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Recurrent thromboembolism

MedGen UID:
892537
•Concept ID:
C4025286
•
Finding
Synonym: Recurrent thromboembolic disease
 
HPO: HP:0004831

Definition

Repeated episodes of obstruction of blood flow due to an embolus, i.e., blood clot that has traveled from its point of origin within the blood stream. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent thromboembolism

Conditions with this feature

Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency
MedGen UID:
416465
•Concept ID:
C2751090
•
Disease or Syndrome
Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency is a rare, genetic, coagulation disorder characterized by a tendency to develop thrombosis, resulting from decreased histidine-rich glycoprotein (HRG) plasma levels. Manifestations are variable depending on location of thrombosis, but may include headaches, diplopia, progressive pain, limb swelling, itching or ulceration, and brownish skin discoloration, among others.
See: Condition Record
Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency

Professional guidelines

PubMed

Management of Patients With Venous Thromboembolism After the Initial Treatment Period.
Fernandes TM, Kanwar M, White R
J Am Board Fam Med 2021 Mar-Apr;34(2):409-419. doi: 10.3122/jabfm.2021.02.200085. PMID: 33833011
Update on the Treatment of Venous Thromboembolism.
Schulman S
Semin Thromb Hemost 2016 Nov;42(8):891-898. Epub 2016 Oct 20 doi: 10.1055/s-0036-1592305. PMID: 27764881
Upper extremity deep vein thrombosis: risk factors, diagnosis, and management.
Bernardi E, Piccioli A, Marchiori A, Girolami B, Prandoni P
Semin Vasc Med 2001;1(1):105-10. doi: 10.1055/s-2001-14547. PMID: 15199520

Recent clinical studies

Etiology

Association Between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study.
Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
Antiphospholipid antibody syndrome.
Lim W
Hematology Am Soc Hematol Educ Program 2009:233-9. doi: 10.1182/asheducation-2009.1.233. PMID: 20008203
Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.
Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M; Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators
N Engl J Med 2003 Jul 10;349(2):146-53. doi: 10.1056/NEJMoa025313. PMID: 12853587
Anticoagulation in the elderly.
Henderson MC, White RH
Curr Opin Pulm Med 2001 Sep;7(5):365-70. doi: 10.1097/00063198-200109000-00020. PMID: 11584191
The weight-based heparin dosing nomogram compared with a "standard care" nomogram. A randomized controlled trial.
Raschke RA, Reilly BM, Guidry JR, Fontana JR, Srinivas S
Ann Intern Med 1993 Nov 1;119(9):874-81. doi: 10.7326/0003-4819-119-9-199311010-00002. PMID: 8214998

Diagnosis

Apixaban Versus Vitamin K Antagonists in Patients With Antiphospholipid Syndrome: A Cohort Study.
Sikorska M, Chmiel J, Papuga-Szela E, Broniatowska E, Undas A
J Cardiovasc Pharmacol 2024 Jul 1;84(1):36-44. doi: 10.1097/FJC.0000000000001578. PMID: 38922590
Ischemic stroke with cancer: Hematologic and embolic biomarkers and clinical outcomes.
Navi BB, Zhang C, Sherman CP, Genova R, LeMoss NM, Kamel H, Tagawa ST, Saxena A, Ocean AJ, Kasner SE, Cushman M, Elkind MSV, Peerschke E, DeAngelis LM
J Thromb Haemost 2022 Sep;20(9):2046-2057. Epub 2022 Jun 21 doi: 10.1111/jth.15779. PMID: 35652416Free PMC Article
Arterial Thrombosis in Patients with Antiphospholipid Syndrome: A Review and Meta-Analysis.
Aibar J, Schulman S
Semin Thromb Hemost 2021 Sep;47(6):709-723. Epub 2021 May 10 doi: 10.1055/s-0041-1725057. PMID: 33971678
Pathogenesis of heparin-induced thrombocytopenia.
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Antiphospholipid antibody syndrome.
Lim W
Hematology Am Soc Hematol Educ Program 2009:233-9. doi: 10.1182/asheducation-2009.1.233. PMID: 20008203

Therapy

A Review of Direct Oral Anticoagulants in Patients With Stage 5 or End-Stage Kidney Disease.
Starr JA, Pinner NA, Mannis M, Stuart MK
Ann Pharmacother 2022 Jun;56(6):691-703. Epub 2021 Aug 29 doi: 10.1177/10600280211040093. PMID: 34459281
Association Between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study.
Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
Pathogenesis of heparin-induced thrombocytopenia.
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Antiphospholipid antibody syndrome.
Lim W
Hematology Am Soc Hematol Educ Program 2009:233-9. doi: 10.1182/asheducation-2009.1.233. PMID: 20008203
Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.
Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M; Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators
N Engl J Med 2003 Jul 10;349(2):146-53. doi: 10.1056/NEJMoa025313. PMID: 12853587

