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Abnormal proportion of naive B cells

MedGen UID:
893042
Concept ID:
C4072909
Finding
Synonym: Abnormal naive B cell count
 
HPO: HP:0030370

Definition

A deviation in the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to the total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen. [from HPO]

Professional guidelines

PubMed

Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255

Recent clinical studies

Etiology

Zhu Y, Wang S, Yang Y, Shen B, Wang A, Zhang X, Zhang X, Li N, Gao Z, Liu Y, Zhu J, Wei Z, Guan J, Su K, Liu F, Gu M, Yin S
Front Immunol 2023;14:1186258. Epub 2023 May 22 doi: 10.3389/fimmu.2023.1186258. PMID: 37283767Free PMC Article
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447
Wong GK, Huissoon AP
J Clin Pathol 2016 Aug;69(8):672-6. Epub 2016 May 6 doi: 10.1136/jclinpath-2015-203351. PMID: 27153873Free PMC Article

Diagnosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R
Front Immunol 2022;13:795209. Epub 2022 Feb 4 doi: 10.3389/fimmu.2022.795209. PMID: 35185888Free PMC Article
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article
Wang Y, Zhu L, Ju B, Luo J, Li Q, Lv X, Pu D, Hao Z, Wang J, He L
Clin Exp Rheumatol 2022 Feb;40(2):260-266. Epub 2021 Dec 10 doi: 10.55563/clinexprheumatol/ohsmuj. PMID: 34905483

Therapy

Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article
Le Goff M, Cornec D, Guellec D, Marhadour T, Devauchelle-Pensec V, Jousse-Joulin S, Herbette M, Cauvin JM, Le Guillou C, Renaudineau Y, Jamin C, Pers JO, Saraux A
PLoS One 2019;14(2):e0211536. Epub 2019 Feb 27 doi: 10.1371/journal.pone.0211536. PMID: 30811404Free PMC Article
Tanko RF, Soares AP, Müller TL, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA
J Immunol 2017 Feb 1;198(3):1220-1228. Epub 2016 Dec 30 doi: 10.4049/jimmunol.1601560. PMID: 28039305Free PMC Article

Prognosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Framme JL, Lundqvist C, Lundell AC, van Schouwenburg PA, Lemarquis AL, Thörn K, Lindgren S, Gudmundsdottir J, Lundberg V, Degerman S, Zetterström RH, Borte S, Hammarström L, Telemo E, Hultdin M, van der Burg M, Fasth A, Oskarsdóttir S, Ekwall O
J Clin Immunol 2022 Apr;42(3):618-633. Epub 2022 Jan 26 doi: 10.1007/s10875-021-01201-5. PMID: 35080750Free PMC Article
Hanley P, Sutter JA, Goodman NG, Du Y, Sekiguchi DR, Meng W, Rickels MR, Naji A, Luning Prak ET
Clin Immunol 2017 Oct;183:336-343. Epub 2017 Sep 23 doi: 10.1016/j.clim.2017.09.021. PMID: 28951327Free PMC Article
Leiva LE, Monjure H, Sorensen RU
J Clin Immunol 2013 Jan;33 Suppl 1:S57-61. Epub 2012 Oct 24 doi: 10.1007/s10875-012-9814-9. PMID: 23093309

Clinical prediction guides

Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R
Front Immunol 2022;13:795209. Epub 2022 Feb 4 doi: 10.3389/fimmu.2022.795209. PMID: 35185888Free PMC Article
Yu TS, Wang HY, Zhao YJ, Yu YF, Hou Y, Liu S, Han PP, Ni XF, Ji XB, Peng J, Liu XG, Hou M
Blood Adv 2021 Oct 26;5(20):4087-4101. doi: 10.1182/bloodadvances.2020003860. PMID: 34507351Free PMC Article
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447

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