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Abnormal inner ear epithelium morphology

MedGen UID:
892772
•Concept ID:
C4073211
•
Anatomical Abnormality
HPO: HP:3000002

Definition

Any structural anomaly of an inner ear epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal inner ear epithelium morphology

Professional guidelines

PubMed

Absence of phenotype-genotype correlation of patients expressing mutations in the SLC4A11 gene.
Mehta JS, Hemadevi B, Vithana EN, Arunkumar J, Srinivasan M, Prajna V, Tan DT, Aung T, Sundaresan P
Cornea 2010 Mar;29(3):302-6. doi: 10.1097/ICO.0b013e3181ae9038. PMID: 20118786

Recent clinical studies

Etiology

New strategies and methods for reconstruction of the outer ear canal (OEC).
Zou Y, Zhang M, Duan X, Wang M, Zhang H, Jin Y, Wang Q, Lin J
Acta Otolaryngol 2023 Nov;143(sup1):S39-S44. Epub 2024 Feb 13 doi: 10.1080/00016489.2023.2275610. PMID: 38063357
Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Peripheral vestibular pathology in Mondini dysplasia.
Kaya S, Hızlı Ö, Kaya FK, Monsanto RD, Paparella MM, Cureoglu S
Laryngoscope 2017 Jan;127(1):206-209. Epub 2016 Apr 14 doi: 10.1002/lary.25995. PMID: 27075694
Do you know this syndrome?
Enei ML, Cassettari A, Córdova S, Torres O, Paschoal F
An Bras Dermatol 2011 Jul-Aug;86(4):819-21. doi: 10.1590/s0365-05962011000400037. PMID: 21987161
Polypoidal choroidal vasculopathy.
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438

Diagnosis

MULTIMODAL IMAGING OF MULTIFOCAL CHOROIDITIS WITH ADAPTIVE OPTICS OPHTHALMOSCOPY.
Amarasekera S, Williams AM, Freund KB, Rossi EA, Dansingani KK
Retin Cases Brief Rep 2022 Nov 1;16(6):747-753. doi: 10.1097/ICB.0000000000001134. PMID: 36288621Free PMC Article
Clinicopathological features of low-grade malignant endolymphatic sac tumors.
Wang HQ, Jie L, Shi HY
Pathol Res Pract 2018 Mar;214(3):431-435. Epub 2017 Dec 14 doi: 10.1016/j.prp.2017.12.007. PMID: 29482989
Endolymphatic sac tumors.
Wick CC, Manzoor NF, Semaan MT, Megerian CA
Otolaryngol Clin North Am 2015 Apr;48(2):317-30. Epub 2015 Jan 31 doi: 10.1016/j.otc.2014.12.006. PMID: 25650230
Do you know this syndrome?
Enei ML, Cassettari A, Córdova S, Torres O, Paschoal F
An Bras Dermatol 2011 Jul-Aug;86(4):819-21. doi: 10.1590/s0365-05962011000400037. PMID: 21987161
Polypoidal choroidal vasculopathy.
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438

Therapy

MULTIMODAL IMAGING OF MULTIFOCAL CHOROIDITIS WITH ADAPTIVE OPTICS OPHTHALMOSCOPY.
Amarasekera S, Williams AM, Freund KB, Rossi EA, Dansingani KK
Retin Cases Brief Rep 2022 Nov 1;16(6):747-753. doi: 10.1097/ICB.0000000000001134. PMID: 36288621Free PMC Article
Acute Solar Retinopathy Imaged With Adaptive Optics, Optical Coherence Tomography Angiography, and En Face Optical Coherence Tomography.
Wu CY, Jansen ME, Andrade J, Chui TYP, Do AT, Rosen RB, Deobhakta A
JAMA Ophthalmol 2018 Jan 1;136(1):82-85. doi: 10.1001/jamaophthalmol.2017.5517. PMID: 29222532Free PMC Article
Computational model of vectorial potassium transport by cochlear marginal cells and vestibular dark cells.
Quraishi IH, Raphael RM
Am J Physiol Cell Physiol 2007 Jan;292(1):C591-602. Epub 2006 Sep 27 doi: 10.1152/ajpcell.00560.2005. PMID: 17005601
Tympanic membrane changes in central tympanic membrane perforations.
Oktay MF, Cureoglu S, Schachern PA, Paparella MM, Kariya S, Fukushima H
Am J Otolaryngol 2005 Nov-Dec;26(6):393-7. doi: 10.1016/j.amjoto.2005.05.005. PMID: 16275408
Inner ear and renal diseases.
Arnold W
Ann Otol Rhinol Laryngol Suppl 1984 Jul-Aug;112:119-24. doi: 10.1177/00034894840930s420. PMID: 6431869

Prognosis

Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Clinicopathological features of low-grade malignant endolymphatic sac tumors.
Wang HQ, Jie L, Shi HY
Pathol Res Pract 2018 Mar;214(3):431-435. Epub 2017 Dec 14 doi: 10.1016/j.prp.2017.12.007. PMID: 29482989
Polypoidal choroidal vasculopathy.
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438
Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9.
Robertson NG, Resendes BL, Lin JS, Lee C, Aster JC, Adams JC, Morton CC
Hum Mol Genet 2001 Oct 15;10(22):2493-500. doi: 10.1093/hmg/10.22.2493. PMID: 11709536
Keratitis, ichthyosis, and deafness (KID syndrome): review of the literature and proposal of a new terminology.
Caceres-Rios H, Tamayo-Sanchez L, Duran-Mckinster C, de la Luz Orozco M, Ruiz-Maldonado R
Pediatr Dermatol 1996 Mar-Apr;13(2):105-13. doi: 10.1111/j.1525-1470.1996.tb01414.x. PMID: 9122065

Clinical prediction guides

Genetic variants and altered expression of SERPINF1 confer disease susceptibility in patients with otosclerosis.
Singh N, Hansdah K, Bouzid A, Ray CS, Desai A, Panda KC, Choudhury JC, Tekari A, Masmoudi S, Ramchander PV
J Hum Genet 2023 Sep;68(9):635-642. Epub 2023 May 18 doi: 10.1038/s10038-023-01158-w. PMID: 37308566
Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study.
Bannai D, Lizano P, Kasetty M, Lutz O, Zeng V, Sarvode S, Kim LA, Hill S, Tamminga C, Clementz B, Gershon E, Pearlson G, Miller JB, Keshavan M
Psychiatry Res Neuroimaging 2020 May 30;299:111061. Epub 2020 Feb 29 doi: 10.1016/j.pscychresns.2020.111061. PMID: 32145500Free PMC Article
Temporal Bone Histopathology in Cockayne Syndrome.
Handzel O, Nadol JB Jr
Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050Free PMC Article
Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9.
Robertson NG, Resendes BL, Lin JS, Lee C, Aster JC, Adams JC, Morton CC
Hum Mol Genet 2001 Oct 15;10(22):2493-500. doi: 10.1093/hmg/10.22.2493. PMID: 11709536
Ocular manifestations of pigmentary disorders.
Park S, Albert DM, Bolognia JL
Dermatol Clin 1992 Jul;10(3):609-22. PMID: 1617818

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