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Recurrent thromboembolism

MedGen UID:
892537
Concept ID:
C4025286
Finding
Synonym: Recurrent thromboembolic disease
 
HPO: HP:0004831

Definition

Repeated episodes of obstruction of blood flow due to an embolus, i.e., blood clot that has traveled from its point of origin within the blood stream. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent thromboembolism

Conditions with this feature

Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency
MedGen UID:
416465
Concept ID:
C2751090
Disease or Syndrome
Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency is a rare, genetic, coagulation disorder characterized by a tendency to develop thrombosis, resulting from decreased histidine-rich glycoprotein (HRG) plasma levels. Manifestations are variable depending on location of thrombosis, but may include headaches, diplopia, progressive pain, limb swelling, itching or ulceration, and brownish skin discoloration, among others.

Professional guidelines

PubMed

Fernandes TM, Kanwar M, White R
J Am Board Fam Med 2021 Mar-Apr;34(2):409-419. doi: 10.3122/jabfm.2021.02.200085. PMID: 33833011
Bernardi E, Piccioli A, Marchiori A, Girolami B, Prandoni P
Semin Vasc Med 2001;1(1):105-10. doi: 10.1055/s-2001-14547. PMID: 15199520
Carter BL, Jones ME, Waickman LA
Clin Pharm 1985 May-Jun;4(3):279-96. PMID: 3891200

Recent clinical studies

Etiology

Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
Menapace LA, McCrae KR, Khorana AA
Thromb Res 2016 Apr;140 Suppl 1:S93-8. doi: 10.1016/S0049-3848(16)30106-2. PMID: 27067987
Lim W
Hematology Am Soc Hematol Educ Program 2009:233-9. doi: 10.1182/asheducation-2009.1.233. PMID: 20008203
Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M; Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators
N Engl J Med 2003 Jul 10;349(2):146-53. doi: 10.1056/NEJMoa025313. PMID: 12853587
Henderson MC, White RH
Curr Opin Pulm Med 2001 Sep;7(5):365-70. doi: 10.1097/00063198-200109000-00020. PMID: 11584191

Diagnosis

Navi BB, Zhang C, Sherman CP, Genova R, LeMoss NM, Kamel H, Tagawa ST, Saxena A, Ocean AJ, Kasner SE, Cushman M, Elkind MSV, Peerschke E, DeAngelis LM
J Thromb Haemost 2022 Sep;20(9):2046-2057. Epub 2022 Jun 21 doi: 10.1111/jth.15779. PMID: 35652416Free PMC Article
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Donnellan E, Khorana AA
Oncologist 2017 Feb;22(2):199-207. Epub 2017 Feb 7 doi: 10.1634/theoncologist.2016-0214. PMID: 28174293Free PMC Article
Dentali F, Crowther M
Crit Care Med 2010 Feb;38(2 Suppl):S51-6. doi: 10.1097/CCM.0b013e3181c9e363. PMID: 20083914
Lim W
Hematology Am Soc Hematol Educ Program 2009:233-9. doi: 10.1182/asheducation-2009.1.233. PMID: 20008203

Therapy

Starr JA, Pinner NA, Mannis M, Stuart MK
Ann Pharmacother 2022 Jun;56(6):691-703. Epub 2021 Aug 29 doi: 10.1177/10600280211040093. PMID: 34459281
Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Lim W
Hematology Am Soc Hematol Educ Program 2009:233-9. doi: 10.1182/asheducation-2009.1.233. PMID: 20008203
Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M; Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators
N Engl J Med 2003 Jul 10;349(2):146-53. doi: 10.1056/NEJMoa025313. PMID: 12853587

