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Abnormal skin morphology of the palm

MedGen UID:: 892900
•Concept ID:: C4073159
•: Anatomical Abnormality

Synonym:	Abnormality of the skin of the palm

HPO:	HP:0040211

Definition

An abnormality of the skin of the palm, that is, the skin of the front of the hand. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal skin morphology of the palm

Phenotypic abnormality
- Abnormality of limbs
  - Abnormality of the upper limb
    - Abnormality of the hand
      - Abnormal palm morphology
        Abnormal skin morphology of the palm
        Abnormal palmar dermatoglyphics
        Abnormal palmar dermal ridges
        Abnormality of the palmar creases
        Aplasia/Hypoplasia of the palmar creases
        Bridged palmar crease
        Deep palmar crease
        Hockey-stick palmar crease
        Multiple palmar creases
        Prominent palmar flexion creases
        Single transverse palmar crease
        Sydney crease
        Complex palmar dermatoglyphic pattern
        Dermatoglyphic ridges abnormal
        Dermatoglyphic variants
        Index finger dermatoglyphic radial loop
        Unusual dermatoglyphics
        High axial triradius
        Increased dermatoglyphic whorls
        Prominent interdigital folds
        Excessive wrinkling of palmar skin
        Palmar edema
        Palmar hyperhidrosis
        Palmar hyperkeratosis
        Palmoplantar keratosis
        Congenital palmoplantar hyperkeratosis
        Congenital symmetrical palmoplantar keratosis
        Diffuse nonepidermolytic palmoplantar keratoderma
        Diffuse palmoplantar hyperkeratosis
        Focal friction-related palmoplantar hyperkeratosis
        Honeycomb palmoplantar hyperkeratosis
        Palmoplantar keratoderma
        Patchy palmoplantar hyperkeratosis
        Punctate palmoplantar hyperkeratosis
        Spinous keratoses of palms and soles
        Punctate palmar hyperkeratosis
        Palmar hyperlinearity
        Palmar warts

Recent clinical studies

Etiology

Pigmentary anomaly caused by mosaic 3q22.2q29 duplication.

Martinez-Falero BS, Koutalopoulou A, Douglas AGL, Kharbanda M, Collinson MN, Lotery A, Lotery H
Clin Exp Dermatol 2022 Dec;47(12):2342-2345. Epub 2022 Sep 30 doi: 10.1111/ced.15355. PMID: 36178237

Loss-of-function variants in KLF4 underlie autosomal dominant palmoplantar keratoderma.

Malovitski K, Sarig O, Assaf S, Mohamad J, Malki L, Bergson S, Peled A, Eskin-Schwartz M, Gat A, Pavlovsky M, Sprecher E
Genet Med 2022 May;24(5):1085-1095. Epub 2022 Feb 12 doi: 10.1016/j.gim.2022.01.009. PMID: 35168889

Vascular pattern of the palms--a clinical feature of atopic skin diathesis.

Schuster C, Smolle J, Aberer W, Kränke B
Allergy 2006 Dec;61(12):1392-6. doi: 10.1111/j.1398-9995.2006.01168.x. PMID: 17073867

Genetic disorders of palm skin and nail.

McLean WH; Epithelial Genetics Group
J Anat 2003 Jan;202(1):133-41. doi: 10.1046/j.1469-7580.2003.00141.x. PMID: 12587928 Free PMC Article

Skin wrinkling for the assessment of sympathetic function in the limbs.

Vasudevan TM, van Rij AM, Nukada H, Taylor PK
Aust N Z J Surg 2000 Jan;70(1):57-9. doi: 10.1046/j.1440-1622.2000.01744.x. PMID: 10696945

See all (23)

Diagnosis

Morphological and radiological features of congenital muscular hypertrophy of the upper limb: experience from a tertiary institution.

Huang Z, Zhao J, Sun L, Zhong W, Yin Y, Tian W
J Hand Surg Eur Vol 2023 Dec;48(11):1144-1150. Epub 2023 Sep 26 doi: 10.1177/17531934231188973. PMID: 37751489

Loss-of-function variants in KLF4 underlie autosomal dominant palmoplantar keratoderma.

Female child with hematidrosis of the palm: Case report and published work review.

Murota H, Kotobuki Y, Yamaga K, Yoshioka Y
J Dermatol 2020 Feb;47(2):166-168. Epub 2019 Dec 2 doi: 10.1111/1346-8138.15179. PMID: 31793058

Characteristics of the local cutaneous sensory thermoneutral zone.

