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Abnormality of the adrenal glands

MedGen UID:
892577
•Concept ID:
C4021794
•
Anatomical Abnormality
Synonyms: Adrenal abnormalities; Adrenal gland disease; adrenal gland disease; adrenal gland disease or disorder; adrenal gland diseases; adrenal gland disorder; adrenal gland disorders; disease of adrenal gland; disease or disorder of adrenal gland; disorder of adrenal gland
 
HPO: HP:0000834
Monarch Initiative: MONDO:0005495

Definition

Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kindneys. [from HPO]

Professional guidelines

PubMed

Pathogenesis and treatment of primary aldosteronism.
Zennaro MC, Boulkroun S, Fernandes-Rosa FL
Nat Rev Endocrinol 2020 Oct;16(10):578-589. Epub 2020 Jul 28 doi: 10.1038/s41574-020-0382-4. PMID: 32724183
Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment.
Vivino FB, Bunya VY, Massaro-Giordano G, Johr CR, Giattino SL, Schorpion A, Shafer B, Peck A, Sivils K, Rasmussen A, Chiorini JA, He J, Ambrus JL Jr
Clin Immunol 2019 Jun;203:81-121. Epub 2019 Apr 29 doi: 10.1016/j.clim.2019.04.009. PMID: 31022578
Update on diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
White PC
Curr Opin Endocrinol Diabetes Obes 2018 Jun;25(3):178-184. doi: 10.1097/MED.0000000000000402. PMID: 29718004

Recent clinical studies

Etiology

Congenital Adrenal Hyperplasia.
Fraga NR, Minaeian N, Kim MS
Pediatr Rev 2024 Feb 1;45(2):74-84. doi: 10.1542/pir.2022-005617. PMID: 38296783
Hypoglycaemia in adrenal insufficiency.
Lee SC, Baranowski ES, Sakremath R, Saraff V, Mohamed Z
Front Endocrinol (Lausanne) 2023;14:1198519. Epub 2023 Nov 20 doi: 10.3389/fendo.2023.1198519. PMID: 38053731Free PMC Article
X-linked adrenoleukodystrophy and primary adrenal insufficiency.
Cappa M, Todisco T, Bizzarri C
Front Endocrinol (Lausanne) 2023;14:1309053. Epub 2023 Nov 16 doi: 10.3389/fendo.2023.1309053. PMID: 38034003Free PMC Article
Rare forms of genetic paediatric adrenal insufficiency: Excluding congenital adrenal hyperplasia.
Hasenmajer V, Ferrigno R, Minnetti M, Pellegrini B, Isidori AM, Lenzi A, Salerno M, Cappa M, Chan L, De Martino MC, Savage MO
Rev Endocr Metab Disord 2023 Apr;24(2):345-363. Epub 2023 Feb 10 doi: 10.1007/s11154-023-09784-7. PMID: 36763264Free PMC Article
Major depressive disorder.
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598

Diagnosis

Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Merke DP, Auchus RJ
N Engl J Med 2020 Sep 24;383(13):1248-1261. doi: 10.1056/NEJMra1909786. PMID: 32966723
Pathogenesis and treatment of primary aldosteronism.
Zennaro MC, Boulkroun S, Fernandes-Rosa FL
Nat Rev Endocrinol 2020 Oct;16(10):578-589. Epub 2020 Jul 28 doi: 10.1038/s41574-020-0382-4. PMID: 32724183
The role of microRNAs in the pathophysiology of adrenal tumors.
Hassan N, Zhao JT, Sidhu SB
Mol Cell Endocrinol 2017 Nov 15;456:36-43. Epub 2016 Dec 20 doi: 10.1016/j.mce.2016.12.011. PMID: 28007658
Major depressive disorder.
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598
Adrenal incidentaloma.
Gajraj H, Young AE
Br J Surg 1993 Apr;80(4):422-6. doi: 10.1002/bjs.1800800405. PMID: 8495301

Therapy

Congenital Adrenal Hyperplasia.
Fraga NR, Minaeian N, Kim MS
Pediatr Rev 2024 Feb 1;45(2):74-84. doi: 10.1542/pir.2022-005617. PMID: 38296783
11-Keto-testosterone and other androgens of adrenal origin.
Stárka L, Dušková M, Vítků J
Physiol Res 2020 Sep 30;69(Suppl 2):S187-S192. doi: 10.33549/physiolres.934516. PMID: 33094617Free PMC Article
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Merke DP, Auchus RJ
N Engl J Med 2020 Sep 24;383(13):1248-1261. doi: 10.1056/NEJMra1909786. PMID: 32966723
Major depressive disorder.
Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF
Nat Rev Dis Primers 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598
Androgens and bone.
De Oliveira DH, Fighera TM, Bianchet LC, Kulak CA, Kulak J
Minerva Endocrinol 2012 Dec;37(4):305-14. PMID: 23235187

