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Recurrent singultus

MedGen UID:
893074
•Concept ID:
C0744897
•
Finding
Synonyms: Hiccup; Hiccups; Recurrent hiccough; Recurrent hiccup; Recurrent synchronous diaphragmatic flutter
 
HPO: HP:0100247

Definition

A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent singultus

Conditions with this feature

Hyperglycinemia, transient neonatal
MedGen UID:
82818
•Concept ID:
C0268560
•
Disease or Syndrome
See: Condition Record
Hyperglycinemia, transient neonatal

Professional guidelines

PubMed

Continuous cervical epidural block: Treatment for intractable hiccups.
Kim JE, Lee MK, Lee DK, Choi SS, Park JS
Medicine (Baltimore) 2018 Feb;97(6):e9444. doi: 10.1097/MD.0000000000009444. PMID: 29419660Free PMC Article
Treatment of dexamethasone-induced hiccup in chemotherapy patients by methylprednisolone rotation.
Lee GW, Oh SY, Kang MH, Kang JH, Park SH, Hwang IG, Yi SY, Choi YJ, Ji JH, Lee HY, Bruera E
Oncologist 2013;18(11):1229-34. Epub 2013 Oct 9 doi: 10.1634/theoncologist.2013-0224. PMID: 24107973Free PMC Article
Management of hiccups in the palliative care population.
Smith HS, Busracamwongs A
Am J Hosp Palliat Care 2003 Mar-Apr;20(2):149-54. doi: 10.1177/104990910302000214. PMID: 12693648

Recent clinical studies

Etiology

Cervical repetitive peripheral magnetic stimulation relieves idiopathic persistent hiccups: A preliminary study of case report.
Cai W, Xu G, Tian Z, Xiong F, Yang J, Wang T
Medicine (Baltimore) 2022 Oct 28;101(43):e31324. doi: 10.1097/MD.0000000000031324. PMID: 36316915Free PMC Article
Stenting in Palliation of Unresectable Esophageal Cancer.
Włodarczyk JR, Kużdżał J
World J Surg 2018 Dec;42(12):3988-3996. doi: 10.1007/s00268-018-4722-7. PMID: 29946788Free PMC Article
Hiccups. Attitude in Otorhinolaryngology Towards Consulting Patients. A Diagnostic and Therapeutic Approach.
García Callejo FJ, Redondo Martínez J, Pérez Carbonell T, Monzó Gandía R, Martínez Beneyto MP, Rincón Piedrahita I
Acta Otorrinolaringol Esp 2017 Mar-Apr;68(2):98-105. Epub 2016 Aug 16 doi: 10.1016/j.otorri.2016.05.005. PMID: 27542994
Hypothalamic abnormality in patients with inflammatory demyelinating disorders.
Gao C, Wu L, Chen X, Long Y, Zhong R, Yang N, Chen Y
Int J Neurosci 2016 Nov;126(11):1036-43. Epub 2016 Feb 5 doi: 10.3109/00207454.2015.1114484. PMID: 26514655
Treatment of dexamethasone-induced hiccup in chemotherapy patients by methylprednisolone rotation.
Lee GW, Oh SY, Kang MH, Kang JH, Park SH, Hwang IG, Yi SY, Choi YJ, Ji JH, Lee HY, Bruera E
Oncologist 2013;18(11):1229-34. Epub 2013 Oct 9 doi: 10.1634/theoncologist.2013-0224. PMID: 24107973Free PMC Article

Diagnosis

Recurrent Persistent Hiccups on Opioid Treatment: A Case Report and Literature Review.
Xausa G, Escher M, Singovski S, Hentsch L
J Pain Palliat Care Pharmacother 2023 Mar;37(1):82-90. Epub 2022 Dec 15 doi: 10.1080/15360288.2022.2157070. PMID: 36520149
Continuous cervical epidural block: Treatment for intractable hiccups.
Kim JE, Lee MK, Lee DK, Choi SS, Park JS
Medicine (Baltimore) 2018 Feb;97(6):e9444. doi: 10.1097/MD.0000000000009444. PMID: 29419660Free PMC Article
Recurrent hiccups may signal brainstem pathology and should be investigated.
Shastin D, Nidamanuri P, Nannapaneni R
BMJ Case Rep 2018 Jan 17;2018 doi: 10.1136/bcr-2017-222926. PMID: 29348287Free PMC Article
Hiccups. Attitude in Otorhinolaryngology Towards Consulting Patients. A Diagnostic and Therapeutic Approach.
García Callejo FJ, Redondo Martínez J, Pérez Carbonell T, Monzó Gandía R, Martínez Beneyto MP, Rincón Piedrahita I
Acta Otorrinolaringol Esp 2017 Mar-Apr;68(2):98-105. Epub 2016 Aug 16 doi: 10.1016/j.otorri.2016.05.005. PMID: 27542994
Typical and atypical clinical presentation of uterine myomas.
Su WH, Lee WL, Cheng MH, Yen MS, Chao KC, Wang PH
J Chin Med Assoc 2012 Oct;75(10):487-93. Epub 2012 Sep 18 doi: 10.1016/j.jcma.2012.07.004. PMID: 23089399

