U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased adiponectin level

MedGen UID:
892903
•Concept ID:
C4073127
•
Finding
HPO: HP:0030685

Definition

A reduced circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased adiponectin level

Conditions with this feature

CIDEC-related familial partial lipodystrophy
MedGen UID:
815270
•Concept ID:
C3808940
•
Disease or Syndrome
A rare genetic lipodystrophy with characteristics of abnormal subcutaneous fat distribution, resulting in preservation of visceral, neck and axillary fat and absence of lower limb and gluteofemoral subcutaneous fat. Additional clinical features are acanthosis nigricans, insulin-resistant type II diabetes mellitus, dyslipidaemia, and hypertension, leading to pancreatitis, hepatomegaly and hepatic steatosis.
See: Condition Record
CIDEC-related familial partial lipodystrophy

Professional guidelines

PubMed

The effect of vitamin D treatment on serum adiponectin levels in children with vitamin D deficiency rickets.
Özkan B, Döneray H, Keskin H
J Clin Res Pediatr Endocrinol 2009;1(6):262-5. Epub 2009 Nov 2 doi: 10.4274/jcrpe.v1i6.262. PMID: 21274306Free PMC Article

Recent clinical studies

Etiology

Adiponectin Genetic Variant and Expression Coupled with Lipid Peroxidation Reveal New Signatures in Diabetic Dyslipidemia.
Ghoshal K, Chatterjee T, Chowdhury S, Sengupta S, Bhattacharyya M
Biochem Genet 2021 Jun;59(3):781-798. Epub 2021 Feb 4 doi: 10.1007/s10528-021-10030-5. PMID: 33543406
Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma.
Guo XH, Wang JY, Gao Y, Gao M, Yu GY, Xiang RL, Li L, Yang NY, Cong X, Xu XY, Li SL, Peng X, Wu LL
Cancer Sci 2013 Feb;104(2):206-13. Epub 2013 Jan 20 doi: 10.1111/cas.12077. PMID: 23181352Free PMC Article
Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children.
Aknc A, Karakurt C, Gurbuz S, Elkran O, Nalbantoglu O, Kocak G, Guldur T, Yologlu S
J Cardiovasc Med (Hagerstown) 2013 Mar;14(3):228-34. doi: 10.2459/JCM.0b013e328351674e. PMID: 22441215
Adiponectin and smoking status: a systematic review.
Kotani K, Hazama A, Hagimoto A, Saika K, Shigeta M, Katanoda K, Nakamura M
J Atheroscler Thromb 2012;19(9):787-94. Epub 2012 May 17 doi: 10.5551/jat.11833. PMID: 22653164
Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein.
Ahonen TM, Kautiainen HJ, Keinänen-Kiukaanniemi SM, Kumpusalo EA, Vanhala MJ
Am J Prev Med 2008 Dec;35(6):598-601. Epub 2008 Oct 8 doi: 10.1016/j.amepre.2008.09.011. PMID: 18842390

Diagnosis

Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis.
Stochmal A, Czuwara J, Zaremba M, Rudnicka L
Arch Dermatol Res 2020 Aug;312(6):453-458. Epub 2019 Oct 30 doi: 10.1007/s00403-019-01993-y. PMID: 31667578Free PMC Article
MORPHOLOGICAL AND FUNCTIONAL MYOCARDIAL ABNORMALITIES IN THE CHORNOBYL NPP ACCIDENT CLEAN-UP WORKERS OF «IODINE» PERIOD HAVING GOT TYPE 2 DIABETES MELLITUS.
Dombrovska NS, Nastina OM, Voloshko VI, Pleskach OY
Probl Radiac Med Radiobiol 2018 Dec;23:302-330. doi: 10.33145/2304-8336-2018-23-302-330. PMID: 30582854
Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein.
Ahonen TM, Kautiainen HJ, Keinänen-Kiukaanniemi SM, Kumpusalo EA, Vanhala MJ
Am J Prev Med 2008 Dec;35(6):598-601. Epub 2008 Oct 8 doi: 10.1016/j.amepre.2008.09.011. PMID: 18842390
Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension.
Tsai WC, Lin CC, Chen JY, Huang YY, Lee CH, Li WT, Weng CM, Chen JH
Blood Press 2008;17(4):233-8. doi: 10.1080/08037050802308895. PMID: 18671144
Possible impairment of transcardiac utilization of adiponectin in patients with type 2 diabetes.
Furuhashi M, Ura N, Moniwa N, Shinshi Y, Kouzu H, Nishihara M, Kokubu N, Takahashi T, Sakamoto K, Hayashi M, Satoh N, Nishitani T, Shikano Y, Shimamoto K
Diabetes Care 2004 Sep;27(9):2217-21. doi: 10.2337/diacare.27.9.2217. PMID: 15333487

