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Biliary hyperplasia

MedGen UID:
892498
Concept ID:
C3686778
Disease or Syndrome
Synonym: Bile duct hyperplasia
 
HPO: HP:0006560

Definition

Hyperplasia of the biliary tree, as manifested by increased size of bile ducts, dilated lumen, and histologically by an increased number of epithelial cells or hyperplasia. [from HPO]

Term Hierarchy

Conditions with this feature

Liver disease, severe congenital
MedGen UID:
1823968
Concept ID:
C5774195
Disease or Syndrome
Severe congenital liver disease (SCOLIV) is an autosomal recessive disorder characterized by the onset of progressive hepatic dysfunction usually in the first years of life. Affected individuals show feeding difficulties with failure to thrive and features such as jaundice, hepatomegaly, and abdominal distension. Laboratory workup is consistent with hepatic insufficiency and may also show coagulation defects, anemia, or metabolic disturbances. Cirrhosis and hypernodularity are commonly observed on liver biopsy. Many patients die of liver failure in early childhood (Moreno Traspas et al., 2022).

Professional guidelines

PubMed

Srinivasa S, Lee WG, Aldameh A, Koea JB
HPB (Oxford) 2015 Oct;17(10):872-80. Epub 2015 Aug 7 doi: 10.1111/hpb.12474. PMID: 26252245Free PMC Article

Recent clinical studies

Etiology

Arunsan P, Ittiprasert W, Smout MJ, Cochran CJ, Mann VH, Chaiyadet S, Karinshak SE, Sripa B, Young ND, Sotillo J, Loukas A, Brindley PJ, Laha T
Elife 2019 Jan 15;8 doi: 10.7554/eLife.41463. PMID: 30644359Free PMC Article
Chaidee A, Onsurathum S, Intuyod K, Pannangpetch P, Pongchaiyakul C, Pinlaor P, Pairojkul C, Ittiprasert W, Cochran CJ, Mann VH, Brindley PJ, Pinlaor S
PLoS Negl Trop Dis 2018 Jun;12(6):e0006611. Epub 2018 Jun 28 doi: 10.1371/journal.pntd.0006611. PMID: 29953446Free PMC Article
Kennedy L, Hargrove L, Demieville J, Karstens W, Jones H, DeMorrow S, Meng F, Invernizzi P, Bernuzzi F, Alpini G, Smith S, Akers A, Meadows V, Francis H
Hepatology 2018 Sep;68(3):1042-1056. Epub 2018 Jun 1 doi: 10.1002/hep.29898. PMID: 29601088Free PMC Article
Terada T, Nakanuma Y, Sirica AE
Hum Pathol 1998 Feb;29(2):175-80. doi: 10.1016/s0046-8177(98)90229-5. PMID: 9490278

Diagnosis

Kim KH, Kim CD, Lee HS, Lee SJ, Jeen YT, Chun HJ, Song CW, Lee SW, Um SH, Choi JH, Ryu HS, Hyun JH
Am J Gastroenterol 1999 Feb;94(2):514-7. doi: 10.1111/j.1572-0241.1999.887_p.x. PMID: 10022657

Therapy

Chaidee A, Onsurathum S, Intuyod K, Pannangpetch P, Pongchaiyakul C, Pinlaor P, Pairojkul C, Ittiprasert W, Cochran CJ, Mann VH, Brindley PJ, Pinlaor S
PLoS Negl Trop Dis 2018 Jun;12(6):e0006611. Epub 2018 Jun 28 doi: 10.1371/journal.pntd.0006611. PMID: 29953446Free PMC Article
Tangkawattana S, Tangkawattana P
Adv Parasitol 2018;101:69-95. Epub 2018 May 29 doi: 10.1016/bs.apar.2018.05.003. PMID: 29907256
Kennedy L, Hargrove L, Demieville J, Karstens W, Jones H, DeMorrow S, Meng F, Invernizzi P, Bernuzzi F, Alpini G, Smith S, Akers A, Meadows V, Francis H
Hepatology 2018 Sep;68(3):1042-1056. Epub 2018 Jun 1 doi: 10.1002/hep.29898. PMID: 29601088Free PMC Article
McMillin M, DeMorrow S, Glaser S, Venter J, Kyritsi K, Zhou T, Grant S, Giang T, Greene JF Jr, Wu N, Jefferson B, Meng F, Alpini G
Am J Physiol Gastrointest Liver Physiol 2017 Nov 1;313(5):G410-G418. Epub 2017 Jul 27 doi: 10.1152/ajpgi.00421.2016. PMID: 28751425Free PMC Article
Dill MT, Tornillo L, Fritzius T, Terracciano L, Semela D, Bettler B, Heim MH, Tchorz JS
Hepatology 2013 Apr;57(4):1607-19. Epub 2013 Mar 14 doi: 10.1002/hep.26165. PMID: 23175466

Clinical prediction guides

Chen L, Zhou T, Wu N, O'Brien A, Venter J, Ceci L, Kyritsi K, Onori P, Gaudio E, Sybenga A, Xie L, Wu C, Fabris L, Invernizzi P, Zawieja D, Liangpunsakul S, Meng F, Francis H, Alpini G, Huang Q, Glaser S
Biochim Biophys Acta Mol Basis Dis 2019 Jun 1;1865(6):1525-1539. Epub 2019 Mar 16 doi: 10.1016/j.bbadis.2019.03.002. PMID: 30890428Free PMC Article
Ehrlich L, O'Brien A, Hall C, White T, Chen L, Wu N, Venter J, Scrushy M, Mubarak M, Meng F, Dostal D, Wu C, Lairmore TC, Alpini G, Glaser S
Gene Expr 2018 Aug 22;18(3):197-207. Epub 2018 Mar 26 doi: 10.3727/105221618X15216453076707. PMID: 29580318Free PMC Article
Marzioni M, Agostinelli L, Candelaresi C, Saccomanno S, De Minicis S, Maroni L, Mingarelli E, Rychlicki C, Trozzi L, Banales JM, Benedetti A, Baroni GS
Hepatology 2014 Oct;60(4):1324-35. Epub 2014 Aug 25 doi: 10.1002/hep.27262. PMID: 24925797
Sun X, Olivier AK, Yi Y, Pope CE, Hayden HS, Liang B, Sui H, Zhou W, Hager KR, Zhang Y, Liu X, Yan Z, Fisher JT, Keiser NW, Song Y, Tyler SR, Goeken JA, Kinyon JM, Radey MC, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Brittnacher MJ, Miller SI, Parekh K, Meyerholz DK, Hoffman LR, Frana T, Stewart ZA, Engelhardt JF
Am J Pathol 2014 May;184(5):1309-22. Epub 2014 Mar 15 doi: 10.1016/j.ajpath.2014.01.035. PMID: 24637292Free PMC Article
Wolfgang GH, McCabe RD, Johnson DE
Toxicol Sci 1998 Mar;42(1):57-63. doi: 10.1006/toxs.1997.2419. PMID: 9538048

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