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Increased proportion of immature B cells

MedGen UID:
892989
Concept ID:
C4072916
Finding
Synonym: Increased immature B cell count
 
HPO: HP:0030377

Definition

An elevation in the proportion above normal of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of immature B cells

Recent clinical studies

Etiology

Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604Free PMC Article
Bae H, Lee H, Ko EJ, Kim CD, Lee SH, Yang CW, Oh EJ, Chung BH
HLA 2023 Sep;102(3):316-330. Epub 2023 Apr 10 doi: 10.1111/tan.15061. PMID: 37038287
Jain H, Sengar M, Goli VB, Thorat J, Tembhare P, Shetty D, Bonda VNA, Nayak L, Subramanian PG, Bagal B, Patkar N, Sharma N, Gupta H, Gujral S
Blood Adv 2021 Sep 14;5(17):3436-3444. doi: 10.1182/bloodadvances.2020003368. PMID: 34461632Free PMC Article
Tsuyama N, Mizuno H, Katafuchi A, Abe Y, Kurosu Y, Yoshida M, Kamiya K, Sakai A
J Radiat Res 2015 Jan;56(1):46-58. Epub 2014 Sep 16 doi: 10.1093/jrr/rru078. PMID: 25227127Free PMC Article
Castiello MC, Bosticardo M, Pala F, Catucci M, Chamberlain N, van Zelm MC, Driessen GJ, Pac M, Bernatowska E, Scaramuzza S, Aiuti A, Sauer AV, Traggiai E, Meffre E, Villa A, van der Burg M
J Autoimmun 2014 May;50(100):42-50. Epub 2013 Dec 25 doi: 10.1016/j.jaut.2013.10.006. PMID: 24369837Free PMC Article

Diagnosis

Jain H, Sengar M, Goli VB, Thorat J, Tembhare P, Shetty D, Bonda VNA, Nayak L, Subramanian PG, Bagal B, Patkar N, Sharma N, Gupta H, Gujral S
Blood Adv 2021 Sep 14;5(17):3436-3444. doi: 10.1182/bloodadvances.2020003368. PMID: 34461632Free PMC Article
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article
Tsuyama N, Mizuno H, Katafuchi A, Abe Y, Kurosu Y, Yoshida M, Kamiya K, Sakai A
J Radiat Res 2015 Jan;56(1):46-58. Epub 2014 Sep 16 doi: 10.1093/jrr/rru078. PMID: 25227127Free PMC Article
Al-Shieban S, Byrne E, Trivedi P, Morilla R, Matutes E, Naresh KN
Br J Haematol 2011 Aug;154(4):466-70. Epub 2011 Jul 2 doi: 10.1111/j.1365-2141.2011.08760.x. PMID: 21722099
Abo W, Takada K, Kamada M, Imamura M, Motoya T, Iwanga M, Aya T, Yano S, Nakao T, Osato T
Lancet 1982 Jun 5;1(8284):1272-6. doi: 10.1016/s0140-6736(82)92842-2. PMID: 6123020

Therapy

Gatto M, Bjursten S, Jonsson CA, Agelii ML, Jonell C, McGrath S, Lönnblom E, Sareila O, Holmdahl R, Rudin A, Levin M, Gjertsson I
Arthritis Rheumatol 2023 May;75(5):856-863. Epub 2023 Mar 14 doi: 10.1002/art.42406. PMID: 36409578
Jain H, Sengar M, Goli VB, Thorat J, Tembhare P, Shetty D, Bonda VNA, Nayak L, Subramanian PG, Bagal B, Patkar N, Sharma N, Gupta H, Gujral S
Blood Adv 2021 Sep 14;5(17):3436-3444. doi: 10.1182/bloodadvances.2020003368. PMID: 34461632Free PMC Article
Miyazaki Y, Niino M, Takahashi E, Suzuki M, Mizuno M, Hisahara S, Fukazawa T, Amino I, Nakano F, Nakamura M, Akimoto S, Minami N, Fujiki N, Doi S, Shimohama S, Terayama Y, Kikuchi S
Clin Immunol 2018 Feb;187:95-101. Epub 2017 Oct 25 doi: 10.1016/j.clim.2017.10.009. PMID: 29079163

Prognosis

Berglund LJ, Wong SW, Fulcher DA
Pathology 2008 Apr;40(3):288-94. doi: 10.1080/00313020801911470. PMID: 18428049

Clinical prediction guides

Chalise JP, Ehsani A, Lemecha M, Hung YW, Zhang G, Larson GP, Itakura K
Front Immunol 2023;14:1170475. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1170475. PMID: 37483604Free PMC Article
Shimojima Y, Kishida D, Ichikawa T, Takamatsu R, Nomura S, Sekijima Y
Clin Exp Immunol 2023 Jul 5;213(1):125-137. doi: 10.1093/cei/uxad024. PMID: 36794867Free PMC Article
Elmér E, Smargianaki S, Pettersson Å, Skattum L, Ohlsson S, Hellmark T, Johansson ÅCM
J Immunol Res 2020;2020:8209737. Epub 2020 Nov 28 doi: 10.1155/2020/8209737. PMID: 33313327Free PMC Article
Fernández ER, Olivera GC, Quebrada Palacio LP, González MN, Hernandez-Vasquez Y, Sirena NM, Morán ML, Ledesma Patiño OS, Postan M
PLoS One 2014;9(8):e104951. Epub 2014 Aug 11 doi: 10.1371/journal.pone.0104951. PMID: 25111833Free PMC Article
Castiello MC, Bosticardo M, Pala F, Catucci M, Chamberlain N, van Zelm MC, Driessen GJ, Pac M, Bernatowska E, Scaramuzza S, Aiuti A, Sauer AV, Traggiai E, Meffre E, Villa A, van der Burg M
J Autoimmun 2014 May;50(100):42-50. Epub 2013 Dec 25 doi: 10.1016/j.jaut.2013.10.006. PMID: 24369837Free PMC Article

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