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Increased risk of giant cell tumor of bone

MedGen UID:
897988
•Concept ID:
C4227672
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of giant cell tumor of bone

Professional guidelines

PubMed

Preoperative denosumab treatment in patients with giant cell bone tumors in limbs: A retrospective study using propensity score matching.
Huang Y, Xu M, Wang B, Zhao Z, Lin T, Huang G, Yin J, Xie X, Shen J, Zou C
Cancer Med 2023 Jun;12(11):12041-12049. Epub 2023 May 22 doi: 10.1002/cam4.5870. PMID: 37212474Free PMC Article
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment.
Karpik M
Ortop Traumatol Rehabil 2010 May-Jun;12(3):207-15. PMID: 20675862

Recent clinical studies

Etiology

Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.
Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, Tsoi K
Eur J Orthop Surg Traumatol 2023 May;33(4):759-772. Epub 2022 Mar 30 doi: 10.1007/s00590-022-03252-9. PMID: 35377078
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Paget's Disease of Bone.
Gennari L, Rendina D, Falchetti A, Merlotti D
Calcif Tissue Int 2019 May;104(5):483-500. Epub 2019 Jan 23 doi: 10.1007/s00223-019-00522-3. PMID: 30671590
How safe and effective is denosumab for bone giant cell tumour?
Errani C, Tsukamoto S, Mavrogenis AF
Int Orthop 2017 Nov;41(11):2397-2400. Epub 2017 Jun 23 doi: 10.1007/s00264-017-3536-9. PMID: 28646421
Giant cell tumour of bone in the denosumab era.
van der Heijden L, Dijkstra PDS, Blay JY, Gelderblom H
Eur J Cancer 2017 May;77:75-83. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.021. PMID: 28365529

Diagnosis

Association between preoperative denosumab and the risk of local recurrence in patients with giant cell tumor of bone: A meta-analysis and systematic review.
Sun Z, Wu Z, Zhang L, Jia Q, Zhou Z, Xiao J
J Cancer Res Ther 2023 Feb;19(1):25-33. doi: 10.4103/jcrt.jcrt_1171_22. PMID: 37006039
Depression and anxiety in recurrent giant cell tumor of bone.
Jidveian Popescu M, Stoicea MC, Marinescu I, Cismaşiu RS, Stovicek PO, Tudose C, Ciobanu AM
Rom J Morphol Embryol 2020 Oct-Dec;61(4):1057-1065. doi: 10.47162/RJME.61.4.08. PMID: 34171055Free PMC Article
Paget's Disease of Bone.
Gennari L, Rendina D, Falchetti A, Merlotti D
Calcif Tissue Int 2019 May;104(5):483-500. Epub 2019 Jan 23 doi: 10.1007/s00223-019-00522-3. PMID: 30671590
Preoperative Denosumab With Curettage and Cryotherapy in Giant Cell Tumor of Bone: Is There an Increased Risk of Local Recurrence?
Scoccianti G, Totti F, Scorianz M, Baldi G, Roselli G, Beltrami G, Franchi A, Capanna R, Campanacci DA
Clin Orthop Relat Res 2018 Sep;476(9):1783-1790. doi: 10.1007/s11999.0000000000000104. PMID: 30778015Free PMC Article
Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment.
Karpik M
Ortop Traumatol Rehabil 2010 May-Jun;12(3):207-15. PMID: 20675862

Therapy

Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Preoperative Denosumab Therapy Against Giant Cell Tumor of Bone is Associated with an Increased Risk of Local Recurrence After Curettage Surgery.
Asano N, Saito M, Kobayashi E, Morii T, Kikuta K, Watanabe I, Anazawa U, Takeuchi K, Suzuki Y, Susa M, Nishimoto K, Ishii R, Miyazaki N, Mrioka H, Kawai A, Horiuchi K, Nakayama R
Ann Surg Oncol 2022 Jun;29(6):3992-4000. Epub 2022 Feb 17 doi: 10.1245/s10434-022-11411-9. PMID: 35175454
Paget's Disease of Bone.
Gennari L, Rendina D, Falchetti A, Merlotti D
Calcif Tissue Int 2019 May;104(5):483-500. Epub 2019 Jan 23 doi: 10.1007/s00223-019-00522-3. PMID: 30671590
How safe and effective is denosumab for bone giant cell tumour?
Errani C, Tsukamoto S, Mavrogenis AF
Int Orthop 2017 Nov;41(11):2397-2400. Epub 2017 Jun 23 doi: 10.1007/s00264-017-3536-9. PMID: 28646421
Giant cell tumour of bone in the denosumab era.
van der Heijden L, Dijkstra PDS, Blay JY, Gelderblom H
Eur J Cancer 2017 May;77:75-83. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.021. PMID: 28365529