Prognosis

Navi BB, Zhang C, Sherman CP, Genova R, LeMoss NM, Kamel H, Tagawa ST, Saxena A, Ocean AJ, Kasner SE, Cushman M, Elkind MSV, Peerschke E, DeAngelis LM
J Thromb Haemost 2022 Sep;20(9):2046-2057. Epub 2022 Jun 21 doi: 10.1111/jth.15779. PMID: 35652416Free PMC Article
Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
De Cobelli F, Palumbo D, Ciceri F, Landoni G, Ruggeri A, Rovere-Querini P, D'Angelo A, Steidler S, Galli L, Poli A, Fominskiy E, Calabrò MG, Colombo S, Monti G, Nicoletti R, Esposito A, Conte C, Dagna L, Ambrosio A, Scarpellini P, Ripa M, Spessot M, Carlucci M, Montorfano M, Agricola E, Baccellieri D, Bosi E, Tresoldi M, Castagna A, Martino G, Zangrillo A
J Cardiothorac Vasc Anesth 2021 Dec;35(12):3631-3641. Epub 2021 Jan 13 doi: 10.1053/j.jvca.2021.01.011. PMID: 33518461Free PMC Article
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Menapace LA, McCrae KR, Khorana AA
Thromb Res 2016 Apr;140 Suppl 1:S93-8. doi: 10.1016/S0049-3848(16)30106-2. PMID: 27067987

Clinical prediction guides

Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
De Cobelli F, Palumbo D, Ciceri F, Landoni G, Ruggeri A, Rovere-Querini P, D'Angelo A, Steidler S, Galli L, Poli A, Fominskiy E, Calabrò MG, Colombo S, Monti G, Nicoletti R, Esposito A, Conte C, Dagna L, Ambrosio A, Scarpellini P, Ripa M, Spessot M, Carlucci M, Montorfano M, Agricola E, Baccellieri D, Bosi E, Tresoldi M, Castagna A, Martino G, Zangrillo A
J Cardiothorac Vasc Anesth 2021 Dec;35(12):3631-3641. Epub 2021 Jan 13 doi: 10.1053/j.jvca.2021.01.011. PMID: 33518461Free PMC Article
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Balahura AM, Guţă A, Mihalcea V, Weiss E, Dorobanţu M, Bartoş D, Bădilă E, Dan GA
Rom J Intern Med 2017 Dec 1;55(4):237-244. doi: 10.1515/rjim-2017-0026. PMID: 28667815
Menapace LA, McCrae KR, Khorana AA
Thromb Res 2016 Apr;140 Suppl 1:S93-8. doi: 10.1016/S0049-3848(16)30106-2. PMID: 27067987

Recent systematic reviews

Espitia O, Raimbeau A, Planquette B, Katsahian S, Sanchez O, Espinasse B, Bénichou A, Murris J
J Vasc Surg Venous Lymphat Disord 2024 Jan;12(1):101688. Epub 2023 Sep 16 doi: 10.1016/j.jvsv.2023.09.002. PMID: 37717788
Hameed I, Lau C, Khan FM, Wingo M, Rahouma M, Leonard JR, Di Franco A, Worku BM, Salemi A, Girardi LN, Gaudino M
J Card Surg 2019 Apr;34(4):170-180. Epub 2019 Mar 6 doi: 10.1111/jocs.14009. PMID: 30843269
Gómez-Outes A, Lecumberri R, Suárez-Gea ML, Terleira-Fernández AI, Monreal M, Vargas-Castrillón E
J Cardiovasc Pharmacol Ther 2015 Sep;20(5):490-500. Epub 2015 Mar 23 doi: 10.1177/1074248415575154. PMID: 25802423
Harel Z, Sholzberg M, Shah PS, Pavenski K, Harel S, Wald R, Bell CM, Perl J
J Am Soc Nephrol 2014 Mar;25(3):431-42. Epub 2014 Jan 2 doi: 10.1681/ASN.2013040361. PMID: 24385595Free PMC Article
Marchiori A, Mosena L, Prins MH, Prandoni P
Haematologica 2007 Aug;92(8):1107-14. doi: 10.3324/haematol.10234. PMID: 17650440

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