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Abnormal level of platelet-activating factor

MedGen UID:
892822
•Concept ID:
C4073142
•
Finding
Synonym: Abnormal level of PAF
 
HPO: HP:0040177

Professional guidelines

PubMed

Increasing numbers of CD19 + CD24(high)CD38(high) regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia.
Hayashi T, Nakamae H, Takeda S, Nakashima Y, Koh H, Nishimoto M, Okamura H, Nanno S, Makuuchi Y, Kuno M, Nakamae M, Hirose A, Hino M
Int J Hematol 2021 Nov;114(5):580-590. Epub 2021 Jul 26 doi: 10.1007/s12185-021-03192-w. PMID: 34309815
Effects of apoC1 genotypes on the hormonal levels, metabolic profile and PAF-AH activity in Chinese women with polycystic ovary syndrome.
Zhang R, Liu Q, Liu H, Bai H, Zhang Y, Guan L, Fan P
Lipids Health Dis 2018 Apr 10;17(1):77. doi: 10.1186/s12944-018-0725-5. PMID: 29636060Free PMC Article
Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica.
Zhang H, Gu J
Chin J Integr Med 2007 Dec;13(4):312-6. doi: 10.1007/s11655-007-0312-5. PMID: 18180899

Recent clinical studies

Etiology

The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factors.
Xiang M, Wu X, Jing H, Liu L, Wang C, Wang Y, Novakovic VA, Shi J
Front Immunol 2022;13:955654. Epub 2022 Sep 28 doi: 10.3389/fimmu.2022.955654. PMID: 36248790Free PMC Article
Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease.
Yi L, Zhang J, Zhong J, Zheng Y
J Interferon Cytokine Res 2020 Mar;40(3):159-167. Epub 2019 Dec 16 doi: 10.1089/jir.2019.0141. PMID: 31841639
Increased endothelial activation in α-thalassemia disease.
Sirivadhanakul P, Chuansumrit A, Songdej D, Kadegasem P, Wongwerawattanakoon P, Sirachainan N
Ann Hematol 2019 Jul;98(7):1593-1602. Epub 2019 Apr 5 doi: 10.1007/s00277-019-03672-4. PMID: 30953084
Cytoskeleton in action: lissencephaly, a neuronal migration disorder.
Moon HM, Wynshaw-Boris A
Wiley Interdiscip Rev Dev Biol 2013 Mar-Apr;2(2):229-45. doi: 10.1002/wdev.67. PMID: 23495356Free PMC Article
Juvenile rheumatoid arthritis.
Gallagher KT, Bernstein B
Curr Opin Rheumatol 1999 Sep;11(5):372-6. doi: 10.1097/00002281-199909000-00008. PMID: 10503657

Diagnosis

GP5 regulates epithelial-mesenchymal transition in breast cancer via the PI3K/AKT signaling pathway.
Xiang K, Yanshan H, Chunmei Z, Minmin G, Yan W, Xiaojia Y
Exp Biol Med (Maywood) 2022 Sep;247(17):1501-1517. Epub 2022 Jul 26 doi: 10.1177/15353702221110642. PMID: 35880886Free PMC Article
Penttinen syndrome-associated PDGFRB Val665Ala variant causes aberrant constitutive STAT1 signalling.
Nédélec A, Guérit EM, Dachy G, Lenglez S, Wong LS, Arts FA, Demoulin JB
J Cell Mol Med 2022 Jul;26(14):3902-3912. Epub 2022 Jun 10 doi: 10.1111/jcmm.17427. PMID: 35689379Free PMC Article
Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease.
Yi L, Zhang J, Zhong J, Zheng Y
J Interferon Cytokine Res 2020 Mar;40(3):159-167. Epub 2019 Dec 16 doi: 10.1089/jir.2019.0141. PMID: 31841639
Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay.
Warkentin TE, Arnold DM, Kelton JG, Sheppard JI, Smith JW, Nazy I
Chest 2018 Jun;153(6):1396-1404. Epub 2018 Jan 8 doi: 10.1016/j.chest.2018.01.001. PMID: 29325985
Juvenile rheumatoid arthritis.
Gallagher KT, Bernstein B
Curr Opin Rheumatol 1999 Sep;11(5):372-6. doi: 10.1097/00002281-199909000-00008. PMID: 10503657

