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Ileal adenocarcinoma

MedGen UID:
893123
•Concept ID:
C4072936
•
Neoplastic Process
HPO: HP:0030412

Definition

A malignant epithelial tumor with a glandular organization that originates in the ileum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIleal adenocarcinoma

Professional guidelines

PubMed

Primary small bowel adenocarcinoma: current view on clinical features, risk and prognostic factors, treatment and outcome.
Lech G, Korcz W, Kowalczyk E, Słotwiński R, Słodkowski M
Scand J Gastroenterol 2017 Nov;52(11):1194-1202. Epub 2017 Jul 24 doi: 10.1080/00365521.2017.1356932. PMID: 28737049
Small bowel adenocarcinoma: epidemiology, risk factors, diagnosis and treatment.
Aparicio T, Zaanan A, Svrcek M, Laurent-Puig P, Carrere N, Manfredi S, Locher C, Afchain P
Dig Liver Dis 2014 Feb;46(2):97-104. Epub 2013 Jun 21 doi: 10.1016/j.dld.2013.04.013. PMID: 23796552
Gastrointestinal carcinoid tumors: diagnosis and treatment.
Stamatakos M, Kontzoglou K, Sargedi C, Tsaknaki S, Iannescu R, Safioleas C, Kaitanidi V, Safioleas M
Chirurgia (Bucur) 2010 Nov-Dec;105(6):759-66. PMID: 21351698

Recent clinical studies

Etiology

Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study.
Nishikawa Y, Horimatsu T, Oka S, Yamada T, Mitsui K, Yamamoto H, Takahashi K, Shiomi A, Hotta K, Takeuchi Y, Kuwai T, Ishida F, Kudo SE, Saito S, Ueno M, Sunami E, Yamano T, Itabashi M, Ohtsuka K, Kinugasa Y, Matsumoto T, Sugai T, Uraoka T, Kurahara K, Yamaguchi S, Kato T, Okajima M, Kashida H, Fujita F, Ikematsu H, Ito M, Esaki M, Kawai M, Yao T, Hamada M, Koda K, Fukai Y, Komori K, Saitoh Y, Kanemitsu Y, Takamaru H, Yamada K, Nozawa H, Takayama T, Togashi K, Shinto E, Torisu T, Toyoshima A, Ohmiya N, Kato T, Otsuji E, Nagata S, Hashiguchi Y, Sugihara K, Ajioka Y, Tanaka S
JCO Glob Oncol 2024 Feb;10:e2300392. doi: 10.1200/GO.23.00392. PMID: 38330276Free PMC Article
Current Oncologic Standards for Surgery of Small Bowel Cancers.
Vashistha N, Singhal D
J Gastrointest Cancer 2022 Jun;53(2):434-438. Epub 2021 Mar 31 doi: 10.1007/s12029-021-00635-9. PMID: 33788156
Vascular endothelial growth factor-A is an Immunohistochemical biomarker for the efficacy of bevacizumab-containing chemotherapy for duodenal and jejunal adenocarcinoma.
Amano T, Iijima H, Shinzaki S, Tashiro T, Iwatani S, Tani M, Otake Y, Yoshihara T, Sugimoto A, Egawa S, Yamaguchi S, Kinoshita K, Araki M, Hirao M, Sakakibara Y, Hiyama S, Ogawa H, Nagaike K, Murata J, Komori M, Okuda Y, Kizu T, Tsujii Y, Hayashi Y, Inoue T, Takahashi H, Mizushima T, Morii E, Takehara T
BMC Cancer 2021 Aug 31;21(1):978. doi: 10.1186/s12885-021-08724-5. PMID: 34465291Free PMC Article
Adenocarcinomas of the jejunum and ileum: a 25-year experience.
Ugurlu MM, Asoglu O, Potter DD, Barnes SA, Harmsen WS, Donohue JH
J Gastrointest Surg 2005 Nov;9(8):1182-8. doi: 10.1016/j.gassur.2005.08.027. PMID: 16269390
Jejunal and ileal adenocarcinoma. Epidemiological considerations.
Arthaud JB, Guinee VF
Am J Gastroenterol 1979 Dec;72(6):638-46. PMID: 539582

