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Broad ulna

MedGen UID:
892713
Concept ID:
C4025460
Anatomical Abnormality
Synonym: Wide ulna
 
HPO: HP:0003993

Definition

Increased width of the ulna. [from HPO]

Conditions with this feature

Langer mesomelic dysplasia syndrome
MedGen UID:
96585
Concept ID:
C0432230
Disease or Syndrome
Langer mesomelic dysplasia (LMD) is characterized by severe limb aplasia or severe hypoplasia of the ulna and fibula, and a thickened and curved radius and tibia. These changes can result in displacement deformities of the hands and feet. Hypoplasia of the mandible is also observed (Langer, 1967). See also Leri-Weill dyschondrosteosis (127300), a less severe phenotype that results from heterozygous defect in the SHOX or SHOXY genes.

Recent clinical studies

Etiology

Lanzerath F, Knifka J, Leschinger T, Ott N, Kahmann S, Hackl M, Müller LP, Wegmann K
Arch Orthop Trauma Surg 2023 Jul;143(7):4229-4237. Epub 2022 Dec 13 doi: 10.1007/s00402-022-04677-x. PMID: 36512058Free PMC Article
Dean C, Davis I, Hunt H
Clin Radiol 2022 Jun;77(6):451-457. Epub 2022 Mar 27 doi: 10.1016/j.crad.2022.02.008. PMID: 35354535
Williams FL, Cunningham DL, Amaral LQ
Homo 2015 Dec;66(6):477-91. Epub 2015 Jul 17 doi: 10.1016/j.jchb.2015.07.001. PMID: 26256651
Samuels JX, Meachen JA, Sakai SA
J Morphol 2013 Feb;274(2):121-46. Epub 2012 Sep 13 doi: 10.1002/jmor.20077. PMID: 22972188
Rehman S, Sokunbi G
Hand Clin 2010 Aug;26(3):391-401, vii. Epub 2010 Jun 11 doi: 10.1016/j.hcl.2010.04.002. PMID: 20670804

Diagnosis

Wall E, Forsyth J, Kinning E, Marton T
Prenat Diagn 2023 Jun;43(6):717-720. Epub 2023 May 17 doi: 10.1002/pd.6353. PMID: 37160698
Cerezal L, Llopis E, Canga A, Piñal FD
Semin Musculoskelet Radiol 2021 Apr;25(2):329-345. Epub 2021 Aug 9 doi: 10.1055/s-0041-1731331. PMID: 34374067
McDonough CM, Colla CH, Carmichael D, Tosteson ANA, Tosteson TD, Bell JE, Cantu RV, Lurie JD, Bynum JPW
Phys Ther 2017 Mar 1;97(3):280-289. doi: 10.1093/ptj/pzx009. PMID: 28340130Free PMC Article
Thompson EM, Hill S, Leonard JV, Pembrey ME
J Med Genet 1987 Apr;24(4):232-4. doi: 10.1136/jmg.24.4.232. PMID: 3585940Free PMC Article
Newman DE, Dunbar JC
J Can Assoc Radiol 1975 Jun;26(2):95-103. PMID: 1158967

Therapy

Rehman S, Sokunbi G
Hand Clin 2010 Aug;26(3):391-401, vii. Epub 2010 Jun 11 doi: 10.1016/j.hcl.2010.04.002. PMID: 20670804
Valdez RM, Barbero PM, Liascovich RC, De Rosa LF, Aguirre MA, Alba LG
Reprod Toxicol 2007 Feb;23(2):253-5. Epub 2006 Nov 28 doi: 10.1016/j.reprotox.2006.11.007. PMID: 17218082
Welkerling H, Geissdörfer W, Aigner T, Forst R
J Clin Microbiol 2006 Oct;44(10):3835-7. doi: 10.1128/JCM.00793-06. PMID: 17021123Free PMC Article
McGinley JC, Hopgood BC, Gaughan JP, Sadeghipour K, Kozin SH
J Bone Joint Surg Am 2003 Dec;85(12):2403-9. PMID: 14668511

Prognosis

McDonough CM, Colla CH, Carmichael D, Tosteson ANA, Tosteson TD, Bell JE, Cantu RV, Lurie JD, Bynum JPW
Phys Ther 2017 Mar 1;97(3):280-289. doi: 10.1093/ptj/pzx009. PMID: 28340130Free PMC Article
Pannu GS, Herman M
Orthop Clin North Am 2015 Apr;46(2):235-48. Epub 2014 Dec 17 doi: 10.1016/j.ocl.2014.11.003. PMID: 25771318
Reinsmith LE, Garcia-Elias M, Gilula LA
Radiology 2013 Jun;267(3):680-9. doi: 10.1148/radiol.13111682. PMID: 23704291
Pfaeffle HJ, Fischer KJ, Srinivasa A, Manson T, Woo SL, Tomaino M
J Biomech Eng 2006 Oct;128(5):725-32. doi: 10.1115/1.2241730. PMID: 16995759
Watson HK, Beebe RD, Cruz NI
J Hand Surg Am 1984 Jul;9(4):541-7. doi: 10.1016/s0363-5023(84)80107-0. PMID: 6747239

Clinical prediction guides

Shin WJ, Kim JP, Yang HM, Lee EY, Go JH, Heo K
J Hand Surg Am 2017 Jul;42(7):517-524. Epub 2017 Apr 25 doi: 10.1016/j.jhsa.2017.03.031. PMID: 28450099
McDonough CM, Colla CH, Carmichael D, Tosteson ANA, Tosteson TD, Bell JE, Cantu RV, Lurie JD, Bynum JPW
Phys Ther 2017 Mar 1;97(3):280-289. doi: 10.1093/ptj/pzx009. PMID: 28340130Free PMC Article
Williams FL, Cunningham DL, Amaral LQ
Homo 2015 Dec;66(6):477-91. Epub 2015 Jul 17 doi: 10.1016/j.jchb.2015.07.001. PMID: 26256651
Reinsmith LE, Garcia-Elias M, Gilula LA
Radiology 2013 Jun;267(3):680-9. doi: 10.1148/radiol.13111682. PMID: 23704291
Pfaeffle HJ, Fischer KJ, Srinivasa A, Manson T, Woo SL, Tomaino M
J Biomech Eng 2006 Oct;128(5):725-32. doi: 10.1115/1.2241730. PMID: 16995759

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