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Abnormal proportion of transitional B cells

MedGen UID:
892859
Concept ID:
C4072918
Finding
Synonym: Abnormal transitional B cell count
 
HPO: HP:0030379

Definition

A deviation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells. [from HPO]

Recent clinical studies

Etiology

Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137
Gjertson C, Sturm KS, Berger CN
Clin Immunol 1999 Apr;91(1):50-60. doi: 10.1006/clim.1998.4685. PMID: 10219254

Diagnosis

Chatterjee G, Sriram H, Ghogale S, Deshpande N, Khanka T, Girase K, Verma S, Arolkar G, Dasgupta N, Narula G, Shetty D, Dhamne C, Moulik NR, Rajpal S, Patkar NV, Banavali S, Gujral S, Subramanian PG, Tembhare PR
Br J Haematol 2022 Jan;196(2):374-379. Epub 2021 Sep 2 doi: 10.1111/bjh.17801. PMID: 34476808

Therapy

Gatto M, Bjursten S, Jonsson CA, Agelii ML, Jonell C, McGrath S, Lönnblom E, Sareila O, Holmdahl R, Rudin A, Levin M, Gjertsson I
Arthritis Rheumatol 2023 May;75(5):856-863. Epub 2023 Mar 14 doi: 10.1002/art.42406. PMID: 36409578
Chatterjee G, Sriram H, Ghogale S, Deshpande N, Khanka T, Girase K, Verma S, Arolkar G, Dasgupta N, Narula G, Shetty D, Dhamne C, Moulik NR, Rajpal S, Patkar NV, Banavali S, Gujral S, Subramanian PG, Tembhare PR
Br J Haematol 2022 Jan;196(2):374-379. Epub 2021 Sep 2 doi: 10.1111/bjh.17801. PMID: 34476808
Hajas A, Barath S, Szodoray P, Nakken B, Gogolak P, Szekanecz Z, Zold E, Zeher M, Szegedi G, Bodolay E
Hum Immunol 2013 Jul;74(7):833-41. Epub 2013 Apr 19 doi: 10.1016/j.humimm.2013.04.007. PMID: 23608739

Prognosis

Chatterjee G, Sriram H, Ghogale S, Deshpande N, Khanka T, Girase K, Verma S, Arolkar G, Dasgupta N, Narula G, Shetty D, Dhamne C, Moulik NR, Rajpal S, Patkar NV, Banavali S, Gujral S, Subramanian PG, Tembhare PR
Br J Haematol 2022 Jan;196(2):374-379. Epub 2021 Sep 2 doi: 10.1111/bjh.17801. PMID: 34476808
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Szabó K, Papp G, Szántó A, Tarr T, Zeher M
Clin Exp Immunol 2016 Jan;183(1):76-89. Epub 2015 Oct 21 doi: 10.1111/cei.12703. PMID: 26358223Free PMC Article

Clinical prediction guides

Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137
Szabó K, Papp G, Szántó A, Tarr T, Zeher M
Clin Exp Immunol 2016 Jan;183(1):76-89. Epub 2015 Oct 21 doi: 10.1111/cei.12703. PMID: 26358223Free PMC Article
Fernández ER, Olivera GC, Quebrada Palacio LP, González MN, Hernandez-Vasquez Y, Sirena NM, Morán ML, Ledesma Patiño OS, Postan M
PLoS One 2014;9(8):e104951. Epub 2014 Aug 11 doi: 10.1371/journal.pone.0104951. PMID: 25111833Free PMC Article
Landolt-Marticorena C, Wither R, Reich H, Herzenberg A, Scholey J, Gladman DD, Urowitz MB, Fortin PR, Wither J
J Rheumatol 2011 Apr;38(4):642-51. Epub 2011 Jan 15 doi: 10.3899/jrheum.100214. PMID: 21239754

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