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Reduced muscle carnitine level

MedGen UID:
892651
Concept ID:
C4072902
Finding
HPO: HP:0030362

Definition

A reduction in the level of carnitine in muscle tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced muscle carnitine level

Conditions with this feature

Professional guidelines

PubMed

Garrett TJ, Puchowicz MA, Park EA, Dong Q, Farage G, Childress R, Guingab J, Simpson CL, Sen S, Brogdon EC, Buchanan LM, Raghow R, Elam MB
PLoS One 2023;18(12):e0294498. Epub 2023 Dec 15 doi: 10.1371/journal.pone.0294498. PMID: 38100464Free PMC Article
Dinicolantonio JJ, Niazi AK, McCarty MF, Lavie CJ, Liberopoulos E, O'Keefe JH
Rev Cardiovasc Med 2014;15(1):52-62. doi: 10.3909/ricm0710. PMID: 24762466
Tousoulis D, Bakogiannis C, Briasoulis A, Papageorgiou N, Androulakis E, Siasos G, Latsios G, Kampoli AM, Charakida M, Toutouzas K, Stefanadis C
Curr Pharm Des 2013;19(9):1587-92. PMID: 23016716

Recent clinical studies

Etiology

Stefan M, Sharp M, Gheith R, Lowery R, Ottinger C, Wilson J, Durkee S, Bellamine A
Nutrients 2021 Sep 28;13(10) doi: 10.3390/nu13103432. PMID: 34684429Free PMC Article
Hanai T, Shiraki M, Imai K, Suetugu A, Takai K, Shimizu M
Nutrients 2020 Jun 29;12(7) doi: 10.3390/nu12071915. PMID: 32610446Free PMC Article
Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K
J Am Coll Nutr 2020 Jul;39(5):457-468. Epub 2020 Mar 10 doi: 10.1080/07315724.2019.1661804. PMID: 32154768
DiNicolantonio JJ
Expert Rev Cardiovasc Ther 2012 Oct;10(10):1329-33. doi: 10.1586/erc.12.92. PMID: 23190071
Calvani M, Reda E, Arrigoni-Martelli E
Basic Res Cardiol 2000 Apr;95(2):75-83. doi: 10.1007/s003950050167. PMID: 10826498

Diagnosis

Garrett TJ, Puchowicz MA, Park EA, Dong Q, Farage G, Childress R, Guingab J, Simpson CL, Sen S, Brogdon EC, Buchanan LM, Raghow R, Elam MB
PLoS One 2023;18(12):e0294498. Epub 2023 Dec 15 doi: 10.1371/journal.pone.0294498. PMID: 38100464Free PMC Article
Vasiljevski ER, Burns J, Bray P, Donlevy G, Mudge AJ, Jones KJ, Summers MA, Biggin A, Munns CF, McKay MJ, Baldwin JN, Little DG, Schindeler A
Am J Med Genet A 2021 Oct;185(10):2976-2985. Epub 2021 Jun 21 doi: 10.1002/ajmg.a.62392. PMID: 34155781Free PMC Article
Manco M, Calvani M, Mingrone G
Diabetes Obes Metab 2004 Nov;6(6):402-13. doi: 10.1111/j.1462-8902.2004.00356.x. PMID: 15479216
Scaglia F, Longo N
Semin Perinatol 1999 Apr;23(2):152-61. doi: 10.1016/s0146-0005(99)80047-0. PMID: 10331466
Taroni F, Verderio E, Dworzak F, Willems PJ, Cavadini P, DiDonato S
Nat Genet 1993 Jul;4(3):314-20. doi: 10.1038/ng0793-314. PMID: 8358442

