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Hyperintensity of MRI T2 signal of the spinal cord

MedGen UID:
896507
•Concept ID:
C4280684
•
Finding
HPO: HP:0040272

Definition

A region of high intensity (brightness) observed upon magnetic resonance imaging (MRI) scans of the spinal cord. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperintensity of MRI T2 signal of the spinal cord

Conditions with this feature

Posterior column ataxia-retinitis pigmentosa syndrome
MedGen UID:
324636
•Concept ID:
C1836916
•
Disease or Syndrome
Posterior column ataxia with retinitis pigmentosa (AXPC1) is an autosomal recessive neurologic disorder characterized by childhood-onset retinitis pigmentosa and later onset of gait ataxia due to sensory loss (summary by Ishiura et al., 2011).
See: Condition Record
Posterior column ataxia-retinitis pigmentosa syndrome

Professional guidelines

PubMed

Abnormal Spinal Cord Magnetic Resonance Signal: Approach to the Differential Diagnosis.
Morales H, Betts A
Semin Ultrasound CT MR 2016 Oct;37(5):372-83. Epub 2016 May 6 doi: 10.1053/j.sult.2016.05.003. PMID: 27616311
Differential diagnosis of T2 hyperintense spinal cord lesions: part B.
Bou-Haidar P, Peduto AJ, Karunaratne N
J Med Imaging Radiat Oncol 2009 Apr;53(2):152-9. doi: 10.1111/j.1754-9485.2009.02067.x. PMID: 19527360
Diagnosis and differential diagnosis of acute transverse myelopathy. The role of neuroradiological investigations and review of the literature.
Scotti G, Gerevini S
Neurol Sci 2001 Nov;22 Suppl 2:S69-73. doi: 10.1007/s100720100038. PMID: 11794482

Recent clinical studies

Therapy

Automated signal intensity analysis of the spinal cord for detection of degenerative cervical myelopathy - a matched-pair MRI study.
Hohenhaus M, Klingler JH, Scholz C, Volz F, Hubbe U, Beck J, Reisert M, Würtemberger U, Kremers N, Wolf K
Neuroradiology 2023 Oct;65(10):1545-1554. Epub 2023 Jun 30 doi: 10.1007/s00234-023-03187-w. PMID: 37386202Free PMC Article
Posterior spinal artery infarct.
Panesar H, Conry A, Finocchi V, Desai C, Bracewell RM
Pract Neurol 2023 Apr;23(2):160-163. Epub 2023 Mar 2 doi: 10.1136/pn-2021-003336. PMID: 36863868
Case Report: Post-Chikungunya-Associated Myeloneuropathy.
Patwardhan A, Nalini A, Baishya PP, Kulanthaivelu K, Krishnareddy H, Dutta D, Chawla T, Chowdary RM, Yadav R, Vengalil S
Am J Trop Med Hyg 2021 Aug 23;105(4):942-945. doi: 10.4269/ajtmh.20-1277. PMID: 34614478Free PMC Article
Prospective Evaluation of the Time Course of White Matter Edema Associated with Implanted Deep Brain Stimulation Electrodes.
Nolt MJ, Polasani RS, Masnyk TW, Rezak M, Rosenow JM
Stereotact Funct Neurosurg 2021;99(3):203-206. Epub 2020 Nov 20 doi: 10.1159/000511115. PMID: 33221795
Recurrent myelitis.
Pandit L, Rao S
J Neurol Neurosurg Psychiatry 1996 Mar;60(3):336-8. doi: 10.1136/jnnp.60.3.336. PMID: 8609515Free PMC Article

Prognosis

Posterior spinal artery infarct.
Panesar H, Conry A, Finocchi V, Desai C, Bracewell RM
Pract Neurol 2023 Apr;23(2):160-163. Epub 2023 Mar 2 doi: 10.1136/pn-2021-003336. PMID: 36863868
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Multicentric Spinal Cord Glioblastoma.
Cabrera-Aldana EE, De la Garza Ramos R, Pichardo-Bahena R
World Neurosurg 2017 Apr;100:707.e11. Epub 2017 Jan 13 doi: 10.1016/j.wneu.2017.01.006. PMID: 28089804
Recurrent myelitis.
Pandit L, Rao S
J Neurol Neurosurg Psychiatry 1996 Mar;60(3):336-8. doi: 10.1136/jnnp.60.3.336. PMID: 8609515Free PMC Article

Clinical prediction guides

Genotypic and phenotypic characteristics of juvenile/adult onset vanishing white matter: a series of 14 Chinese patients.
Ren Y, Yu X, Chen B, Tang H, Niu S, Wang X, Pan H, Zhang Z
Neurol Sci 2022 Aug;43(8):4961-4977. Epub 2022 Apr 7 doi: 10.1007/s10072-022-06011-0. PMID: 35389136
Surfer Myelopathy in Children: A Case Series Study.
Wang Y, Zhu F, Zeng L, Wang S, Liu Y, Yang L, Zhao W, Zhou Y, Wu Z, Li M, Feng Y, Shen X, Guo X
World Neurosurg 2021 Apr;148:e227-e241. Epub 2021 Jan 5 doi: 10.1016/j.wneu.2020.12.135. PMID: 33418121
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Does the type of T2-weighted hyperintensity influence surgical outcome in patients with cervical spondylotic myelopathy? A review.
Vedantam A, Rajshekhar V
Eur Spine J 2013 Jan;22(1):96-106. Epub 2012 Aug 25 doi: 10.1007/s00586-012-2483-9. PMID: 22926434Free PMC Article

Recent systematic reviews

The Dark side of the White Matter. Diffuse subcortical White Matter Hypointensity on T2/FLAIR: A systematic review of a frequently underrecognized sign.
Magro G, Tosto F, Laterza V, Di Benedetto O
J Neurol Sci 2024 Feb 15;457:122882. Epub 2024 Jan 11 doi: 10.1016/j.jns.2024.122882. PMID: 38224629
Surgical Decompression for Cervical Spondylotic Myelopathy in Patients with Associated Hypertension: A Single-Center Retrospective Cohort and Systematic Review of the Literature.
Perdomo-Pantoja A, Chara A, Liu A, Jin Y, Taylor M, El Demerdash N, Ahmed AK, Pennington Z, Cottrill E, Westbroek EM, Bydon A, Theodore N, Witham TF
World Neurosurg 2021 Nov;155:e119-e130. Epub 2021 Aug 13 doi: 10.1016/j.wneu.2021.08.038. PMID: 34400323
Frequency, timing, and predictors of neurological dysfunction in the nonmyelopathic patient with cervical spinal cord compression, canal stenosis, and/or ossification of the posterior longitudinal ligament.
Wilson JR, Barry S, Fischer DJ, Skelly AC, Arnold PM, Riew KD, Shaffrey CI, Traynelis VC, Fehlings MG
Spine (Phila Pa 1976) 2013 Oct 15;38(22 Suppl 1):S37-54. doi: 10.1097/BRS.0b013e3182a7f2e7. PMID: 23963005

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