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Osteolysis involving bones of the upper limbs

MedGen UID:: 892512
•Concept ID:: C4073167
•: Pathologic Function

HPO:	HP:0045039

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOsteolysis involving bones of the upper limbs

Phenotypic abnormality
- Abnormality of limbs
  - Abnormality of the upper limb
    - Abnormal upper limb bone morphology
      - Osteolysis involving bones of the upper limbs
        Carpal osteolysis
        Lytic defects of carpal bones
        Lytic defects of ulnar metaphysis
        Metacarpal osteolysis
        Osteolytic defects of the hand bones
        Acroosteolysis
        Hajdu-Cheney syndrome
        Osteolytic defect of thumb phalanx
        Osteolytic defects of the phalanges of the 2nd finger
        Osteolytic defects of the phalanges of the 3rd finger
        Osteolytic defects of the phalanges of the 4th finger
        Osteolytic defects of the phalanges of the 5th finger
        Osteolysis of scaphoids

Recent clinical studies

Etiology

Multicentric carpotarsal osteolysis syndrome: long-term follow-up of three patients.

Klein C, Bellity J, Finidori G, Glorion C, Pannier S
Skeletal Radiol 2018 Jul;47(7):1015-1019. Epub 2018 Feb 3 doi: 10.1007/s00256-018-2874-z. PMID: 29396697

Identical Presentation of Scapular Osteolysis in Two Patients with Thoracic Kaposiform Hemangioendothelioma.

Alonso Arroyo V, Lopez-Gutierrez JC, Martinez R, Fernandez-Pineda I
Pediatr Dermatol 2017 May;34(3):e146-e149. Epub 2017 Apr 6 doi: 10.1111/pde.13114. PMID: 28382716

Multicentric carpotarsal osteolysis syndrome is caused by only a few domain-specific mutations in MAFB, a negative regulator of RANKL-induced osteoclastogenesis.

Mumm S, Huskey M, Duan S, Wenkert D, Madson KL, Gottesman GS, Nenninger AR, Laxer RM, McAlister WH, Whyte MP
Am J Med Genet A 2014 Sep;164A(9):2287-93. Epub 2014 Jul 2 doi: 10.1002/ajmg.a.36641. PMID: 24989131 Free PMC Article

Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study.

Avouac J, Mogavero G, Guerini H, Drapé JL, Mathieu A, Kahan A, Allanore Y
Ann Rheum Dis 2011 Apr;70(4):630-3. Epub 2010 Dec 3 doi: 10.1136/ard.2010.134304. PMID: 21131648

Granuloma annulare: radiographic demonstration of progressive mutilating arthropathy with vanishing bones.

Bancroft LW, Perniciaro C, Berquist TH
Skeletal Radiol 1998 Apr;27(4):211-4. doi: 10.1007/s002560050367. PMID: 9592904

See all (7)

Diagnosis

Gorham-Stout disease involving ipsilateral clavicle and scapula in a child - a case report focusing on imaging and histopathological features of this extremely rare condition.

Duczkowski M, Palczewski P, Wagrodzki M, Duczkowska A, Klepacka T, Szymborska A, Raciborska A, Czubak J, Bekiesinska-Figatowska M
Pol J Pathol 2021;72(2):174-179. doi: 10.5114/pjp.2021.109521. PMID: 34706526

Gorham-Stout Disease with Multiple Bone Involvement-Challenging Diagnosis of a Rare Disease and Literature Review.

Momanu A, Caba L, Gorduza NC, Arhire OE, Popa AD, Ianole V, Gorduza EV
Medicina (Kaunas) 2021 Jul 2;57(7) doi: 10.3390/medicina57070681. PMID: 34356962 Free PMC Article

Identical Presentation of Scapular Osteolysis in Two Patients with Thoracic Kaposiform Hemangioendothelioma.