Prognosis

Giant cell tumor of bone with secondary aneurysmal bone cyst does not have a higher risk of local recurrence.
Tsukamoto S, Aiba H, Righi A, Nitta Y, Traversari M, Mavrogenis AF, Honoki K, Tanaka Y, Donati DM, Errani C
J Surg Oncol 2023 Aug;128(2):350-358. Epub 2023 Apr 13 doi: 10.1002/jso.27283. PMID: 37053028
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Clinical and Radiologic Response of Central Giant Cell Granuloma to Denosumab: A 6-Year Prospective Observational Study.
Rhou YJJ, Wang CJ, Nguyen M, Vanderniet JA, Munns CF, Coleman H, Kim J, Holmes-Walker DJ, Lim L, Girgis CM
Calcif Tissue Int 2022 Apr;110(4):464-474. Epub 2022 Jan 28 doi: 10.1007/s00223-021-00935-z. PMID: 35088118
Giant cell tumor of bone - Analysis of 213 cases involving extra-craniofacial bones.
Konishi E, Outani H, Mano M, Nagata S, Shirai T, Naka N, Hori Y, Takenaka S, Haga H, Toguchida J, Kakunaga S, Kuwae Y, Hoshi M, Inoue T, Aono M, Morinaga Y, Nakashima Y
Pathol Int 2021 Aug;71(8):500-511. Epub 2021 Jun 14 doi: 10.1111/pin.13107. PMID: 34125982Free PMC Article
Circulating Candidate Biomarkers in Giant Cell Tumors of Bone.
Conti A, Luchini A, Benassi MS, Magagnoli G, Pierini M, Piccinni-Leopardi M, Quattrini I, Pollino S, Picci P, Liotta LA, Pazzaglia L
Proteomics Clin Appl 2018 Nov;12(6):e1800041. Epub 2018 Aug 28 doi: 10.1002/prca.201800041. PMID: 30054970

Clinical prediction guides

Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.
Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, Tsoi K
Eur J Orthop Surg Traumatol 2023 May;33(4):759-772. Epub 2022 Mar 30 doi: 10.1007/s00590-022-03252-9. PMID: 35377078
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Clinical and Radiologic Response of Central Giant Cell Granuloma to Denosumab: A 6-Year Prospective Observational Study.
Rhou YJJ, Wang CJ, Nguyen M, Vanderniet JA, Munns CF, Coleman H, Kim J, Holmes-Walker DJ, Lim L, Girgis CM
Calcif Tissue Int 2022 Apr;110(4):464-474. Epub 2022 Jan 28 doi: 10.1007/s00223-021-00935-z. PMID: 35088118
Giant cell tumor of bone - Analysis of 213 cases involving extra-craniofacial bones.
Konishi E, Outani H, Mano M, Nagata S, Shirai T, Naka N, Hori Y, Takenaka S, Haga H, Toguchida J, Kakunaga S, Kuwae Y, Hoshi M, Inoue T, Aono M, Morinaga Y, Nakashima Y
Pathol Int 2021 Aug;71(8):500-511. Epub 2021 Jun 14 doi: 10.1111/pin.13107. PMID: 34125982Free PMC Article
Circulating Candidate Biomarkers in Giant Cell Tumors of Bone.
Conti A, Luchini A, Benassi MS, Magagnoli G, Pierini M, Piccinni-Leopardi M, Quattrini I, Pollino S, Picci P, Liotta LA, Pazzaglia L
Proteomics Clin Appl 2018 Nov;12(6):e1800041. Epub 2018 Aug 28 doi: 10.1002/prca.201800041. PMID: 30054970

Recent systematic reviews

Association between preoperative denosumab and the risk of local recurrence in patients with giant cell tumor of bone: A meta-analysis and systematic review.
Sun Z, Wu Z, Zhang L, Jia Q, Zhou Z, Xiao J
J Cancer Res Ther 2023 Feb;19(1):25-33. doi: 10.4103/jcrt.jcrt_1171_22. PMID: 37006039
Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.
Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, Tsoi K
Eur J Orthop Surg Traumatol 2023 May;33(4):759-772. Epub 2022 Mar 30 doi: 10.1007/s00590-022-03252-9. PMID: 35377078
Pre-operative denosumab is associated with higher risk of local recurrence in giant cell tumor of bone: a systematic review and meta-analysis.
Chen X, Li H, Zhu S, Wang Y, Qian W
BMC Musculoskelet Disord 2020 Apr 20;21(1):256. doi: 10.1186/s12891-020-03294-2. PMID: 32312263Free PMC Article
Is Treatment with Denosumab Associated with Local Recurrence in Patients with Giant Cell Tumor of Bone Treated with Curettage? A Systematic Review.
Tsukamoto S, Tanaka Y, Mavrogenis AF, Kido A, Kawaguchi M, Errani C
Clin Orthop Relat Res 2020 May;478(5):1076-1085. doi: 10.1097/CORR.0000000000001074. PMID: 31794487Free PMC Article
Increased Risk of Lung Metastases in Patients with Giant Cell Bone Tumors: A Systematic Review.
Yayan J
Adv Exp Med Biol 2019;1176:1-17. doi: 10.1007/5584_2019_372. PMID: 30989587

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