Prognosis

Pathophysiological interpretation of fetal heart rate tracings in clinical practice.
Jia YJ, Ghi T, Pereira S, Gracia Perez-Bonfils A, Chandraharan E
Am J Obstet Gynecol 2023 Jun;228(6):622-644. doi: 10.1016/j.ajog.2022.05.023. PMID: 37270259
Models of Congenital Adrenal Hyperplasia for Gene Therapies Testing.
Glazova O, Bastrich A, Deviatkin A, Onyanov N, Kaziakhmedova S, Shevkova L, Sakr N, Petrova D, Vorontsova MV, Volchkov P
Int J Mol Sci 2023 Mar 10;24(6) doi: 10.3390/ijms24065365. PMID: 36982440Free PMC Article
Imaging of Adrenal-Related Endocrine Disorders.
Yalniz C, Morani AC, Waguespack SG, Elsayes KM
Radiol Clin North Am 2020 Nov;58(6):1099-1113. Epub 2020 Sep 17 doi: 10.1016/j.rcl.2020.07.010. PMID: 33040851
Fat Quantification in the Abdomen.
Hong CW, Fazeli Dehkordy S, Hooker JC, Hamilton G, Sirlin CB
Top Magn Reson Imaging 2017 Dec;26(6):221-227. doi: 10.1097/RMR.0000000000000141. PMID: 29176468Free PMC Article
Carney complex.
Espiard S, Bertherat J
Front Horm Res 2013;41:50-62. Epub 2013 Mar 19 doi: 10.1159/000345669. PMID: 23652670

Clinical prediction guides

X-linked adrenoleukodystrophy and primary adrenal insufficiency.
Cappa M, Todisco T, Bizzarri C
Front Endocrinol (Lausanne) 2023;14:1309053. Epub 2023 Nov 16 doi: 10.3389/fendo.2023.1309053. PMID: 38034003Free PMC Article
Pathophysiological interpretation of fetal heart rate tracings in clinical practice.
Jia YJ, Ghi T, Pereira S, Gracia Perez-Bonfils A, Chandraharan E
Am J Obstet Gynecol 2023 Jun;228(6):622-644. doi: 10.1016/j.ajog.2022.05.023. PMID: 37270259
Origin and initiation mechanisms of neuroblastoma.
Tsubota S, Kadomatsu K
Cell Tissue Res 2018 May;372(2):211-221. Epub 2018 Feb 14 doi: 10.1007/s00441-018-2796-z. PMID: 29445860
Adrenal myelolipoma: a comprehensive review.
Decmann Á, Perge P, Tóth M, Igaz P
Endocrine 2018 Jan;59(1):7-15. Epub 2017 Nov 21 doi: 10.1007/s12020-017-1473-4. PMID: 29164520
Carney complex.
Espiard S, Bertherat J
Front Horm Res 2013;41:50-62. Epub 2013 Mar 19 doi: 10.1159/000345669. PMID: 23652670

Recent systematic reviews

Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.
Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586Free PMC Article
Ethnic and National Differences in Congenital Adrenal Hyperplasia Incidence: A Systematic Review and Meta-Analysis.
Navarro-Zambrana AN, Sheets LR
Horm Res Paediatr 2023;96(3):249-258. Epub 2022 Aug 16 doi: 10.1159/000526401. PMID: 35973409
Congenital Adrenal Hyperplasia and Brain Health: A Systematic Review of Structural, Functional, and Diffusion Magnetic Resonance Imaging (MRI) Investigations.
Khalifeh N, Omary A, Cotter DL, Kim MS, Geffner ME, Herting MM
J Child Neurol 2022 Aug;37(8-9):758-783. Epub 2022 Jun 23 doi: 10.1177/08830738221100886. PMID: 35746874Free PMC Article
Human parasitic protozoan infection to infertility: a systematic review.
Shiadeh MN, Niyyati M, Fallahi S, Rostami A
Parasitol Res 2016 Feb;115(2):469-77. Epub 2015 Nov 16 doi: 10.1007/s00436-015-4827-y. PMID: 26573517
Exploration and management of adrenal incidentalomas. French Society of Endocrinology Consensus.
Tabarin A, Bardet S, Bertherat J, Dupas B, Chabre O, Hamoir E, Laurent F, Tenenbaum F, Cazalda M, Lefebvre H, Valli N, Rohmer V; French Society of Endocrinology Consensus
Ann Endocrinol (Paris) 2008 Dec;69(6):487-500. Epub 2008 Nov 20 doi: 10.1016/j.ando.2008.09.003. PMID: 19022420

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