Prognosis

Ischemic stroke with cancer: Hematologic and embolic biomarkers and clinical outcomes.
Navi BB, Zhang C, Sherman CP, Genova R, LeMoss NM, Kamel H, Tagawa ST, Saxena A, Ocean AJ, Kasner SE, Cushman M, Elkind MSV, Peerschke E, DeAngelis LM
J Thromb Haemost 2022 Sep;20(9):2046-2057. Epub 2022 Jun 21 doi: 10.1111/jth.15779. PMID: 35652416Free PMC Article
Association Between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study.
Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
Pathogenesis of heparin-induced thrombocytopenia.
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Predictors of recurrent venous thromboembolism and bleeding on anticoagulation.
Menapace LA, McCrae KR, Khorana AA
Thromb Res 2016 Apr;140 Suppl 1:S93-8. doi: 10.1016/S0049-3848(16)30106-2. PMID: 27067987
Recurrent thromboembolism in cancer patients: incidence and risk factors.
Prandoni P, Piccioli A, Pagnan A
Semin Thromb Hemost 2003 Dec;29 Suppl 1:3-8. doi: 10.1055/s-2003-45411. PMID: 14730471

Clinical prediction guides

Apixaban Versus Vitamin K Antagonists in Patients With Antiphospholipid Syndrome: A Cohort Study.
Sikorska M, Chmiel J, Papuga-Szela E, Broniatowska E, Undas A
J Cardiovasc Pharmacol 2024 Jul 1;84(1):36-44. doi: 10.1097/FJC.0000000000001578. PMID: 38922590
Association Between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study.
Gronich N, Stein N, Muszkat M
Clin Pharmacol Ther 2021 Dec;110(6):1526-1536. Epub 2021 Aug 10 doi: 10.1002/cpt.2369. PMID: 34287842Free PMC Article
Pathogenesis of heparin-induced thrombocytopenia.
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Pulmonary thromboembolism in an emergency hospital: Are our patients different?
Balahura AM, Guţă A, Mihalcea V, Weiss E, Dorobanţu M, Bartoş D, Bădilă E, Dan GA
Rom J Intern Med 2017 Dec 1;55(4):237-244. doi: 10.1515/rjim-2017-0026. PMID: 28667815
Predictors of recurrent venous thromboembolism and bleeding on anticoagulation.
Menapace LA, McCrae KR, Khorana AA
Thromb Res 2016 Apr;140 Suppl 1:S93-8. doi: 10.1016/S0049-3848(16)30106-2. PMID: 27067987

Recent systematic reviews

A systematic review and meta-analysis of the incidence of post-thrombotic syndrome, recurrent thromboembolism, and bleeding after upper extremity vein thrombosis.
Espitia O, Raimbeau A, Planquette B, Katsahian S, Sanchez O, Espinasse B, Bénichou A, Murris J
J Vasc Surg Venous Lymphat Disord 2024 Jan;12(1):101688. Epub 2023 Sep 16 doi: 10.1016/j.jvsv.2023.09.002. PMID: 37717788Free PMC Article
AngioVac for extraction of venous thromboses and endocardial vegetations: A meta-analysis.
Hameed I, Lau C, Khan FM, Wingo M, Rahouma M, Leonard JR, Di Franco A, Worku BM, Salemi A, Girardi LN, Gaudino M
J Card Surg 2019 Apr;34(4):170-180. Epub 2019 Mar 6 doi: 10.1111/jocs.14009. PMID: 30843269
Case Fatality Rates of Recurrent Thromboembolism and Bleeding in Patients Receiving Direct Oral Anticoagulants for the Initial and Extended Treatment of Venous Thromboembolism: A Systematic Review.
Gómez-Outes A, Lecumberri R, Suárez-Gea ML, Terleira-Fernández AI, Monreal M, Vargas-Castrillón E
J Cardiovasc Pharmacol Ther 2015 Sep;20(5):490-500. Epub 2015 Mar 23 doi: 10.1177/1074248415575154. PMID: 25802423
Comparisons between novel oral anticoagulants and vitamin K antagonists in patients with CKD.
Harel Z, Sholzberg M, Shah PS, Pavenski K, Harel S, Wald R, Bell CM, Perl J
J Am Soc Nephrol 2014 Mar;25(3):431-42. Epub 2014 Jan 2 doi: 10.1681/ASN.2013040361. PMID: 24385595Free PMC Article
The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies.
Marchiori A, Mosena L, Prins MH, Prandoni P
Haematologica 2007 Aug;92(8):1107-14. doi: 10.3324/haematol.10234. PMID: 17650440

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