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Non-radiographic axial spondyloarthritis

MedGen UID:
891368
•Concept ID:
C3889038
•
Disease or Syndrome
Synonyms: Axial Spondyloarthritis, Non-Radiographic; Non Radiographic Axial Spondyloarthritis; Non-Radiographic Axial Spondyloarthritides; Non-Radiographic Axial Spondyloarthritis; Nr-axSpA; Spondyloarthritis, Non-Radiographic Axial
SNOMED CT: Axial spondyloarthritis without radiographic evidence of ankylosing spondylitis (713777005); Non-radiographic axial spondyloarthritis (713777005); nr-axSpA - non-radiographic axial spondylitis (713777005)

Definition

A form of spondyloarthritis in which the predominant symptom is back pain, and where radiographic sacroiliitis might or might not be present. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-radiographic axial spondyloarthritis

Professional guidelines

PubMed

Emerging Immunomodulatory Therapies and New Treatment Paradigms for Axial Spondyloarthritis.
Mease P
Curr Rheumatol Rep 2019 Jun 6;21(7):35. doi: 10.1007/s11926-019-0830-0. PMID: 31172311
Golimumab for the treatment of axial spondyloarthritis.
Gelfer G, Perry L, Deodhar A
Expert Rev Clin Immunol 2016;12(1):9-18. Epub 2015 Nov 2 doi: 10.1586/1744666X.2016.1106941. PMID: 26523483
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717

Recent clinical studies

Etiology

Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Deodhar A, Van den Bosch F, Poddubnyy D, Maksymowych WP, van der Heijde D, Kim TH, Kishimoto M, Blanco R, Duan Y, Li Y, Pangan AL, Wung P, Song IH
Lancet 2022 Jul 30;400(10349):369-379. doi: 10.1016/S0140-6736(22)01212-0. PMID: 35908570
Radiographic progression in non-radiographic axial spondyloarthritis.
Protopopov M, Poddubnyy D
Expert Rev Clin Immunol 2018 Jun;14(6):525-533. Epub 2018 May 24 doi: 10.1080/1744666X.2018.1477591. PMID: 29774755
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717

Diagnosis

Efficacy and safety of bimekizumab in axial spondyloarthritis: results of two parallel phase 3 randomised controlled trials.
van der Heijde D, Deodhar A, Baraliakos X, Brown MA, Dobashi H, Dougados M, Elewaut D, Ellis AM, Fleurinck C, Gaffney K, Gensler LS, Haroon N, Magrey M, Maksymowych WP, Marten A, Massow U, Oortgiesen M, Poddubnyy D, Rudwaleit M, Shepherd-Smith J, Tomita T, Van den Bosch F, Vaux T, Xu H
Ann Rheum Dis 2023 Apr;82(4):515-526. Epub 2023 Jan 17 doi: 10.1136/ard-2022-223595. PMID: 36649967Free PMC Article
Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Deodhar A, Van den Bosch F, Poddubnyy D, Maksymowych WP, van der Heijde D, Kim TH, Kishimoto M, Blanco R, Duan Y, Li Y, Pangan AL, Wung P, Song IH
Lancet 2022 Jul 30;400(10349):369-379. doi: 10.1016/S0140-6736(22)01212-0. PMID: 35908570
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Axial spondyloarthritis.
Sieper J, Poddubnyy D
Lancet 2017 Jul 1;390(10089):73-84. Epub 2017 Jan 20 doi: 10.1016/S0140-6736(16)31591-4. PMID: 28110981
Ankylosing spondylitis: an update.
Golder V, Schachna L
Aust Fam Physician 2013 Nov;42(11):780-4. PMID: 24217097

Therapy

Efficacy and safety of bimekizumab in axial spondyloarthritis: results of two parallel phase 3 randomised controlled trials.
van der Heijde D, Deodhar A, Baraliakos X, Brown MA, Dobashi H, Dougados M, Elewaut D, Ellis AM, Fleurinck C, Gaffney K, Gensler LS, Haroon N, Magrey M, Maksymowych WP, Marten A, Massow U, Oortgiesen M, Poddubnyy D, Rudwaleit M, Shepherd-Smith J, Tomita T, Van den Bosch F, Vaux T, Xu H
Ann Rheum Dis 2023 Apr;82(4):515-526. Epub 2023 Jan 17 doi: 10.1136/ard-2022-223595. PMID: 36649967Free PMC Article
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Deodhar A, Van den Bosch F, Poddubnyy D, Maksymowych WP, van der Heijde D, Kim TH, Kishimoto M, Blanco R, Duan Y, Li Y, Pangan AL, Wung P, Song IH
Lancet 2022 Jul 30;400(10349):369-379. doi: 10.1016/S0140-6736(22)01212-0. PMID: 35908570
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Ankylosing spondylitis: an update.
Golder V, Schachna L
Aust Fam Physician 2013 Nov;42(11):780-4. PMID: 24217097