Alonso Arroyo V, Lopez-Gutierrez JC, Martinez R, Fernandez-Pineda I
Pediatr Dermatol 2017 May;34(3):e146-e149. Epub 2017 Apr 6 doi: 10.1111/pde.13114. PMID: 28382716

Neuropathic arthropathy of the shoulder associated with syringomyelia: a report of six cases.

Atalar AC, Sungur M, Demirhan M, Ozger H
Acta Orthop Traumatol Turc 2010;44(4):328-36. doi: 10.3944/AOTT.2010.2216. PMID: 21252611

Sarcoidosis of the hand and wrist: a report of two cases.

González del Pino J, Diez Ulloa A, Lovic A, Relea MF
J Hand Surg Am 1997 Sep;22(5):942-5. doi: 10.1016/s0363-5023(97)80095-0. PMID: 9330159

See all (15)

Therapy

Identical Presentation of Scapular Osteolysis in Two Patients with Thoracic Kaposiform Hemangioendothelioma.

Alonso Arroyo V, Lopez-Gutierrez JC, Martinez R, Fernandez-Pineda I
Pediatr Dermatol 2017 May;34(3):e146-e149. Epub 2017 Apr 6 doi: 10.1111/pde.13114. PMID: 28382716

See all (1)

Prognosis

Gorham-Stout Disease with Multiple Bone Involvement-Challenging Diagnosis of a Rare Disease and Literature Review.

Momanu A, Caba L, Gorduza NC, Arhire OE, Popa AD, Ianole V, Gorduza EV
Medicina (Kaunas) 2021 Jul 2;57(7) doi: 10.3390/medicina57070681. PMID: 34356962 Free PMC Article

Multicentric carpotarsal osteolysis syndrome: long-term follow-up of three patients.

Klein C, Bellity J, Finidori G, Glorion C, Pannier S
Skeletal Radiol 2018 Jul;47(7):1015-1019. Epub 2018 Feb 3 doi: 10.1007/s00256-018-2874-z. PMID: 29396697

Identical Presentation of Scapular Osteolysis in Two Patients with Thoracic Kaposiform Hemangioendothelioma.

Alonso Arroyo V, Lopez-Gutierrez JC, Martinez R, Fernandez-Pineda I
Pediatr Dermatol 2017 May;34(3):e146-e149. Epub 2017 Apr 6 doi: 10.1111/pde.13114. PMID: 28382716

Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study.

Avouac J, Mogavero G, Guerini H, Drapé JL, Mathieu A, Kahan A, Allanore Y
Ann Rheum Dis 2011 Apr;70(4):630-3. Epub 2010 Dec 3 doi: 10.1136/ard.2010.134304. PMID: 21131648

Cystic angiomatosis with splenic involvement: unusual MRI findings.

Vanhoenacker FM, Schepper AM, Raeve H, Berneman Z
Eur Radiol 2003 Dec;13 Suppl 6:L35-9. Epub 2003 Feb 4 doi: 10.1007/s00330-002-1805-4. PMID: 16440230

See all (9)

Clinical prediction guides

Identical Presentation of Scapular Osteolysis in Two Patients with Thoracic Kaposiform Hemangioendothelioma.

Alonso Arroyo V, Lopez-Gutierrez JC, Martinez R, Fernandez-Pineda I
Pediatr Dermatol 2017 May;34(3):e146-e149. Epub 2017 Apr 6 doi: 10.1111/pde.13114. PMID: 28382716

Hand osteolysis in patients with adult T-cell leukemia-lymphoma: radiographic characteristics.

Ehara S, Takahashi K, Nishida J, Uetani M, Ohashi K, Aoki T
Tohoku J Exp Med 2015 May;236(1):63-9. doi: 10.1620/tjem.236.63. PMID: 25985828

Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study.

Avouac J, Mogavero G, Guerini H, Drapé JL, Mathieu A, Kahan A, Allanore Y
Ann Rheum Dis 2011 Apr;70(4):630-3. Epub 2010 Dec 3 doi: 10.1136/ard.2010.134304. PMID: 21131648

See all (3)

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Osteolysis involving bones of the upper limbs

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Clinical resources

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