Therapy

Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer.
Liu Z, Parveen N, Rehman U, Aziz A, Sheikh A, Abourehab MAS, Guo W, Huang J, Wang Z, Kesharwani P
Mol Cancer 2023 Jan 12;22(1):8. doi: 10.1186/s12943-022-01696-5. PMID: 36635659Free PMC Article
Recurrent Persistent Hiccups on Opioid Treatment: A Case Report and Literature Review.
Xausa G, Escher M, Singovski S, Hentsch L
J Pain Palliat Care Pharmacother 2023 Mar;37(1):82-90. Epub 2022 Dec 15 doi: 10.1080/15360288.2022.2157070. PMID: 36520149
Stenting in Palliation of Unresectable Esophageal Cancer.
Włodarczyk JR, Kużdżał J
World J Surg 2018 Dec;42(12):3988-3996. doi: 10.1007/s00268-018-4722-7. PMID: 29946788Free PMC Article
Continuous cervical epidural block: Treatment for intractable hiccups.
Kim JE, Lee MK, Lee DK, Choi SS, Park JS
Medicine (Baltimore) 2018 Feb;97(6):e9444. doi: 10.1097/MD.0000000000009444. PMID: 29419660Free PMC Article
Management of hiccups in the palliative care population.
Smith HS, Busracamwongs A
Am J Hosp Palliat Care 2003 Mar-Apr;20(2):149-54. doi: 10.1177/104990910302000214. PMID: 12693648

Prognosis

Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer.
Liu Z, Parveen N, Rehman U, Aziz A, Sheikh A, Abourehab MAS, Guo W, Huang J, Wang Z, Kesharwani P
Mol Cancer 2023 Jan 12;22(1):8. doi: 10.1186/s12943-022-01696-5. PMID: 36635659Free PMC Article
The adjuvant use of lansoprazole, clonazepam and dimenhydrinate for treating intractable hiccups in a patient with gastritis and reflux esophagitis complicated with myocardial infarction: a case report.
Maximov G, Kamnasaran D
BMC Res Notes 2013 Aug 16;6:327. doi: 10.1186/1756-0500-6-327. PMID: 23954069Free PMC Article
A case of cerebral aquaporinopathy.
Tanaka A, Yoshida T, Yamada T, Isayama R, Fujiwara Y, Shiga K, Yamada K, Tanaka K, Nakagawa M
Mult Scler 2010 Oct;16(10):1252-4. Epub 2010 Jul 29 doi: 10.1177/1352458510377906. PMID: 20670980
Laparoscopic resection of an intradiaphragmatic bronchogenic cyst.
Zügel NP, Kox M, Lang RA, Hüttl TP
JSLS 2008 Jul-Sep;12(3):318-20. PMID: 18765062Free PMC Article
Management of hiccups in the palliative care population.
Smith HS, Busracamwongs A
Am J Hosp Palliat Care 2003 Mar-Apr;20(2):149-54. doi: 10.1177/104990910302000214. PMID: 12693648

Clinical prediction guides

Cervical repetitive peripheral magnetic stimulation relieves idiopathic persistent hiccups: A preliminary study of case report.
Cai W, Xu G, Tian Z, Xiong F, Yang J, Wang T
Medicine (Baltimore) 2022 Oct 28;101(43):e31324. doi: 10.1097/MD.0000000000031324. PMID: 36316915Free PMC Article
Hiccups. Attitude in Otorhinolaryngology Towards Consulting Patients. A Diagnostic and Therapeutic Approach.
García Callejo FJ, Redondo Martínez J, Pérez Carbonell T, Monzó Gandía R, Martínez Beneyto MP, Rincón Piedrahita I
Acta Otorrinolaringol Esp 2017 Mar-Apr;68(2):98-105. Epub 2016 Aug 16 doi: 10.1016/j.otorri.2016.05.005. PMID: 27542994
Hypothalamic abnormality in patients with inflammatory demyelinating disorders.
Gao C, Wu L, Chen X, Long Y, Zhong R, Yang N, Chen Y
Int J Neurosci 2016 Nov;126(11):1036-43. Epub 2016 Feb 5 doi: 10.3109/00207454.2015.1114484. PMID: 26514655
Does (supra)gastric belching trigger recurrent hiccups?
Hopman WP, van Kouwen MC, Smout AJ
World J Gastroenterol 2010 Apr 14;16(14):1795-9. doi: 10.3748/wjg.v16.i14.1795. PMID: 20380015Free PMC Article
Hiccups and esophageal dysfunction.
Triadafilopoulos G
Am J Gastroenterol 1989 Feb;84(2):164-9. PMID: 2916528

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