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Increased serum testosterone level

MedGen UID:
Concept ID:
Synonyms: High serum testosterone level; High serum testosterone levels; Increased serum testosterone levels; Increased testosterone
HPO: HP:0030088


An elevated circulating testosterone level in the blood. [from HPO]

Term Hierarchy

Conditions with this feature

Deficiency of steroid 11-beta-monooxygenase
MedGen UID:
Concept ID:
Disease or Syndrome
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency is an autosomal recessive disorder of corticosteroid biosynthesis resulting in androgen excess, virilization, and hypertension. The defect causes decreased synthesis of cortisol and corticosterone in the zona fasciculata of the adrenal gland, resulting in accumulation of the precursors 11-deoxycortisol and 11-deoxycorticosterone; the latter is a potent salt-retaining mineralocorticoid that leads to arterial hypertension (White et al., 1991). CAH due to 11-beta-hydroxylase deficiency accounts for approximately 5 to 8% of all CAH cases; approximately 90% of cases are caused by 21-hydroxylase deficiency (201910) (White et al., 1991).
Neonatal pseudo-hydrocephalic progeroid syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
Wiedemann-Rautenstrauch syndrome (WDRTS) is a rare autosomal recessive neonatal progeroid disorder characterized by intrauterine growth retardation, failure to thrive, short stature, a progeroid appearance, hypotonia, and variable mental impairment (summary by Toriello, 1990). Average survival in WDRTS is 7 months, although survival into the third decade of life has been reported (Akawi et al., 2013).
Glucocorticoid resistance
MedGen UID:
Concept ID:
Disease or Syndrome
Generalized glucocorticoid resistance is an autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of clinical stigmata of Cushing syndrome. The clinical expression of the disease is variable. Common features include hypoglycemia, hypertension, and metabolic alkalosis. In females, overproduction of adrenal androgens has been associated with infertility, male-pattern baldness, hirsutism, and menstrual irregularities. Other features include chronic fatigue and profound anxiety (summary by Chrousos et al., 1983; Donner et al., 2013).
Pigmented nodular adrenocortical disease, primary, 1
MedGen UID:
Concept ID:
Disease or Syndrome
Primary pigmented micronodular adrenocortical disease is a form of ACTH-independent adrenal hyperplasia resulting in Cushing syndrome. It is usually seen as a manifestation of the Carney complex (CNC1; 160980), a multiple neoplasia syndrome. However, PPNAD can also occur in isolation (Groussin et al., 2002). Genetic Heterogeneity of Primary Pigmented Micronodular Adrenocortical Disease See also PPNAD2 (610475), caused by mutation in the PDE11A gene (604961) on chromosome 2q31; PPNAD3 (614190), caused by mutation in the PDE8B gene (603390) on chromosome 5q13; and PPNAD4 (615830), caused by a duplication on chromosome 19p13 that includes the PRKACA gene (601639).
46,xx sex reversal 5
MedGen UID:
Concept ID:
Disease or Syndrome
SRXX5 is characterized by genital virilization in 46,XX individuals, associated with congenital heart disease and variable somatic anomalies including blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) and congenital diaphragmatic hernia (Bashamboo et al., 2018).

Professional guidelines


Lin GW, Yao XD, Ye DW, Zhu Y, Zhang SL, Dai B, Zhang HL, Shen YJ, Ma CG
Asian J Androl 2012 Sep;14(5):732-7. Epub 2012 Aug 20 doi: 10.1038/aja.2012.57. PMID: 22902911Free PMC Article
Jungwirth A, Plas E, Geurts P
Aging Male 2007 Dec;10(4):183-7. doi: 10.1080/13685530701495088. PMID: 18033627

Recent clinical studies


Alam MM, Rahman MA, Naser MF, Hossain MS, Islam MA
Mymensingh Med J 2010 Oct;19(4):632-5. PMID: 20956912
Ryan JJ, Rezkalla MA, Rizk SN, Peterson KG, Wiebe RH
Mayo Clin Proc 1995 Apr;70(4):380-3. doi: 10.4065/70.4.380. PMID: 7898146


Mishra RK, Singh SK
Andrologia 2016 Nov;48(9):923-932. Epub 2016 Feb 3 doi: 10.1111/and.12533. PMID: 26840772
Kikuchi K, Kaji M, Momoi T, Mikawa H, Shigematsu Y, Sudo M
Acta Endocrinol (Copenh) 1987 Jan;114(1):153-60. doi: 10.1530/acta.0.1140153. PMID: 3101337

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