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Hyperpigmented genitalia

MedGen UID:
892441
•Concept ID:
C4022554
•
Finding
Synonyms: Increased genital pigmentation; Penile melanosis
 
HPO: HP:0030258

Definition

Localized or generalized increased genital pigmentation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperpigmented genitalia

Recent clinical studies

Etiology

Exclusive extragenital lichen sclerosis in a child presenting in a lichen planus distribution.
Murshidi R, AlSamhori JF, AlSamhouri ARF, Hamad SB, Abdaljaleel M, AlShammas F
Dermatol Online J 2024 Jun 15;30(3) doi: 10.5070/D330363865. PMID: 39090038
Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
Preputial skin can be used in all boys with burns requiring grafting.
Doğrul AB, Aytaç O, Kiliç YA, Konan A, Yorganci K
Ulus Travma Acil Cerrahi Derg 2009 Jan;15(1):58-61. PMID: 19130339
Linear and whorled nevoid hypermelanosis.
Yuksek J, Sezer E, Erbil AH, Arca E, Taştan HB, Kurumlu Z, Demiriz M
Dermatol Online J 2007 Jul 13;13(3):23. PMID: 18328217

Diagnosis

Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
Large neurofibroma of the labia majora: A case report.
Kidanto HL, Garrison J, Wangwe P
Tanzan J Health Res 2013 Jan;15(1):71-2. doi: 10.4314/thrb.v15i1.10. PMID: 26591676
Linear and whorled nevoid hypermelanosis.
Yuksek J, Sezer E, Erbil AH, Arca E, Taştan HB, Kurumlu Z, Demiriz M
Dermatol Online J 2007 Jul 13;13(3):23. PMID: 18328217
Abdominal elephantiasis: a case report.
Hanna D, Cloutier R, Lapointe R, Desgagné A
J Cutan Med Surg 2004 Jul-Aug;8(4):229-32. doi: 10.1007/s10227-003-0104-2. PMID: 16092000
Acquired vulvar smooth muscle hamartoma: a case report and review of the literature.
Kwon KS, Lee CW, Seo KH, Park JH, Oh CK, Jang HS, Chung TA
J Dermatol 2000 Jan;27(1):56-9. doi: 10.1111/j.1346-8138.2000.tb02120.x. PMID: 10692828

Therapy

Exclusive extragenital lichen sclerosis in a child presenting in a lichen planus distribution.
Murshidi R, AlSamhori JF, AlSamhouri ARF, Hamad SB, Abdaljaleel M, AlShammas F
Dermatol Online J 2024 Jun 15;30(3) doi: 10.5070/D330363865. PMID: 39090038
Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report.
Vikramjeet S, Angelika B, Nishtha M
Curr Drug Saf 2019;14(1):72-76. doi: 10.2174/1574886313666180807095559. PMID: 30084337
Fixed drug eruption in Nigeria.
Nnoruka EN, Ikeh VO, Mbah AU
Int J Dermatol 2006 Sep;45(9):1062-5. doi: 10.1111/j.1365-4632.2006.02912.x. PMID: 16961509
Hyperpigmentation mimicking Laugier syndrome, levodopa therapy and Addison's disease.
Vega Gutiérrez J, Miranda Romero A, Martínez G, Torrero MV, López de Juan M
J Eur Acad Dermatol Venereol 2003 May;17(3):324-7. doi: 10.1046/j.1468-3083.2003.00431.x. PMID: 12702077

Prognosis

Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
Linear and whorled nevoid hypermelanosis.
Yuksek J, Sezer E, Erbil AH, Arca E, Taştan HB, Kurumlu Z, Demiriz M
Dermatol Online J 2007 Jul 13;13(3):23. PMID: 18328217
A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online.
Marui S, Torrealba IM, Russell AJ, Latronico AC, Sutcliffe RG, Mendonca BB
Hum Mutat 1998;12(2):139. doi: 10.1002/(SICI)1098-1004(1998)12:2<139::AID-HUMU19>3.0.CO;2-4. PMID: 10694926

Clinical prediction guides

Exclusive extragenital lichen sclerosis in a child presenting in a lichen planus distribution.
Murshidi R, AlSamhori JF, AlSamhouri ARF, Hamad SB, Abdaljaleel M, AlShammas F
Dermatol Online J 2024 Jun 15;30(3) doi: 10.5070/D330363865. PMID: 39090038
Penile Median Raphe Anomalies as an Indicator of Megameatus Intact Prepuce Anomaly in Children Undergoing Routine Circumcision.
Fahmy MAB, Shenawy AAE, Altramsy A, Samahy OA, Yehya A, Othman D
Urology 2018 Nov;121:164-167. Epub 2018 Aug 7 doi: 10.1016/j.urology.2018.07.036. PMID: 30096348
A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online.
Marui S, Torrealba IM, Russell AJ, Latronico AC, Sutcliffe RG, Mendonca BB
Hum Mutat 1998;12(2):139. doi: 10.1002/(SICI)1098-1004(1998)12:2<139::AID-HUMU19>3.0.CO;2-4. PMID: 10694926

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