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Abnormality of the menstrual cycle

MedGen UID:
893088
Concept ID:
C4025888
Finding
Synonym: Menstrual abnormalities
 
HPO: HP:0000140

Definition

An abnormality of the ovulation cycle. [from HPO]

Conditions with this feature

46,XY sex reversal 1
MedGen UID:
412662
Concept ID:
C2748896
Disease or Syndrome
Sex reversal in an individual with 46,XY karyotype caused by point mutations or deletions in the SRY gene, encoding sex-determining region Y protein.
Oocyte maturation defect 8
MedGen UID:
1776094
Concept ID:
C5436597
Disease or Syndrome
Oocyte/zygote/embryo maturation arrest-8 (OZEMA8) is characterized by female infertility due to failure of the fertilized ovum to undergo zygotic cleavage (Zheng et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.
Oocyte maturation defect 9
MedGen UID:
1724427
Concept ID:
C5436599
Disease or Syndrome
Oocyte/zygote/embryo maturation arrest-9 (OZEMA9) is characterized by female infertility due to oocyte meiotic arrest at metaphase I in most patients. Abnormal zygotic cleavage has also been observed (Zhang et al., 2020). For a discussion of genetic heterogeneity of OZEMA, see 615774.

Professional guidelines

PubMed

Moisidis-Tesch CM, Shulman LP
Adv Ther 2022 Jun;39(6):2438-2451. Epub 2022 Apr 30 doi: 10.1007/s12325-022-02157-7. PMID: 35488139
Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility
Fertil Steril 2021 Jun;115(6):1416-1423. Epub 2021 Apr 4 doi: 10.1016/j.fertnstert.2021.02.010. PMID: 33827766
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855

Recent clinical studies

Etiology

Zhong X, Lu K, Liang W, Jihu L, Zeng A, Ding M, Chen D, Xie M
BMC Womens Health 2023 Nov 16;23(1):611. doi: 10.1186/s12905-023-02697-2. PMID: 37974147Free PMC Article
Heiman DL
Prim Care 2009 Mar;36(1):1-17, vii. doi: 10.1016/j.pop.2008.10.005. PMID: 19231599
Bostwick JR, Guthrie SK, Ellingrod VL
Pharmacotherapy 2009 Jan;29(1):64-73. doi: 10.1592/phco.29.1.64. PMID: 19113797
Harel Z
Ann N Y Acad Sci 2008;1135:185-95. doi: 10.1196/annals.1429.007. PMID: 18574224
ESHRE Capri Workshop Group, Collins J, Crosignani PG
Hum Reprod Update 2007 Sep-Oct;13(5):421-31. Epub 2007 Mar 2 doi: 10.1093/humupd/dmm001. PMID: 17337477

Diagnosis

Siddiqui S, Mateen S, Ahmad R, Moin S
J Assist Reprod Genet 2022 Nov;39(11):2439-2473. Epub 2022 Oct 3 doi: 10.1007/s10815-022-02625-7. PMID: 36190593Free PMC Article
Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, Boyle J, Teede HJ
Lancet Diabetes Endocrinol 2022 Sep;10(9):668-680. Epub 2022 Aug 4 doi: 10.1016/S2213-8587(22)00163-2. PMID: 35934017
Yaşa C, Güngör Uğurlucan F
J Clin Res Pediatr Endocrinol 2020 Feb 6;12(Suppl 1):1-6. doi: 10.4274/jcrpe.galenos.2019.2019.S0200. PMID: 32041387Free PMC Article
Ryu A, Kim TH
Maturitas 2015 Dec;82(4):436-40. Epub 2015 Aug 28 doi: 10.1016/j.maturitas.2015.08.010. PMID: 26351143
Deligeoroglou E, Creatsas G
Endocr Dev 2012;22:160-170. Epub 2012 Jul 25 doi: 10.1159/000331697. PMID: 22846527