Prognosis

Two-year imaging outcomes from a phase 3 randomized trial of secukinumab in patients with non-radiographic axial spondyloarthritis.
Braun J, Blanco R, Marzo-Ortega H, Gensler LS, Van den Bosch F, Hall S, Kameda H, Poddubnyy D, van de Sande M, van der Heijde D, Zhuang T, Stefanska A, Readie A, Richards HB, Deodhar A
Arthritis Res Ther 2023 May 16;25(1):80. doi: 10.1186/s13075-023-03051-5. PMID: 37194094Free PMC Article
Axial spondyloarthritis in the USA: diagnostic challenges and missed opportunities.
Danve A, Deodhar A
Clin Rheumatol 2019 Mar;38(3):625-634. Epub 2018 Dec 26 doi: 10.1007/s10067-018-4397-3. PMID: 30588555
Radiographic progression in non-radiographic axial spondyloarthritis.
Protopopov M, Poddubnyy D
Expert Rev Clin Immunol 2018 Jun;14(6):525-533. Epub 2018 May 24 doi: 10.1080/1744666X.2018.1477591. PMID: 29774755
The classification and diagnostic criteria of ankylosing spondylitis.
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717
Non-radiographic axial spondyloarthritis: what is it?
Fianyo E, Wendling D, Poulain C, Farrenq V, Claudepierre P
Clin Exp Rheumatol 2014 Jan-Feb;32(1):1-4. Epub 2013 Sep 10 PMID: 24021580

Clinical prediction guides

Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies.
Baraliakos X, Deodhar A, van der Heijde D, Magrey M, Maksymowych WP, Tomita T, Xu H, Massow U, Fleurinck C, Ellis AM, Vaux T, Shepherd-Smith J, Marten A, Gensler LS
Ann Rheum Dis 2024 Jan 11;83(2):199-213. doi: 10.1136/ard-2023-224803. PMID: 37793792
Efficacy and safety of bimekizumab in axial spondyloarthritis: results of two parallel phase 3 randomised controlled trials.
van der Heijde D, Deodhar A, Baraliakos X, Brown MA, Dobashi H, Dougados M, Elewaut D, Ellis AM, Fleurinck C, Gaffney K, Gensler LS, Haroon N, Magrey M, Maksymowych WP, Marten A, Massow U, Oortgiesen M, Poddubnyy D, Rudwaleit M, Shepherd-Smith J, Tomita T, Van den Bosch F, Vaux T, Xu H
Ann Rheum Dis 2023 Apr;82(4):515-526. Epub 2023 Jan 17 doi: 10.1136/ard-2022-223595. PMID: 36649967Free PMC Article
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Axial spondyloarthritis.
Navarro-Compán V, Sepriano A, El-Zorkany B, van der Heijde D
Ann Rheum Dis 2021 Dec;80(12):1511-1521. Epub 2021 Oct 6 doi: 10.1136/annrheumdis-2021-221035. PMID: 34615639
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article

Recent systematic reviews

Cardiovascular risk in axial spondyloarthritis-a systematic review.
Hintenberger R, Affenzeller B, Vladychuk V, Pieringer H
Clin Rheumatol 2023 Oct;42(10):2621-2633. Epub 2023 Jul 7 doi: 10.1007/s10067-023-06655-z. PMID: 37418034Free PMC Article
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.
Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review.
Strand V, Balsa A, Al-Saleh J, Barile-Fabris L, Horiuchi T, Takeuchi T, Lula S, Hawes C, Kola B, Marshall L
BioDrugs 2017 Aug;31(4):299-316. doi: 10.1007/s40259-017-0231-8. PMID: 28612180Free PMC Article
Systematic review of clinical, humanistic, and economic outcome comparisons between radiographic and non-radiographic axial spondyloarthritis.
Sieper J, Hu X, Black CM, Grootscholten K, van den Broek RWM, Kachroo S
Semin Arthritis Rheum 2017 Jun;46(6):746-753. Epub 2016 Sep 13 doi: 10.1016/j.semarthrit.2016.09.002. PMID: 27855973
Prevalence and factors associated with disturbed sleep in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review.
Leverment S, Clarke E, Wadeley A, Sengupta R
Rheumatol Int 2017 Feb;37(2):257-271. Epub 2016 Oct 28 doi: 10.1007/s00296-016-3589-x. PMID: 27796520

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