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Chemical and Drug Induced Liver Injury

MedGen UID:
896461
Concept ID:
C4277682
Disease or Syndrome

Definition

A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChemical and Drug Induced Liver Injury

Professional guidelines

PubMed

Jácome AA, Ohinata A, Mahvash A, Overman MJ, Kee B, Fogelman D, Morris VK, Johnson B, Rothschild ND, Wolff RA, Eng C
Clin Colorectal Cancer 2020 Dec;19(4):e189-e199. Epub 2020 Jun 12 doi: 10.1016/j.clcc.2020.04.007. PMID: 32680816
Chiew AL, Reith D, Pomerleau A, Wong A, Isoardi KZ, Soderstrom J, Buckley NA
Med J Aust 2020 Mar;212(4):175-183. Epub 2019 Dec 1 doi: 10.5694/mja2.50428. PMID: 31786822

Recent clinical studies

Etiology

Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article

Diagnosis

Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article
Park SH, Ishino R
Curr Drug Saf 2013 Jul;8(3):207-23. doi: 10.2174/1574886311308030011. PMID: 23914755

Therapy

Dauvilliers Y, Mignot E, Del Río Villegas R, Du Y, Hanson E, Inoue Y, Kadali H, Koundourakis E, Meyer S, Rogers R, Scammell TE, Sheikh SI, Swick T, Szakács Z, von Rosenstiel P, Wu J, Zeitz H, Murthy NV, Plazzi G, von Hehn C
N Engl J Med 2023 Jul 27;389(4):309-321. doi: 10.1056/NEJMoa2301940. PMID: 37494485
Hassan A, Fontana RJ
Liver Int 2019 Jan;39(1):31-41. Epub 2018 Aug 19 doi: 10.1111/liv.13931. PMID: 30003672
Hsu WH, Yang JC, Mok TS, Loong HH
Ann Oncol 2018 Jan 1;29(suppl_1):i3-i9. doi: 10.1093/annonc/mdx702. PMID: 29462253
Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW, Feng Y
Int J Mol Sci 2015 Nov 2;16(11):26087-124. doi: 10.3390/ijms161125942. PMID: 26540040Free PMC Article
Floyd J, Mirza I, Sachs B, Perry MC
Semin Oncol 2006 Feb;33(1):50-67. doi: 10.1053/j.seminoncol.2005.11.002. PMID: 16473644

Prognosis

Floreani A, Bizzaro D, Shalaby S, Taliani G, Burra P; Special Interest Group Gender in Hepatology of the Italian Association for the Study of the Liver (AISF)
Dig Liver Dis 2023 Jan;55(1):21-28. Epub 2022 Jul 15 doi: 10.1016/j.dld.2022.06.025. PMID: 35843842
Li X, Tang J, Mao Y
Liver Int 2022 Aug;42(9):1999-2014. Epub 2022 Apr 2 doi: 10.1111/liv.15262. PMID: 35353431
Devarbhavi H, Aithal G, Treeprasertsuk S, Takikawa H, Mao Y, Shasthry SM, Hamid S, Tan SS, Philips CA, George J, Jafri W, Sarin SK; Asia Pacific Association of Study of Liver
Hepatol Int 2021 Apr;15(2):258-282. Epub 2021 Feb 27 doi: 10.1007/s12072-021-10144-3. PMID: 33641080
Shen T, Liu Y, Shang J, Xie Q, Li J, Yan M, Xu J, Niu J, Liu J, Watkins PB, Aithal GP, Andrade RJ, Dou X, Yao L, Lv F, Wang Q, Li Y, Zhou X, Zhang Y, Zong P, Wan B, Zou Z, Yang D, Nie Y, Li D, Wang Y, Han X, Zhuang H, Mao Y, Chen C
Gastroenterology 2019 Jun;156(8):2230-2241.e11. Epub 2019 Feb 8 doi: 10.1053/j.gastro.2019.02.002. PMID: 30742832
Tostmann A, Boeree MJ, Aarnoutse RE, de Lange WC, van der Ven AJ, Dekhuijzen R
J Gastroenterol Hepatol 2008 Feb;23(2):192-202. Epub 2007 Nov 6 doi: 10.1111/j.1440-1746.2007.05207.x. PMID: 17995946

Clinical prediction guides

Zhang CJ, Meyer SR, O'Meara MJ, Huang S, Capeling MM, Ferrer-Torres D, Childs CJ, Spence JR, Fontana RJ, Sexton JZ
J Hepatol 2023 May;78(5):998-1006. Epub 2023 Feb 3 doi: 10.1016/j.jhep.2023.01.019. PMID: 36738840
Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR; Practice Parameters Committee of the American College of Gastroenterology
Am J Gastroenterol 2021 May 1;116(5):878-898. doi: 10.14309/ajg.0000000000001259. PMID: 33929376
Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK
Nat Rev Drug Discov 2020 Feb;19(2):131-148. Epub 2019 Nov 20 doi: 10.1038/s41573-019-0048-x. PMID: 31748707
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
Danan G, Teschke R
Int J Mol Sci 2015 Dec 24;17(1) doi: 10.3390/ijms17010014. PMID: 26712744Free PMC Article

Recent systematic reviews

Takesue Y, Hanai Y, Oda K, Hamada Y, Ueda T, Mayumi T, Matsumoto K, Fujii S, Takahashi Y, Miyazaki Y, Kimura T; Japanese Antimicrobial Therapeutic Drug Monitoring Guideline Committee
Clin Ther 2022 Dec;44(12):1604-1623. Epub 2022 Nov 22 doi: 10.1016/j.clinthera.2022.10.005. PMID: 36424314
Piloiu C, Dumitrascu DL
Am J Ther 2021 Feb 3;28(3):e335-e340. doi: 10.1097/MJT.0000000000001341. PMID: 33590990
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613
Yebyo HG, Aschmann HE, Kaufmann M, Puhan MA
Am Heart J 2019 Apr;210:18-28. Epub 2019 Jan 10 doi: 10.1016/j.ahj.2018.12.007. PMID: 30716508
Alfaro-Lara R, Espinosa-Ortega HF, Arce-Salinas CA; PRECIS study group, all physicians belong to Division of Internal Medicine. Hospital Central Sur de Pemex
Reumatol Clin (Engl Ed) 2019 May-Jun;15(3):133-139. Epub 2017 Sep 1 doi: 10.1016/j.reuma.2017.07.020. PMID: 28867467

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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