Therapy

Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease.
Yi L, Zhang J, Zhong J, Zheng Y
J Interferon Cytokine Res 2020 Mar;40(3):159-167. Epub 2019 Dec 16 doi: 10.1089/jir.2019.0141. PMID: 31841639
Increased endothelial activation in α-thalassemia disease.
Sirivadhanakul P, Chuansumrit A, Songdej D, Kadegasem P, Wongwerawattanakoon P, Sirachainan N
Ann Hematol 2019 Jul;98(7):1593-1602. Epub 2019 Apr 5 doi: 10.1007/s00277-019-03672-4. PMID: 30953084
Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica.
Zhang H, Gu J
Chin J Integr Med 2007 Dec;13(4):312-6. doi: 10.1007/s11655-007-0312-5. PMID: 18180899
Effect of hypolipidemic drugs on lipoprotein-associated platelet activating factor acetylhydrolase. Implication for atherosclerosis.
Eisaf M, Tselepis AD
Biochem Pharmacol 2003 Dec 1;66(11):2069-73. doi: 10.1016/s0006-2952(03)00559-8. PMID: 14609731
Juvenile rheumatoid arthritis.
Gallagher KT, Bernstein B
Curr Opin Rheumatol 1999 Sep;11(5):372-6. doi: 10.1097/00002281-199909000-00008. PMID: 10503657

Prognosis

Differential expression of serum TM, PAF, and CD62P in patients with autologous arteriovenous fistula and the correlation with vascular access function.
Jiang Y, Liu Z, Liu L, Xiong Z, Chen Y, Zhang S, Su C
Immun Inflamm Dis 2024 Mar;12(3):e1227. doi: 10.1002/iid3.1227. PMID: 38533915Free PMC Article
Increasing numbers of CD19 + CD24(high)CD38(high) regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia.
Hayashi T, Nakamae H, Takeda S, Nakashima Y, Koh H, Nishimoto M, Okamura H, Nanno S, Makuuchi Y, Kuno M, Nakamae M, Hirose A, Hino M
Int J Hematol 2021 Nov;114(5):580-590. Epub 2021 Jul 26 doi: 10.1007/s12185-021-03192-w. PMID: 34309815
Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease.
Yi L, Zhang J, Zhong J, Zheng Y
J Interferon Cytokine Res 2020 Mar;40(3):159-167. Epub 2019 Dec 16 doi: 10.1089/jir.2019.0141. PMID: 31841639
Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay.
Warkentin TE, Arnold DM, Kelton JG, Sheppard JI, Smith JW, Nazy I
Chest 2018 Jun;153(6):1396-1404. Epub 2018 Jan 8 doi: 10.1016/j.chest.2018.01.001. PMID: 29325985
Activity and distribution of plasma platelet-activating factor acetylhydrolase in women with gestational diabetes mellitus and their neonates.
Gao Q, He GL, Zhang L, Bai H, Liu XH, Fan P
Diabetes Metab Res Rev 2016 Sep;32(6):634-42. Epub 2016 Mar 7 doi: 10.1002/dmrr.2782. PMID: 26789131

Clinical prediction guides

The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factors.
Xiang M, Wu X, Jing H, Liu L, Wang C, Wang Y, Novakovic VA, Shi J
Front Immunol 2022;13:955654. Epub 2022 Sep 28 doi: 10.3389/fimmu.2022.955654. PMID: 36248790Free PMC Article
Penttinen syndrome-associated PDGFRB Val665Ala variant causes aberrant constitutive STAT1 signalling.
Nédélec A, Guérit EM, Dachy G, Lenglez S, Wong LS, Arts FA, Demoulin JB
J Cell Mol Med 2022 Jul;26(14):3902-3912. Epub 2022 Jun 10 doi: 10.1111/jcmm.17427. PMID: 35689379Free PMC Article
Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease.
Yi L, Zhang J, Zhong J, Zheng Y
J Interferon Cytokine Res 2020 Mar;40(3):159-167. Epub 2019 Dec 16 doi: 10.1089/jir.2019.0141. PMID: 31841639
Increased endothelial activation in α-thalassemia disease.
Sirivadhanakul P, Chuansumrit A, Songdej D, Kadegasem P, Wongwerawattanakoon P, Sirachainan N
Ann Hematol 2019 Jul;98(7):1593-1602. Epub 2019 Apr 5 doi: 10.1007/s00277-019-03672-4. PMID: 30953084
Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica.
Zhang H, Gu J
Chin J Integr Med 2007 Dec;13(4):312-6. doi: 10.1007/s11655-007-0312-5. PMID: 18180899

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