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Hyperpigmented genitalia

MedGen UID:
892441
•Concept ID:
C4022554
•
Finding
Synonyms: Increased genital pigmentation; Penile melanosis
 
HPO: HP:0030258

Definition

Localized or generalized increased genital pigmentation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperpigmented genitalia

Recent clinical studies

Etiology

Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
Preputial skin can be used in all boys with burns requiring grafting.
Doğrul AB, Aytaç O, Kiliç YA, Konan A, Yorganci K
Ulus Travma Acil Cerrahi Derg 2009 Jan;15(1):58-61. PMID: 19130339
Linear and whorled nevoid hypermelanosis.
Yuksek J, Sezer E, Erbil AH, Arca E, Taştan HB, Kurumlu Z, Demiriz M
Dermatol Online J 2007 Jul 13;13(3):23. PMID: 18328217

Diagnosis

Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report.
Vikramjeet S, Angelika B, Nishtha M
Curr Drug Saf 2019;14(1):72-76. doi: 10.2174/1574886313666180807095559. PMID: 30084337
Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
Linear and whorled nevoid hypermelanosis.
Yuksek J, Sezer E, Erbil AH, Arca E, Taştan HB, Kurumlu Z, Demiriz M
Dermatol Online J 2007 Jul 13;13(3):23. PMID: 18328217
Abdominal elephantiasis: a case report.
Hanna D, Cloutier R, Lapointe R, Desgagné A
J Cutan Med Surg 2004 Jul-Aug;8(4):229-32. doi: 10.1007/s10227-003-0104-2. PMID: 16092000
The black disease of Arabia, Sowda-onchocerciasis. New findings.
Siddiqui MA, al-Khawajah MM
Int J Dermatol 1991 Feb;30(2):130-3. doi: 10.1111/j.1365-4362.1991.tb04226.x. PMID: 2001904

Therapy

Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report.
Vikramjeet S, Angelika B, Nishtha M
Curr Drug Saf 2019;14(1):72-76. doi: 10.2174/1574886313666180807095559. PMID: 30084337
Fixed drug eruption in Nigeria.
Nnoruka EN, Ikeh VO, Mbah AU
Int J Dermatol 2006 Sep;45(9):1062-5. doi: 10.1111/j.1365-4632.2006.02912.x. PMID: 16961509
Hyperpigmentation mimicking Laugier syndrome, levodopa therapy and Addison's disease.
Vega Gutiérrez J, Miranda Romero A, Martínez G, Torrero MV, López de Juan M
J Eur Acad Dermatol Venereol 2003 May;17(3):324-7. doi: 10.1046/j.1468-3083.2003.00431.x. PMID: 12702077

Prognosis

Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
Linear and whorled nevoid hypermelanosis.
Yuksek J, Sezer E, Erbil AH, Arca E, Taştan HB, Kurumlu Z, Demiriz M
Dermatol Online J 2007 Jul 13;13(3):23. PMID: 18328217
A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online.
Marui S, Torrealba IM, Russell AJ, Latronico AC, Sutcliffe RG, Mendonca BB
Hum Mutat 1998;12(2):139. doi: 10.1002/(SICI)1098-1004(1998)12:2<139::AID-HUMU19>3.0.CO;2-4. PMID: 10694926

Clinical prediction guides

Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online.
Marui S, Torrealba IM, Russell AJ, Latronico AC, Sutcliffe RG, Mendonca BB
Hum Mutat 1998;12(2):139. doi: 10.1002/(SICI)1098-1004(1998)12:2<139::AID-HUMU19>3.0.CO;2-4. PMID: 10694926

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