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Non-radiographic axial spondyloarthritis

MedGen UID:
891368
•Concept ID:
C3889038
•
Disease or Syndrome
Synonyms: Axial Spondyloarthritis, Non-Radiographic; Non Radiographic Axial Spondyloarthritis; Non-Radiographic Axial Spondyloarthritides; Non-Radiographic Axial Spondyloarthritis; Nr-axSpA; Spondyloarthritis, Non-Radiographic Axial
SNOMED CT: Axial spondyloarthritis without radiographic evidence of ankylosing spondylitis (713777005); Non-radiographic axial spondyloarthritis (713777005); nr-axSpA - non-radiographic axial spondylitis (713777005)

Definition

A form of spondyloarthritis in which the predominant symptom is back pain, and where radiographic sacroiliitis might or might not be present. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-radiographic axial spondyloarthritis

Professional guidelines

PubMed

A critical review of upadacitinib for the treatment of adults with moderately to severely active ulcerative colitis.
Law CCY, Kayal M, Mehandru S, Colombel JF
Expert Rev Gastroenterol Hepatol 2023 Feb;17(2):109-117. Epub 2023 Jan 27 doi: 10.1080/17474124.2023.2172399. PMID: 36681073
Golimumab for the treatment of axial spondyloarthritis.
Gelfer G, Perry L, Deodhar A
Expert Rev Clin Immunol 2016;12(1):9-18. Epub 2015 Nov 2 doi: 10.1586/1744666X.2016.1106941. PMID: 26523483
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717

Recent clinical studies

Etiology

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Deodhar A, Van den Bosch F, Poddubnyy D, Maksymowych WP, van der Heijde D, Kim TH, Kishimoto M, Blanco R, Duan Y, Li Y, Pangan AL, Wung P, Song IH
Lancet 2022 Jul 30;400(10349):369-379. doi: 10.1016/S0140-6736(22)01212-0. PMID: 35908570
Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial.
Deodhar A, van der Heijde D, Gensler LS, Kim TH, Maksymowych WP, Østergaard M, Poddubnyy D, Marzo-Ortega H, Bessette L, Tomita T, Leung A, Hojnik M, Gallo G, Li X, Adams D, Carlier H, Sieper J; COAST-X Study Group
Lancet 2020 Jan 4;395(10217):53-64. Epub 2019 Dec 5 doi: 10.1016/S0140-6736(19)32971-X. PMID: 31813637
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717

Diagnosis

Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Deodhar A, Van den Bosch F, Poddubnyy D, Maksymowych WP, van der Heijde D, Kim TH, Kishimoto M, Blanco R, Duan Y, Li Y, Pangan AL, Wung P, Song IH
Lancet 2022 Jul 30;400(10349):369-379. doi: 10.1016/S0140-6736(22)01212-0. PMID: 35908570
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Non-radiographic axial spondyloarthritis.
Kameda H, Kobayashi S, Tamura N, Kadono Y, Tada K, Yamamura M, Tomita T
Mod Rheumatol 2021 Mar;31(2):277-282. Epub 2020 Oct 12 doi: 10.1080/14397595.2020.1830512. PMID: 32996809
Axial spondyloarthritis.
Sieper J, Poddubnyy D
Lancet 2017 Jul 1;390(10089):73-84. Epub 2017 Jan 20 doi: 10.1016/S0140-6736(16)31591-4. PMID: 28110981
Ankylosing spondylitis: an update.
Golder V, Schachna L
Aust Fam Physician 2013 Nov;42(11):780-4. PMID: 24217097

Therapy

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Deodhar A, Van den Bosch F, Poddubnyy D, Maksymowych WP, van der Heijde D, Kim TH, Kishimoto M, Blanco R, Duan Y, Li Y, Pangan AL, Wung P, Song IH
Lancet 2022 Jul 30;400(10349):369-379. doi: 10.1016/S0140-6736(22)01212-0. PMID: 35908570
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Non-radiographic axial spondyloarthritis.
Kameda H, Kobayashi S, Tamura N, Kadono Y, Tada K, Yamamura M, Tomita T
Mod Rheumatol 2021 Mar;31(2):277-282. Epub 2020 Oct 12 doi: 10.1080/14397595.2020.1830512. PMID: 32996809
Ankylosing spondylitis: an update.
Golder V, Schachna L
Aust Fam Physician 2013 Nov;42(11):780-4. PMID: 24217097

Prognosis

Axial spondyloarthritis in the USA: diagnostic challenges and missed opportunities.
Danve A, Deodhar A
Clin Rheumatol 2019 Mar;38(3):625-634. Epub 2018 Dec 26 doi: 10.1007/s10067-018-4397-3. PMID: 30588555
Radiographic progression in non-radiographic axial spondyloarthritis.
Protopopov M, Poddubnyy D
Expert Rev Clin Immunol 2018 Jun;14(6):525-533. Epub 2018 May 24 doi: 10.1080/1744666X.2018.1477591. PMID: 29774755
Consensus statement on the investigation and management of non-radiographic axial spondyloarthritis (nr-axSpA).
Robinson PC, Bird P, Lim I, Saad N, Schachna L, Taylor AL, Whittle SL, Brown MA
Int J Rheum Dis 2014 Jun;17(5):548-56. Epub 2014 Mar 28 doi: 10.1111/1756-185X.12358. PMID: 24673897
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717
Non-radiographic axial spondyloarthritis: what is it?
Fianyo E, Wendling D, Poulain C, Farrenq V, Claudepierre P
Clin Exp Rheumatol 2014 Jan-Feb;32(1):1-4. Epub 2013 Sep 10 PMID: 24021580

Clinical prediction guides

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Secukinumab in non-radiographic axial spondyloarthritis: subgroup analysis based on key baseline characteristics from a randomized phase III study, PREVENT.
Braun J, Blanco R, Marzo-Ortega H, Gensler LS, van den Bosch F, Hall S, Kameda H, Poddubnyy D, van de Sande M, Wiksten AS, Porter BO, Shete A, Richards HB, Haemmerle S, Deodhar A
Arthritis Res Ther 2021 Sep 4;23(1):231. doi: 10.1186/s13075-021-02613-9. PMID: 34481517Free PMC Article
Radiographic progression in non-radiographic axial spondyloarthritis.
Protopopov M, Poddubnyy D
Expert Rev Clin Immunol 2018 Jun;14(6):525-533. Epub 2018 May 24 doi: 10.1080/1744666X.2018.1477591. PMID: 29774755
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article

Recent systematic reviews

Cardiovascular risk in axial spondyloarthritis-a systematic review.
Hintenberger R, Affenzeller B, Vladychuk V, Pieringer H
Clin Rheumatol 2023 Oct;42(10):2621-2633. Epub 2023 Jul 7 doi: 10.1007/s10067-023-06655-z. PMID: 37418034Free PMC Article
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article
Systematic review of clinical, humanistic, and economic outcome comparisons between radiographic and non-radiographic axial spondyloarthritis.
Sieper J, Hu X, Black CM, Grootscholten K, van den Broek RWM, Kachroo S
Semin Arthritis Rheum 2017 Jun;46(6):746-753. Epub 2016 Sep 13 doi: 10.1016/j.semarthrit.2016.09.002. PMID: 27855973
Efficacy, safety and cost per responder of biologics in the treatment of non-radiographic axial spondyloarthritis.
Olivieri I, Fanizza C, Gilio M, Ravasio R
Clin Exp Rheumatol 2016 Sep-Oct;34(5):935-940. Epub 2016 Jul 4 PMID: 27385374

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