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Infective dermatitis associated with HTLV-1

MedGen UID:
895843
Concept ID:
C4274291
Disease or Syndrome
Synonyms: IDH; IDH Gene family; infective dermatitis associated with HTLV-1; Infective dermatitis associated with human T-lymphotropic virus type 1; infective dermatitis associated with human T-lymphotropic virus type 1; Infective dermatitis associated with human T-lymphotropic virus type I; infective dermatitis associated with human T-lymphotropic virus type I; isocitrate dehydrogenase Gene family
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017326
Orphanet: ORPHA289347

Definition

Infective dermatitis associated with HTLV-1 is a rare and severe chronic disease characterized by recurrent chronic eczema (with erythematous, scaly and crusted lesions) mainly affecting seborrheic areas (e.g. scalp, forehead, eyelids, paranasal and periauricular skin, neck, axillae, and groin), a generalized fine papular rash, chronic nasal discharge with crusting of the anterior nares, and non-virulent <i>Staphylococcus aureus</i> or beta-hemolytic <i>Streptococcus</i> infections, thought to be a result of HTLV-1-induced immunosuppression. Lymphadenopathy, anemia, mild to moderate pruritus and increased incidence of other infections (e.g. crusted scabies) have also been reported in some patients. Patients may subsequently develop other HTLV-1 associated conditions such as adult T-cell leukemia/lymphoma and tropical spastic paraparesis (see these terms). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfective dermatitis associated with HTLV-1

Recent clinical studies

Etiology

Batista ES, Oliveira PD, Primo J, Varandas CMN, Nunes AP, Bittencourt AL, Farre L
PLoS Negl Trop Dis 2019 Dec;13(12):e0007705. Epub 2019 Dec 18 doi: 10.1371/journal.pntd.0007705. PMID: 31851683Free PMC Article
Hlela C, Bittencourt A
Dermatol Clin 2014 Apr;32(2):237-48. Epub 2014 Jan 22 doi: 10.1016/j.det.2013.11.006. PMID: 24680009
Gillet NA, Cook L, Laydon DJ, Hlela C, Verdonck K, Alvarez C, Gotuzzo E, Clark D, Farré L, Bittencourt A, Asquith B, Taylor GP, Bangham CR
PLoS Pathog 2013;9(4):e1003263. Epub 2013 Apr 4 doi: 10.1371/journal.ppat.1003263. PMID: 23592987Free PMC Article
de Oliveira Mde F, Vieira Md, Primo J, Siqueira IC, Carvalho EM, Farré L, Fatal PL, Bittencourt AL
J Clin Virol 2010 Aug;48(4):288-90. Epub 2010 Jun 11 doi: 10.1016/j.jcv.2010.05.005. PMID: 20541459
Nascimento MC, Primo J, Bittencourt A, Siqueira I, de Fátima Oliveira M, Meyer R, Schriefer A, Santos SB, Carvalho EM
Clin Exp Immunol 2009 Jun;156(3):455-62. doi: 10.1111/j.1365-2249.2008.03869.x. PMID: 19438598Free PMC Article

Diagnosis

Bittencourt AL, Farre L
Int J Infect Dis 2024 Aug;145:107058. Epub 2024 Apr 30 doi: 10.1016/j.ijid.2024.107058. PMID: 38697604
Souza LS, Silva TS, de Oliveira MFP, Farre L, Bittencourt AL
PLoS Negl Trop Dis 2020 Apr;14(4):e0008241. Epub 2020 Apr 24 doi: 10.1371/journal.pntd.0008241. PMID: 32330142Free PMC Article
Weiler N, Mayer EF, Kazlouskaya V, Bamgbola OF, Banniettis N, Heilman E, Glick SA
Pediatr Dermatol 2019 Jan;36(1):e12-e16. Epub 2018 Oct 18 doi: 10.1111/pde.13702. PMID: 30338553
Hlela C, Bittencourt A
Dermatol Clin 2014 Apr;32(2):237-48. Epub 2014 Jan 22 doi: 10.1016/j.det.2013.11.006. PMID: 24680009
Bittencourt AL, de Oliveira Mde F
Int J Dermatol 2010 Oct;49(10):1099-110. doi: 10.1111/j.1365-4632.2010.04568.x. PMID: 20883400

Therapy

Avallone G, Trunfio M, Mastorino L, Agostini A, Merli M, Rubatto M, Caracciolo D, Calcagno A, Senetta R, Fierro MT, Quaglino P, Ribero S
Am J Trop Med Hyg 2021 Oct 11;105(6):1590-1593. doi: 10.4269/ajtmh.21-0630. PMID: 34634767Free PMC Article
Weiler N, Mayer EF, Kazlouskaya V, Bamgbola OF, Banniettis N, Heilman E, Glick SA
Pediatr Dermatol 2019 Jan;36(1):e12-e16. Epub 2018 Oct 18 doi: 10.1111/pde.13702. PMID: 30338553
Varandas CMN, da Silva JLS, Primo JRL, de Oliveira MFSP, Moreno-Carvalho O, Farre L, Bittencourt AL
Clin Infect Dis 2018 Oct 15;67(9):1427-1433. doi: 10.1093/cid/ciy289. PMID: 29912303
Bittencourt AL, Oliveira PD, Bittencourt VG, Carvalho EM, Farre L
J Clin Virol 2013 Oct;58(2):494-6. Epub 2013 Aug 1 doi: 10.1016/j.jcv.2013.07.011. PMID: 23911677
Bittencourt AL, de Oliveira Mde F
Int J Dermatol 2010 Oct;49(10):1099-110. doi: 10.1111/j.1365-4632.2010.04568.x. PMID: 20883400

Prognosis

Rosa BL, Silva TS, Dias MA, Araujo I, Bittencourt AL
Am J Dermatopathol 2022 May 1;44(5):368-371. doi: 10.1097/DAD.0000000000002044. PMID: 35220325
Varandas CMN, da Silva JLS, Primo JRL, de Oliveira MFSP, Moreno-Carvalho O, Farre L, Bittencourt AL
Clin Infect Dis 2018 Oct 15;67(9):1427-1433. doi: 10.1093/cid/ciy289. PMID: 29912303

Clinical prediction guides

Bittencourt AL, Farre L
Int J Infect Dis 2024 Aug;145:107058. Epub 2024 Apr 30 doi: 10.1016/j.ijid.2024.107058. PMID: 38697604
Souza LS, Silva TS, de Oliveira MFP, Farre L, Bittencourt AL
PLoS Negl Trop Dis 2020 Apr;14(4):e0008241. Epub 2020 Apr 24 doi: 10.1371/journal.pntd.0008241. PMID: 32330142Free PMC Article
Batista ES, Oliveira PD, Primo J, Varandas CMN, Nunes AP, Bittencourt AL, Farre L
PLoS Negl Trop Dis 2019 Dec;13(12):e0007705. Epub 2019 Dec 18 doi: 10.1371/journal.pntd.0007705. PMID: 31851683Free PMC Article
Weiler N, Mayer EF, Kazlouskaya V, Bamgbola OF, Banniettis N, Heilman E, Glick SA
Pediatr Dermatol 2019 Jan;36(1):e12-e16. Epub 2018 Oct 18 doi: 10.1111/pde.13702. PMID: 30338553
Hlela C, Bittencourt A
Dermatol Clin 2014 Apr;32(2):237-48. Epub 2014 Jan 22 doi: 10.1016/j.det.2013.11.006. PMID: 24680009

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