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Increased proportion of memory B cells

MedGen UID:
893115
•Concept ID:
C4072914
•
Finding
Synonym: Increased memory B cell count
 
HPO: HP:0030375

Definition

An elevation in the proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of memory B cells

Professional guidelines

PubMed

Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients.
Ruschil C, Gabernet G, Kemmerer CL, Jarboui MA, Klose F, Poli S, Ziemann U, Nahnsen S, Kowarik MC
Front Immunol 2023;14:1133967. Epub 2023 Mar 7 doi: 10.3389/fimmu.2023.1133967. PMID: 36960053Free PMC Article
RNA sequencing of single allergen-specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect.
McKenzie CI, Varese N, Aui PM, Reinwald S, Wines BD, Hogarth PM, Thien F, Hew M, Rolland JM, O'Hehir RE, van Zelm MC
Allergy 2023 Mar;78(3):822-835. Epub 2022 Oct 1 doi: 10.1111/all.15529. PMID: 36153670Free PMC Article
Efficacy of low dose rituximab in treatment-resistant CIDP with antibodies against NF-155.
Jiao L, Xiang Y, Li S, Zhang F, Ruan X, Guo S
J Neuroimmunol 2020 Aug 15;345:577280. Epub 2020 Jun 5 doi: 10.1016/j.jneuroim.2020.577280. PMID: 32563125

Recent clinical studies

Etiology

Causal effects of gut microbiota, metabolites, immune cells, liposomes, and inflammatory proteins on anorexia nervosa: A mediation joint multi-omics Mendelian randomization analysis.
Li Z, Bi T
J Affect Disord 2025 Jan 1;368:343-358. Epub 2024 Sep 17 doi: 10.1016/j.jad.2024.09.115. PMID: 39299582
Immune reconstitution and evolution of B-cell-stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL.
Liévin R, Maillard A, Hendel-Chavez H, Krzysiek R, Lancar R, Algarte-Genin M, Costagliola D, Assoumou L, Taoufik Y, Besson C
Blood Adv 2024 Dec 10;8(23):6017-6027. doi: 10.1182/bloodadvances.2024014116. PMID: 39348664Free PMC Article
Comprehensive Analysis of the Immune Microenvironment in Checkpoint Inhibitor Pneumonitis.
Lin X, Deng J, Deng H, Yang Y, Sun N, Zhou M, Qin Y, Xie X, Li S, Zhong N, Song Y, Zhou C
Front Immunol 2021;12:818492. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.818492. PMID: 35095920Free PMC Article
Altered B lymphocyte homeostasis and functions in systemic sclerosis.
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447
Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Diagnosis

Causal effects of gut microbiota, metabolites, immune cells, liposomes, and inflammatory proteins on anorexia nervosa: A mediation joint multi-omics Mendelian randomization analysis.
Li Z, Bi T
J Affect Disord 2025 Jan 1;368:343-358. Epub 2024 Sep 17 doi: 10.1016/j.jad.2024.09.115. PMID: 39299582
Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing.
Sun Y, Zhang Z, Qiao Q, Zou Y, Wang L, Wang T, Lou B, Li G, Xu M, Wang Y, Zhang Z, Hou X, Chen L, Zhao R
J Transl Med 2024 Oct 11;22(1):925. doi: 10.1186/s12967-024-05710-w. PMID: 39394558Free PMC Article
Correlation of cTfh cells and memory B cells with AMR after renal transplantation.
Liu J, Yue WL, Fan HZ, Luo YS, Feng GW, Li JF
Transpl Immunol 2024 Oct;86:102095. Epub 2024 Jul 20 doi: 10.1016/j.trim.2024.102095. PMID: 39038741
Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis.
Peng L, Jin X, Li BY, Zeng X, Liao BH, Jin T, Chen JW, Gao XS, Wang W, He Q, Chen G, Gong LN, Shen H, Wang KJ, Li H, Luo DY
Signal Transduct Target Ther 2022 May 20;7(1):161. doi: 10.1038/s41392-022-00962-8. PMID: 35589692Free PMC Article
Comprehensive Analysis of the Immune Microenvironment in Checkpoint Inhibitor Pneumonitis.
Lin X, Deng J, Deng H, Yang Y, Sun N, Zhou M, Qin Y, Xie X, Li S, Zhong N, Song Y, Zhou C
Front Immunol 2021;12:818492. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.818492. PMID: 35095920Free PMC Article