Therapy

Siddiqui S, Mateen S, Ahmad R, Moin S
J Assist Reprod Genet 2022 Nov;39(11):2439-2473. Epub 2022 Oct 3 doi: 10.1007/s10815-022-02625-7. PMID: 36190593Free PMC Article
Itriyeva K
Curr Probl Pediatr Adolesc Health Care 2022 May;52(5):101187. Epub 2022 May 6 doi: 10.1016/j.cppeds.2022.101187. PMID: 35534402
Ryu A, Kim TH
Maturitas 2015 Dec;82(4):436-40. Epub 2015 Aug 28 doi: 10.1016/j.maturitas.2015.08.010. PMID: 26351143
Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB, Fauser BC
Hum Reprod Update 2015 Sep-Oct;21(5):575-92. Epub 2015 Jun 27 doi: 10.1093/humupd/dmv029. PMID: 26117684
Bostwick JR, Guthrie SK, Ellingrod VL
Pharmacotherapy 2009 Jan;29(1):64-73. doi: 10.1592/phco.29.1.64. PMID: 19113797

Prognosis

Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility
Fertil Steril 2021 Jun;115(6):1416-1423. Epub 2021 Apr 4 doi: 10.1016/j.fertnstert.2021.02.010. PMID: 33827766
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855
Solnik MJ, Alexander C
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):105-16. doi: 10.1016/j.beem.2011.07.002. PMID: 22305456
Jose-Miller AB, Boyden JW, Frey KA
Am Fam Physician 2007 Mar 15;75(6):849-56. PMID: 17390595
Kailas NA, Sifakis S, Koumantakis E
Eur J Contracept Reprod Health Care 2005 Mar;10(1):19-25. doi: 10.1080/13625180400020861. PMID: 16036294

Clinical prediction guides

Majeed J, Sharma P, Ajmera P, Dalal K
Reprod Health 2022 Jun 23;19(1):148. doi: 10.1186/s12978-022-01453-3. PMID: 35739585Free PMC Article
Practice Committees of the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility
Fertil Steril 2021 Jun;115(6):1416-1423. Epub 2021 Apr 4 doi: 10.1016/j.fertnstert.2021.02.010. PMID: 33827766
Yaşa C, Güngör Uğurlucan F
J Clin Res Pediatr Endocrinol 2020 Feb 6;12(Suppl 1):1-6. doi: 10.4274/jcrpe.galenos.2019.2019.S0200. PMID: 32041387Free PMC Article
Muñoz-Calvo MT, Argente J
Endocr Dev 2016;29:153-73. Epub 2015 Dec 17 doi: 10.1159/000438884. PMID: 26680577
Solnik MJ, Alexander C
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):105-16. doi: 10.1016/j.beem.2011.07.002. PMID: 22305456

Recent systematic reviews

Jeon B, Baek J
BMC Womens Health 2023 Sep 1;23(1):470. doi: 10.1186/s12905-023-02629-0. PMID: 37658359Free PMC Article
Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SM
Pan Afr Med J 2023;44:134. Epub 2023 Mar 16 doi: 10.11604/pamj.2023.44.134.32404. PMID: 37333786Free PMC Article
Murji A, Sanders AP, Monteiro I, Haiderbhai S, Matelski J, Walsh C, Abbott JA, Munro MG, Maheux-Lacroix S; International Federation of Gynecology and Obstetrics (FIGO) Committee on Menstrual Disorders and Related Health Impacts
Fertil Steril 2022 Oct;118(4):758-766. Epub 2022 Aug 17 doi: 10.1016/j.fertnstert.2022.06.031. PMID: 35985862
Majeed J, Sharma P, Ajmera P, Dalal K
Reprod Health 2022 Jun 23;19(1):148. doi: 10.1186/s12978-022-01453-3. PMID: 35739585Free PMC Article
Matteson KA, Rahn DD, Wheeler TL 2nd, Casiano E, Siddiqui NY, Harvie HS, Mamik MM, Balk EM, Sung VW; Society of Gynecologic Surgeons Systematic Review Group
Obstet Gynecol 2013 Mar;121(3):632-643. doi: 10.1097/AOG.0b013e3182839e0e. PMID: 23635628Free PMC Article

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