Therapy

MORPHOLOGICAL AND FUNCTIONAL MYOCARDIAL ABNORMALITIES IN THE CHORNOBYL NPP ACCIDENT CLEAN-UP WORKERS OF «IODINE» PERIOD HAVING GOT TYPE 2 DIABETES MELLITUS.
Dombrovska NS, Nastina OM, Voloshko VI, Pleskach OY
Probl Radiac Med Radiobiol 2018 Dec;23:302-330. doi: 10.33145/2304-8336-2018-23-302-330. PMID: 30582854
Adiponectin and smoking status: a systematic review.
Kotani K, Hazama A, Hagimoto A, Saika K, Shigeta M, Katanoda K, Nakamura M
J Atheroscler Thromb 2012;19(9):787-94. Epub 2012 May 17 doi: 10.5551/jat.11833. PMID: 22653164
Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein.
Ahonen TM, Kautiainen HJ, Keinänen-Kiukaanniemi SM, Kumpusalo EA, Vanhala MJ
Am J Prev Med 2008 Dec;35(6):598-601. Epub 2008 Oct 8 doi: 10.1016/j.amepre.2008.09.011. PMID: 18842390
Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension.
Tsai WC, Lin CC, Chen JY, Huang YY, Lee CH, Li WT, Weng CM, Chen JH
Blood Press 2008;17(4):233-8. doi: 10.1080/08037050802308895. PMID: 18671144
Does birthweight predict adolescent adiponectin levels?
Kim CS, Park JS, Park J, Nam JS, Kang ES, Ahn CW, Cha BS, Lim SK, Kim KR, Lee HC, Huh KB, Kim DJ
Clin Endocrinol (Oxf) 2006 Feb;64(2):162-8. doi: 10.1111/j.1365-2265.2006.02443.x. PMID: 16430715

Prognosis

A single nucleotide polymorphism in ADIPOQ predicts biochemical recurrence after radical prostatectomy in localized prostate cancer.
Gu C, Qu Y, Zhang G, Sun L, Zhu Y, Ye D
Oncotarget 2015 Oct 13;6(31):32205-11. doi: 10.18632/oncotarget.4980. PMID: 26320190Free PMC Article
Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma.
Guo XH, Wang JY, Gao Y, Gao M, Yu GY, Xiang RL, Li L, Yang NY, Cong X, Xu XY, Li SL, Peng X, Wu LL
Cancer Sci 2013 Feb;104(2):206-13. Epub 2013 Jan 20 doi: 10.1111/cas.12077. PMID: 23181352Free PMC Article
Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children.
Aknc A, Karakurt C, Gurbuz S, Elkran O, Nalbantoglu O, Kocak G, Guldur T, Yologlu S
J Cardiovasc Med (Hagerstown) 2013 Mar;14(3):228-34. doi: 10.2459/JCM.0b013e328351674e. PMID: 22441215
Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein.
Ahonen TM, Kautiainen HJ, Keinänen-Kiukaanniemi SM, Kumpusalo EA, Vanhala MJ
Am J Prev Med 2008 Dec;35(6):598-601. Epub 2008 Oct 8 doi: 10.1016/j.amepre.2008.09.011. PMID: 18842390
Does birthweight predict adolescent adiponectin levels?
Kim CS, Park JS, Park J, Nam JS, Kang ES, Ahn CW, Cha BS, Lim SK, Kim KR, Lee HC, Huh KB, Kim DJ
Clin Endocrinol (Oxf) 2006 Feb;64(2):162-8. doi: 10.1111/j.1365-2265.2006.02443.x. PMID: 16430715

Clinical prediction guides

Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis.
Stochmal A, Czuwara J, Zaremba M, Rudnicka L
Arch Dermatol Res 2020 Aug;312(6):453-458. Epub 2019 Oct 30 doi: 10.1007/s00403-019-01993-y. PMID: 31667578Free PMC Article
Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma.
Guo XH, Wang JY, Gao Y, Gao M, Yu GY, Xiang RL, Li L, Yang NY, Cong X, Xu XY, Li SL, Peng X, Wu LL
Cancer Sci 2013 Feb;104(2):206-13. Epub 2013 Jan 20 doi: 10.1111/cas.12077. PMID: 23181352Free PMC Article
Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children.
Aknc A, Karakurt C, Gurbuz S, Elkran O, Nalbantoglu O, Kocak G, Guldur T, Yologlu S
J Cardiovasc Med (Hagerstown) 2013 Mar;14(3):228-34. doi: 10.2459/JCM.0b013e328351674e. PMID: 22441215
Combination of serum adiponectin level and metabolic syndrome is closely associated with coronary artery disease in Japanese subjects with good glycemic control.
Yamashita T, Matsuda M, Nishimoto O, Nakamoto K, Nishiyama H, Matsumoto K, Tamura R, Kawamoto T
Intern Med 2010;49(8):721-7. Epub 2010 Apr 15 doi: 10.2169/internalmedicine.49.2897. PMID: 20424361
Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein.
Ahonen TM, Kautiainen HJ, Keinänen-Kiukaanniemi SM, Kumpusalo EA, Vanhala MJ
Am J Prev Med 2008 Dec;35(6):598-601. Epub 2008 Oct 8 doi: 10.1016/j.amepre.2008.09.011. PMID: 18842390

Recent systematic reviews

Adiponectin and smoking status: a systematic review.
Kotani K, Hazama A, Hagimoto A, Saika K, Shigeta M, Katanoda K, Nakamura M
J Atheroscler Thromb 2012;19(9):787-94. Epub 2012 May 17 doi: 10.5551/jat.11833. PMID: 22653164

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...