Therapy

Causal effects of gut microbiota, metabolites, immune cells, liposomes, and inflammatory proteins on anorexia nervosa: A mediation joint multi-omics Mendelian randomization analysis.
Li Z, Bi T
J Affect Disord 2025 Jan 1;368:343-358. Epub 2024 Sep 17 doi: 10.1016/j.jad.2024.09.115. PMID: 39299582
Immune reconstitution and evolution of B-cell-stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL.
Liévin R, Maillard A, Hendel-Chavez H, Krzysiek R, Lancar R, Algarte-Genin M, Costagliola D, Assoumou L, Taoufik Y, Besson C
Blood Adv 2024 Dec 10;8(23):6017-6027. doi: 10.1182/bloodadvances.2024014116. PMID: 39348664Free PMC Article
Baicalein alleviates fibrosis and inflammation in systemic sclerosis by regulating B-cell abnormalities.
Peng B, Hu Q, He R, Hou H, Lian D, Chen Y, Li H, Song L, Gao Y, Chen T, Zhang G, Li J
BMC Complement Med Ther 2023 Feb 21;23(1):62. doi: 10.1186/s12906-023-03885-1. PMID: 36810081Free PMC Article
Comprehensive Analysis of the Immune Microenvironment in Checkpoint Inhibitor Pneumonitis.
Lin X, Deng J, Deng H, Yang Y, Sun N, Zhou M, Qin Y, Xie X, Li S, Zhong N, Song Y, Zhou C
Front Immunol 2021;12:818492. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.818492. PMID: 35095920Free PMC Article
Assessment of selected B cells populations in the workers of X-ray departments.
Kłuciński P, Mazur B, Sędek Ł, Aptekorz M, Cieślik P, Hrycek AH, Martirosian G
Int J Occup Med Environ Health 2014 Jun;27(3):467-73. Epub 2014 Jun 21 doi: 10.2478/s13382-014-0242-3. PMID: 24952144

Prognosis

Immune reconstitution and evolution of B-cell-stimulating cytokines after R-CHOP therapy for HIV-associated DLBCL.
Liévin R, Maillard A, Hendel-Chavez H, Krzysiek R, Lancar R, Algarte-Genin M, Costagliola D, Assoumou L, Taoufik Y, Besson C
Blood Adv 2024 Dec 10;8(23):6017-6027. doi: 10.1182/bloodadvances.2024014116. PMID: 39348664Free PMC Article
Correlation of cTfh cells and memory B cells with AMR after renal transplantation.
Liu J, Yue WL, Fan HZ, Luo YS, Feng GW, Li JF
Transpl Immunol 2024 Oct;86:102095. Epub 2024 Jul 20 doi: 10.1016/j.trim.2024.102095. PMID: 39038741
RNA sequencing of single allergen-specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect.
McKenzie CI, Varese N, Aui PM, Reinwald S, Wines BD, Hogarth PM, Thien F, Hew M, Rolland JM, O'Hehir RE, van Zelm MC
Allergy 2023 Mar;78(3):822-835. Epub 2022 Oct 1 doi: 10.1111/all.15529. PMID: 36153670Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Clinical prediction guides

Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing.
Sun Y, Zhang Z, Qiao Q, Zou Y, Wang L, Wang T, Lou B, Li G, Xu M, Wang Y, Zhang Z, Hou X, Chen L, Zhao R
J Transl Med 2024 Oct 11;22(1):925. doi: 10.1186/s12967-024-05710-w. PMID: 39394558Free PMC Article
Features of BAFF and APRIL receptors on circulating B cells in antineutrophil cytoplasmic antibody-associated vasculitis.
Shimojima Y, Kishida D, Ichikawa T, Takamatsu R, Nomura S, Sekijima Y
Clin Exp Immunol 2023 Jul 5;213(1):125-137. doi: 10.1093/cei/uxad024. PMID: 36794867Free PMC Article
Effect of climatic environment on immunological features of rheumatoid arthritis.
Kondo Y, Abe S, Toko H, Hirota T, Takahashi H, Shimizu M, Noma H, Tsuboi H, Matsumoto I, Inaba T, Sumida T
Sci Rep 2023 Jan 24;13(1):1304. doi: 10.1038/s41598-022-27153-3. PMID: 36693893Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Altered B lymphocyte homeostasis and functions in systemic sclerosis.
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447

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