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Abnormal serum insulin-like growth factor 1 level

MedGen UID:
892647
•Concept ID:
C4072896
•
Finding
HPO: HP:0030352

Definition

An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal serum insulin-like growth factor 1 level

Professional guidelines

PubMed

The Effects of 5 Years of Growth Hormone Treatment on Growth and Body Composition in Patients with Temple Syndrome.
Juriaans AF, Trueba-Timmermans DJ, Kerkhof GF, Grootjen LN, Walet S, Sas TCJ, Rotteveel J, Zwaveling-Soonawala N, Verrijn Stuart AA, Hokken-Koelega ACS
Horm Res Paediatr 2023;96(5):483-494. Epub 2023 Mar 28 doi: 10.1159/000530420. PMID: 36977395
Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
In patients with controlled acromegaly, indices of glucose homeostasis correlate with IGF-1 levels rather than with type of treatment.
Decock A, Verroken C, Van de Velde F, Vilsbøll T, Holst JJ, T'Sjoen G, Lapauw B
Clin Endocrinol (Oxf) 2021 Jul;95(1):65-73. Epub 2021 Mar 29 doi: 10.1111/cen.14461. PMID: 33715210

Recent clinical studies

Etiology

Growth hormone replacement in adults with cured acromegaly: Efficacy and safety.
Tritos NA
Best Pract Res Clin Endocrinol Metab 2023 Dec;37(6):101790. Epub 2023 Jun 8 doi: 10.1016/j.beem.2023.101790. PMID: 37328323
Correlation of Serum IGF-1 and sFlt-1 Levels with Adverse Pregnancy Outcomes in Patients with Severe Preeclampsia.
Sun Y, Meng C, Yu L
Altern Ther Health Med 2023 Jul;29(5):364-369. PMID: 37171953
Glutamate-Related Antibodies and Peripheral Insulin-Like Growth Factor in Bipolar Disorder and Lithium Prophylaxis.
Ferensztajn-Rochowiak E, Kaczmarek M, Wójcicka M, Kaufman-Szukalska E, Dziuda S, Remlinger-Molenda A, Szeliga-Neymann A, Losy J, Rybakowski JK
Neuropsychobiology 2019;77(1):49-56. Epub 2018 Oct 18 doi: 10.1159/000493740. PMID: 30336492
Insulin-like growth factor (IGF) parameters and tools for efficacy: the IGF-I generation test in children.
Rosenfeld RG, Buckway C, Selva K, Pratt KL, Guevara-Aguirre J
Horm Res 2004;62 Suppl 1:37-43. doi: 10.1159/000080757. PMID: 15761231
Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes.
Dunger DB, Ong KK, Sandhu MS
Horm Res 2003;60 Suppl 3:131-5. doi: 10.1159/000074514. PMID: 14671410

Diagnosis

Growth hormone replacement in adults with cured acromegaly: Efficacy and safety.
Tritos NA
Best Pract Res Clin Endocrinol Metab 2023 Dec;37(6):101790. Epub 2023 Jun 8 doi: 10.1016/j.beem.2023.101790. PMID: 37328323
Correlation of Serum IGF-1 and sFlt-1 Levels with Adverse Pregnancy Outcomes in Patients with Severe Preeclampsia.
Sun Y, Meng C, Yu L
Altern Ther Health Med 2023 Jul;29(5):364-369. PMID: 37171953
Serum IGF-I levels in the diagnosis and monitoring of acromegaly.
Brooke AM, Drake WM
Pituitary 2007;10(2):173-9. doi: 10.1007/s11102-007-0036-8. PMID: 17431794
Insulin-like growth factor (IGF) parameters and tools for efficacy: the IGF-I generation test in children.
Rosenfeld RG, Buckway C, Selva K, Pratt KL, Guevara-Aguirre J
Horm Res 2004;62 Suppl 1:37-43. doi: 10.1159/000080757. PMID: 15761231
Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes.
Dunger DB, Ong KK, Sandhu MS
Horm Res 2003;60 Suppl 3:131-5. doi: 10.1159/000074514. PMID: 14671410

