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Decreased proportion of immature B cells

MedGen UID:
892741
•Concept ID:
C4072917
•
Finding
Synonym: Decreased immature B cell count
 
HPO: HP:0030378

Definition

A reduction in normal proportion of immature B cells (CD19+/ CD21low)in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased proportion of immature B cells

Recent clinical studies

Etiology

ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604Free PMC Article
Discovery of cellular and genetic signatures of immune tolerance in kidney transplant recipients through single cell RNA sequencing analysis.
Bae H, Lee H, Ko EJ, Kim CD, Lee SH, Yang CW, Oh EJ, Chung BH
HLA 2023 Sep;102(3):316-330. Epub 2023 Apr 10 doi: 10.1111/tan.15061. PMID: 37038287
Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans.
Castiello MC, Bosticardo M, Pala F, Catucci M, Chamberlain N, van Zelm MC, Driessen GJ, Pac M, Bernatowska E, Scaramuzza S, Aiuti A, Sauer AV, Traggiai E, Meffre E, Villa A, van der Burg M
J Autoimmun 2014 May;50(100):42-50. Epub 2013 Dec 25 doi: 10.1016/j.jaut.2013.10.006. PMID: 24369837Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis.
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article
Identification of low-dose responsive metabolites in X-irradiated human B lymphoblastoid cells and fibroblasts.
Tsuyama N, Mizuno H, Katafuchi A, Abe Y, Kurosu Y, Yoshida M, Kamiya K, Sakai A
J Radiat Res 2015 Jan;56(1):46-58. Epub 2014 Sep 16 doi: 10.1093/jrr/rru078. PMID: 25227127Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Therapy

Early Increase of Circulating Transitional B Cells and Autoantibodies to Joint-Related Proteins in Patients With Metastatic Melanoma Developing Checkpoint Inhibitor-Induced Inflammatory Arthritis.
Gatto M, Bjursten S, Jonsson CA, Agelii ML, Jonell C, McGrath S, Lönnblom E, Sareila O, Holmdahl R, Rudin A, Levin M, Gjertsson I
Arthritis Rheumatol 2023 May;75(5):856-863. Epub 2023 Mar 14 doi: 10.1002/art.42406. PMID: 36409578
Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
Decrease of immature B cell and interleukin-10 during early-post-transplant period in renal transplant recipients under tacrolimus based immunosuppression.
Chung BH, Kim KW, Yu JH, Kim BM, Choi BS, Park CW, Kim YS, Cho ML, Yang CW
Transpl Immunol 2014 May;30(4):159-67. Epub 2014 Apr 5 doi: 10.1016/j.trim.2014.03.003. PMID: 24709525
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Prognosis

Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
Low-Grade Myelodysplastic Syndromes with Preserved CD34+ B-Cell Precursors (CD34+ Hematogones).
Chen Z, Ok CY, Wang W, Goswami M, Tang G, Routbort M, Jorgensen JL, Medeiros LJ, Wang SA
Cytometry B Clin Cytom 2020 Jan;98(1):36-42. Epub 2019 Jun 18 doi: 10.1002/cyto.b.21830. PMID: 31211490
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
B-cell maturation defects in common variable immunodeficiency and association with clinical features.
Berglund LJ, Wong SW, Fulcher DA
Pathology 2008 Apr;40(3):288-94. doi: 10.1080/00313020801911470. PMID: 18428049

Clinical prediction guides

ARID5B regulates fatty acid metabolism and proliferation at the Pre-B cell stage during B cell development.
Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604Free PMC Article
Features of BAFF and APRIL receptors on circulating B cells in antineutrophil cytoplasmic antibody-associated vasculitis.
Shimojima Y, Kishida D, Ichikawa T, Takamatsu R, Nomura S, Sekijima Y
Clin Exp Immunol 2023 Jul 5;213(1):125-137. doi: 10.1093/cei/uxad024. PMID: 36794867Free PMC Article
Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.
Mimpen M, Damoiseaux J, van Doorn W, Rolf L, Muris AH, Hupperts R, van Luijn MM, Gerlach O, Smolders J
J Neuroimmunol 2021 Sep 15;358:577664. Epub 2021 Jul 14 doi: 10.1016/j.jneuroim.2021.577664. PMID: 34280843
Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis.
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article
Altered distribution of peripheral blood memory B cells in humans chronically infected with Trypanosoma cruzi.
Fernández ER, Olivera GC, Quebrada Palacio LP, González MN, Hernandez-Vasquez Y, Sirena NM, Morán ML, Ledesma Patiño OS, Postan M
PLoS One 2014;9(8):e104951. Epub 2014 Aug 11 doi: 10.1371/journal.pone.0104951. PMID: 25111833Free PMC Article

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