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Divergence nystagmus

MedGen UID:
Concept ID:
HPO: HP:0030691


A condition in which both eyes beat outward simultaneously. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDivergence nystagmus

Conditions with this feature

Intellectual disability, autosomal recessive 42
MedGen UID:
Concept ID:
Disease or Syndrome
Neurodevelopmental disorder with dysmorphic features, spasticity, and brain abnormalities (NEDDSBA) is an autosomal recessive neurodevelopmental disorder characterized by severely delayed global development, with hypotonia, impaired intellectual development, and poor or absent speech. Most patients have spasticity with limb hypertonia and brisk tendon reflexes. Additional features include nonspecific dysmorphic facial features, structural brain abnormalities, and cortical visual impairment (summary by Bosch et al., 2015). Novarino et al. (2014) labeled the disorder 'spastic paraplegia-67' (SPG67). The disorder is caused by a defect in glycosylphosphatidylinositol (GPI) biosynthesis. For a discussion of genetic heterogeneity of GPI biosynthesis defects, see GPIBD1 (610293).

Recent clinical studies


Pratt-Johnson JA, Tillson G
Can J Ophthalmol 1983 Jun;18(4):175-7. PMID: 6883194


Kwon E, Lee JY, Kim HJ, Choi JY, Kim JS
Neurology 2021 Feb 9;96(6):290-293. Epub 2020 Dec 4 doi: 10.1212/WNL.0000000000011273. PMID: 33277418
Sakata E, Teramoto K, Baba K, Ohtsu K
Auris Nasus Larynx 1985;12(3):169-82. doi: 10.1016/s0385-8146(85)80016-x. PMID: 3834896


Pratt-Johnson JA, Tillson G
Can J Ophthalmol 1983 Jun;18(4):175-7. PMID: 6883194

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