Diagnosis

Adenocarcinoma in Orthotopic Neobladder 19 Years After Radical Cystoprostatectomy.
Ozkaptan O, Cubuk A, Dincer E, Ipek OM
J Coll Physicians Surg Pak 2021 May;31(5):588-590. doi: 10.29271/jcpsp.2021.05.588. PMID: 34027875
Adenocarcinoma of an ileal conduit developing 8 years after cystoprostatectomy for locally advanced prostate carcinoma.
Boettge KR, Paasch C, Schrader M, Strik M
BMJ Case Rep 2020 Mar 25;13(3) doi: 10.1136/bcr-2018-227015. PMID: 32213502Free PMC Article
Disfiguring facial pyoderma vegetans with an excellent outcome.
Keitley J, Griffin L, Motta L, Ferguson J, Young H
BMJ Case Rep 2017 Oct 13;2017 doi: 10.1136/bcr-2017-220779. PMID: 29030376Free PMC Article
Sporadic flat ileal adenocarcinoma: an intriguing challenge in the comprehension of a rare neoplasia and its genesis. Case report and review of literature.
Erra S, Costamagna D, Botto G, Gemme C, Durando R
G Chir 2009 Mar;30(3):87-92. PMID: 19351457
Adenocarcinomas of the jejunum and ileum: a 25-year experience.
Ugurlu MM, Asoglu O, Potter DD, Barnes SA, Harmsen WS, Donohue JH
J Gastrointest Surg 2005 Nov;9(8):1182-8. doi: 10.1016/j.gassur.2005.08.027. PMID: 16269390

Therapy

Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study.
Nishikawa Y, Horimatsu T, Oka S, Yamada T, Mitsui K, Yamamoto H, Takahashi K, Shiomi A, Hotta K, Takeuchi Y, Kuwai T, Ishida F, Kudo SE, Saito S, Ueno M, Sunami E, Yamano T, Itabashi M, Ohtsuka K, Kinugasa Y, Matsumoto T, Sugai T, Uraoka T, Kurahara K, Yamaguchi S, Kato T, Okajima M, Kashida H, Fujita F, Ikematsu H, Ito M, Esaki M, Kawai M, Yao T, Hamada M, Koda K, Fukai Y, Komori K, Saitoh Y, Kanemitsu Y, Takamaru H, Yamada K, Nozawa H, Takayama T, Togashi K, Shinto E, Torisu T, Toyoshima A, Ohmiya N, Kato T, Otsuji E, Nagata S, Hashiguchi Y, Sugihara K, Ajioka Y, Tanaka S
JCO Glob Oncol 2024 Feb;10:e2300392. doi: 10.1200/GO.23.00392. PMID: 38330276Free PMC Article
Vascular endothelial growth factor-A is an Immunohistochemical biomarker for the efficacy of bevacizumab-containing chemotherapy for duodenal and jejunal adenocarcinoma.
Amano T, Iijima H, Shinzaki S, Tashiro T, Iwatani S, Tani M, Otake Y, Yoshihara T, Sugimoto A, Egawa S, Yamaguchi S, Kinoshita K, Araki M, Hirao M, Sakakibara Y, Hiyama S, Ogawa H, Nagaike K, Murata J, Komori M, Okuda Y, Kizu T, Tsujii Y, Hayashi Y, Inoue T, Takahashi H, Mizushima T, Morii E, Takehara T
BMC Cancer 2021 Aug 31;21(1):978. doi: 10.1186/s12885-021-08724-5. PMID: 34465291Free PMC Article
Disfiguring facial pyoderma vegetans with an excellent outcome.
Keitley J, Griffin L, Motta L, Ferguson J, Young H
BMJ Case Rep 2017 Oct 13;2017 doi: 10.1136/bcr-2017-220779. PMID: 29030376Free PMC Article
Late malignant change in an ileal conduit.
Wielding S, Fineron P, Driscoll PJ, Anderson DN
Int J Urol 2008 Jan;15(1):99-101. doi: 10.1111/j.1442-2042.2007.01930.x. PMID: 18184185
Clinical outcome of patients examined by capsule endoscopy for suspected small bowel Crohn's disease.
Girelli CM, Porta P, Malacrida V, Barzaghi F, Rocca F
Dig Liver Dis 2007 Feb;39(2):148-54. Epub 2006 Dec 29 doi: 10.1016/j.dld.2006.10.018. PMID: 17196893