Therapy

Growth hormone replacement in adults with cured acromegaly: Efficacy and safety.
Tritos NA
Best Pract Res Clin Endocrinol Metab 2023 Dec;37(6):101790. Epub 2023 Jun 8 doi: 10.1016/j.beem.2023.101790. PMID: 37328323
Growth hormone (GH) deficiency and GH replacement therapy in patients previously treated for Cushing's disease.
Boguszewski CL
Pituitary 2022 Oct;25(5):760-763. Epub 2022 May 13 doi: 10.1007/s11102-022-01225-z. PMID: 35552989
Prader-Willi syndrome and growth hormone deficiency.
Aycan Z, Baş VN
J Clin Res Pediatr Endocrinol 2014;6(2):62-7. doi: 10.4274/Jcrpe.1228. PMID: 24932597Free PMC Article
Hormone therapy in acne.
Lakshmi C
Indian J Dermatol Venereol Leprol 2013 May-Jun;79(3):322-37. doi: 10.4103/0378-6323.110765. PMID: 23619437
Growth hormone receptor antagonists.
Kohn DT, Kopchick JJ
Minerva Endocrinol 2002 Dec;27(4):287-98. PMID: 12511851

Prognosis

Correlation of Serum IGF-1 and sFlt-1 Levels with Adverse Pregnancy Outcomes in Patients with Severe Preeclampsia.
Sun Y, Meng C, Yu L
Altern Ther Health Med 2023 Jul;29(5):364-369. PMID: 37171953
The role of insulin-like growth factor I components in the regulation of vitamin D.
Gómez JM
Curr Pharm Biotechnol 2006 Apr;7(2):125-32. doi: 10.2174/138920106776597621. PMID: 16724947
Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases.
Denko CW, Malemud CJ
Semin Arthritis Rheum 2005 Aug;35(1):24-34. doi: 10.1016/j.semarthrit.2005.03.001. PMID: 16084221
Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes.
Dunger DB, Ong KK, Sandhu MS
Horm Res 2003;60 Suppl 3:131-5. doi: 10.1159/000074514. PMID: 14671410
Growth in Crohn's disease.
Savage MO, Beattie RM, Camacho-Hübner C, Walker-Smith JA, Sanderson IR
Acta Paediatr Suppl 1999 Feb;88(428):89-92. doi: 10.1111/j.1651-2227.1999.tb14360.x. PMID: 10102061

Clinical prediction guides

Correlation of Serum IGF-1 and sFlt-1 Levels with Adverse Pregnancy Outcomes in Patients with Severe Preeclampsia.
Sun Y, Meng C, Yu L
Altern Ther Health Med 2023 Jul;29(5):364-369. PMID: 37171953
Serum Insulin-like growth factor-1 levels of healthy adults in southern China.
Liao ZH, Yin QQ, Wan JX, He W, Ji W, Zhang LY, Li YB
Endocr J 2016 Dec 30;63(12):1081-1086. Epub 2016 Aug 26 doi: 10.1507/endocrj.EJ16-0144. PMID: 27569688
Growth hormone/insulin-like growth factor-I axis in obstructive sleep apnea syndrome: an update.
Lanfranco F, Motta G, Minetto MA, Ghigo E, Maccario M
J Endocrinol Invest 2010 Mar;33(3):192-6. doi: 10.1007/BF03346580. PMID: 20418654
The role of insulin-like growth factor I components in the regulation of vitamin D.
Gómez JM
Curr Pharm Biotechnol 2006 Apr;7(2):125-32. doi: 10.2174/138920106776597621. PMID: 16724947
Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes.
Dunger DB, Ong KK, Sandhu MS
Horm Res 2003;60 Suppl 3:131-5. doi: 10.1159/000074514. PMID: 14671410

Recent systematic reviews

ORAL VERSUS TRANSDERMAL ESTROGEN IN TURNER SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Zaiem F, Alahdab F, Al Nofal A, Murad MH, Javed A
Endocr Pract 2017 Apr 2;23(4):408-421. Epub 2017 Jan 17 doi: 10.4158/EP161622.OR. PMID: 28095041

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