Therapy

Lu Z, Wang L, Huo Z, Li N, Tong N, Chong F, Liu J, Zhang Y, Xu H
J Cachexia Sarcopenia Muscle 2024 Oct;15(5):1953-1964. Epub 2024 Aug 2 doi: 10.1002/jcsm.13544. PMID: 39091264Free PMC Article
Stefan M, Sharp M, Gheith R, Lowery R, Ottinger C, Wilson J, Durkee S, Bellamine A
Nutrients 2021 Sep 28;13(10) doi: 10.3390/nu13103432. PMID: 34684429Free PMC Article
Mollazadeh H, Tavana E, Fanni G, Bo S, Banach M, Pirro M, von Haehling S, Jamialahmadi T, Sahebkar A
J Cachexia Sarcopenia Muscle 2021 Apr;12(2):237-251. Epub 2021 Jan 29 doi: 10.1002/jcsm.12654. PMID: 33511728Free PMC Article
Hanai T, Shiraki M, Imai K, Suetugu A, Takai K, Shimizu M
Nutrients 2020 Jun 29;12(7) doi: 10.3390/nu12071915. PMID: 32610446Free PMC Article
DiNicolantonio JJ
Expert Rev Cardiovasc Ther 2012 Oct;10(10):1329-33. doi: 10.1586/erc.12.92. PMID: 23190071

Prognosis

Bekfani T, Bekhite Elsaied M, Derlien S, Nisser J, Westermann M, Nietzsche S, Hamadanchi A, Fröb E, Westphal J, Haase D, Kretzschmar T, Schlattmann P, Smolenski UC, Lichtenauer M, Wernly B, Jirak P, Lehmann G, Möbius-Winkler S, Schulze PC
Circ Heart Fail 2020 Dec;13(12):e007198. Epub 2020 Dec 11 doi: 10.1161/CIRCHEARTFAILURE.120.007198. PMID: 33302709
Tousoulis D, Bakogiannis C, Briasoulis A, Papageorgiou N, Androulakis E, Siasos G, Latsios G, Kampoli AM, Charakida M, Toutouzas K, Stefanadis C
Curr Pharm Des 2013;19(9):1587-92. PMID: 23016716
Constantin-Teodosiu D, Young S, Wellock F, Short AH, Burden RP, Morgan AG, Greenhaff PL
Nephrol Dial Transplant 2002 Oct;17(10):1808-13. doi: 10.1093/ndt/17.10.1808. PMID: 12270989
Witte KK, Clark AL, Cleland JG
J Am Coll Cardiol 2001 Jun 1;37(7):1765-74. doi: 10.1016/s0735-1097(01)01227-x. PMID: 11401109
Smelt AH, Poorthuis BJ, Onkenhout W, Scholte HR, Andresen BS, van Duinen SG, Gregersen N, Wintzen AR
Ann Neurol 1998 Apr;43(4):540-4. doi: 10.1002/ana.410430422. PMID: 9546340

Clinical prediction guides

Huang TS, Wu T, Fu XL, Ren HL, He XD, Zheng DH, Tan J, Shen CH, Xiong SJ, Qian J, Zou Y, Wan JH, Ji YJ, Liu MY, Wu YD, Li XH, Li H, Zheng K, Yang XF, Wang H, Ren M, Cai WB
Redox Biol 2024 Dec;78:103412. Epub 2024 Oct 28 doi: 10.1016/j.redox.2024.103412. PMID: 39476450Free PMC Article
Lu Z, Wang L, Huo Z, Li N, Tong N, Chong F, Liu J, Zhang Y, Xu H
J Cachexia Sarcopenia Muscle 2024 Oct;15(5):1953-1964. Epub 2024 Aug 2 doi: 10.1002/jcsm.13544. PMID: 39091264Free PMC Article
Stefan M, Sharp M, Gheith R, Lowery R, Ottinger C, Wilson J, Durkee S, Bellamine A
Nutrients 2021 Sep 28;13(10) doi: 10.3390/nu13103432. PMID: 34684429Free PMC Article
Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K
J Am Coll Nutr 2020 Jul;39(5):457-468. Epub 2020 Mar 10 doi: 10.1080/07315724.2019.1661804. PMID: 32154768
Calvani M, Reda E, Arrigoni-Martelli E
Basic Res Cardiol 2000 Apr;95(2):75-83. doi: 10.1007/s003950050167. PMID: 10826498

Recent systematic reviews

Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K
J Am Coll Nutr 2020 Jul;39(5):457-468. Epub 2020 Mar 10 doi: 10.1080/07315724.2019.1661804. PMID: 32154768

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