavrnic S, Soldatovic I, Djukic A, Petakov M
Pituitary 2018 Dec;21(6):605-614. doi: 10.1007/s11102-018-0914-2. PMID: 30276501
An unusual pituitary stalk lesion: What is the place of surgery?
Todeschi J, Chibbaro S, Clavier JB, Lhermitte B, Goichot B, Proust F
Neurochirurgie 2016 Dec;62(6):339-343. Epub 2016 Oct 26 doi: 10.1016/j.neuchi.2016.08.002. PMID: 28120772
Pituitary stalk lesion in a 13-year-old female.
Zilbermint M, Ramnitz MS, Lodish MB, Kanaka-Gantenbein C, Kattamis A, Lyssikatos C, Patronas NJ, Quezado MM, Stratakis CA
J Pediatr Endocrinol Metab 2014 Mar;27(3-4):359-62. doi: 10.1515/jpem-2013-0274. PMID: 24129100Free PMC Article
Pituitary stalk thickening with diabetes insipidus preceding typical manifestations of Langerhans cell histiocytosis in children.
Schmitt S, Wichmann W, Martin E, Zachmann M, Schoenle EJ
Eur J Pediatr 1993 May;152(5):399-401. doi: 10.1007/BF01955896. PMID: 8319704

Therapy

Central diabetes insipidus caused by a pituitary stalk germinoma resembling infundibuloneurohypophysitis.
Dias D, Vilar H, Passos J, Leite V
BMJ Case Rep 2020 Sep 9;13(9) doi: 10.1136/bcr-2020-234724. PMID: 32912882Free PMC Article
Isolated Langerhans cell histiocytosis in the hypothalamic-pituitary region: a case report.
Zhou W, Rao J, Li C
BMC Endocr Disord 2019 Dec 19;19(1):143. doi: 10.1186/s12902-019-0474-0. PMID: 31856773Free PMC Article
An unusual pituitary stalk lesion: What is the place of surgery?
Todeschi J, Chibbaro S, Clavier JB, Lhermitte B, Goichot B, Proust F
Neurochirurgie 2016 Dec;62(6):339-343. Epub 2016 Oct 26 doi: 10.1016/j.neuchi.2016.08.002. PMID: 28120772
A case of lymphocytic infundibuloneurohypophysitis associated with systemic lupus erythematosus.
Hashimoto K, Asaba K, Tamura K, Takao T, Nakamura T
Endocr J 2002 Dec;49(6):605-10. doi: 10.1507/endocrj.49.605. PMID: 12625409

Prognosis

Hypophysitis - new insights into diagnosis and treatment.
Kluczyński Ł, Gilis-Januszewska A, Rogoziński D, Pantofliński J, Hubalewska-Dydejczyk A
Endokrynol Pol 2019;70(3):260-269. doi: 10.5603/EP.a2019.0015. PMID: 31290557
Single center study of 53 consecutive patients with pituitary stalk lesions.
Doknic M, Miljic D, Pekic S, Stojanovic M, Savic D, Manojlovic-Gacic E, Milenkovic T, Zdravkovic V, Jesic M, Damjanovic D, Lavrnic S, Soldatovic I, Djukic A, Petakov M
Pituitary 2018 Dec;21(6):605-614. doi: 10.1007/s11102-018-0914-2. PMID: 30276501
An unusual pituitary stalk lesion: What is the place of surgery?
Todeschi J, Chibbaro S, Clavier JB, Lhermitte B, Goichot B, Proust F
Neurochirurgie 2016 Dec;62(6):339-343. Epub 2016 Oct 26 doi: 10.1016/j.neuchi.2016.08.002. PMID: 28120772
Low grade astrocytoma of the pituitary stalk.
Yap L, Crooks D, Warnke P
Acta Neurochir (Wien) 2007 Mar;149(3):307-11; discussion 311-2. Epub 2007 Jan 31 doi: 10.1007/s00701-006-1090-0. PMID: 17242848
Pituitary stalk thickening with diabetes insipidus preceding typical manifestations of Langerhans cell histiocytosis in children.
Schmitt S, Wichmann W, Martin E, Zachmann M, Schoenle EJ
Eur J Pediatr 1993 May;152(5):399-401. doi: 10.1007/BF01955896. PMID: 8319704

Clinical prediction guides

Single center study of 53 consecutive patients with pituitary stalk lesions.
Doknic M, Miljic D, Pekic S, Stojanovic M, Savic D, Manojlovic-Gacic E, Milenkovic T, Zdravkovic V, Jesic M, Damjanovic D, Lavrnic S, Soldatovic I, Djukic A, Petakov M
Pituitary 2018 Dec;21(6):605-614. doi: 10.1007/s11102-018-0914-2. PMID: 30276501
Central diabetes insipidus: Is it Langerhans cell histiocytosis of the pituitary stalk? A diagnostic pitfall.
Prosch H, Grois N, Bökkerink J, Prayer D, Leuschner I, Minkov M, Gadner H
Pediatr Blood Cancer 2006 Mar;46(3):363-6. doi: 10.1002/pbc.20027. PMID: 15942956
Uncommon manifestations of sarcoidosis.
Sharma SK, Mohan A
J Assoc Physicians India 2004 Mar;52:210-4. PMID: 15636311

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