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Abnormal circulating insulin concentration

MedGen UID:
893016
•Concept ID:
C4073160
•
Finding
Synonym: Abnormal insulin level
 
HPO: HP:0040214

Definition

An abnormal concentration of insulin in the body. [from HPO]

Professional guidelines

PubMed

Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Quantitative measurement of IGF-I and its use in diagnosing and monitoring treatment of disorders of growth hormone secretion.
Clemmons DR
Endocr Dev 2005;9:55-65. doi: 10.1159/000085756. PMID: 15879688
Clinical utility of sex hormone-binding globulin measurement.
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent clinical studies

Etiology

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
The biology of human overfeeding: A systematic review.
Bray GA, Bouchard C
Obes Rev 2020 Sep;21(9):e13040. Epub 2020 Jun 8 doi: 10.1111/obr.13040. PMID: 32515127
Cholecystectomy and risk of metabolic syndrome.
Di Ciaula A, Garruti G, Wang DQ, Portincasa P
Eur J Intern Med 2018 Jul;53:3-11. Epub 2018 Apr 26 doi: 10.1016/j.ejim.2018.04.019. PMID: 29706426Free PMC Article
Measurement of Gastrointestinal Hormones.
Albrechtsen NJW
Dan Med J 2017 Nov;64(11) PMID: 29115211

Diagnosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
The biology of human overfeeding: A systematic review.
Bray GA, Bouchard C
Obes Rev 2020 Sep;21(9):e13040. Epub 2020 Jun 8 doi: 10.1111/obr.13040. PMID: 32515127
Exercise and Regulation of Carbohydrate Metabolism.
Mul JD, Stanford KI, Hirshman MF, Goodyear LJ
Prog Mol Biol Transl Sci 2015;135:17-37. Epub 2015 Aug 20 doi: 10.1016/bs.pmbts.2015.07.020. PMID: 26477909Free PMC Article
Control of glycaemia.
Gerich JE
Baillieres Clin Endocrinol Metab 1993 Jul;7(3):551-86. doi: 10.1016/s0950-351x(05)80207-1. PMID: 8379904
Mutant insulin syndromes.
Vinik A, Bell G
Horm Metab Res 1988 Jan;20(1):1-10. doi: 10.1055/s-2007-1010736. PMID: 3286444

Therapy

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Systemic and ovarian inflammation in women with polycystic ovary syndrome.
Zhai Y, Pang Y
J Reprod Immunol 2022 Jun;151:103628. Epub 2022 Apr 16 doi: 10.1016/j.jri.2022.103628. PMID: 35472833
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Dichloroacetate.
Stacpoole PW, Greene YJ
Diabetes Care 1992 Jun;15(6):785-91. doi: 10.2337/diacare.15.6.785. PMID: 1600837
Diabetes and exercise.
Zinman B, Vranic M
Med Clin North Am 1985 Jan;69(1):145-57. doi: 10.1016/s0025-7125(16)31062-8. PMID: 3883072

Prognosis

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Oxidative stress and cardiovascular complications in polycystic ovarian syndrome.
Hyderali BN, Mala K
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:15-22. Epub 2015 Jun 2 doi: 10.1016/j.ejogrb.2015.05.005. PMID: 26066290
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Clinical prediction guides

SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C
Diabetologia 2023 Nov;66(11):2042-2061. Epub 2023 Aug 4 doi: 10.1007/s00125-023-05979-4. PMID: 37537395Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Circulating sDPP-4 is Increased in Obesity and Insulin Resistance but Is Not Related to Systemic Metabolic Inflammation.
Rohmann N, Schlicht K, Geisler C, Hollstein T, Knappe C, Krause L, Hagen S, Beckmann A, Seoudy AK, Wietzke-Braun P, Hartmann K, Schulte D, Türk K, Beckmann J, von Schönfels W, Hägele FA, Bosy-Westphal A, Franke A, Schreiber S, Laudes M
J Clin Endocrinol Metab 2021 Jan 23;106(2):e592-e601. doi: 10.1210/clinem/dgaa758. PMID: 33084870
Pycnodysostosis: clinical, radiologic, and endocrine evaluation and linear growth after growth hormone therapy.
Soliman AT, Ramadan MA, Sherif A, Aziz Bedair ES, Rizk MM
Metabolism 2001 Aug;50(8):905-11. doi: 10.1053/meta.2001.24924. PMID: 11474477

Recent systematic reviews

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis.
Ren M, Wang L, Wen L, Chen J, Quan S, Shi X
Front Endocrinol (Lausanne) 2023;14:1216507. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1216507. PMID: 37711903Free PMC Article
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
The biology of human overfeeding: A systematic review.
Bray GA, Bouchard C
Obes Rev 2020 Sep;21(9):e13040. Epub 2020 Jun 8 doi: 10.1111/obr.13040. PMID: 32515127

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