Filingeri D, Zhang H, Arens EA
J Neurophysiol 2017 Apr 1;117(4):1797-1806. Epub 2017 Feb 1 doi: 10.1152/jn.00845.2016. PMID: 28148644 Free PMC Article

The cutaneous manifestations of gastrointestinal malignancy.

Schadt CR
Semin Oncol 2016 Jun;43(3):341-6. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.028. PMID: 27178686

See all (31)

Therapy

Female child with hematidrosis of the palm: Case report and published work review.

Murota H, Kotobuki Y, Yamaga K, Yoshioka Y
J Dermatol 2020 Feb;47(2):166-168. Epub 2019 Dec 2 doi: 10.1111/1346-8138.15179. PMID: 31793058

Testing Assumptions in Human Pain Models: Psychophysical Differences Between First and Second Pain.

Eckert NR, Vierck CJ, Simon CB, Cruz-Almeida Y, Fillingim RB, Riley JL 3rd
J Pain 2017 Mar;18(3):266-273. Epub 2016 Nov 22 doi: 10.1016/j.jpain.2016.10.019. PMID: 27888117 Free PMC Article

Ethanol embolotherapy of hand arteriovenous malformations.

Park HS, Do YS, Park KB, Kim DI, Kim YW, Kim MJ, Shin BS, Choo IW
J Vasc Surg 2011 Mar;53(3):725-31. Epub 2010 Dec 10 doi: 10.1016/j.jvs.2010.09.028. PMID: 21145689

Olmsted syndrome.

Ali ME, Sikdar AU, Akhtar N, Islam ZM
Mymensingh Med J 2007 Jan;16(1):100-3. doi: 10.3329/mmj.v16i1.262. PMID: 17344790

Vascular pattern of the palms--a clinical feature of atopic skin diathesis.

Schuster C, Smolle J, Aberer W, Kränke B
Allergy 2006 Dec;61(12):1392-6. doi: 10.1111/j.1398-9995.2006.01168.x. PMID: 17073867

See all (12)

Prognosis

The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes.

Khaodhiar L, Dinh T, Schomacker KT, Panasyuk SV, Freeman JE, Lew R, Vo T, Panasyuk AA, Lima C, Giurini JM, Lyons TE, Veves A
Diabetes Care 2007 Apr;30(4):903-10. Epub 2007 Feb 15 doi: 10.2337/dc06-2209. PMID: 17303790

An unusual termination of the ulnar nerve in the palm.

Bozkurt MC, Cezayirli E, Tagil SM
Ann Anat 2002 May;184(3):271-3. doi: 10.1016/S0940-9602(02)80123-6. PMID: 12056758

Afferent pathways of sympathetic skin response in spinal cord: a clinical and electrophysiological study.

Nair KP, Taly AB, Rao S, Murali T
J Neurol Sci 2001 Jun 15;187(1-2):77-80. doi: 10.1016/s0022-510x(01)00528-7. PMID: 11440748

Skin wrinkling for the assessment of sympathetic function in the limbs.

Vasudevan TM, van Rij AM, Nukada H, Taylor PK
Aust N Z J Surg 2000 Jan;70(1):57-9. doi: 10.1046/j.1440-1622.2000.01744.x. PMID: 10696945

Properties of cutaneous mechanosensitive afferents during the early stages of regeneration in man.

Mackel R, Brink EE, Wittkowsky G
Brain Res 1985 Mar 11;329(1-2):49-69. doi: 10.1016/0006-8993(85)90511-6. PMID: 3978462

See all (12)

Clinical prediction guides

Syndromes presenting adducted thumb with/without clubfoot and Dundar syndrome.

Uzak AS, Fryns JP, Dundar M
Genet Couns 2014;25(2):159-69. PMID: 25059014

The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes.

Vascular pattern of the palms--a clinical feature of atopic skin diathesis.

Schuster C, Smolle J, Aberer W, Kränke B
Allergy 2006 Dec;61(12):1392-6. doi: 10.1111/j.1398-9995.2006.01168.x. PMID: 17073867

Skin wrinkling for the assessment of sympathetic function in the limbs.

Vasudevan TM, van Rij AM, Nukada H, Taylor PK
Aust N Z J Surg 2000 Jan;70(1):57-9. doi: 10.1046/j.1440-1622.2000.01744.x. PMID: 10696945

Regional difference in expression of characteristic abnormality of harlequin ichthyosis in affected fetuses.

Akiyama M, Dale BA, Smith LT, Shimizu H, Holbrook KA
Prenat Diagn 1998 May;18(5):425-36. PMID: 9621376

See all (11)

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Abnormal skin morphology of the palm

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Consumer resources

Reviews

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