Prognosis

Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study.
Nishikawa Y, Horimatsu T, Oka S, Yamada T, Mitsui K, Yamamoto H, Takahashi K, Shiomi A, Hotta K, Takeuchi Y, Kuwai T, Ishida F, Kudo SE, Saito S, Ueno M, Sunami E, Yamano T, Itabashi M, Ohtsuka K, Kinugasa Y, Matsumoto T, Sugai T, Uraoka T, Kurahara K, Yamaguchi S, Kato T, Okajima M, Kashida H, Fujita F, Ikematsu H, Ito M, Esaki M, Kawai M, Yao T, Hamada M, Koda K, Fukai Y, Komori K, Saitoh Y, Kanemitsu Y, Takamaru H, Yamada K, Nozawa H, Takayama T, Togashi K, Shinto E, Torisu T, Toyoshima A, Ohmiya N, Kato T, Otsuji E, Nagata S, Hashiguchi Y, Sugihara K, Ajioka Y, Tanaka S
JCO Glob Oncol 2024 Feb;10:e2300392. doi: 10.1200/GO.23.00392. PMID: 38330276Free PMC Article
A rare case of long-term survival of a patient who underwent radical operations for sextuple malignancies.
Nanashima A, Imamura N, Nishida T, Hiyoshi M, Uchise Y, Hamada T, Yano K, Tsuchimochi Y
Clin J Gastroenterol 2022 Dec;15(6):1169-1172. Epub 2022 Oct 15 doi: 10.1007/s12328-022-01714-5. PMID: 36242750
Vascular endothelial growth factor-A is an Immunohistochemical biomarker for the efficacy of bevacizumab-containing chemotherapy for duodenal and jejunal adenocarcinoma.
Amano T, Iijima H, Shinzaki S, Tashiro T, Iwatani S, Tani M, Otake Y, Yoshihara T, Sugimoto A, Egawa S, Yamaguchi S, Kinoshita K, Araki M, Hirao M, Sakakibara Y, Hiyama S, Ogawa H, Nagaike K, Murata J, Komori M, Okuda Y, Kizu T, Tsujii Y, Hayashi Y, Inoue T, Takahashi H, Mizushima T, Morii E, Takehara T
BMC Cancer 2021 Aug 31;21(1):978. doi: 10.1186/s12885-021-08724-5. PMID: 34465291Free PMC Article
Adenocarcinoma of an ileal conduit developing 8 years after cystoprostatectomy for locally advanced prostate carcinoma.
Boettge KR, Paasch C, Schrader M, Strik M
BMJ Case Rep 2020 Mar 25;13(3) doi: 10.1136/bcr-2018-227015. PMID: 32213502Free PMC Article
Abdominal wall infiltration by small bowel adenocarcinoma in a patient with Crohn's disease--a case report.
Nihon-Yanagi Y, Ooshiro M, Yamada A, Suzuki Y, Kameda N, Okazumi S
Gan To Kagaku Ryoho 2011 Jun;38(6):1011-6. PMID: 21677498

Clinical prediction guides

Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study.
Nishikawa Y, Horimatsu T, Oka S, Yamada T, Mitsui K, Yamamoto H, Takahashi K, Shiomi A, Hotta K, Takeuchi Y, Kuwai T, Ishida F, Kudo SE, Saito S, Ueno M, Sunami E, Yamano T, Itabashi M, Ohtsuka K, Kinugasa Y, Matsumoto T, Sugai T, Uraoka T, Kurahara K, Yamaguchi S, Kato T, Okajima M, Kashida H, Fujita F, Ikematsu H, Ito M, Esaki M, Kawai M, Yao T, Hamada M, Koda K, Fukai Y, Komori K, Saitoh Y, Kanemitsu Y, Takamaru H, Yamada K, Nozawa H, Takayama T, Togashi K, Shinto E, Torisu T, Toyoshima A, Ohmiya N, Kato T, Otsuji E, Nagata S, Hashiguchi Y, Sugihara K, Ajioka Y, Tanaka S
JCO Glob Oncol 2024 Feb;10:e2300392. doi: 10.1200/GO.23.00392. PMID: 38330276Free PMC Article
Vascular endothelial growth factor-A is an Immunohistochemical biomarker for the efficacy of bevacizumab-containing chemotherapy for duodenal and jejunal adenocarcinoma.
Amano T, Iijima H, Shinzaki S, Tashiro T, Iwatani S, Tani M, Otake Y, Yoshihara T, Sugimoto A, Egawa S, Yamaguchi S, Kinoshita K, Araki M, Hirao M, Sakakibara Y, Hiyama S, Ogawa H, Nagaike K, Murata J, Komori M, Okuda Y, Kizu T, Tsujii Y, Hayashi Y, Inoue T, Takahashi H, Mizushima T, Morii E, Takehara T
BMC Cancer 2021 Aug 31;21(1):978. doi: 10.1186/s12885-021-08724-5. PMID: 34465291Free PMC Article
Ileal adenocarcinoma in Crohn's disease: magnetic resonance enterography features.
Placé V, Hristova L, Dray X, Lavergne-Slove A, Boudiaf M, Soyer P
Clin Imaging 2012 Jan-Feb;36(1):24-8. doi: 10.1016/j.clinimag.2011.03.006. PMID: 22226439
Clinical outcome of patients examined by capsule endoscopy for suspected small bowel Crohn's disease.
Girelli CM, Porta P, Malacrida V, Barzaghi F, Rocca F
Dig Liver Dis 2007 Feb;39(2):148-54. Epub 2006 Dec 29 doi: 10.1016/j.dld.2006.10.018. PMID: 17196893
Adenocarcinomas of the jejunum and ileum: a 25-year experience.
Ugurlu MM, Asoglu O, Potter DD, Barnes SA, Harmsen WS, Donohue JH
J Gastrointest Surg 2005 Nov;9(8):1182-8. doi: 10.1016/j.gassur.2005.08.027. PMID: 16269390

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